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The map label for this gene is aatA [H]

Identifier: 88658023

GI number: 88658023

Start: 743338

End: 744534

Strand: Reverse

Name: aatA [H]

Synonym: ECH_0732

Alternate gene names: 88658023

Gene position: 744534-743338 (Counterclockwise)

Preceding gene: 88657767

Following gene: 88658449

Centisome position: 63.3

GC content: 31.66

Gene sequence:

>1197_bases
ATGTCACTTATAGCTGAAAGAATGGGGTGTATCAAACCTTCACCTACACTTGAAATTGCAAATCAAGCTCAAAAATTAAA
AATGTCAGGAGTAGATGTAATTTCTTTGAGTGCTGGTGAACCTGATTTTGATACACCACAGCATATTAAGCAAGCAGCTA
TTGATGCAATTAATTCTGGTAAAACTAAATATACAGCAGTTAATGGTATTATTGAATTGAAAAAAGTGATTATTGATCGT
TTCAAACAGGATCATGATTTAATTTATAATGTCAATCAGATTTCTGTTGGAAATGGTGCAAAACAATGTATTTATAATTT
ATTTATGGCTACTATAAATAGTGGTGATGAGGTAATAATACCATCCCCATATTGGGTGTCTTATCCAGATGTGGTAAAAA
TATCTGGAGGAAATCCTGTTATTGTTGATTGTGGTGAAACATTTAAATTAACTCCTGATATATTAGAATCTGTAATTACT
GAGAAAACTAAGTGGTTAATTATGAATTCTCCGAATAATCCTACAGGGTTAGTATATACATATGAAGAATTAAAAAGTAT
TGCTGAAGTTTTATTGAAATACCCAAATATTTATGTAATGACTGATGATATATATTCAAAGATAATATATGATGATCTTG
AATTTTTCACTATTGCCCAAGTTGAGCCACGCTTATATGATAGAGTCTTTACAATTAATGGTGTCTCAAAAGCGTATGCC
ATGACTGGATGGAGAATAGGGTATATAGCTGGTGATTCGAGAGTTATTAGTGCGATTTCTGTTATACAATCGCAAAGTAC
AACAAATCCTAATAGTATTGCACAGTTTGCATCAATACAGGCTTTAGCTGGTGATCAAGAATTTTTAAAAGAACGAAATA
AAATATTTGCGGCACGTCGTGATATGATGGTAGATATGGTAAATAATACCTCATTGTTATCTGTTAAAAAGCCTCAAGGT
GCGTTTTATGTATTTATTTCTTGTAAAAAGTTGATAGGTAAAAGTACAAGGAATGGTTTGGTTATAAATAGTGCTATGGA
TTTTACTAAGTACTTATTAGAAGATTACAATGTTGCTGTAGTGCCAGGTGAAGCGTTTGGAGCACAAGGATTTTTTAGAA
TATCTTATGCTACTTCTACTGAACATTTATCTAAAGCTTGTGATCGTATTTTAGATGCGTGTGGTAAATTATCATAG

Upstream 100 bases:

>100_bases
ATTAATACATTATATAATTATGATGTGGATAACAATAATATTGAATATTAGTTGAAGTGTACTAGAATACATTTGTTTAT
ATAAAAATGTTAGGGTAATT

Downstream 100 bases:

>100_bases
AGTGCTAAACAATAGTATTACATTTTTAAATTATGTTAGATACGTAAGCATGTGTTTTACGCGAAACAAGGTTGTAAATA
AAAATATTACCATGAATAGT

Product: aspartate aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSLIAERMGCIKPSPTLEIANQAQKLKMSGVDVISLSAGEPDFDTPQHIKQAAIDAINSGKTKYTAVNGIIELKKVIIDR
FKQDHDLIYNVNQISVGNGAKQCIYNLFMATINSGDEVIIPSPYWVSYPDVVKISGGNPVIVDCGETFKLTPDILESVIT
EKTKWLIMNSPNNPTGLVYTYEELKSIAEVLLKYPNIYVMTDDIYSKIIYDDLEFFTIAQVEPRLYDRVFTINGVSKAYA
MTGWRIGYIAGDSRVISAISVIQSQSTTNPNSIAQFASIQALAGDQEFLKERNKIFAARRDMMVDMVNNTSLLSVKKPQG
AFYVFISCKKLIGKSTRNGLVINSAMDFTKYLLEDYNVAVVPGEAFGAQGFFRISYATSTEHLSKACDRILDACGKLS

Sequences:

>Translated_398_residues
MSLIAERMGCIKPSPTLEIANQAQKLKMSGVDVISLSAGEPDFDTPQHIKQAAIDAINSGKTKYTAVNGIIELKKVIIDR
FKQDHDLIYNVNQISVGNGAKQCIYNLFMATINSGDEVIIPSPYWVSYPDVVKISGGNPVIVDCGETFKLTPDILESVIT
EKTKWLIMNSPNNPTGLVYTYEELKSIAEVLLKYPNIYVMTDDIYSKIIYDDLEFFTIAQVEPRLYDRVFTINGVSKAYA
MTGWRIGYIAGDSRVISAISVIQSQSTTNPNSIAQFASIQALAGDQEFLKERNKIFAARRDMMVDMVNNTSLLSVKKPQG
AFYVFISCKKLIGKSTRNGLVINSAMDFTKYLLEDYNVAVVPGEAFGAQGFFRISYATSTEHLSKACDRILDACGKLS
>Mature_397_residues
SLIAERMGCIKPSPTLEIANQAQKLKMSGVDVISLSAGEPDFDTPQHIKQAAIDAINSGKTKYTAVNGIIELKKVIIDRF
KQDHDLIYNVNQISVGNGAKQCIYNLFMATINSGDEVIIPSPYWVSYPDVVKISGGNPVIVDCGETFKLTPDILESVITE
KTKWLIMNSPNNPTGLVYTYEELKSIAEVLLKYPNIYVMTDDIYSKIIYDDLEFFTIAQVEPRLYDRVFTINGVSKAYAM
TGWRIGYIAGDSRVISAISVIQSQSTTNPNSIAQFASIQALAGDQEFLKERNKIFAARRDMMVDMVNNTSLLSVKKPQGA
FYVFISCKKLIGKSTRNGLVINSAMDFTKYLLEDYNVAVVPGEAFGAQGFFRISYATSTEHLSKACDRILDACGKLS

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=413, Percent_Identity=24.9394673123487, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI169881279, Length=413, Percent_Identity=24.9394673123487, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI56713254, Length=360, Percent_Identity=26.9444444444444, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI56713256, Length=360, Percent_Identity=26.9444444444444, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI169881281, Length=301, Percent_Identity=22.9235880398671, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4507369, Length=376, Percent_Identity=23.1382978723404, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1788627, Length=323, Percent_Identity=30.9597523219814, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788722, Length=392, Percent_Identity=28.8265306122449, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1786816, Length=371, Percent_Identity=24.2587601078167, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17567663, Length=396, Percent_Identity=23.4848484848485, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71994476, Length=433, Percent_Identity=26.0969976905312, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71994472, Length=433, Percent_Identity=26.0969976905312, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17567369, Length=363, Percent_Identity=26.4462809917355, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6322401, Length=398, Percent_Identity=23.6180904522613, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323118, Length=361, Percent_Identity=24.0997229916898, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320317, Length=341, Percent_Identity=24.0469208211144, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573069, Length=389, Percent_Identity=24.1645244215938, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24646114, Length=389, Percent_Identity=24.1645244215938, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28573067, Length=389, Percent_Identity=24.1645244215938, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28573065, Length=389, Percent_Identity=24.1645244215938, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI18859735, Length=384, Percent_Identity=21.3541666666667, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 44073; Mature: 43942

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIAERMGCIKPSPTLEIANQAQKLKMSGVDVISLSAGEPDFDTPQHIKQAAIDAINSG
CCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCC
KTKYTAVNGIIELKKVIIDRFKQDHDLIYNVNQISVGNGAKQCIYNLFMATINSGDEVII
CEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEE
PSPYWVSYPDVVKISGGNPVIVDCGETFKLTPDILESVITEKTKWLIMNSPNNPTGLVYT
CCCCEECCCCEEEECCCCEEEEECCCCEEECHHHHHHHHCCCEEEEEEECCCCCCEEEEE
YEELKSIAEVLLKYPNIYVMTDDIYSKIIYDDLEFFTIAQVEPRLYDRVFTINGVSKAYA
HHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCEEEEEECCHHHHHEEEEECCCHHHHE
MTGWRIGYIAGDSRVISAISVIQSQSTTNPNSIAQFASIQALAGDQEFLKERNKIFAARR
ECCEEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DMMVDMVNNTSLLSVKKPQGAFYVFISCKKLIGKSTRNGLVINSAMDFTKYLLEDYNVAV
HHHEEEECCCEEEEEECCCCCEEEEEEEHHHHCCCCCCCEEEECHHHHHHHHHHCCCEEE
VPGEAFGAQGFFRISYATSTEHLSKACDRILDACGKLS
ECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLIAERMGCIKPSPTLEIANQAQKLKMSGVDVISLSAGEPDFDTPQHIKQAAIDAINSG
CCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCC
KTKYTAVNGIIELKKVIIDRFKQDHDLIYNVNQISVGNGAKQCIYNLFMATINSGDEVII
CEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEE
PSPYWVSYPDVVKISGGNPVIVDCGETFKLTPDILESVITEKTKWLIMNSPNNPTGLVYT
CCCCEECCCCEEEECCCCEEEEECCCCEEECHHHHHHHHCCCEEEEEEECCCCCCEEEEE
YEELKSIAEVLLKYPNIYVMTDDIYSKIIYDDLEFFTIAQVEPRLYDRVFTINGVSKAYA
HHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCEEEEEECCHHHHHEEEEECCCHHHHE
MTGWRIGYIAGDSRVISAISVIQSQSTTNPNSIAQFASIQALAGDQEFLKERNKIFAARR
ECCEEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DMMVDMVNNTSLLSVKKPQGAFYVFISCKKLIGKSTRNGLVINSAMDFTKYLLEDYNVAV
HHHEEEECCCEEEEEECCCCCEEEEEEEHHHHCCCCCCCEEEECHHHHHHHHHHCCCEEE
VPGEAFGAQGFFRISYATSTEHLSKACDRILDACGKLS
ECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA