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The map label for this gene is hemA [H]

Identifier: 88658613

GI number: 88658613

Start: 83016

End: 84221

Strand: Direct

Name: hemA [H]

Synonym: ECH_0092

Alternate gene names: 88658613

Gene position: 83016-84221 (Clockwise)

Preceding gene: 88658503

Following gene: 88658466

Centisome position: 7.06

GC content: 32.59

Gene sequence:

>1206_bases
ATGATAGATTATGAAGAGATATTTTGTAGCAAGATTAAGCGTATAAAAGATGAAGGTCGATATAGAGAATTTACAGGATT
CTCACGTATTCCTGGTCAGTTTCCTTATGCTATAGAATGTGATGTAAATAACGTAGTTACTCTATGGTGTAGCAATGATT
ATTTGGGTATGGGACAAAATGAACATATGATTCTTGCTATCAAAAATTATAGTAGTAGTGTAGGTGCTGGTGGTACACGG
AATATCTCTGGCACTACAAAGGAGATTATTGAGCTTGAAAAATCATTAGCAGATTTACATAAAAAACCAGCTGCTCTGAC
TTTTGTGTGTGGCTATATTGCAAATCAGACTACTATTAGTACAGTGCTTTCTGTAATACCAGATATTGTAGTTTTTTCAG
ATGAGAAAAATCATTCTTCTATGATAGAAGGTATTAGATCTACTAATAGAGCAAAGCATATATTTAGGCACAATGATCTT
AATCACCTTGAGACTTTGTTAAAATCTGTTGATATATCTGTACCTAAGATCATAATATTTGAATCCTTGTATTCTATGGA
TGGAGATATAGCTCCAATTGCAAAAATTTGTGATTTAGCTGATAAATATAATGCAATAACTTATTTAGATGAAGTACATG
CAGTTGGTATGTATGGAAGTCGTGGAGGAGGTATATCAGAACAAGAAAATATATCTGATAGAGTGACAATTATTCAAGGA
ACTCTTTCCAAAGCTTTTGGAGTTATGGGTGGATATATTACTGGATCAAAAAATGTGGTAGATGTTGTCAGAAGCTTTGC
TCCTGGTTTTATTTTTACTACAGCATTATCACCTCTTATTGCATCATCTGCTAGAATAAGTGTTGAGCATTTAAAGAATA
GTTCTATTGAGAGAGAAAAGCAACGTGAGGTTGTTAACAAAGTAAAAGAATCTTTTTCTAAGGCTGGTATTGACTTTGTC
AAAACGGATACACATATAATTCCTGTAATTATAGGTGATTCAGTGGCTTGTACAGAGATTTCACGAGTGTTACTTAAGGA
ATATAGGATATATATACAATCTATTAATTATCCTACTGTGCCTGTAGGTACAGAGAGATTAAGGATTACTCCAACACCTT
ATCATACAGATGAAATGATAGATAAATTAACCCAAGCGTTGGTTGATGTTTTGTGTAGGTTTAAAATAATGAATAAGCAA
AATTAA

Upstream 100 bases:

>100_bases
CTATGTTAAATTAAGTTGTGGGAAGAAGCGTCATTTAAAAGTAATGTTAGAGAGTGATTTTTGATAGGGTTTTATATTAA
AACATAGGATAGAGGTAATT

Downstream 100 bases:

>100_bases
AATTCTTGCCAAGCGTGAGGAATGTGTATTAATCCTTTTGAAAGTGAAAAAAAGTATAAGTCAAATCTTATATTGTATTC
TTCAAATTTTGTATGATAAG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MIDYEEIFCSKIKRIKDEGRYREFTGFSRIPGQFPYAIECDVNNVVTLWCSNDYLGMGQNEHMILAIKNYSSSVGAGGTR
NISGTTKEIIELEKSLADLHKKPAALTFVCGYIANQTTISTVLSVIPDIVVFSDEKNHSSMIEGIRSTNRAKHIFRHNDL
NHLETLLKSVDISVPKIIIFESLYSMDGDIAPIAKICDLADKYNAITYLDEVHAVGMYGSRGGGISEQENISDRVTIIQG
TLSKAFGVMGGYITGSKNVVDVVRSFAPGFIFTTALSPLIASSARISVEHLKNSSIEREKQREVVNKVKESFSKAGIDFV
KTDTHIIPVIIGDSVACTEISRVLLKEYRIYIQSINYPTVPVGTERLRITPTPYHTDEMIDKLTQALVDVLCRFKIMNKQ
N

Sequences:

>Translated_401_residues
MIDYEEIFCSKIKRIKDEGRYREFTGFSRIPGQFPYAIECDVNNVVTLWCSNDYLGMGQNEHMILAIKNYSSSVGAGGTR
NISGTTKEIIELEKSLADLHKKPAALTFVCGYIANQTTISTVLSVIPDIVVFSDEKNHSSMIEGIRSTNRAKHIFRHNDL
NHLETLLKSVDISVPKIIIFESLYSMDGDIAPIAKICDLADKYNAITYLDEVHAVGMYGSRGGGISEQENISDRVTIIQG
TLSKAFGVMGGYITGSKNVVDVVRSFAPGFIFTTALSPLIASSARISVEHLKNSSIEREKQREVVNKVKESFSKAGIDFV
KTDTHIIPVIIGDSVACTEISRVLLKEYRIYIQSINYPTVPVGTERLRITPTPYHTDEMIDKLTQALVDVLCRFKIMNKQ
N
>Mature_401_residues
MIDYEEIFCSKIKRIKDEGRYREFTGFSRIPGQFPYAIECDVNNVVTLWCSNDYLGMGQNEHMILAIKNYSSSVGAGGTR
NISGTTKEIIELEKSLADLHKKPAALTFVCGYIANQTTISTVLSVIPDIVVFSDEKNHSSMIEGIRSTNRAKHIFRHNDL
NHLETLLKSVDISVPKIIIFESLYSMDGDIAPIAKICDLADKYNAITYLDEVHAVGMYGSRGGGISEQENISDRVTIIQG
TLSKAFGVMGGYITGSKNVVDVVRSFAPGFIFTTALSPLIASSARISVEHLKNSSIEREKQREVVNKVKESFSKAGIDFV
KTDTHIIPVIIGDSVACTEISRVLLKEYRIYIQSINYPTVPVGTERLRITPTPYHTDEMIDKLTQALVDVLCRFKIMNKQ
N

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=397, Percent_Identity=42.3173803526448, Blast_Score=354, Evalue=8e-98,
Organism=Homo sapiens, GI83977440, Length=397, Percent_Identity=42.3173803526448, Blast_Score=354, Evalue=9e-98,
Organism=Homo sapiens, GI83977444, Length=397, Percent_Identity=42.3173803526448, Blast_Score=354, Evalue=9e-98,
Organism=Homo sapiens, GI4502025, Length=396, Percent_Identity=44.1919191919192, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI40316939, Length=396, Percent_Identity=44.1919191919192, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI7657118, Length=361, Percent_Identity=32.1329639889197, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=32.7536231884058, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI119220554, Length=330, Percent_Identity=28.4848484848485, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=26.7955801104972, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI5454084, Length=250, Percent_Identity=28, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1790046, Length=347, Percent_Identity=34.0057636887608, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=28.1524926686217, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71994529, Length=347, Percent_Identity=34.0057636887608, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32566772, Length=401, Percent_Identity=28.6783042394015, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=378, Percent_Identity=27.5132275132275, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=378, Percent_Identity=27.5132275132275, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=257, Percent_Identity=28.7937743190661, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=257, Percent_Identity=28.7937743190661, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=419, Percent_Identity=43.1980906921241, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320267, Length=424, Percent_Identity=28.3018867924528, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=291, Percent_Identity=24.3986254295533, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137420, Length=395, Percent_Identity=44.3037974683544, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24662918, Length=352, Percent_Identity=32.9545454545455, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI17136286, Length=338, Percent_Identity=28.4023668639053, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24653280, Length=284, Percent_Identity=26.056338028169, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653276, Length=284, Percent_Identity=26.056338028169, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653278, Length=284, Percent_Identity=26.056338028169, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44651; Mature: 44651

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYEEIFCSKIKRIKDEGRYREFTGFSRIPGQFPYAIECDVNNVVTLWCSNDYLGMGQN
CCCHHHHHHHHHHHHHHCCCEEHHCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCC
EHMILAIKNYSSSVGAGGTRNISGTTKEIIELEKSLADLHKKPAALTFVCGYIANQTTIS
CEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHH
TVLSVIPDIVVFSDEKNHSSMIEGIRSTNRAKHIFRHNDLNHLETLLKSVDISVPKIIIF
HHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
ESLYSMDGDIAPIAKICDLADKYNAITYLDEVHAVGMYGSRGGGISEQENISDRVTIIQG
HHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHH
TLSKAFGVMGGYITGSKNVVDVVRSFAPGFIFTTALSPLIASSARISVEHLKNSSIEREK
HHHHHHHHHCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHH
QREVVNKVKESFSKAGIDFVKTDTHIIPVIIGDSVACTEISRVLLKEYRIYIQSINYPTV
HHHHHHHHHHHHHHCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PVGTERLRITPTPYHTDEMIDKLTQALVDVLCRFKIMNKQN
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDYEEIFCSKIKRIKDEGRYREFTGFSRIPGQFPYAIECDVNNVVTLWCSNDYLGMGQN
CCCHHHHHHHHHHHHHHCCCEEHHCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCC
EHMILAIKNYSSSVGAGGTRNISGTTKEIIELEKSLADLHKKPAALTFVCGYIANQTTIS
CEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHH
TVLSVIPDIVVFSDEKNHSSMIEGIRSTNRAKHIFRHNDLNHLETLLKSVDISVPKIIIF
HHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
ESLYSMDGDIAPIAKICDLADKYNAITYLDEVHAVGMYGSRGGGISEQENISDRVTIIQG
HHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHH
TLSKAFGVMGGYITGSKNVVDVVRSFAPGFIFTTALSPLIASSARISVEHLKNSSIEREK
HHHHHHHHHCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHH
QREVVNKVKESFSKAGIDFVKTDTHIIPVIIGDSVACTEISRVLLKEYRIYIQSINYPTV
HHHHHHHHHHHHHHCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PVGTERLRITPTPYHTDEMIDKLTQALVDVLCRFKIMNKQN
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]