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The map label for this gene is pyrH [H]

Identifier: 88658317

GI number: 88658317

Start: 250612

End: 251346

Strand: Direct

Name: pyrH [H]

Synonym: ECH_0266

Alternate gene names: 88658317

Gene position: 250612-251346 (Clockwise)

Preceding gene: 88657810

Following gene: 88658452

Centisome position: 21.31

GC content: 37.55

Gene sequence:

>735_bases
ATGAGTGAGGCCTCTGCTACTAAAGTTAAGTATTCTAGAGTTTTACTAAAAGTGTCTGGTGAAGCGTTAATGGGAAAAAA
AGGCTTTGGGTGTGATATAGAGGTGCTGGATAAGCTATCTCATGATCTCAAAGAAGTCCATAGTTTTGGAGTACAGCTGT
GTTTGGTTGTAGGTGGTGGAAATATATTCCGTGGTGCATCAGCCTCAGCATCTTTTGGATTTGAGCGAGCTAGTAATGAC
TATATAGGAATGCTAGCTACTATGATGAATGCTTTATCTCTACAGAATGCTTTGGAAAAAGTAAATGTTCAATCTAGAGT
TTTGTCAGCTATTCCTATTACTGCTGTCTGTGAAACATACATTAGAAGACGTGCTATACGTCATTTAGAAAAAGGGAGAG
TAGTTATATGTGCTGCCGGAGTAGGTAGCCCATTCTTTACTACAGATACTGCAGCTGCGTTACGTGGTATAGAAATGGGT
TGTGATGCTATATTTAAAGGTACACAGGTTGATGGGGTATATTCTGCTGACCCTAAAAAAAATGCTGATGCGGTAAGATA
TGATAAAATTTCTTATCGTGATTTATTATCGTTAGATCTTAAAATTATGGATGTTGCTGCTGTTTCTTTGGCTAGAGAGC
ATTCAGTACCTATTATTGTATTTAATCTGGGTCAACCTGGTAGTTTTGCGGATATAATCCGTGGAGATGGTTTGTATACG
ACAATATATAATTAA

Upstream 100 bases:

>100_bases
ATATTGGGAATTTGTATATTGCATCTTTTTGTAGCTAAGATATAATTTATCGTATCTGTGTTTGCTATATTTTAGTTACT
AGCTAAGAAAAGGAAAGTTA

Downstream 100 bases:

>100_bases
GTTAAAGTATTGGTATAAGTGAATGATAAGTGAAGTTAAACAAGATGCTAAAAGTAGAATGGAAAAGAGTTTATCTGTAT
ATTTAAGTGATATTGATGGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSEASATKVKYSRVLLKVSGEALMGKKGFGCDIEVLDKLSHDLKEVHSFGVQLCLVVGGGNIFRGASASASFGFERASND
YIGMLATMMNALSLQNALEKVNVQSRVLSAIPITAVCETYIRRRAIRHLEKGRVVICAAGVGSPFFTTDTAAALRGIEMG
CDAIFKGTQVDGVYSADPKKNADAVRYDKISYRDLLSLDLKIMDVAAVSLAREHSVPIIVFNLGQPGSFADIIRGDGLYT
TIYN

Sequences:

>Translated_244_residues
MSEASATKVKYSRVLLKVSGEALMGKKGFGCDIEVLDKLSHDLKEVHSFGVQLCLVVGGGNIFRGASASASFGFERASND
YIGMLATMMNALSLQNALEKVNVQSRVLSAIPITAVCETYIRRRAIRHLEKGRVVICAAGVGSPFFTTDTAAALRGIEMG
CDAIFKGTQVDGVYSADPKKNADAVRYDKISYRDLLSLDLKIMDVAAVSLAREHSVPIIVFNLGQPGSFADIIRGDGLYT
TIYN
>Mature_243_residues
SEASATKVKYSRVLLKVSGEALMGKKGFGCDIEVLDKLSHDLKEVHSFGVQLCLVVGGGNIFRGASASASFGFERASNDY
IGMLATMMNALSLQNALEKVNVQSRVLSAIPITAVCETYIRRRAIRHLEKGRVVICAAGVGSPFFTTDTAAALRGIEMGC
DAIFKGTQVDGVYSADPKKNADAVRYDKISYRDLLSLDLKIMDVAAVSLAREHSVPIIVFNLGQPGSFADIIRGDGLYTT
IYN

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=47.6394849785408, Blast_Score=244, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26266; Mature: 26134

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEASATKVKYSRVLLKVSGEALMGKKGFGCDIEVLDKLSHDLKEVHSFGVQLCLVVGGG
CCCCHHHHHHHHEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECC
NIFRGASASASFGFERASNDYIGMLATMMNALSLQNALEKVNVQSRVLSAIPITAVCETY
CEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IRRRAIRHLEKGRVVICAAGVGSPFFTTDTAAALRGIEMGCDAIFKGTQVDGVYSADPKK
HHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHCHHHHCCCCCCCCEECCCCCC
NADAVRYDKISYRDLLSLDLKIMDVAAVSLAREHSVPIIVFNLGQPGSFADIIRGDGLYT
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCEEE
TIYN
EECC
>Mature Secondary Structure 
SEASATKVKYSRVLLKVSGEALMGKKGFGCDIEVLDKLSHDLKEVHSFGVQLCLVVGGG
CCCHHHHHHHHEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECC
NIFRGASASASFGFERASNDYIGMLATMMNALSLQNALEKVNVQSRVLSAIPITAVCETY
CEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IRRRAIRHLEKGRVVICAAGVGSPFFTTDTAAALRGIEMGCDAIFKGTQVDGVYSADPKK
HHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHCHHHHCCCCCCCCEECCCCCC
NADAVRYDKISYRDLLSLDLKIMDVAAVSLAREHSVPIIVFNLGQPGSFADIIRGDGLYT
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCEEE
TIYN
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA