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The map label for this gene is bioC [H]

Identifier: 88658129

GI number: 88658129

Start: 30385

End: 31134

Strand: Direct

Name: bioC [H]

Synonym: ECH_0035

Alternate gene names: 88658129

Gene position: 30385-31134 (Clockwise)

Preceding gene: 88657644

Following gene: 88657840

Centisome position: 2.58

GC content: 27.87

Gene sequence:

>750_bases
ATGGGTCTTATTACTCAAAAAATACAAAAAGCATTCGATAATGCAGCAAGTTCGTATGATAAATACTCTCATATACAAGA
CGTGATTTTGCGTGAATTATGTAGCACTGTGGTGTTAGAAAGTTGTGATAAGAGAAACATATTAGATGTAGGGTGTGGTA
CTGGAAATATGAGTAAATTCTTAAATGTTGCAAATCATAATTTGATTCAAGTAGATTTATCTCGGGAAATGTGTGTTTTA
GCTAAGAAAAAGAATAATGCATTGTCAGTAAATTGCCATATGGATGTAATGCCATTTTATGAAAATTTTTTTGATGTTAT
TATTGCCTCAATGGTTTTACAATGGTCTCGTGATGTTAGCATTTCTTTATTGGAATTGTTTCGAGTCATGAAATCTGATG
GTATATTGTATGTGGCAATTCCAATATTTGGAACTCTAATCGAATTGAATAATGTAATTGAAAAAGTAGGAGGATCTTTT
AGTCAATTTTATAAAATGAATGAATTTATAAATATAGTAAATTCCTTTAATGTTAAAGTACAATATGCATTTTGTTGTAA
TTATCGTCAATATCATAAGTCATTTCGTGCTTTCTTATTGAGTATGAAATTGACAGGTGTATATACAAAAAAAGTTAGTG
ATGAACAATATAATATATTTGAAATAAGCAAGATTTATAAGGAATTATATTCTTTGCAGAATTGTATTTTTAACTCGTGG
AACATTATGTATTTGGTTGTTAAAAAGTAA

Upstream 100 bases:

>100_bases
TGAGCTGATAAGTATTTGTATAATTTGTAATGACTTTAATGTACGTTGCTATTTTGCCTTTATTTATGAATATTGTTTTT
GTTGTTAGTAATTATACAAT

Downstream 100 bases:

>100_bases
TTTTTTTGTCATAATGATTAAATGAAAGAACTTGATGTCATAACACTATTGCAAGAAATACGTCATTTGGCTCAGGAAAG
TAATGCTGTAATTCTTGCTC

Product: putative biotin synthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MGLITQKIQKAFDNAASSYDKYSHIQDVILRELCSTVVLESCDKRNILDVGCGTGNMSKFLNVANHNLIQVDLSREMCVL
AKKKNNALSVNCHMDVMPFYENFFDVIIASMVLQWSRDVSISLLELFRVMKSDGILYVAIPIFGTLIELNNVIEKVGGSF
SQFYKMNEFINIVNSFNVKVQYAFCCNYRQYHKSFRAFLLSMKLTGVYTKKVSDEQYNIFEISKIYKELYSLQNCIFNSW
NIMYLVVKK

Sequences:

>Translated_249_residues
MGLITQKIQKAFDNAASSYDKYSHIQDVILRELCSTVVLESCDKRNILDVGCGTGNMSKFLNVANHNLIQVDLSREMCVL
AKKKNNALSVNCHMDVMPFYENFFDVIIASMVLQWSRDVSISLLELFRVMKSDGILYVAIPIFGTLIELNNVIEKVGGSF
SQFYKMNEFINIVNSFNVKVQYAFCCNYRQYHKSFRAFLLSMKLTGVYTKKVSDEQYNIFEISKIYKELYSLQNCIFNSW
NIMYLVVKK
>Mature_248_residues
GLITQKIQKAFDNAASSYDKYSHIQDVILRELCSTVVLESCDKRNILDVGCGTGNMSKFLNVANHNLIQVDLSREMCVLA
KKKNNALSVNCHMDVMPFYENFFDVIIASMVLQWSRDVSISLLELFRVMKSDGILYVAIPIFGTLIELNNVIEKVGGSFS
QFYKMNEFINIVNSFNVKVQYAFCCNYRQYHKSFRAFLLSMKLTGVYTKKVSDEQYNIFEISKIYKELYSLQNCIFNSWN
IMYLVVKK

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786994, Length=112, Percent_Identity=29.4642857142857, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 28773; Mature: 28642

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLITQKIQKAFDNAASSYDKYSHIQDVILRELCSTVVLESCDKRNILDVGCGTGNMSKF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHH
LNVANHNLIQVDLSREMCVLAKKKNNALSVNCHMDVMPFYENFFDVIIASMVLQWSRDVS
HHHHCCCEEEEECCCCCEEEEECCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCH
ISLLELFRVMKSDGILYVAIPIFGTLIELNNVIEKVGGSFSQFYKMNEFINIVNSFNVKV
HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEE
QYAFCCNYRQYHKSFRAFLLSMKLTGVYTKKVSDEQYNIFEISKIYKELYSLQNCIFNSW
EEEEECCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
NIMYLVVKK
CEEEEEEEC
>Mature Secondary Structure 
GLITQKIQKAFDNAASSYDKYSHIQDVILRELCSTVVLESCDKRNILDVGCGTGNMSKF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHH
LNVANHNLIQVDLSREMCVLAKKKNNALSVNCHMDVMPFYENFFDVIIASMVLQWSRDVS
HHHHCCCEEEEECCCCCEEEEECCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCH
ISLLELFRVMKSDGILYVAIPIFGTLIELNNVIEKVGGSFSQFYKMNEFINIVNSFNVKV
HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEE
QYAFCCNYRQYHKSFRAFLLSMKLTGVYTKKVSDEQYNIFEISKIYKELYSLQNCIFNSW
EEEEECCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
NIMYLVVKK
CEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]