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The map label for this gene is guaA

Identifier: 88658530

GI number: 88658530

Start: 109470

End: 111050

Strand: Direct

Name: guaA

Synonym: ECH_0123

Alternate gene names: 88658530

Gene position: 109470-111050 (Clockwise)

Preceding gene: 88658059

Following gene: 88657897

Centisome position: 9.31

GC content: 34.41

Gene sequence:

>1581_bases
ATGTCAAGGGTGGCAATTATTGATTTTGGTTCGCAATTTACACAATTGCTTGCTAGAAGGATAAGAGAACTAAATGTTTA
TTCTGAAATTTTTCCGCATGATATAGCATTTGATTACATAAAAGATAGTAAAGCATTTATTTTATCTGGAGGTCCTAAGT
CGGTTCTGGATTTTACAGGAATGCCTCCAATAGTTCACGATATTATTGAATTGAATAAAAAAACTTCCGTTCCAGTATTG
GGAGTGTGTTATGGATTACAACTTTTAAGTAATTATTTTAACTCGACAATTGTACATGGGTGTGGTCAGGAATTTGGGAA
AGCTATTCTAAATGTTGTCAAAAAATCAGAAATGATAAAAGATGTGTGGAAAGTAGGAGACCAACCCTATGTGTGGATGA
GTCATGCAGATAGTGTATATGATACTCCATGCGGATTTGAAGTCATAGCATGTAGTGTAGTGAATAATGCAATTGCGATG
ATCAGCAATGAGGAAAGAAGAATTTATGGTGTACAATTTCATCCTGAAGTATATCACACTCCGGATGGGGTAAAATTACT
TGCTAATTTTGTCAGAATAGCAGGTTGTGACAATAACTGGACAGTGGAATCCTTTTTAGATGAGCAAGAGAATCTTATAA
AGAAACAAGTGGGAGATAAAAAAGTAATTGCTGCTCTTAGTGGTGGTGTTGATTCTAGTGTTGCTGCAGCTTTGACTTAT
CGAGCAATAGGTGATCAATTACACTGTATCTTTATTGATAATGGCTTACTGCGCTATAATGAAGCAGAAAAAGTAAGACA
ATCGTTTGTTGATCAGTTTCAAATGCCTGTAACTATTGTTGATAGATCATCAGTATTTTTAGATAAACTTCAATTTGTTA
CTGATCCAGAGCAAAAGCGAAAAATAATAGGAAAAACGTTTATTGAAGTATTTGAAGAAGAAGCGAATAAGATAGGGAAC
GTAGAATTTTTAATGCAAGGTACTATATACCCTGATGTTATAGAATCTGGTGGCTCTGTTGGGAAAGAAAGTGTTACTAT
CAAATCACATCATAATGTTGGTGGACTACCTGATATAATGAAGTTACAGCTTGTTGAACCACTAAAGCTTTTGTTTAAAG
ATGAAGTGAGATTGTTGGGGAAAAAACTTGGTATATCAGATGAAATATTAATGCGTCATCCATTCCCAGGACCTGGTTTA
GCAATTAGAATAATAGGTGAAATTACTCAAGAGAAGGTTAATATGTTGCAGGCTGCCGATGAGATATATATTAATCTTAT
CAAAAAATATAATTTGTACGATGTTATATGGCAAGCGTTTGCAGTGCTATTGCCAGTGAAAACAGTGGGTGTAATGGGTG
ATAGTAGAACTTATGGTTATACTTGTGCTTTAAGAGCAGTTACTTCTAGTGATGGTATGACTGCAGAATGTTTCCCATTT
GGTGTAGACTTGGAAACTAAGATAATCTTTTATGAGTTTCTACAGGATGTTAGTAATACTATTGTGAATAATGTTCAAGG
AATTAATAGAGTGGTATATGATACTACATCTAAACCTCCAGCTACAATTGAATGGGAATAG

Upstream 100 bases:

>100_bases
TCTTTACAAAGCTACTATAGTTGTAGTTCTGATGTTAATAGTGGATATTATCAAAACAAATGATGGACTTTTATTTTGTA
CAGTTATAAAGGTAATATAA

Downstream 100 bases:

