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The map label for this gene is dxs2

Identifier: 89052661

GI number: 89052661

Start: 162315

End: 164225

Strand: Reverse

Name: dxs2

Synonym: Jann_0170

Alternate gene names: 89052661

Gene position: 164225-162315 (Counterclockwise)

Preceding gene: 89052662

Following gene: 89052653

Centisome position: 3.8

GC content: 63.11

Gene sequence:

>1911_bases
ATGGACCGCCCACATACCCCCATTCTTGATCAGGTTAACTATCCGTCCGACCTGCGTCGCATGTCCAACGCGGATCTCGC
ACAATGCGCCGATGAGTTGCGGGCCGAAGTCATTTCCGCCGTCTCTGAAACCGGCGGACATCTGGGATCATCGCTTGGCG
TAGTGGAACTTTCAGTCGCCATCCATGCCGTGTTCAACACGCCCTATGACAAGCTGGTTTGGGACGTTGGCCACCAATGC
TACCCCCACAAGGTGCTGACCGGACGGCGGGATCGGATCCGCACGCTGCGCCAGAAGGATGGCCTGTCTGGGTTCACCAA
ACGGTCTGAGTCTGAGTACGATCCGTTTGGCGCTGCGCATTCGTCCACCTCCATCTCTGCCGCGCTTGGCTTTGCCGCCG
CGCAGGATCTTGGCGAGGCAACCGGCGACGGGATCGCGGTCATCGGCGACGGTTCCATCAGCGCGGGCATGGCCTATGAG
GCGCTGAACAACGCGGGCGATCTGGGCAAGCGGCTGTTTGTCATCCTCAACGACAATGAGATGTCGATCGCCCCGCCCGT
GGGTGCCATGTCGAAATACCTCACGGATCTGTCCGCCAAGTCGCCACTCGCGACTCTCAAGGACATCGCGGACGGTGTCG
CCTCCCACCTGCCCGAACCGATCCGCCAAGGGGCCGAACGCGCGCGGGAGCTTGTGACCGGCCACCAACCCTCGGCCACA
TTGTTCGAGCATCTGGGTTTCACCTATATCGGCCCAGTCGACGGCCACGATATGGAAGAGCTGCTGACCACTCTTCGTGC
CGCAAAGGCCCGCGCCACCGGACCCGTCCTGATCCACGCGGTCACCGTGAAGGGGAAGGGATACAGCCCCGCCGAACTGT
CGGACGATTGCTACCACGGCGTCGCCAAGTTTGACGTCGCCACCGGTCAGCAGAAGAAGTCCGCGCCCAATGCACCGAGC
TATACCAGCGTGTTTGGGCAGACCCTGCTGAACATGGCAGAGGCGGACAGCCGCATTGTGGGGGTCACGGCCGCCATGCC
CGGCGGCACCGGTATTTCGACCCTGCAAAAGGCCAAACCCAATCGCGTGTTTGATGTCGGCATTGCCGAGCAGCACGCGG
TCACATTCTCGGCCGGGATGGCCGCCGGTGGCCTGAAACCCTTCTGCGCGATCTATTCCAGTTTCCTCCAGCGGGGTTAT
GACCAGATCGTCCATGATGTGGCTCTGCAAAGCCTGCCCGTCCGCTTCATGATTGACCGCGCGGGCCTGGTTGGTGCCGA
TGGTCCGACCCACGCTGGCGCATTCGACATTGGCTACCTCTCTGCGCTGCCGAATATGACGGTCATGGCCTGCGCCGATG
AGGCGGAGCTTGTCCACATGATGGCAACGGCTGCCGCCCACAACGACGGCCCCATCGCCCTGCGCTATCCGCGTGGGGAG
GGTACGGGCGTGGCGCTGCCAGATCAGGGTGACGTGCTTGAAATCGGCAAAGGTCGTGTGATCCAGGACGGTCACGATGT
CGCTATTCTATCCTTCGGCGCGCATCTGGAGGAGGCGAAGGACGCCGCGACGGCGCTGGAGGCTCGGGGCCTGTCCGTGA
CTGTCGCCGACGCGCGCTTCGCCAAACCGCTGGATACCACGCTGATCGATGATCTGATGACGAAGCACAGCGCGCTGATC
ACGGTAGAGCAGGGGGCCGTGTTGGGGTTTGGCGGCCTCGTCCTGCACCATCTGGCCGCGACTGGTCAGCTGGATGGACG
CTGCGCCGTGCGGACATTGCACCTGCCCGACCGCTTCATTGATCAGGCAAGCCCCGCCGAGATGTATGCAGATGCGGGCC
TGACCGCCGATGACATCGCCCAAGCTGCACTAGAGGCGATGGGTGTTGAGGTTCTGGCCGCGCGGGCGTGA

Upstream 100 bases:

>100_bases
CTGCTGCTTTTCCCGGGGGATGTCAGACCCCTCCGGCGCTACCCGGAATACGGTCGTTTCAGTCTCAAACGTGCGTATTC
GAGACAAAGGAATGACCCAA

Downstream 100 bases:

>100_bases
TCACCCGGCACCCTGGTGAACGACGATGATTTGAGGCGTTCCACCGAAGCCAAAAATCTCGACAAAGATATAAGCCTGAT
GCCCTTGAACGACCCGGTTC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 2; DXP synthase 2; DXPS 2

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MDRPHTPILDQVNYPSDLRRMSNADLAQCADELRAEVISAVSETGGHLGSSLGVVELSVAIHAVFNTPYDKLVWDVGHQC
YPHKVLTGRRDRIRTLRQKDGLSGFTKRSESEYDPFGAAHSSTSISAALGFAAAQDLGEATGDGIAVIGDGSISAGMAYE
ALNNAGDLGKRLFVILNDNEMSIAPPVGAMSKYLTDLSAKSPLATLKDIADGVASHLPEPIRQGAERARELVTGHQPSAT
LFEHLGFTYIGPVDGHDMEELLTTLRAAKARATGPVLIHAVTVKGKGYSPAELSDDCYHGVAKFDVATGQQKKSAPNAPS
YTSVFGQTLLNMAEADSRIVGVTAAMPGGTGISTLQKAKPNRVFDVGIAEQHAVTFSAGMAAGGLKPFCAIYSSFLQRGY
DQIVHDVALQSLPVRFMIDRAGLVGADGPTHAGAFDIGYLSALPNMTVMACADEAELVHMMATAAAHNDGPIALRYPRGE
GTGVALPDQGDVLEIGKGRVIQDGHDVAILSFGAHLEEAKDAATALEARGLSVTVADARFAKPLDTTLIDDLMTKHSALI
TVEQGAVLGFGGLVLHHLAATGQLDGRCAVRTLHLPDRFIDQASPAEMYADAGLTADDIAQAALEAMGVEVLAARA

Sequences:

>Translated_636_residues
MDRPHTPILDQVNYPSDLRRMSNADLAQCADELRAEVISAVSETGGHLGSSLGVVELSVAIHAVFNTPYDKLVWDVGHQC
YPHKVLTGRRDRIRTLRQKDGLSGFTKRSESEYDPFGAAHSSTSISAALGFAAAQDLGEATGDGIAVIGDGSISAGMAYE
ALNNAGDLGKRLFVILNDNEMSIAPPVGAMSKYLTDLSAKSPLATLKDIADGVASHLPEPIRQGAERARELVTGHQPSAT
LFEHLGFTYIGPVDGHDMEELLTTLRAAKARATGPVLIHAVTVKGKGYSPAELSDDCYHGVAKFDVATGQQKKSAPNAPS
YTSVFGQTLLNMAEADSRIVGVTAAMPGGTGISTLQKAKPNRVFDVGIAEQHAVTFSAGMAAGGLKPFCAIYSSFLQRGY
DQIVHDVALQSLPVRFMIDRAGLVGADGPTHAGAFDIGYLSALPNMTVMACADEAELVHMMATAAAHNDGPIALRYPRGE
GTGVALPDQGDVLEIGKGRVIQDGHDVAILSFGAHLEEAKDAATALEARGLSVTVADARFAKPLDTTLIDDLMTKHSALI
TVEQGAVLGFGGLVLHHLAATGQLDGRCAVRTLHLPDRFIDQASPAEMYADAGLTADDIAQAALEAMGVEVLAARA
>Mature_636_residues
MDRPHTPILDQVNYPSDLRRMSNADLAQCADELRAEVISAVSETGGHLGSSLGVVELSVAIHAVFNTPYDKLVWDVGHQC
YPHKVLTGRRDRIRTLRQKDGLSGFTKRSESEYDPFGAAHSSTSISAALGFAAAQDLGEATGDGIAVIGDGSISAGMAYE
ALNNAGDLGKRLFVILNDNEMSIAPPVGAMSKYLTDLSAKSPLATLKDIADGVASHLPEPIRQGAERARELVTGHQPSAT
LFEHLGFTYIGPVDGHDMEELLTTLRAAKARATGPVLIHAVTVKGKGYSPAELSDDCYHGVAKFDVATGQQKKSAPNAPS
YTSVFGQTLLNMAEADSRIVGVTAAMPGGTGISTLQKAKPNRVFDVGIAEQHAVTFSAGMAAGGLKPFCAIYSSFLQRGY
DQIVHDVALQSLPVRFMIDRAGLVGADGPTHAGAFDIGYLSALPNMTVMACADEAELVHMMATAAAHNDGPIALRYPRGE
GTGVALPDQGDVLEIGKGRVIQDGHDVAILSFGAHLEEAKDAATALEARGLSVTVADARFAKPLDTTLIDDLMTKHSALI
TVEQGAVLGFGGLVLHHLAATGQLDGRCAVRTLHLPDRFIDQASPAEMYADAGLTADDIAQAALEAMGVEVLAARA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=424, Percent_Identity=25.4716981132075, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI4507521, Length=424, Percent_Identity=25.4716981132075, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI133778974, Length=459, Percent_Identity=24.400871459695, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI225637459, Length=364, Percent_Identity=23.9010989010989, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI225637461, Length=364, Percent_Identity=23.9010989010989, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI225637463, Length=456, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786622, Length=610, Percent_Identity=47.7049180327869, Blast_Score=554, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17539652, Length=350, Percent_Identity=26.8571428571429, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24645119, Length=437, Percent_Identity=25.629290617849, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551847, Length=437, Percent_Identity=25.629290617849, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45550715, Length=437, Percent_Identity=25.629290617849, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24666278, Length=429, Percent_Identity=24.9417249417249, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS2_JANSC (Q28W25)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508112.1
- ProteinModelPortal:   Q28W25
- SMR:   Q28W25
- STRING:   Q28W25
- GeneID:   3932607
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0170
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   HATPDES
- PhylomeDB:   Q28W25
- ProtClustDB:   PRK12571
- BioCyc:   JSP290400:JANN_0170-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 66801; Mature: 66801

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRPHTPILDQVNYPSDLRRMSNADLAQCADELRAEVISAVSETGGHLGSSLGVVELSVA
CCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHH
IHAVFNTPYDKLVWDVGHQCYPHKVLTGRRDRIRTLRQKDGLSGFTKRSESEYDPFGAAH
HHHHHCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCC
SSTSISAALGFAAAQDLGEATGDGIAVIGDGSISAGMAYEALNNAGDLGKRLFVILNDNE
CCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCHHCCCCEEEEEECCCC
MSIAPPVGAMSKYLTDLSAKSPLATLKDIADGVASHLPEPIRQGAERARELVTGHQPSAT
CEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHH
LFEHLGFTYIGPVDGHDMEELLTTLRAAKARATGPVLIHAVTVKGKGYSPAELSDDCYHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCHHHHC
VAKFDVATGQQKKSAPNAPSYTSVFGQTLLNMAEADSRIVGVTAAMPGGTGISTLQKAKP
HHHEEECCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCC
NRVFDVGIAEQHAVTFSAGMAAGGLKPFCAIYSSFLQRGYDQIVHDVALQSLPVRFMIDR
CCEEEECCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEC
AGLVGADGPTHAGAFDIGYLSALPNMTVMACADEAELVHMMATAAAHNDGPIALRYPRGE
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCC
GTGVALPDQGDVLEIGKGRVIQDGHDVAILSFGAHLEEAKDAATALEARGLSVTVADARF
CCEEECCCCCCEEECCCCCEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCHH
AKPLDTTLIDDLMTKHSALITVEQGAVLGFGGLVLHHLAATGQLDGRCAVRTLHLPDRFI
CCCHHHHHHHHHHHCCCEEEEEECCCEEEHHHHHHHHHHHCCCCCCCEEEEEEECCHHHH
DQASPAEMYADAGLTADDIAQAALEAMGVEVLAARA
CCCCCHHHHHHCCCCHHHHHHHHHHHHCHHHHEECC
>Mature Secondary Structure
MDRPHTPILDQVNYPSDLRRMSNADLAQCADELRAEVISAVSETGGHLGSSLGVVELSVA
CCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHH
IHAVFNTPYDKLVWDVGHQCYPHKVLTGRRDRIRTLRQKDGLSGFTKRSESEYDPFGAAH
HHHHHCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCC
SSTSISAALGFAAAQDLGEATGDGIAVIGDGSISAGMAYEALNNAGDLGKRLFVILNDNE
CCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCHHCCCCEEEEEECCCC
MSIAPPVGAMSKYLTDLSAKSPLATLKDIADGVASHLPEPIRQGAERARELVTGHQPSAT
CEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHH
LFEHLGFTYIGPVDGHDMEELLTTLRAAKARATGPVLIHAVTVKGKGYSPAELSDDCYHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCHHHHC
VAKFDVATGQQKKSAPNAPSYTSVFGQTLLNMAEADSRIVGVTAAMPGGTGISTLQKAKP
HHHEEECCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCC
NRVFDVGIAEQHAVTFSAGMAAGGLKPFCAIYSSFLQRGYDQIVHDVALQSLPVRFMIDR
CCEEEECCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEC
AGLVGADGPTHAGAFDIGYLSALPNMTVMACADEAELVHMMATAAAHNDGPIALRYPRGE
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCC
GTGVALPDQGDVLEIGKGRVIQDGHDVAILSFGAHLEEAKDAATALEARGLSVTVADARF
CCEEECCCCCCEEECCCCCEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCHH
AKPLDTTLIDDLMTKHSALITVEQGAVLGFGGLVLHHLAATGQLDGRCAVRTLHLPDRFI
CCCHHHHHHHHHHHCCCEEEEEECCCEEEHHHHHHHHHHHCCCCCCCEEEEEEECCHHHH
DQASPAEMYADAGLTADDIAQAALEAMGVEVLAARA
CCCCCHHHHHHCCCCHHHHHHHHHHHHCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA