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The map label for this gene is ispA [H]

Identifier: 89052580

GI number: 89052580

Start: 84769

End: 85635

Strand: Reverse

Name: ispA [H]

Synonym: Jann_0089

Alternate gene names: 89052580

Gene position: 85635-84769 (Counterclockwise)

Preceding gene: 89052581

Following gene: 89052579

Centisome position: 1.98

GC content: 64.13

Gene sequence:

>867_bases
GTGTTCAAGACGGCGCTGAGGGATGCGCAAACCCGTATCGGCGATTTTCTGACGCGGCAACTGGCGGACCTTGGGGATGA
CACGATCGCCCAGGGGATGCGCTATGCGACGGGCGGCGGCAAACGCCTGCGTGGATTTCTGGCGCTGGAAAGTGCGGCGC
TGTTTGATGTGCCCCCCGGGCAGGCGCTGTACGCGGCGGGGGCTGTGGAATGTCTTCACGCCTATTCCCTGGTGCATGAT
GATCTGCCGTGTATGGACGACGACGACCTGCGTCGGGGGCAACCGACGGTGCATAAGAAATGGGATGACGCGACCGCCGT
TCTGGTCGGCGATGCCCTGCAAACCTTTGCGTTCGAGTTGATCAGCCGCGAGGACGCTGGAACAGCGGAGGAGCGTGTGG
CCCTGACAGCGAGCCTCGCGAAAGCGAGCGGAGCGCAGGGAATGGTTCTGGGCCAGGCCCAGGATATTGCAGCGGAAACC
GCAGGTCGCGCGCTGACCCTGCAAGAGATCACCGGCCTGCAAGCCAACAAGACCGGTCGCCTGATCGAATGGCCCGCCCA
TGCCGGTGCAGTGCTTGGTGGTGCCGATCCCGCGCCTTTGCAGCGCTACGCGCGGGCCATCGGCCTGGCCTTTCAGATCG
CCGATGACATCCTTGATGTCGAAGGGGATGCGGCCAAGGCGGGCAAGGCGCTGCGCAAGGACGCTGATGCCGGGAAAGCC
ACCTTCGTGTCCCTTCTTGGGATGGAGGCGGCCAAGGCCCGTTCGGCAGCGCTTGTCGCAGACGCCACTGCGGCACTGGC
GCCCTACGGCGATAAGGCGCAGACCCTTCGCGATCTGGCGCAGTATATAGTGACTCGTGATAAGTGA

Upstream 100 bases:

>100_bases
TGAGGCGAAGCTGAAAGAGGCGGAAGAAAAGGTCGCGCAGATCACGCTCGACGCCAATGGCCAGCCCACCGGAGCCAAAA
CGGTCGAAGGACTGTAGCAC

Downstream 100 bases:

>100_bases
CCGCAAAGGCCAGCCAACCGCCGAACGCAGCGTGACGCGCGACGGCGGAGAAGGAATAATATGAGTGATCGCCCCTCCAC
CCCGCTCTTGGACAACGTCC

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MFKTALRDAQTRIGDFLTRQLADLGDDTIAQGMRYATGGGKRLRGFLALESAALFDVPPGQALYAAGAVECLHAYSLVHD
DLPCMDDDDLRRGQPTVHKKWDDATAVLVGDALQTFAFELISREDAGTAEERVALTASLAKASGAQGMVLGQAQDIAAET
AGRALTLQEITGLQANKTGRLIEWPAHAGAVLGGADPAPLQRYARAIGLAFQIADDILDVEGDAAKAGKALRKDADAGKA
TFVSLLGMEAAKARSAALVADATAALAPYGDKAQTLRDLAQYIVTRDK

Sequences:

>Translated_288_residues
MFKTALRDAQTRIGDFLTRQLADLGDDTIAQGMRYATGGGKRLRGFLALESAALFDVPPGQALYAAGAVECLHAYSLVHD
DLPCMDDDDLRRGQPTVHKKWDDATAVLVGDALQTFAFELISREDAGTAEERVALTASLAKASGAQGMVLGQAQDIAAET
AGRALTLQEITGLQANKTGRLIEWPAHAGAVLGGADPAPLQRYARAIGLAFQIADDILDVEGDAAKAGKALRKDADAGKA
TFVSLLGMEAAKARSAALVADATAALAPYGDKAQTLRDLAQYIVTRDK
>Mature_288_residues
MFKTALRDAQTRIGDFLTRQLADLGDDTIAQGMRYATGGGKRLRGFLALESAALFDVPPGQALYAAGAVECLHAYSLVHD
DLPCMDDDDLRRGQPTVHKKWDDATAVLVGDALQTFAFELISREDAGTAEERVALTASLAKASGAQGMVLGQAQDIAAET
AGRALTLQEITGLQANKTGRLIEWPAHAGAVLGGADPAPLQRYARAIGLAFQIADDILDVEGDAAKAGKALRKDADAGKA
TFVSLLGMEAAKARSAALVADATAALAPYGDKAQTLRDLAQYIVTRDK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=285, Percent_Identity=43.5087719298246, Blast_Score=170, Evalue=9e-44,
Organism=Escherichia coli, GI1789578, Length=238, Percent_Identity=31.0924369747899, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24651612, Length=238, Percent_Identity=30.672268907563, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30251; Mature: 30251

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTALRDAQTRIGDFLTRQLADLGDDTIAQGMRYATGGGKRLRGFLALESAALFDVPPG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEECCCCCHHHHHHHHHHCCCEEECCCC
QALYAAGAVECLHAYSLVHDDLPCMDDDDLRRGQPTVHKKWDDATAVLVGDALQTFAFEL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHH
ISREDAGTAEERVALTASLAKASGAQGMVLGQAQDIAAETAGRALTLQEITGLQANKTGR
HHCCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHCCCEEEHHHHCCCCCCCCCC
LIEWPAHAGAVLGGADPAPLQRYARAIGLAFQIADDILDVEGDAAKAGKALRKDADAGKA
EEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHH
TFVSLLGMEAAKARSAALVADATAALAPYGDKAQTLRDLAQYIVTRDK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFKTALRDAQTRIGDFLTRQLADLGDDTIAQGMRYATGGGKRLRGFLALESAALFDVPPG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEECCCCCHHHHHHHHHHCCCEEECCCC
QALYAAGAVECLHAYSLVHDDLPCMDDDDLRRGQPTVHKKWDDATAVLVGDALQTFAFEL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHH
ISREDAGTAEERVALTASLAKASGAQGMVLGQAQDIAAETAGRALTLQEITGLQANKTGR
HHCCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHCCCEEEHHHHCCCCCCCCCC
LIEWPAHAGAVLGGADPAPLQRYARAIGLAFQIADDILDVEGDAAKAGKALRKDADAGKA
EEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHH
TFVSLLGMEAAKARSAALVADATAALAPYGDKAQTLRDLAQYIVTRDK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]