>100_bases
ATATTGAACACTTATAAGTTGGAGTGTTATTATTTGATTAATGTGTCATAGAGTTTGATTGAGTCATTTTATGAGTATTT
AAGTTTTACAAGGAAAATTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSRVAIIDFGSQFTQLLARRIRELNVYSEIFPHDIAFDYIKDSKAFILSGGPKSVLDFTGMPPIVHDIIELNKKTSVPVL
GVCYGLQLLSNYFNSTIVHGCGQEFGKAILNVVKKSEMIKDVWKVGDQPYVWMSHADSVYDTPCGFEVIACSVVNNAIAM
ISNEERRIYGVQFHPEVYHTPDGVKLLANFVRIAGCDNNWTVESFLDEQENLIKKQVGDKKVIAALSGGVDSSVAAALTY
RAIGDQLHCIFIDNGLLRYNEAEKVRQSFVDQFQMPVTIVDRSSVFLDKLQFVTDPEQKRKIIGKTFIEVFEEEANKIGN
VEFLMQGTIYPDVIESGGSVGKESVTIKSHHNVGGLPDIMKLQLVEPLKLLFKDEVRLLGKKLGISDEILMRHPFPGPGL
AIRIIGEITQEKVNMLQAADEIYINLIKKYNLYDVIWQAFAVLLPVKTVGVMGDSRTYGYTCALRAVTSSDGMTAECFPF
GVDLETKIIFYEFLQDVSNTIVNNVQGINRVVYDTTSKPPATIEWE

Sequences:

>Translated_526_residues
MSRVAIIDFGSQFTQLLARRIRELNVYSEIFPHDIAFDYIKDSKAFILSGGPKSVLDFTGMPPIVHDIIELNKKTSVPVL
GVCYGLQLLSNYFNSTIVHGCGQEFGKAILNVVKKSEMIKDVWKVGDQPYVWMSHADSVYDTPCGFEVIACSVVNNAIAM
ISNEERRIYGVQFHPEVYHTPDGVKLLANFVRIAGCDNNWTVESFLDEQENLIKKQVGDKKVIAALSGGVDSSVAAALTY
RAIGDQLHCIFIDNGLLRYNEAEKVRQSFVDQFQMPVTIVDRSSVFLDKLQFVTDPEQKRKIIGKTFIEVFEEEANKIGN
VEFLMQGTIYPDVIESGGSVGKESVTIKSHHNVGGLPDIMKLQLVEPLKLLFKDEVRLLGKKLGISDEILMRHPFPGPGL
AIRIIGEITQEKVNMLQAADEIYINLIKKYNLYDVIWQAFAVLLPVKTVGVMGDSRTYGYTCALRAVTSSDGMTAECFPF
GVDLETKIIFYEFLQDVSNTIVNNVQGINRVVYDTTSKPPATIEWE
>Mature_525_residues
SRVAIIDFGSQFTQLLARRIRELNVYSEIFPHDIAFDYIKDSKAFILSGGPKSVLDFTGMPPIVHDIIELNKKTSVPVLG
VCYGLQLLSNYFNSTIVHGCGQEFGKAILNVVKKSEMIKDVWKVGDQPYVWMSHADSVYDTPCGFEVIACSVVNNAIAMI
SNEERRIYGVQFHPEVYHTPDGVKLLANFVRIAGCDNNWTVESFLDEQENLIKKQVGDKKVIAALSGGVDSSVAAALTYR
AIGDQLHCIFIDNGLLRYNEAEKVRQSFVDQFQMPVTIVDRSSVFLDKLQFVTDPEQKRKIIGKTFIEVFEEEANKIGNV
EFLMQGTIYPDVIESGGSVGKESVTIKSHHNVGGLPDIMKLQLVEPLKLLFKDEVRLLGKKLGISDEILMRHPFPGPGLA
IRIIGEITQEKVNMLQAADEIYINLIKKYNLYDVIWQAFAVLLPVKTVGVMGDSRTYGYTCALRAVTSSDGMTAECFPFG
VDLETKIIFYEFLQDVSNTIVNNVQGINRVVYDTTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=568, Percent_Identity=34.8591549295775, Blast_Score=276, Evalue=4e-74,
Organism=Escherichia coli, GI1788854, Length=532, Percent_Identity=49.0601503759398, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71992717, Length=585, Percent_Identity=34.7008547008547, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=585, Percent_Identity=34.7008547008547, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI133901714, Length=585, Percent_Identity=34.7008547008547, Blast_Score=278, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=531, Percent_Identity=49.5291902071563, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI281365319, Length=518, Percent_Identity=34.3629343629344, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_EHRCR (Q2GHY2)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_506951.1
- ProteinModelPortal:   Q2GHY2
- SMR:   Q2GHY2
- STRING:   Q2GHY2
- GeneID:   3928057
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0123
- TIGR:   ECH_0123
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- BioCyc:   ECHA205920:ECH_0123-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 58823; Mature: 58691

