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The map label for this gene is hslU

Identifier: 89052678

GI number: 89052678

Start: 179780

End: 181096

Strand: Direct

Name: hslU

Synonym: Jann_0187

Alternate gene names: 89052678

Gene position: 179780-181096 (Clockwise)

Preceding gene: 89052677

Following gene: 89052679

Centisome position: 4.16

GC content: 59.23

Gene sequence:

>1317_bases
ATGAGTGATCTGACCCCCCGCGAAATCGTCTCGGAACTTGACCGGTTCATCATTGGCCAGTCCGACGCCAAACGCGCCGT
GGCCGTGGCCTTGCGCAATCGGTGGCGGCGCAAGCAATTGGGCGATGACCTGCGCGACGAAGTCTACCCGAAGAATATCC
TGATGATTGGGCCCACAGGCGTCGGCAAGACCGAAATCTCTCGCCGTCTGGCAAAGCTCGCCAAAGCCCCGTTCATCAAG
GTGGAGGCCACGAAATTCACCGAAGTGGGCTATGTCGGACGTGATGTGGAACAGATCATCCGCGATCTGGTTGACGCCGC
CCAGGTCATGATCCGAGAAAACATGCGCGAAGAGGTTAAAGCCAAGGCCCATGACGCGGCAGAGGAGCGTGTGATCGAAG
CGCTCGCCGGAAAAGACGCCCGCGAACAGACCCGTGACATGTTCCGCAAGAAACTCCGCGCCGGAGAGTTGGACGATACC
GTGATCGAGCTGGAAGTGGCCGACAATTCCAACCCCCTAGGCGGGTTCGAGATCCCCAGCCAACCGGGCGGTATGGGTGG
CATGGGTCCGGGCATGATGAACCTGGGAGATCTGTTCAAAGGTATGGGCGGGCGCACGGTGAAGCGACGCCTGACGGTCG
CCGCAAGCTATGATTTGCTGATCGAAGACGAGGCCGACAAACTGCTGGACGCGGAAACCGTCACGAAGGAGGCACTGAGC
GCGGTGGAGCAAAGCGGGATCGTGTTCATCGACGAGATCGACAAGGTCTGTGCCAAGTCCGATGCTCGCGGCGCGGATGT
GTCCCGTGAAGGCGTGCAACGGGATCTGTTGCCACTGATCGAGGGAACGACGGTATCGACCAAGCACGGGCCGGTGAAAA
CGGACCATATCCTGTTTATCGCATCGGGCGCGTTTCACATTGCCAAGCCCTCGGACCTGTTGCCGGAACTCCAGGGCCGT
TTGCCGATCCGCGTCAATCTGCGCGCGCTCACAGAAGATGACTTTGTACGCATTCTCACGGAAACGGATAATGCGCTGAC
CCGGCAATACACGGCCTTGATGGCCACGGAAGAGGTGGCGGTCGAATTTACCGACGGCGGCATTCGTGCACTGGCCCATA
TCGCGGCGGAGGTGAATGAAAGCGTAGAGAATATCGGCGCGCGCAGGCTCTACACCGTGTTGGAACGGGTGTTTGAAGAG
CTGAGTTTCACCGCGCCAGACCGTTCAGGCGATGCAGTGACCGTGGACGAGGCATTCGTTGAACAGAACCTTGGCGAATT
GACCCGGAGTACGGATCTCAGCCGTTATGTTCTGTGA

Upstream 100 bases:

>100_bases
AACGCCTGCGCGGCGTGATCATGCGGGCGCTTCCCCGCTTTCCTGGAAAAACACGCTTGCCCCCATGGTCTGATCCTGGG
GCAGCAAAGGAGACTCTTGC

Downstream 100 bases:

>100_bases
CAGGTTGCGCTAAAAGGGGCCATGACCCGCGCCAAGATTAATCGACGATCCCTTTTGGCCACGGCCTCCGCGTTGTCACT
GACGGCTTGTGTGCGGGTGC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSDLTPREIVSELDRFIIGQSDAKRAVAVALRNRWRRKQLGDDLRDEVYPKNILMIGPTGVGKTEISRRLAKLAKAPFIK
VEATKFTEVGYVGRDVEQIIRDLVDAAQVMIRENMREEVKAKAHDAAEERVIEALAGKDAREQTRDMFRKKLRAGELDDT
VIELEVADNSNPLGGFEIPSQPGGMGGMGPGMMNLGDLFKGMGGRTVKRRLTVAASYDLLIEDEADKLLDAETVTKEALS
AVEQSGIVFIDEIDKVCAKSDARGADVSREGVQRDLLPLIEGTTVSTKHGPVKTDHILFIASGAFHIAKPSDLLPELQGR
LPIRVNLRALTEDDFVRILTETDNALTRQYTALMATEEVAVEFTDGGIRALAHIAAEVNESVENIGARRLYTVLERVFEE
LSFTAPDRSGDAVTVDEAFVEQNLGELTRSTDLSRYVL

Sequences:

>Translated_438_residues
MSDLTPREIVSELDRFIIGQSDAKRAVAVALRNRWRRKQLGDDLRDEVYPKNILMIGPTGVGKTEISRRLAKLAKAPFIK
VEATKFTEVGYVGRDVEQIIRDLVDAAQVMIRENMREEVKAKAHDAAEERVIEALAGKDAREQTRDMFRKKLRAGELDDT
VIELEVADNSNPLGGFEIPSQPGGMGGMGPGMMNLGDLFKGMGGRTVKRRLTVAASYDLLIEDEADKLLDAETVTKEALS
AVEQSGIVFIDEIDKVCAKSDARGADVSREGVQRDLLPLIEGTTVSTKHGPVKTDHILFIASGAFHIAKPSDLLPELQGR
LPIRVNLRALTEDDFVRILTETDNALTRQYTALMATEEVAVEFTDGGIRALAHIAAEVNESVENIGARRLYTVLERVFEE
LSFTAPDRSGDAVTVDEAFVEQNLGELTRSTDLSRYVL
>Mature_437_residues
SDLTPREIVSELDRFIIGQSDAKRAVAVALRNRWRRKQLGDDLRDEVYPKNILMIGPTGVGKTEISRRLAKLAKAPFIKV
EATKFTEVGYVGRDVEQIIRDLVDAAQVMIRENMREEVKAKAHDAAEERVIEALAGKDAREQTRDMFRKKLRAGELDDTV
IELEVADNSNPLGGFEIPSQPGGMGGMGPGMMNLGDLFKGMGGRTVKRRLTVAASYDLLIEDEADKLLDAETVTKEALSA
VEQSGIVFIDEIDKVCAKSDARGADVSREGVQRDLLPLIEGTTVSTKHGPVKTDHILFIASGAFHIAKPSDLLPELQGRL
PIRVNLRALTEDDFVRILTETDNALTRQYTALMATEEVAVEFTDGGIRALAHIAAEVNESVENIGARRLYTVLERVFEEL
SFTAPDRSGDAVTVDEAFVEQNLGELTRSTDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Homo sapiens, GI7242140, Length=109, Percent_Identity=35.7798165137615, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790366, Length=450, Percent_Identity=59.7777777777778, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI1786642, Length=113, Percent_Identity=44.2477876106195, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_JANSC (Q28W08)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508129.1
- ProteinModelPortal:   Q28W08
- SMR:   Q28W08
- STRING:   Q28W08
- GeneID:   3932624
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0187
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- PhylomeDB:   Q28W08
- ProtClustDB:   PRK05201
- BioCyc:   JSP290400:JANN_0187-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2

EC number: NA

Molecular weight: Translated: 48292; Mature: 48160

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: BINDING 18-18 BINDING 251-251 BINDING 316-316 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLTPREIVSELDRFIIGQSDAKRAVAVALRNRWRRKQLGDDLRDEVYPKNILMIGPTG
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAKAPFIKVEATKFTEVGYVGRDVEQIIRDLVDAAQVMIRENMREEVK
CCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAHDAAEERVIEALAGKDAREQTRDMFRKKLRAGELDDTVIELEVADNSNPLGGFEIPS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCC
QPGGMGGMGPGMMNLGDLFKGMGGRTVKRRLTVAASYDLLIEDEADKLLDAETVTKEALS
CCCCCCCCCCCCCCHHHHHHCCCCHHHHHHEEEEEEEEEEEECCHHHHHHHHHHHHHHHH
AVEQSGIVFIDEIDKVCAKSDARGADVSREGVQRDLLPLIEGTTVSTKHGPVKTDHILFI
HHHHCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEE
ASGAFHIAKPSDLLPELQGRLPIRVNLRALTEDDFVRILTETDNALTRQYTALMATEEVA
ECCCEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHEE
VEFTDGGIRALAHIAAEVNESVENIGARRLYTVLERVFEELSFTAPDRSGDAVTVDEAFV
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHH
EQNLGELTRSTDLSRYVL
HHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
SDLTPREIVSELDRFIIGQSDAKRAVAVALRNRWRRKQLGDDLRDEVYPKNILMIGPTG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAKAPFIKVEATKFTEVGYVGRDVEQIIRDLVDAAQVMIRENMREEVK
CCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAHDAAEERVIEALAGKDAREQTRDMFRKKLRAGELDDTVIELEVADNSNPLGGFEIPS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCC
QPGGMGGMGPGMMNLGDLFKGMGGRTVKRRLTVAASYDLLIEDEADKLLDAETVTKEALS
CCCCCCCCCCCCCCHHHHHHCCCCHHHHHHEEEEEEEEEEEECCHHHHHHHHHHHHHHHH
AVEQSGIVFIDEIDKVCAKSDARGADVSREGVQRDLLPLIEGTTVSTKHGPVKTDHILFI
HHHHCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEE
ASGAFHIAKPSDLLPELQGRLPIRVNLRALTEDDFVRILTETDNALTRQYTALMATEEVA
ECCCEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHEE
VEFTDGGIRALAHIAAEVNESVENIGARRLYTVLERVFEELSFTAPDRSGDAVTVDEAFV
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHH
EQNLGELTRSTDLSRYVL
HHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA