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The map label for this gene is hemA [H]

Identifier: 89052640

GI number: 89052640

Start: 139789

End: 141003

Strand: Reverse

Name: hemA [H]

Synonym: Jann_0149

Alternate gene names: 89052640

Gene position: 141003-139789 (Counterclockwise)

Preceding gene: 89052641

Following gene: 89052639

Centisome position: 3.27

GC content: 60.74

Gene sequence:

>1215_bases
ATGAATTTTGACCAGCTGTTTCAAACCCAGCTCGACGCCCTGAAAGACGAGGGCAACTACCGTGTCTTTGCCGAGTTGGA
GCGCGCTTGCGGCGAATTTCCCCGCGTGAAGAGCCATGGCGACCATGGCCCGGATGAGGTGACAGTCTGGTGTTCCAACG
ATTACCTCGGCATGGGCAACAACCCCAAGGTGATGCAGGTCATGATGGACACTGTGGCCACCTGCGGCACCGGCGCGGGC
GGGACGCGGAATATCTCGGGCAACGCGCATCATCACAAGCTGCTGGAGGCTGAACTCGCCGACCTCCACGGCAAGGAAGC
CGCGTTGCTGTTCACGTCGGGCTATGTGTCGAACTGGGCGTCGCTGTCGACATTGGGTTCTCGCTTGCCCAATGCAGTGA
TCCTGTCCGACAGCCTCAACCACGCCTCCATGATCGAAGGCATTCGCCACGCGAAATGCGACAAGGTGATCTGGAAGCAC
AACGACCCCGAGGATCTGGACCGCAAGCTGGCCGCGCTGCCCGCCAATGCGACGCCCATCGTGGCGTTTGAGAGCGTGTA
TTCCATGGACGGCGATATCGCGCCGATCGCGGCGATCCTGGATGTCTGCGAAAAGCACGGTGCGATGAGCTACATTGATG
AGGTCCACGCCGTTGGCATGTACGGCCCCCGCGGCGGTGGCGTGGCCGAGCAGGACGGCTTGATGGACCGGATCACGCTG
ATCGAGGGGACATTGGGCAAAGCCTTCGGGTGCGTCGGTGGCTACATCACCGGATCCCACGCGCTGATCGATTTCATCCG
GTCCTTCGCGTCCGGTTTTATTTTCACCACGGCGCTGCCGCCTGCTGTGGCGGCCGCTGCCACGGCCTCTGTGAAGCACC
TGAAGGAATCGCAATGGGAACGCGCGATGCAGAAGCGGCAAGTGGCGCGTCTGCGTGCCCGTCTGGATGCCGAGGGGATC
CCCCATGAGCACAACCCGTCCCATATCATCCCCGTGATGGTGAAGGATCCGGTCAAGTGTAAGATGCTGTCCGACATCCT
GATGGACCAGTTCGGCATTTATGTGCAGCCGATCAACTACCCCACCGTGCCCAAGGGAACCGAGCGTCTGCGTTTCACAC
CCGGCCCGCTCCATAGCGATGCGGACATCGAATATCTTGTGATGGCTCTGAAAACGCTGTGGAAGCAGTGCGCGATTGCG
CATGCGGTTGCGTAA

Upstream 100 bases:

>100_bases
GGTTCATGGTGCTTCCGCTGCCCGACGAAAAACTATGGCGCTGGATGCTGCCCGCGCGGCCCCAACCTGCCCAAGCGACA
AGACTAAGCGAGGAAACGTT

Downstream 100 bases:

>100_bases
TGACGCCTAACACCCGAAAAAGTCACAAAAAGGTGTGGACGAACCCGGTGAAACATTAGGTATACAGGGGTGAGCACTTA
ATTAGGGAGACTACCCATGC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNFDQLFQTQLDALKDEGNYRVFAELERACGEFPRVKSHGDHGPDEVTVWCSNDYLGMGNNPKVMQVMMDTVATCGTGAG
GTRNISGNAHHHKLLEAELADLHGKEAALLFTSGYVSNWASLSTLGSRLPNAVILSDSLNHASMIEGIRHAKCDKVIWKH
NDPEDLDRKLAALPANATPIVAFESVYSMDGDIAPIAAILDVCEKHGAMSYIDEVHAVGMYGPRGGGVAEQDGLMDRITL
IEGTLGKAFGCVGGYITGSHALIDFIRSFASGFIFTTALPPAVAAAATASVKHLKESQWERAMQKRQVARLRARLDAEGI
PHEHNPSHIIPVMVKDPVKCKMLSDILMDQFGIYVQPINYPTVPKGTERLRFTPGPLHSDADIEYLVMALKTLWKQCAIA
HAVA

Sequences:

>Translated_404_residues
MNFDQLFQTQLDALKDEGNYRVFAELERACGEFPRVKSHGDHGPDEVTVWCSNDYLGMGNNPKVMQVMMDTVATCGTGAG
GTRNISGNAHHHKLLEAELADLHGKEAALLFTSGYVSNWASLSTLGSRLPNAVILSDSLNHASMIEGIRHAKCDKVIWKH
NDPEDLDRKLAALPANATPIVAFESVYSMDGDIAPIAAILDVCEKHGAMSYIDEVHAVGMYGPRGGGVAEQDGLMDRITL
IEGTLGKAFGCVGGYITGSHALIDFIRSFASGFIFTTALPPAVAAAATASVKHLKESQWERAMQKRQVARLRARLDAEGI
PHEHNPSHIIPVMVKDPVKCKMLSDILMDQFGIYVQPINYPTVPKGTERLRFTPGPLHSDADIEYLVMALKTLWKQCAIA
HAVA
>Mature_404_residues
MNFDQLFQTQLDALKDEGNYRVFAELERACGEFPRVKSHGDHGPDEVTVWCSNDYLGMGNNPKVMQVMMDTVATCGTGAG
GTRNISGNAHHHKLLEAELADLHGKEAALLFTSGYVSNWASLSTLGSRLPNAVILSDSLNHASMIEGIRHAKCDKVIWKH
NDPEDLDRKLAALPANATPIVAFESVYSMDGDIAPIAAILDVCEKHGAMSYIDEVHAVGMYGPRGGGVAEQDGLMDRITL
IEGTLGKAFGCVGGYITGSHALIDFIRSFASGFIFTTALPPAVAAAATASVKHLKESQWERAMQKRQVARLRARLDAEGI
PHEHNPSHIIPVMVKDPVKCKMLSDILMDQFGIYVQPINYPTVPKGTERLRFTPGPLHSDADIEYLVMALKTLWKQCAIA
HAVA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=398, Percent_Identity=47.2361809045226, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI83977440, Length=398, Percent_Identity=47.2361809045226, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI83977444, Length=398, Percent_Identity=47.2361809045226, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=48.1389578163772, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=48.1389578163772, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=34.1968911917098, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI284448556, Length=342, Percent_Identity=36.8421052631579, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI119220554, Length=387, Percent_Identity=27.390180878553, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4758668, Length=364, Percent_Identity=30.4945054945055, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI5454084, Length=282, Percent_Identity=25.531914893617, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1790046, Length=362, Percent_Identity=32.8729281767956, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1786993, Length=343, Percent_Identity=32.6530612244898, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994529, Length=401, Percent_Identity=32.6683291770574, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32566772, Length=366, Percent_Identity=30.0546448087432, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=317, Percent_Identity=27.4447949526814, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17560912, Length=317, Percent_Identity=27.4447949526814, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71982617, Length=256, Percent_Identity=25, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=256, Percent_Identity=25, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=421, Percent_Identity=44.4180522565321, Blast_Score=361, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320267, Length=385, Percent_Identity=26.7532467532467, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323954, Length=253, Percent_Identity=24.5059288537549, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137420, Length=397, Percent_Identity=48.1108312342569, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=33.4190231362468, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI17136286, Length=351, Percent_Identity=26.7806267806268, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24653280, Length=267, Percent_Identity=26.2172284644195, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24653276, Length=267, Percent_Identity=26.2172284644195, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24653278, Length=267, Percent_Identity=26.2172284644195, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 43956; Mature: 43956

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDQLFQTQLDALKDEGNYRVFAELERACGEFPRVKSHGDHGPDEVTVWCSNDYLGMGN
CCHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEECCCC
NPKVMQVMMDTVATCGTGAGGTRNISGNAHHHKLLEAELADLHGKEAALLFTSGYVSNWA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
SLSTLGSRLPNAVILSDSLNHASMIEGIRHAKCDKVIWKHNDPEDLDRKLAALPANATPI
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCE
VAFESVYSMDGDIAPIAAILDVCEKHGAMSYIDEVHAVGMYGPRGGGVAEQDGLMDRITL
EEHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
IEGTLGKAFGCVGGYITGSHALIDFIRSFASGFIFTTALPPAVAAAATASVKHLKESQWE
HHCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RAMQKRQVARLRARLDAEGIPHEHNPSHIIPVMVKDPVKCKMLSDILMDQFGIYVQPINY
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCC
PTVPKGTERLRFTPGPLHSDADIEYLVMALKTLWKQCAIAHAVA
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFDQLFQTQLDALKDEGNYRVFAELERACGEFPRVKSHGDHGPDEVTVWCSNDYLGMGN
CCHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEECCCC
NPKVMQVMMDTVATCGTGAGGTRNISGNAHHHKLLEAELADLHGKEAALLFTSGYVSNWA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
SLSTLGSRLPNAVILSDSLNHASMIEGIRHAKCDKVIWKHNDPEDLDRKLAALPANATPI
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCE
VAFESVYSMDGDIAPIAAILDVCEKHGAMSYIDEVHAVGMYGPRGGGVAEQDGLMDRITL
EEHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
IEGTLGKAFGCVGGYITGSHALIDFIRSFASGFIFTTALPPAVAAAATASVKHLKESQWE
HHCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RAMQKRQVARLRARLDAEGIPHEHNPSHIIPVMVKDPVKCKMLSDILMDQFGIYVQPINY
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCC
PTVPKGTERLRFTPGPLHSDADIEYLVMALKTLWKQCAIAHAVA
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]