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 83-83 ACT_SITE 174-174 ACT_SITE 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVAIIDFGSQFTQLLARRIRELNVYSEIFPHDIAFDYIKDSKAFILSGGPKSVLDFTG
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCHHHHHCCC
MPPIVHDIIELNKKTSVPVLGVCYGLQLLSNYFNSTIVHGCGQEFGKAILNVVKKSEMIK
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DVWKVGDQPYVWMSHADSVYDTPCGFEVIACSVVNNAIAMISNEERRIYGVQFHPEVYHT
HHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCEEC
PDGVKLLANFVRIAGCDNNWTVESFLDEQENLIKKQVGDKKVIAALSGGVDSSVAAALTY
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHH
RAIGDQLHCIFIDNGLLRYNEAEKVRQSFVDQFQMPVTIVDRSSVFLDKLQFVTDPEQKR
HHHCCCEEEEEEECCEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCHHHH
KIIGKTFIEVFEEEANKIGNVEFLMQGTIYPDVIESGGSVGKESVTIKSHHNVGGLPDIM
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCCCCEEEEEECCCCCCCCHHH
KLQLVEPLKLLFKDEVRLLGKKLGISDEILMRHPFPGPGLAIRIIGEITQEKVNMLQAAD
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCCCCEEEEHHHHHHHHHHHHHHHHH
EIYINLIKKYNLYDVIWQAFAVLLPVKTVGVMGDSRTYGYTCALRAVTSSDGMTAECFPF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEEEECCCCCEEEEEEE
GVDLETKIIFYEFLQDVSNTIVNNVQGINRVVYDTTSKPPATIEWE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC
>Mature Secondary Structure 
SRVAIIDFGSQFTQLLARRIRELNVYSEIFPHDIAFDYIKDSKAFILSGGPKSVLDFTG
CCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCHHHHHCCC
MPPIVHDIIELNKKTSVPVLGVCYGLQLLSNYFNSTIVHGCGQEFGKAILNVVKKSEMIK
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DVWKVGDQPYVWMSHADSVYDTPCGFEVIACSVVNNAIAMISNEERRIYGVQFHPEVYHT
HHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCEEC
PDGVKLLANFVRIAGCDNNWTVESFLDEQENLIKKQVGDKKVIAALSGGVDSSVAAALTY
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHH
RAIGDQLHCIFIDNGLLRYNEAEKVRQSFVDQFQMPVTIVDRSSVFLDKLQFVTDPEQKR
HHHCCCEEEEEEECCEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCHHHH
KIIGKTFIEVFEEEANKIGNVEFLMQGTIYPDVIESGGSVGKESVTIKSHHNVGGLPDIM
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCCCCEEEEEECCCCCCCCHHH
KLQLVEPLKLLFKDEVRLLGKKLGISDEILMRHPFPGPGLAIRIIGEITQEKVNMLQAAD
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCCCCEEEEHHHHHHHHHHHHHHHHH
EIYINLIKKYNLYDVIWQAFAVLLPVKTVGVMGDSRTYGYTCALRAVTSSDGMTAECFPF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEEEECCCCCEEEEEEE
GVDLETKIIFYEFLQDVSNTIVNNVQGINRVVYDTTSKPPATIEWE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA