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The map label for this gene is hemH

Identifier: 89052784

GI number: 89052784

Start: 300891

End: 302003

Strand: Reverse

Name: hemH

Synonym: Jann_0293

Alternate gene names: 89052784

Gene position: 302003-300891 (Counterclockwise)

Preceding gene: 89052785

Following gene: 89052780

Centisome position: 6.99

GC content: 58.85

Gene sequence:

>1113_bases
ATGAACATGATGCCAGCCGGAGATGCGCCAGCACTGATGGATACAGATGCGCCAGCTTTGACGACGACGGATGCGCCAGC
CCTCGCCCACGCGCCCTCGGACCACCCTCGGGTGAAAATGGGGAAGGTGGGTGTGCTTCTGGCCAATCTCGGCACGCCGG
ACAATTACGACTATTGGTCCATGCGCCGCTATCTGAACGAGTTTCTCAGTGACAAGCGCGTCATCGACTACAGCCCGTGG
ATCTGGCAGCCATTGCTGCAACTGGTGATCCTGAGCAAACGCCCGTTCAGCTCGGGCGCGGCATATAAATCGATCTGGAA
TCATGAGGCCGGTGAATCGCCCCTGGCCACGATCACCAAGGACCAGACCGCAAAGATGAAGGCGTTGATGGCCGACCGGT
ACGGCGACGATGTCGTGGTCGATTACTGCATGCGCTACGGCAACCCGTCCACCAAGTCGAAGGTGGATGAACTTGTCGCC
CAGGGCTGTACCAAGATCCTGTTTTTCCCGCTTTACCCGCAATATGCGGGCGCGACCTCGGCCACCGCGTGTGATCAGTT
CTTCCGCTCGCTGGAGAACATCAAATGGCAGCCGCAGGTGCGCACGGTGGAGCCCTATTATGCCAACCCGCTCTATATCG
ACGCGCTGGCGCAATCGATTGAGCGGGCCTACGCCGCGATGGACGTGAAGCCCGATCTTCTGGTGACCAGCTACCATGGC
GTGCCGAAGCGGTATTTGATGGAGGGCGACCCCTATCATTGCCAATGCCAGAAGACCTCACGCCTGTTGAAAGAGCGTCT
GGGGTGGGACGACACGCAGATCGTCACGACCTTTCAATCGAAATTCGGTCCCGAGGAATGGCTTCAGCCCTACACGGTGG
AAGAGGTCGCGCGGCTGGCTGAGAAGGGCAAGAAACGCATCGCCGTCTGTGCGCCCGCATTCTCTGCCGATTGCATCGAG
ACACTGGAAGAGATCAACGAAGAGATTCGCGAGAGTTTCGAGGAAGCGGGCGGCGAGAGCTTCACGTATATCCCATGCCT
CAACGACGATGACGCGCATATGAACGCGTTGGCCACTGTGGTGGACGACAACCTGCGTGGTTGGATCGGCTAA

Upstream 100 bases:

>100_bases
CAGCGACATCTCGTTTAGCGGATGCTCTGGGCACCACGGAATTTGACGAGGGGGCCAATCCGGTCCATGACCTCCCCGAC
GACGAAAGTTTGAAACAGAC

Downstream 100 bases:

>100_bases
GATTTTTTCGCCATCATCACGACAGGAAAAAGCGGGCCGGACGGTCCGCTTTATTTTTGAGATATCAGAAAGTTTATGTG
CAGTTAGGCCGCTTGCGCGT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNMMPAGDAPALMDTDAPALTTTDAPALAHAPSDHPRVKMGKVGVLLANLGTPDNYDYWSMRRYLNEFLSDKRVIDYSPW
IWQPLLQLVILSKRPFSSGAAYKSIWNHEAGESPLATITKDQTAKMKALMADRYGDDVVVDYCMRYGNPSTKSKVDELVA
QGCTKILFFPLYPQYAGATSATACDQFFRSLENIKWQPQVRTVEPYYANPLYIDALAQSIERAYAAMDVKPDLLVTSYHG
VPKRYLMEGDPYHCQCQKTSRLLKERLGWDDTQIVTTFQSKFGPEEWLQPYTVEEVARLAEKGKKRIAVCAPAFSADCIE
TLEEINEEIRESFEEAGGESFTYIPCLNDDDAHMNALATVVDDNLRGWIG

Sequences:

>Translated_370_residues
MNMMPAGDAPALMDTDAPALTTTDAPALAHAPSDHPRVKMGKVGVLLANLGTPDNYDYWSMRRYLNEFLSDKRVIDYSPW
IWQPLLQLVILSKRPFSSGAAYKSIWNHEAGESPLATITKDQTAKMKALMADRYGDDVVVDYCMRYGNPSTKSKVDELVA
QGCTKILFFPLYPQYAGATSATACDQFFRSLENIKWQPQVRTVEPYYANPLYIDALAQSIERAYAAMDVKPDLLVTSYHG
VPKRYLMEGDPYHCQCQKTSRLLKERLGWDDTQIVTTFQSKFGPEEWLQPYTVEEVARLAEKGKKRIAVCAPAFSADCIE
TLEEINEEIRESFEEAGGESFTYIPCLNDDDAHMNALATVVDDNLRGWIG
>Mature_370_residues
MNMMPAGDAPALMDTDAPALTTTDAPALAHAPSDHPRVKMGKVGVLLANLGTPDNYDYWSMRRYLNEFLSDKRVIDYSPW
IWQPLLQLVILSKRPFSSGAAYKSIWNHEAGESPLATITKDQTAKMKALMADRYGDDVVVDYCMRYGNPSTKSKVDELVA
QGCTKILFFPLYPQYAGATSATACDQFFRSLENIKWQPQVRTVEPYYANPLYIDALAQSIERAYAAMDVKPDLLVTSYHG
VPKRYLMEGDPYHCQCQKTSRLLKERLGWDDTQIVTTFQSKFGPEEWLQPYTVEEVARLAEKGKKRIAVCAPAFSADCIE
TLEEINEEIRESFEEAGGESFTYIPCLNDDDAHMNALATVVDDNLRGWIG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=347, Percent_Identity=25.9365994236311, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI60499025, Length=341, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786681, Length=324, Percent_Identity=42.5925925925926, Blast_Score=244, Evalue=5e-66,
Organism=Drosophila melanogaster, GI17864156, Length=344, Percent_Identity=26.1627906976744, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=25.2788104089219, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 41619; Mature: 41619

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01164 COPPER_AMINE_OXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMMPAGDAPALMDTDAPALTTTDAPALAHAPSDHPRVKMGKVGVLLANLGTPDNYDYWS
CCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCHHH
MRRYLNEFLSDKRVIDYSPWIWQPLLQLVILSKRPFSSGAAYKSIWNHEAGESPLATITK
HHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEECCC
DQTAKMKALMADRYGDDVVVDYCMRYGNPSTKSKVDELVAQGCTKILFFPLYPQYAGATS
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCHHHEEEEECCCCCCCCCC
ATACDQFFRSLENIKWQPQVRTVEPYYANPLYIDALAQSIERAYAAMDVKPDLLVTSYHG
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCC
VPKRYLMEGDPYHCQCQKTSRLLKERLGWDDTQIVTTFQSKFGPEEWLQPYTVEEVARLA
CCHHHHCCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
EKGKKRIAVCAPAFSADCIETLEEINEEIRESFEEAGGESFTYIPCLNDDDAHMNALATV
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHH
VDDNLRGWIG
HHCCCCCCCC
>Mature Secondary Structure
MNMMPAGDAPALMDTDAPALTTTDAPALAHAPSDHPRVKMGKVGVLLANLGTPDNYDYWS
CCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCHHH
MRRYLNEFLSDKRVIDYSPWIWQPLLQLVILSKRPFSSGAAYKSIWNHEAGESPLATITK
HHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEECCC
DQTAKMKALMADRYGDDVVVDYCMRYGNPSTKSKVDELVAQGCTKILFFPLYPQYAGATS
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCHHHEEEEECCCCCCCCCC
ATACDQFFRSLENIKWQPQVRTVEPYYANPLYIDALAQSIERAYAAMDVKPDLLVTSYHG
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCC
VPKRYLMEGDPYHCQCQKTSRLLKERLGWDDTQIVTTFQSKFGPEEWLQPYTVEEVARLA
CCHHHHCCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
EKGKKRIAVCAPAFSADCIETLEEINEEIRESFEEAGGESFTYIPCLNDDDAHMNALATV
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHH
VDDNLRGWIG
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592455 [H]