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The map label for this gene is pepA [H]

Identifier: 88658513

GI number: 88658513

Start: 361011

End: 362513

Strand: Direct

Name: pepA [H]

Synonym: ECH_0369

Alternate gene names: 88658513

Gene position: 361011-362513 (Clockwise)

Preceding gene: 88658213

Following gene: 88657719

Centisome position: 30.69

GC content: 35.46

Gene sequence:

>1503_bases
ATGATAGATATATCGTTTTCAAGTTTAATGCCAGGGGTATCTTTGTTTTTAAAGACAACAGCAATAGTTGTGGGTATCTT
TGAAGGTAGTAATCACTTGGAAGACTATAGTGCCTTAGCTGAGCGTAGTGAGCAAATTATGAAGGTGGTAGAAGGTTACA
AGTCTTTTGATGGTAAGTTTGCAGAAGTATTGCCAATTACTGGATTAGATGCAGGGTATCCTATAGTAATAGTAGTAGGG
TTGGGTAAACCTGAAGAGTTTGATGAAAACAAATCTTTAAGGATTGGTGGTGTTATATATTCTGAACTTAATAGGATGAA
AATATCAGAGGCCTCAATTATAAGTAGTAATGATAGTGATATTATGGCTAATGTTGCCTATGGGGCATTTTTACGCAGTT
TTAAGTTTGATAAATATTTTGTTCAGAAAAAAGATGAAAATGCAACTTATGTGCGTAAGTTAGAGTTCTTTTCAAAAACT
AATCCTCAAAAAACAGCTGTTTTGTTTGATAATTTAAAAGCCGAAGGTGAGTCAGTATTTTTAGCTCGTTCTTTTGTTTC
AGAACCTCCTAATATTCTTTATCCAGAAATTTATGCTCAGATGATATATGAGGAATTAAGTAAAGTAGATGTTAAAGTTG
AAATATTTGATGAAGATTATATGAAAGCAAATCAGATGATGGCACTTCTAGGTGTAGGACAAGGTAGTGCTAAGAAATCT
AGGCTTGTGGTTATGAGGTGGAATGGAGGAAAAGAAACAGACAGTCCGATAGCATTTGTTGGAAAAGGAGTGACGTTTGA
TACTGGTGGAATATCTTTAAAACCTTCTAGGGGTATGTGGGATATGAAATATGATATGGCTGGTTCTGCGTCTGTTGTAG
GTATTATGCGGACTCTTGCAGCAAGAAAAGCAAAAGTTAATGCTGTAGGTGTAGTAGGGTTAGTTGAAAATGCTGTAGGA
GGAAATGCGCAAAGACCAAGTGATGTTGTAACTTCAATGTCTGGGCAAACTATTGAAGTATTGAATACTGATGCAGAAGG
TAGACTAGTTTTGGCTGATGCTTTATGGTATACTCAGAAAATGTTTTCTCCAAAATTAATGATAGATTTAGCAACATTAA
CTGGTGCAGTGGTTGTAGCACTAGGAAATAATCAATATGGTGGGATTTTTTCAAACGATGATGCAATTGCCAATCAATTA
ATTGTTGCTGGTAATGAGTCCGGTGAGAAATTGTGGAGATTACCTTTAGATGATGCATATGATAAACTTATAGATTCTTC
GATTGCTGATGTGCAAAATATTTCAACAAAAGGGTATGGTGCAGATAGCATTACTGCTGCACAATTTTTACAGAGATTTG
TAAATAAGACTCCTTGGGTGCATCTGGATATTGCTGGAATGGCGTGGGATAATGAAGGTAATGAAATATGCCCTAAAGGT
GCAACTGGGTTTGGTGTAAGGTTACTGAATAGGTTGATTTTAAAATACTATGAGGCTAATTAA

Upstream 100 bases:

>100_bases
TTATTAAATAATTAATTATTATTCACTTAATTTTACTTGAAAAGTTTCTAAAAAGAGTTAAAGTAAAAATTACATGTAAA
TGCCAATTTAGGATAACCAT

Downstream 100 bases:

>100_bases
ACTATTGTAATAGTGTTTTGTTAACAAATTTATATAGTTATGATTTTATAAAGATTCTGGAGTACTAGTCAATTTGGGAT
ATAATATGATTTATTTTACG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MIDISFSSLMPGVSLFLKTTAIVVGIFEGSNHLEDYSALAERSEQIMKVVEGYKSFDGKFAEVLPITGLDAGYPIVIVVG
LGKPEEFDENKSLRIGGVIYSELNRMKISEASIISSNDSDIMANVAYGAFLRSFKFDKYFVQKKDENATYVRKLEFFSKT
NPQKTAVLFDNLKAEGESVFLARSFVSEPPNILYPEIYAQMIYEELSKVDVKVEIFDEDYMKANQMMALLGVGQGSAKKS
RLVVMRWNGGKETDSPIAFVGKGVTFDTGGISLKPSRGMWDMKYDMAGSASVVGIMRTLAARKAKVNAVGVVGLVENAVG
GNAQRPSDVVTSMSGQTIEVLNTDAEGRLVLADALWYTQKMFSPKLMIDLATLTGAVVVALGNNQYGGIFSNDDAIANQL
IVAGNESGEKLWRLPLDDAYDKLIDSSIADVQNISTKGYGADSITAAQFLQRFVNKTPWVHLDIAGMAWDNEGNEICPKG
ATGFGVRLLNRLILKYYEAN

Sequences:

>Translated_500_residues
MIDISFSSLMPGVSLFLKTTAIVVGIFEGSNHLEDYSALAERSEQIMKVVEGYKSFDGKFAEVLPITGLDAGYPIVIVVG
LGKPEEFDENKSLRIGGVIYSELNRMKISEASIISSNDSDIMANVAYGAFLRSFKFDKYFVQKKDENATYVRKLEFFSKT
NPQKTAVLFDNLKAEGESVFLARSFVSEPPNILYPEIYAQMIYEELSKVDVKVEIFDEDYMKANQMMALLGVGQGSAKKS
RLVVMRWNGGKETDSPIAFVGKGVTFDTGGISLKPSRGMWDMKYDMAGSASVVGIMRTLAARKAKVNAVGVVGLVENAVG
GNAQRPSDVVTSMSGQTIEVLNTDAEGRLVLADALWYTQKMFSPKLMIDLATLTGAVVVALGNNQYGGIFSNDDAIANQL
IVAGNESGEKLWRLPLDDAYDKLIDSSIADVQNISTKGYGADSITAAQFLQRFVNKTPWVHLDIAGMAWDNEGNEICPKG
ATGFGVRLLNRLILKYYEAN
>Mature_500_residues
MIDISFSSLMPGVSLFLKTTAIVVGIFEGSNHLEDYSALAERSEQIMKVVEGYKSFDGKFAEVLPITGLDAGYPIVIVVG
LGKPEEFDENKSLRIGGVIYSELNRMKISEASIISSNDSDIMANVAYGAFLRSFKFDKYFVQKKDENATYVRKLEFFSKT
NPQKTAVLFDNLKAEGESVFLARSFVSEPPNILYPEIYAQMIYEELSKVDVKVEIFDEDYMKANQMMALLGVGQGSAKKS
RLVVMRWNGGKETDSPIAFVGKGVTFDTGGISLKPSRGMWDMKYDMAGSASVVGIMRTLAARKAKVNAVGVVGLVENAVG
GNAQRPSDVVTSMSGQTIEVLNTDAEGRLVLADALWYTQKMFSPKLMIDLATLTGAVVVALGNNQYGGIFSNDDAIANQL
IVAGNESGEKLWRLPLDDAYDKLIDSSIADVQNISTKGYGADSITAAQFLQRFVNKTPWVHLDIAGMAWDNEGNEICPKG
ATGFGVRLLNRLILKYYEAN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=510, Percent_Identity=32.7450980392157, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI47155554, Length=384, Percent_Identity=31.5104166666667, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1790710, Length=501, Percent_Identity=37.5249500998004, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=35.5345911949685, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=410, Percent_Identity=30, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=357, Percent_Identity=29.1316526610644, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20129969, Length=432, Percent_Identity=31.4814814814815, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI21355725, Length=284, Percent_Identity=38.3802816901408, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24661038, Length=284, Percent_Identity=38.7323943661972, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24662227, Length=391, Percent_Identity=31.7135549872123, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI161077148, Length=423, Percent_Identity=29.7872340425532, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20130057, Length=423, Percent_Identity=29.7872340425532, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19922386, Length=454, Percent_Identity=28.8546255506608, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20129963, Length=445, Percent_Identity=31.0112359550562, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21355645, Length=409, Percent_Identity=30.0733496332518, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24662223, Length=409, Percent_Identity=30.0733496332518, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI21357381, Length=267, Percent_Identity=37.8277153558052, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI221379063, Length=267, Percent_Identity=37.8277153558052, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI221379062, Length=267, Percent_Identity=37.8277153558052, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24646701, Length=181, Percent_Identity=30.3867403314917, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646703, Length=181, Percent_Identity=30.3867403314917, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21358201, Length=181, Percent_Identity=30.3867403314917, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54686; Mature: 54686

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDISFSSLMPGVSLFLKTTAIVVGIFEGSNHLEDYSALAERSEQIMKVVEGYKSFDGKF
CEECCHHHHCCHHHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
AEVLPITGLDAGYPIVIVVGLGKPEEFDENKSLRIGGVIYSELNRMKISEASIISSNDSD
EEEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEECHHHHHHHHHEEECCCEEECCCCCC
IMANVAYGAFLRSFKFDKYFVQKKDENATYVRKLEFFSKTNPQKTAVLFDNLKAEGESVF
HHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEE
LARSFVSEPPNILYPEIYAQMIYEELSKVDVKVEIFDEDYMKANQMMALLGVGQGSAKKS
EEHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHEEEEEECCCCCCCCC
RLVVMRWNGGKETDSPIAFVGKGVTFDTGGISLKPSRGMWDMKYDMAGSASVVGIMRTLA
EEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCCCEEEECCCCCHHHHHHHHHHH
ARKAKVNAVGVVGLVENAVGGNAQRPSDVVTSMSGQTIEVLNTDAEGRLVLADALWYTQK
HHHHCCCEEEEEEHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHH
MFSPKLMIDLATLTGAVVVALGNNQYGGIFSNDDAIANQLIVAGNESGEKLWRLPLDDAY
HCCCCCEEEEEHHCCEEEEEECCCCCCCEECCCHHHHCEEEEECCCCCCEEEECCCHHHH
DKLIDSSIADVQNISTKGYGADSITAAQFLQRFVNKTPWVHLDIAGMAWDNEGNEICPKG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCC
ATGFGVRLLNRLILKYYEAN
CCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDISFSSLMPGVSLFLKTTAIVVGIFEGSNHLEDYSALAERSEQIMKVVEGYKSFDGKF
CEECCHHHHCCHHHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
AEVLPITGLDAGYPIVIVVGLGKPEEFDENKSLRIGGVIYSELNRMKISEASIISSNDSD
EEEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEECHHHHHHHHHEEECCCEEECCCCCC
IMANVAYGAFLRSFKFDKYFVQKKDENATYVRKLEFFSKTNPQKTAVLFDNLKAEGESVF
HHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEE
LARSFVSEPPNILYPEIYAQMIYEELSKVDVKVEIFDEDYMKANQMMALLGVGQGSAKKS
EEHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHEEEEEECCCCCCCCC
RLVVMRWNGGKETDSPIAFVGKGVTFDTGGISLKPSRGMWDMKYDMAGSASVVGIMRTLA
EEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCCCEEEECCCCCHHHHHHHHHHH
ARKAKVNAVGVVGLVENAVGGNAQRPSDVVTSMSGQTIEVLNTDAEGRLVLADALWYTQK
HHHHCCCEEEEEEHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHH
MFSPKLMIDLATLTGAVVVALGNNQYGGIFSNDDAIANQLIVAGNESGEKLWRLPLDDAY
HCCCCCEEEEEHHCCEEEEEECCCCCCCEECCCHHHHCEEEEECCCCCCEEEECCCHHHH
DKLIDSSIADVQNISTKGYGADSITAAQFLQRFVNKTPWVHLDIAGMAWDNEGNEICPKG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCC
ATGFGVRLLNRLILKYYEAN
CCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA