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The map label for this gene is hrcA

Identifier: 89052698

GI number: 89052698

Start: 198317

End: 199381

Strand: Direct

Name: hrcA

Synonym: Jann_0207

Alternate gene names: 89052698

Gene position: 198317-199381 (Clockwise)

Preceding gene: 89052694

Following gene: 89052699

Centisome position: 4.59

GC content: 57.56

Gene sequence:

>1065_bases
ATGACGGACCAAGGCAAAATCCTGGACGATCTCAATGACCGCTCGCGAGAGGTCTTTCGCCGTGTGGTTGAAGGGTATCT
GGAGACCGGTGCGCCCGTCGGATCGAGAACGTTGACGCGGACATTGTCCGAGAATGTCTCTGCCGCGACGGTTCGGAATA
CGATGCAGGACCTGGAGCATATGGGCCTTCTGGATAGCCCTCATTCTTCCGCGGGTCGCATGCCAACGCAACAGGGTCTG
CGCATGTTCGTCGATGGGTTTCTTGAGGTTGGTGATCTGTCCCGCGACGATAAGCGAGCGCTCGACGACACAATGGGCGA
CAATGCGACAGACGTCTCTGGCCTGCTGGACAGGGTCGGTTCTGCTCTCTCTTCCGCGACCCATGGGGCAAGTCTTGTCC
TGACCCCAAAGCATGAAGCGCCGATCCAACATATCGAGTTTGTGACGCTGTCGGCGACGCAATGCCTTGTGGTTCTCGTC
TTCTCCGACGGCCATGTGGAGAATCGTTTGTTCACCCCACCCGCTGGCATGACGCAAAGCGCGATGCGGGAGGCCGCGAA
TTTCCTGAATGCGCGGATCGAAGGGCAGACTGTCAGCACAATCCGGGCGCAGCTGGAGGTCGATATCGAAACCCGCAGGC
GCGAGATTGATGACCTGGCCTCGGGTCTGATCGATTCGGGCCTCGCCGTTTGGGATGGAACCGGCGATAACACGGCGCGG
TTGATTGTGCGGGGGCGGTCGAATCTCCTCTCTGACAGTCAGGAATCCGAGGATCTCGATCGTATTCGACAGCTTTTCGA
CGATCTCGAACGCAAGCGTGACATCACCGAATTCCTTGAACTGACGGAAGATGGCGACGGTGTGCGCATTTTCATTGGCT
CAGAGAACAAGTTGTTCTCACTTTCGGGTTCCTCTCTGGTGGTGTCTCCCTATATGAACTCTGATCGAAAGATCGTCGGA
GCGGTCGGGGTCATTGGTCCCACCCGTCTGAACTACGGACGCATCGTTCCGATTGTGGATTACACGGCGCAGCTAGTTGG
ACGGCTGATTTCCGACCGGTCCTGA

Upstream 100 bases:

>100_bases
AAATATCTCCTGATACATGCTGAGTTTGGTGCAGTCGGGATAGTCCGGCGCGCCCGCATTCTGCAACCCCGAACGCTGCG
AAACCTGACTGTAGATTGAC

Downstream 100 bases:

>100_bases
GAGGCCAAAGAGGGTATAATGGGCGAGAGAGACGACGAATTTTATGAAGATCAGACGGCGGATGCTCAGGACAAGGCGGA
TGTTTCGCTTGCGCCAGAGG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTDQGKILDDLNDRSREVFRRVVEGYLETGAPVGSRTLTRTLSENVSAATVRNTMQDLEHMGLLDSPHSSAGRMPTQQGL
RMFVDGFLEVGDLSRDDKRALDDTMGDNATDVSGLLDRVGSALSSATHGASLVLTPKHEAPIQHIEFVTLSATQCLVVLV
FSDGHVENRLFTPPAGMTQSAMREAANFLNARIEGQTVSTIRAQLEVDIETRRREIDDLASGLIDSGLAVWDGTGDNTAR
LIVRGRSNLLSDSQESEDLDRIRQLFDDLERKRDITEFLELTEDGDGVRIFIGSENKLFSLSGSSLVVSPYMNSDRKIVG
AVGVIGPTRLNYGRIVPIVDYTAQLVGRLISDRS

Sequences:

>Translated_354_residues
MTDQGKILDDLNDRSREVFRRVVEGYLETGAPVGSRTLTRTLSENVSAATVRNTMQDLEHMGLLDSPHSSAGRMPTQQGL
RMFVDGFLEVGDLSRDDKRALDDTMGDNATDVSGLLDRVGSALSSATHGASLVLTPKHEAPIQHIEFVTLSATQCLVVLV
FSDGHVENRLFTPPAGMTQSAMREAANFLNARIEGQTVSTIRAQLEVDIETRRREIDDLASGLIDSGLAVWDGTGDNTAR
LIVRGRSNLLSDSQESEDLDRIRQLFDDLERKRDITEFLELTEDGDGVRIFIGSENKLFSLSGSSLVVSPYMNSDRKIVG
AVGVIGPTRLNYGRIVPIVDYTAQLVGRLISDRS
>Mature_353_residues
TDQGKILDDLNDRSREVFRRVVEGYLETGAPVGSRTLTRTLSENVSAATVRNTMQDLEHMGLLDSPHSSAGRMPTQQGLR
MFVDGFLEVGDLSRDDKRALDDTMGDNATDVSGLLDRVGSALSSATHGASLVLTPKHEAPIQHIEFVTLSATQCLVVLVF
SDGHVENRLFTPPAGMTQSAMREAANFLNARIEGQTVSTIRAQLEVDIETRRREIDDLASGLIDSGLAVWDGTGDNTARL
IVRGRSNLLSDSQESEDLDRIRQLFDDLERKRDITEFLELTEDGDGVRIFIGSENKLFSLSGSSLVVSPYMNSDRKIVGA
VGVIGPTRLNYGRIVPIVDYTAQLVGRLISDRS

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 38765; Mature: 38634

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00136 SUBTILASE_ASP ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQGKILDDLNDRSREVFRRVVEGYLETGAPVGSRTLTRTLSENVSAATVRNTMQDLEH
CCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
MGLLDSPHSSAGRMPTQQGLRMFVDGFLEVGDLSRDDKRALDDTMGDNATDVSGLLDRVG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
SALSSATHGASLVLTPKHEAPIQHIEFVTLSATQCLVVLVFSDGHVENRLFTPPAGMTQS
HHHHHHCCCCEEEEECCCCCCHHHHEEEEEECCCEEEEEEECCCCCCCEEECCCCCCHHH
AMREAANFLNARIEGQTVSTIRAQLEVDIETRRREIDDLASGLIDSGLAVWDGTGDNTAR
HHHHHHHHHHHHCCCCHHHHHHHHHEECHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEE
LIVRGRSNLLSDSQESEDLDRIRQLFDDLERKRDITEFLELTEDGDGVRIFIGSENKLFS
EEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEE
LSGSSLVVSPYMNSDRKIVGAVGVIGPTRLNYGRIVPIVDYTAQLVGRLISDRS
ECCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDQGKILDDLNDRSREVFRRVVEGYLETGAPVGSRTLTRTLSENVSAATVRNTMQDLEH
CCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
MGLLDSPHSSAGRMPTQQGLRMFVDGFLEVGDLSRDDKRALDDTMGDNATDVSGLLDRVG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
SALSSATHGASLVLTPKHEAPIQHIEFVTLSATQCLVVLVFSDGHVENRLFTPPAGMTQS
HHHHHHCCCCEEEEECCCCCCHHHHEEEEEECCCEEEEEEECCCCCCCEEECCCCCCHHH
AMREAANFLNARIEGQTVSTIRAQLEVDIETRRREIDDLASGLIDSGLAVWDGTGDNTAR
HHHHHHHHHHHHCCCCHHHHHHHHHEECHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEE
LIVRGRSNLLSDSQESEDLDRIRQLFDDLERKRDITEFLELTEDGDGVRIFIGSENKLFS
EEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEE
LSGSSLVVSPYMNSDRKIVGAVGVIGPTRLNYGRIVPIVDYTAQLVGRLISDRS
ECCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]