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The map label for this gene is frr [H]

Identifier: 88658452

GI number: 88658452

Start: 251369

End: 251926

Strand: Direct

Name: frr [H]

Synonym: ECH_0267

Alternate gene names: 88658452

Gene position: 251369-251926 (Clockwise)

Preceding gene: 88658317

Following gene: 88658570

Centisome position: 21.37

GC content: 31.36

Gene sequence:

>558_bases
ATGATAAGTGAAGTTAAACAAGATGCTAAAAGTAGAATGGAAAAGAGTTTATCTGTATATTTAAGTGATATTGATGGTAT
TAGAACTGGAAGAGCAAGAACTTCTGTATTGAATGGAATTGTTGTTGAAACTTATGGTGGACGTGTAAAATTGAATACAA
TATCAAGTGTATCTGTATCTGATAATAAAACCTTGATGATTAAAGTATGGGATTCTAACAACATAGGGGCTATCAAAACT
GCAATTATGAATTCGAATCTTGGATTTGGGATTTCTTGTGAAGCAACAACAATTCGATTGACTGTTCCAGATATGACACA
GGATATGAGAAAAAATTTGGTTAAGTTATTGGGTAAAATTTCAGAAGACTGTAGAGTTTCTATCCGTAATATACGTAGAG
ATATCATGGATAGATTAAAGGTCATGCAAGATAGTAAAGAGATTTCTGAAGATGATTTACGTGTAGCTGGAGTAGAAATA
CAAAAGATCACAGATGATATTATGAAAAAAGTAAATGATGCTTTTACTTCGAAGGAGAAGGAATTGTTACATGTTTAA

Upstream 100 bases:

>100_bases
GTATTTAATCTGGGTCAACCTGGTAGTTTTGCGGATATAATCCGTGGAGATGGTTTGTATACGACAATATATAATTAAGT
TAAAGTATTGGTATAAGTGA

Downstream 100 bases:

>100_bases
TTCTAATTATGGTTTTACAGAAGTCAGTTGCTTTGTTTTGATATTTCAAAGAATAAATTTTTAAAAAGTTGATAGATGCA
TGACTTTGAGTATTAGGAAG

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MISEVKQDAKSRMEKSLSVYLSDIDGIRTGRARTSVLNGIVVETYGGRVKLNTISSVSVSDNKTLMIKVWDSNNIGAIKT
AIMNSNLGFGISCEATTIRLTVPDMTQDMRKNLVKLLGKISEDCRVSIRNIRRDIMDRLKVMQDSKEISEDDLRVAGVEI
QKITDDIMKKVNDAFTSKEKELLHV

Sequences:

>Translated_185_residues
MISEVKQDAKSRMEKSLSVYLSDIDGIRTGRARTSVLNGIVVETYGGRVKLNTISSVSVSDNKTLMIKVWDSNNIGAIKT
AIMNSNLGFGISCEATTIRLTVPDMTQDMRKNLVKLLGKISEDCRVSIRNIRRDIMDRLKVMQDSKEISEDDLRVAGVEI
QKITDDIMKKVNDAFTSKEKELLHV
>Mature_185_residues
MISEVKQDAKSRMEKSLSVYLSDIDGIRTGRARTSVLNGIVVETYGGRVKLNTISSVSVSDNKTLMIKVWDSNNIGAIKT
AIMNSNLGFGISCEATTIRLTVPDMTQDMRKNLVKLLGKISEDCRVSIRNIRRDIMDRLKVMQDSKEISEDDLRVAGVEI
QKITDDIMKKVNDAFTSKEKELLHV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another [H]

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family [H]

Homologues:

Organism=Homo sapiens, GI20270317, Length=184, Percent_Identity=29.8913043478261, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI291042689, Length=157, Percent_Identity=31.2101910828025, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI1786368, Length=184, Percent_Identity=42.3913043478261, Blast_Score=155, Evalue=2e-39,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002661
- InterPro:   IPR015998 [H]

Pfam domain/function: PF01765 RRF [H]

EC number: NA

Molecular weight: Translated: 20710; Mature: 20710

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEVKQDAKSRMEKSLSVYLSDIDGIRTGRARTSVLNGIVVETYGGRVKLNTISSVSVS
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEECCCEEEEEEEEEEEEC
DNKTLMIKVWDSNNIGAIKTAIMNSNLGFGISCEATTIRLTVPDMTQDMRKNLVKLLGKI
CCCEEEEEEECCCCCCHHHHHEECCCCCCCEEECCEEEEEECCHHHHHHHHHHHHHHHHC
SEDCRVSIRNIRRDIMDRLKVMQDSKEISEDDLRVAGVEIQKITDDIMKKVNDAFTSKEK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCH
ELLHV
HHCCC
>Mature Secondary Structure
MISEVKQDAKSRMEKSLSVYLSDIDGIRTGRARTSVLNGIVVETYGGRVKLNTISSVSVS
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEECCCEEEEEEEEEEEEC
DNKTLMIKVWDSNNIGAIKTAIMNSNLGFGISCEATTIRLTVPDMTQDMRKNLVKLLGKI
CCCEEEEEEECCCCCCHHHHHEECCCCCCCEEECCEEEEEECCHHHHHHHHHHHHHHHHC
SEDCRVSIRNIRRDIMDRLKVMQDSKEISEDDLRVAGVEIQKITDDIMKKVNDAFTSKEK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCH
ELLHV
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA