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The map label for this gene is dnaA

Identifier: 89052492

GI number: 89052492

Start: 48

End: 1475

Strand: Direct

Name: dnaA

Synonym: Jann_0001

Alternate gene names: 89052492

Gene position: 48-1475 (Clockwise)

Preceding gene: NA

Following gene: 89052493

Centisome position: 0.0

GC content: 58.54

Gene sequence:

>1428_bases
ATGACGAACGACACTTGGAACGAAGTGCGCCAAGATCTGTTGAAGGTTGTCGGCAAGAACAACTTTTCAGCATGGATTGA
ACCAATCGATTTTGATCGCATTGATGAGCGAACCGCCCATTTCCATGTGCCCACGAATTTCATTGGCTCCTGGGTGACCA
ACAACTTCGGCGACCTGATTCTGCGTCAATTGTCGGCCCATGGTGCCGGCGCGGATCGTGTGAAGTTCACGGTGTCCCCG
AAAGCGGGTGCTGCCGTTGCCGCACCGGCCAATACATCTGCCCCAAGACCTGTCCCGGAAATGGCTGCGGCTGCTCCGGC
GCCTGCCCCTGTTCATCACACCGCACCTGCGCCCGCTCCTGTCGCGGCCCCGGCGCAACCGCGTGAGCTGCCCGGTGCCA
AGCTGAACCCGAACTTTACCTTTGCCAATTTCGTCGTCGGCAAGCCGAACGAGCTGGCCCATGCCGCCGCCCGTCGCGTG
GCCGAGACGTTGGACGTCACCTTCAACCCGCTGTTTCTGTATGGCGGCGTTGGCCTCGGCAAGACGCATCTGATGCACGC
CATCGCCTGGGATCTGCAGGACCGTCATCCCGACGCCAAGATCCTGTTTCTGTCGGCTGAGCAGTTCATGCACCGGTTCG
TGCGGGCGCTCCGCGAGCAAGACACGTTCAATTTCAAGGAAACGTTCCGCTCGGTCGATATCCTGATGGTCGATGATGTG
CAGTTTATCGCTGGCAAAACCTCCACCCAGCAGGAATTCTTCCACACATTCAACGCGTTGGTTGAGATGGGCAAGCAAAT
CGTCATCTCTGGTGACCGTGCGCCCGTCGACATGGAAGAGCTCGACAATCGCATCGCGTCGCGCCTTCAGTGCGGCCTTG
TCGTGGACATCCACCCCACCGATTACGAACTTCGCCTGGGCGTGCTGCAACATAAGGCTGAGCTTTTGGGCGCAAAGTAT
CCGCACATCACCTTTGCCACCGGCGTGTTGGAATATCTGGCCCAGAAGATCTCGTCCAACGTTCGGGTGCTGGAAGGCGC
GCTGACGCGTCTCTTTGCCTTCGCCGATCTGGTGCGGCGTGAAGTGACCGTCGATCTTGCCAAGGAATGTCTCACCGATG
TTCTGCGCGCGACTGACAAGAAGGTCACGATGGATGAGATCCTGAAAAAGACCTGCGAATACTACAAGATCCGCCAAGTC
GATATGATCAGCCAGAACCGACAGCGCGTGATCGCACGGCCCCGGCAGATGGCGATGTATCTGTGCAAGCGCCTGACCAC
GCGCTCCCTTCCTGAGATCGGGAAGAAATTCGGCGGGCGCGATCACACCACAATCCTCTACGGCGTGCGCAAGATCGAAG
AGCTGATGCAGGCCGATAGTCAGATTGCCGAGGACGCAGAACTGTTGCGCCGGACACTGGAAGCCTAG

Upstream 100 bases:

>100_bases
AAAACGCCACGGTGACAAGGCAGGACGCCTCGCAGGCAGAAACTGGTGAGAACCTGGTCGCGAGACGACGAACCGGGTAG
CAAAAGGACGGGACGAAGGC

Downstream 100 bases:

>100_bases
GTTTCCGCGCTGCAATCCACGCTTGCCACTTGACGCTGGCAAGCGCGCAGGCAGTATCTTATTCAACTTGTGAATTTCTG
GGGTCCGAGTAGTCTCGCGG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTNDTWNEVRQDLLKVVGKNNFSAWIEPIDFDRIDERTAHFHVPTNFIGSWVTNNFGDLILRQLSAHGAGADRVKFTVSP
KAGAAVAAPANTSAPRPVPEMAAAAPAPAPVHHTAPAPAPVAAPAQPRELPGAKLNPNFTFANFVVGKPNELAHAAARRV
AETLDVTFNPLFLYGGVGLGKTHLMHAIAWDLQDRHPDAKILFLSAEQFMHRFVRALREQDTFNFKETFRSVDILMVDDV
QFIAGKTSTQQEFFHTFNALVEMGKQIVISGDRAPVDMEELDNRIASRLQCGLVVDIHPTDYELRLGVLQHKAELLGAKY
PHITFATGVLEYLAQKISSNVRVLEGALTRLFAFADLVRREVTVDLAKECLTDVLRATDKKVTMDEILKKTCEYYKIRQV
DMISQNRQRVIARPRQMAMYLCKRLTTRSLPEIGKKFGGRDHTTILYGVRKIEELMQADSQIAEDAELLRRTLEA

Sequences:

>Translated_475_residues
MTNDTWNEVRQDLLKVVGKNNFSAWIEPIDFDRIDERTAHFHVPTNFIGSWVTNNFGDLILRQLSAHGAGADRVKFTVSP
KAGAAVAAPANTSAPRPVPEMAAAAPAPAPVHHTAPAPAPVAAPAQPRELPGAKLNPNFTFANFVVGKPNELAHAAARRV
AETLDVTFNPLFLYGGVGLGKTHLMHAIAWDLQDRHPDAKILFLSAEQFMHRFVRALREQDTFNFKETFRSVDILMVDDV
QFIAGKTSTQQEFFHTFNALVEMGKQIVISGDRAPVDMEELDNRIASRLQCGLVVDIHPTDYELRLGVLQHKAELLGAKY
PHITFATGVLEYLAQKISSNVRVLEGALTRLFAFADLVRREVTVDLAKECLTDVLRATDKKVTMDEILKKTCEYYKIRQV
DMISQNRQRVIARPRQMAMYLCKRLTTRSLPEIGKKFGGRDHTTILYGVRKIEELMQADSQIAEDAELLRRTLEA
>Mature_474_residues
TNDTWNEVRQDLLKVVGKNNFSAWIEPIDFDRIDERTAHFHVPTNFIGSWVTNNFGDLILRQLSAHGAGADRVKFTVSPK
AGAAVAAPANTSAPRPVPEMAAAAPAPAPVHHTAPAPAPVAAPAQPRELPGAKLNPNFTFANFVVGKPNELAHAAARRVA
ETLDVTFNPLFLYGGVGLGKTHLMHAIAWDLQDRHPDAKILFLSAEQFMHRFVRALREQDTFNFKETFRSVDILMVDDVQ
FIAGKTSTQQEFFHTFNALVEMGKQIVISGDRAPVDMEELDNRIASRLQCGLVVDIHPTDYELRLGVLQHKAELLGAKYP
HITFATGVLEYLAQKISSNVRVLEGALTRLFAFADLVRREVTVDLAKECLTDVLRATDKKVTMDEILKKTCEYYKIRQVD
MISQNRQRVIARPRQMAMYLCKRLTTRSLPEIGKKFGGRDHTTILYGVRKIEELMQADSQIAEDAELLRRTLEA

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=480, Percent_Identity=40.625, Blast_Score=352, Evalue=3e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_JANSC (Q28WI0)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_507943.1
- ProteinModelPortal:   Q28WI0
- STRING:   Q28WI0
- GeneID:   3932437
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0001
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- PhylomeDB:   Q28WI0
- ProtClustDB:   PRK00149
- BioCyc:   JSP290400:JANN_0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 53130; Mature: 52998

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDTWNEVRQDLLKVVGKNNFSAWIEPIDFDRIDERTAHFHVPTNFIGSWVTNNFGDLI
CCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHCCHHHHH
LRQLSAHGAGADRVKFTVSPKAGAAVAAPANTSAPRPVPEMAAAAPAPAPVHHTAPAPAP
HHHHHHCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
VAAPAQPRELPGAKLNPNFTFANFVVGKPNELAHAAARRVAETLDVTFNPLFLYGGVGLG
CCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
KTHLMHAIAWDLQDRHPDAKILFLSAEQFMHRFVRALREQDTFNFKETFRSVDILMVDDV
HHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEECCH
QFIAGKTSTQQEFFHTFNALVEMGKQIVISGDRAPVDMEELDNRIASRLQCGLVVDIHPT
HHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCC
DYELRLGVLQHKAELLGAKYPHITFATGVLEYLAQKISSNVRVLEGALTRLFAFADLVRR
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EVTVDLAKECLTDVLRATDKKVTMDEILKKTCEYYKIRQVDMISQNRQRVIARPRQMAMY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LCKRLTTRSLPEIGKKFGGRDHTTILYGVRKIEELMQADSQIAEDAELLRRTLEA
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNDTWNEVRQDLLKVVGKNNFSAWIEPIDFDRIDERTAHFHVPTNFIGSWVTNNFGDLI
CCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHCCHHHHH
LRQLSAHGAGADRVKFTVSPKAGAAVAAPANTSAPRPVPEMAAAAPAPAPVHHTAPAPAP
HHHHHHCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
VAAPAQPRELPGAKLNPNFTFANFVVGKPNELAHAAARRVAETLDVTFNPLFLYGGVGLG
CCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
KTHLMHAIAWDLQDRHPDAKILFLSAEQFMHRFVRALREQDTFNFKETFRSVDILMVDDV
HHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEECCH
QFIAGKTSTQQEFFHTFNALVEMGKQIVISGDRAPVDMEELDNRIASRLQCGLVVDIHPT
HHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCC
DYELRLGVLQHKAELLGAKYPHITFATGVLEYLAQKISSNVRVLEGALTRLFAFADLVRR
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EVTVDLAKECLTDVLRATDKKVTMDEILKKTCEYYKIRQVDMISQNRQRVIARPRQMAMY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LCKRLTTRSLPEIGKKFGGRDHTTILYGVRKIEELMQADSQIAEDAELLRRTLEA
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA