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The map label for this gene is polC [H]

Identifier: 89052623

GI number: 89052623

Start: 121202

End: 121792

Strand: Direct

Name: polC [H]

Synonym: Jann_0132

Alternate gene names: 89052623

Gene position: 121202-121792 (Clockwise)

Preceding gene: 89052622

Following gene: 89052624

Centisome position: 2.81

GC content: 59.39

Gene sequence:

>591_bases
GTGAACACCTTCGGCCATCTCCAGTCTGTCCCCGATGGACCGTTTCGCTTCATTGCGGTTGATGTCGAGACGGCAAACAA
CGCCCAGGGCAGCATTTGCCAAATCGGCCTGTGCTGTGTCGGATCGGATGACAGCCTGAACACGGTCTCGACCCTTATCG
ACCCGGAGCAGAGCTTTTCTCCATTCAACACGGATCTTCACGGGATCTCTGCCGAAACGGTCAATGGCGCGCCAACATTC
CCGCAGGCTTACGCGTCGCTCTACCCTGTCCTGAACGCCCATCGTCTTGTGCAGCATTCCCGTTTTGACGAAGCGGCCTT
TACCGCAGCGTGCGCGCGATATGACGTGCCGATGGTGACGTCGCATTGGACGGATAGCGTCAAGATCGCACGACAGGCTT
GGCCCGAGTTGAAGGGCGCGGGCGGTCATGGGTTGGCGAGTCTGAAAAAGGCTCTTGGCCTGTCGTTTCATCACCACGAC
GCCGGTGAAGACGCGCGCGCCTCGGCCACCGTGATCTTGCGGGCAGAGGCTCGCATCAGTAAAGCCGTCGCGCATCTGCG
CTTTGATCCGCAGCTAGCGTTTGAGTTCTAG

Upstream 100 bases:

>100_bases
CCAACACTCAGATCCCTACATCCGCTATGATCCAAGGGGCATCTTGGCGCTCAATGTCACCGATTTGATCCCACCATCGC
GTTCGGGTTACGTTTGAGGC

Downstream 100 bases:

>100_bases
GAGGCGCCATCCCTTGCACCCACTCCTCACCGAGCCGTTGATCACCGAGTTTCAAACCAAAGGTGTCACCGTCATCCGTG
GCCTCTTCGCGGGTCATGTC

Product: exonuclease

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MNTFGHLQSVPDGPFRFIAVDVETANNAQGSICQIGLCCVGSDDSLNTVSTLIDPEQSFSPFNTDLHGISAETVNGAPTF
PQAYASLYPVLNAHRLVQHSRFDEAAFTAACARYDVPMVTSHWTDSVKIARQAWPELKGAGGHGLASLKKALGLSFHHHD
AGEDARASATVILRAEARISKAVAHLRFDPQLAFEF

Sequences:

>Translated_196_residues
MNTFGHLQSVPDGPFRFIAVDVETANNAQGSICQIGLCCVGSDDSLNTVSTLIDPEQSFSPFNTDLHGISAETVNGAPTF
PQAYASLYPVLNAHRLVQHSRFDEAAFTAACARYDVPMVTSHWTDSVKIARQAWPELKGAGGHGLASLKKALGLSFHHHD
AGEDARASATVILRAEARISKAVAHLRFDPQLAFEF
>Mature_196_residues
MNTFGHLQSVPDGPFRFIAVDVETANNAQGSICQIGLCCVGSDDSLNTVSTLIDPEQSFSPFNTDLHGISAETVNGAPTF
PQAYASLYPVLNAHRLVQHSRFDEAAFTAACARYDVPMVTSHWTDSVKIARQAWPELKGAGGHGLASLKKALGLSFHHHD
AGEDARASATVILRAEARISKAVAHLRFDPQLAFEF

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 21119; Mature: 21119

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFGHLQSVPDGPFRFIAVDVETANNAQGSICQIGLCCVGSDDSLNTVSTLIDPEQSFS
CCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCHHCCC
PFNTDLHGISAETVNGAPTFPQAYASLYPVLNAHRLVQHSRFDEAAFTAACARYDVPMVT
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
SHWTDSVKIARQAWPELKGAGGHGLASLKKALGLSFHHHDAGEDARASATVILRAEARIS
CCCCCHHHHHHHHCHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEHHHHH
KAVAHLRFDPQLAFEF
HHHHHHCCCCCEEECC
>Mature Secondary Structure
MNTFGHLQSVPDGPFRFIAVDVETANNAQGSICQIGLCCVGSDDSLNTVSTLIDPEQSFS
CCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCHHCCC
PFNTDLHGISAETVNGAPTFPQAYASLYPVLNAHRLVQHSRFDEAAFTAACARYDVPMVT
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
SHWTDSVKIARQAWPELKGAGGHGLASLKKALGLSFHHHDAGEDARASATVILRAEARIS
CCCCCHHHHHHHHCHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEHHHHH
KAVAHLRFDPQLAFEF
HHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]