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The map label for this gene is dxs1

Identifier: 89052579

GI number: 89052579

Start: 82789

End: 84708

Strand: Reverse

Name: dxs1

Synonym: Jann_0088

Alternate gene names: 89052579

Gene position: 84708-82789 (Counterclockwise)

Preceding gene: 89052580

Following gene: 89052569

Centisome position: 1.96

GC content: 61.93

Gene sequence:

>1920_bases
ATGAGTGATCGCCCCTCCACCCCGCTCTTGGACAACGTCCAATCTCCTAACGACCTCAAAGGGTTGAGTGACTTTGATCT
CAAGCGTCTGGCCGATGAGCTGCGCGCCGAGATGATCTGGACGGTGAGCAAGACGGGCGGGCATTTCGGGGCCGGTCTGG
GTGTGGTGGAACTGACGGTCGCGCTGCACTCCGTCTTTGACACGCCGCGCGACAAGCTGGTCTGGGACGTCTCGCACCAA
TGCTACCCGCATAAGATCCTGACCGGGCGGCGGGATCAGATGCTGACGATCCGCCAGAAAGACGGGCTGTCCGGCTTCAC
GAAACGCAGCGAGTCGCCGTTTGATCCCTTTGGCGCGGCGCATTCCTCCACGTCGATTTCCGCCGCGCTGGGCTTTGCCG
TCGCACGCGATCTGGGTGGCGATAGCGATACCGGCCACGGCGATGCGATTGCGGTGATCGGGGATGGGGCGATGTCCGGC
GGCATGGCGTTTGAGGCGATGAACAATGCGGGGCATCTGGGCAAGCGCCTGATCGTGATCCTAAATGACAATGAGATGTC
GATTGCCCCGCCCACGGGCGCGCTTTCATCTTATCTGTCAAGGCTTTACGCAGGGGCTCCGTTCCAGGAATTCAAGGCCG
CCGCCAAGGGTGCCGTGTCCCTGCTGCCAGAGCCGTTCCAGGAAGGCGCCCGCCGTGCGAAGGAGTTGCTGAAATCCGCG
ACCGTCGGCGGGACGCTGTTTGAAGAGTTGGGCTTTTCCTATGTCGGCCCCATCGACGGCCACGATATGGAAAGCCTTCT
GTCGGTTCTGCGCACCGTCAAAGCCCGCGCCGATGGCCCGATCCTGATCCACGCGATCACGAAGAAGGGGAAGGGATATT
CGGAACATCGCGCGGATCGCGGCCACGCCACCGCCAAGTTCAACATCGCCACCGGAGAGCAGGTGAAAGCGCCCTCCAAC
GCGCCAAGCTACACCAAAGTCTTCGCCCAAAGCCTGATTGCAGAGGCCGAAGATGACCCCAAGGTCGTGGCGGTGACGGC
GGCGATGCCCGATGGCACCGGCCTTGATCTATTTGCCGAACGCTTCCCAAGCCGCTGTTTTGACGTGGGAATTGCCGAGC
AACATGGCGTGACTTTTGCCGCAGGTATGGCTGCCGGGGGCCTGAAACCCTTCGCGGCGATCTATTCCACCTTCCTGCAA
CGGGGCTATGATCAGGTGGTCCACGACGTCGCGATCCAGCGGCTTCCGGTCCGCTTTGCCATCGACCGTGCAGGTCTTGT
CGGCGCGGATGGCTGCACCCACGCGGGCAGCTACGACATCAGCTACCTTGCCAACCTGCCCGGGTTCGTCGTTATGGCCG
CCGCCGATGAGGCAGAGTTGCGCCACATGGTCCGCACCGCGCTGGAAATTGATGACCGCCCCAGCGCGTTCCGCTTTCCC
CGTGGCGAAGGTATGGGCGTGGATATGCCGGATCGCGGTACCGCGCTGGAGATCGGAAAAGGTCGCATGATTTCAGAGGG
TAACAGGGTCGCGATCCTGAATTTTGGCACCCGTTTGAAAGAGGTGCAGGAGGCCGCCGAGACCCTGTCCCAACGTGGCA
TCACCCCAACAATCGCCGACGCGCGCTTCGCCAAACCGCTGGACGAGGCGCTGATCCTGCAACTCGCCCGCCACCACGAG
GCGCTGATCACCGTAGAAGAAGGTGCTGTCGGTGGGTTCGGATCCCATGTCGCGCACTTGCTTGCCGAAAACGCGGTGTT
TGATACCGGGATCAAGTACCGCTCCATGGTGCTGCCCGATATCTTCATTGATCAGGCCAGCCCAAAGGACATGTACGCCG
TCGCGGGGATGAATGCGGAGGATATCGTGGCCAAGGTTCTGACGACTTTGGGGGTCGAGGTGCTGAGCCAGCGGGCCTAG

Upstream 100 bases:

>100_bases
TCGCGATCTGGCGCAGTATATAGTGACTCGTGATAAGTGACCGCAAAGGCCAGCCAACCGCCGAACGCAGCGTGACGCGC
GACGGCGGAGAAGGAATAAT

Downstream 100 bases:

>100_bases
TTTCCACGGCTCGGGTATATCAATGGTATATCAATTGCGTTTGTCCAGCCGCGCCTCGATCGCCCTCAACTTCTCCATCA
CCTCGTCGCGGTAAGCGTCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 1; DXP synthase 1; DXPS 1

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MSDRPSTPLLDNVQSPNDLKGLSDFDLKRLADELRAEMIWTVSKTGGHFGAGLGVVELTVALHSVFDTPRDKLVWDVSHQ
CYPHKILTGRRDQMLTIRQKDGLSGFTKRSESPFDPFGAAHSSTSISAALGFAVARDLGGDSDTGHGDAIAVIGDGAMSG
GMAFEAMNNAGHLGKRLIVILNDNEMSIAPPTGALSSYLSRLYAGAPFQEFKAAAKGAVSLLPEPFQEGARRAKELLKSA
TVGGTLFEELGFSYVGPIDGHDMESLLSVLRTVKARADGPILIHAITKKGKGYSEHRADRGHATAKFNIATGEQVKAPSN
APSYTKVFAQSLIAEAEDDPKVVAVTAAMPDGTGLDLFAERFPSRCFDVGIAEQHGVTFAAGMAAGGLKPFAAIYSTFLQ
RGYDQVVHDVAIQRLPVRFAIDRAGLVGADGCTHAGSYDISYLANLPGFVVMAAADEAELRHMVRTALEIDDRPSAFRFP
RGEGMGVDMPDRGTALEIGKGRMISEGNRVAILNFGTRLKEVQEAAETLSQRGITPTIADARFAKPLDEALILQLARHHE
ALITVEEGAVGGFGSHVAHLLAENAVFDTGIKYRSMVLPDIFIDQASPKDMYAVAGMNAEDIVAKVLTTLGVEVLSQRA

Sequences:

>Translated_639_residues
MSDRPSTPLLDNVQSPNDLKGLSDFDLKRLADELRAEMIWTVSKTGGHFGAGLGVVELTVALHSVFDTPRDKLVWDVSHQ
CYPHKILTGRRDQMLTIRQKDGLSGFTKRSESPFDPFGAAHSSTSISAALGFAVARDLGGDSDTGHGDAIAVIGDGAMSG
GMAFEAMNNAGHLGKRLIVILNDNEMSIAPPTGALSSYLSRLYAGAPFQEFKAAAKGAVSLLPEPFQEGARRAKELLKSA
TVGGTLFEELGFSYVGPIDGHDMESLLSVLRTVKARADGPILIHAITKKGKGYSEHRADRGHATAKFNIATGEQVKAPSN
APSYTKVFAQSLIAEAEDDPKVVAVTAAMPDGTGLDLFAERFPSRCFDVGIAEQHGVTFAAGMAAGGLKPFAAIYSTFLQ
RGYDQVVHDVAIQRLPVRFAIDRAGLVGADGCTHAGSYDISYLANLPGFVVMAAADEAELRHMVRTALEIDDRPSAFRFP
RGEGMGVDMPDRGTALEIGKGRMISEGNRVAILNFGTRLKEVQEAAETLSQRGITPTIADARFAKPLDEALILQLARHHE
ALITVEEGAVGGFGSHVAHLLAENAVFDTGIKYRSMVLPDIFIDQASPKDMYAVAGMNAEDIVAKVLTTLGVEVLSQRA
>Mature_638_residues
SDRPSTPLLDNVQSPNDLKGLSDFDLKRLADELRAEMIWTVSKTGGHFGAGLGVVELTVALHSVFDTPRDKLVWDVSHQC
YPHKILTGRRDQMLTIRQKDGLSGFTKRSESPFDPFGAAHSSTSISAALGFAVARDLGGDSDTGHGDAIAVIGDGAMSGG
MAFEAMNNAGHLGKRLIVILNDNEMSIAPPTGALSSYLSRLYAGAPFQEFKAAAKGAVSLLPEPFQEGARRAKELLKSAT
VGGTLFEELGFSYVGPIDGHDMESLLSVLRTVKARADGPILIHAITKKGKGYSEHRADRGHATAKFNIATGEQVKAPSNA
PSYTKVFAQSLIAEAEDDPKVVAVTAAMPDGTGLDLFAERFPSRCFDVGIAEQHGVTFAAGMAAGGLKPFAAIYSTFLQR
GYDQVVHDVAIQRLPVRFAIDRAGLVGADGCTHAGSYDISYLANLPGFVVMAAADEAELRHMVRTALEIDDRPSAFRFPR
GEGMGVDMPDRGTALEIGKGRMISEGNRVAILNFGTRLKEVQEAAETLSQRGITPTIADARFAKPLDEALILQLARHHEA
LITVEEGAVGGFGSHVAHLLAENAVFDTGIKYRSMVLPDIFIDQASPKDMYAVAGMNAEDIVAKVLTTLGVEVLSQRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=366, Percent_Identity=24.5901639344262, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI4507521, Length=366, Percent_Identity=24.5901639344262, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI133778974, Length=426, Percent_Identity=23.0046948356808, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI225637459, Length=284, Percent_Identity=26.7605633802817, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI225637463, Length=284, Percent_Identity=26.7605633802817, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI225637461, Length=299, Percent_Identity=26.4214046822742, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786622, Length=634, Percent_Identity=48.7381703470032, Blast_Score=570, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17539652, Length=425, Percent_Identity=23.2941176470588, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666278, Length=516, Percent_Identity=25.3875968992248, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551847, Length=542, Percent_Identity=22.6937269372694, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550715, Length=542, Percent_Identity=22.6937269372694, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645119, Length=542, Percent_Identity=22.6937269372694, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS1_JANSC (Q28WA7)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508030.1
- ProteinModelPortal:   Q28WA7
- SMR:   Q28WA7
- STRING:   Q28WA7
- GeneID:   3932524
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0088
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   DEAELFH
- PhylomeDB:   Q28WA7
- ProtClustDB:   PRK05444
- BioCyc:   JSP290400:JANN_0088-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68187; Mature: 68056

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRPSTPLLDNVQSPNDLKGLSDFDLKRLADELRAEMIWTVSKTGGHFGAGLGVVELTV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHH
ALHSVFDTPRDKLVWDVSHQCYPHKILTGRRDQMLTIRQKDGLSGFTKRSESPFDPFGAA
HHHHHHCCCCHHEEEECCCCCCCHHHHCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCC
HSSTSISAALGFAVARDLGGDSDTGHGDAIAVIGDGAMSGGMAFEAMNNAGHLGKRLIVI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEE
LNDNEMSIAPPTGALSSYLSRLYAGAPFQEFKAAAKGAVSLLPEPFQEGARRAKELLKSA
ECCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHH
TVGGTLFEELGFSYVGPIDGHDMESLLSVLRTVKARADGPILIHAITKKGKGYSEHRADR
CCCHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHCCCC
GHATAKFNIATGEQVKAPSNAPSYTKVFAQSLIAEAEDDPKVVAVTAAMPDGTGLDLFAE
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHH
RFPSRCFDVGIAEQHGVTFAAGMAAGGLKPFAAIYSTFLQRGYDQVVHDVAIQRLPVRFA
HCCHHHHHCCCCCCCCCEEEECHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IDRAGLVGADGCTHAGSYDISYLANLPGFVVMAAADEAELRHMVRTALEIDDRPSAFRFP
ECCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCC
RGEGMGVDMPDRGTALEIGKGRMISEGNRVAILNFGTRLKEVQEAAETLSQRGITPTIAD
CCCCCCCCCCCCCCEEEECCCCEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCC
ARFAKPLDEALILQLARHHEALITVEEGAVGGFGSHVAHLLAENAVFDTGIKYRSMVLPD
HHHHCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHCCH
IFIDQASPKDMYAVAGMNAEDIVAKVLTTLGVEVLSQRA
HEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDRPSTPLLDNVQSPNDLKGLSDFDLKRLADELRAEMIWTVSKTGGHFGAGLGVVELTV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHH
ALHSVFDTPRDKLVWDVSHQCYPHKILTGRRDQMLTIRQKDGLSGFTKRSESPFDPFGAA
HHHHHHCCCCHHEEEECCCCCCCHHHHCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCC
HSSTSISAALGFAVARDLGGDSDTGHGDAIAVIGDGAMSGGMAFEAMNNAGHLGKRLIVI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEE
LNDNEMSIAPPTGALSSYLSRLYAGAPFQEFKAAAKGAVSLLPEPFQEGARRAKELLKSA
ECCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHH
TVGGTLFEELGFSYVGPIDGHDMESLLSVLRTVKARADGPILIHAITKKGKGYSEHRADR
CCCHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHCCCC
GHATAKFNIATGEQVKAPSNAPSYTKVFAQSLIAEAEDDPKVVAVTAAMPDGTGLDLFAE
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHH
RFPSRCFDVGIAEQHGVTFAAGMAAGGLKPFAAIYSTFLQRGYDQVVHDVAIQRLPVRFA
HCCHHHHHCCCCCCCCCEEEECHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IDRAGLVGADGCTHAGSYDISYLANLPGFVVMAAADEAELRHMVRTALEIDDRPSAFRFP
ECCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCC
RGEGMGVDMPDRGTALEIGKGRMISEGNRVAILNFGTRLKEVQEAAETLSQRGITPTIAD
CCCCCCCCCCCCCCEEEECCCCEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCC
ARFAKPLDEALILQLARHHEALITVEEGAVGGFGSHVAHLLAENAVFDTGIKYRSMVLPD
HHHHCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHCCH
IFIDQASPKDMYAVAGMNAEDIVAKVLTTLGVEVLSQRA
HEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA