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The map label for this gene is nuoD [H]

Identifier: 88658000

GI number: 88658000

Start: 621177

End: 622358

Strand: Reverse

Name: nuoD [H]

Synonym: ECH_0616

Alternate gene names: 88658000

Gene position: 622358-621177 (Counterclockwise)

Preceding gene: 88658474

Following gene: 88658623

Centisome position: 52.91

GC content: 33.16

Gene sequence:

>1182_bases
ATGTCTGATCGAGTCAAAATTACACCAATGACTTTAAATTTTGGTCCTCAACATCCCGCAGCTCATGGTGTAATGCGTTT
GGTTTTAGAAATGGGTGGTGAAGTTATAGAAAGGATAGATCCACATATTGGGTTATTGCATAGAGGAACAGAAAAATTAA
TAGAATATAAAACATATTTACAAGCTTTACCATATTTTGACCGTCTTGATTATGTATCTCCAATGTGTCAAGAGCATGCT
TATTCTTTATGTGTGGAGAAGTTATTAAAATGTGAAATACCAATTAGAGCTAAATATTTACGTGTTATTTTTTGTGAGTT
AACTAGAATATTGAATCATTTGTTAAATATATCAAGCCAAGCGCTAGATATAGGTGCTATGACACCTTTACTATGGATGT
TTGAAGAAAGAGAGAAGATTTTAGGTTTTTATGAAAGAGCATCAGGTGCGAGGTTTCATTCTGCTTATATTCGTCCTGGA
GGTGTAGCAGCTGATGTTCCAGATGATTTGATTGATGATATATTTAAATTTATTAAAACTTTCCCTAAGTTTATAGATGA
TGTAGATGAGTTGTTAACTGAAAATAGGATTTGGAAACAACGTAATGTTGATATTGGTATTGTATCAAAAGAACAGGCAT
TAGATTGGGGTTTTTCTGGTCCAATGTTAAGGGCTTGTGGTATTCCTTGGGATTTACGTAAAAGTCAACCTTATGAAATA
TATGAAGATTTAGAATTTGAAATTCCTATTGGAAAAAAAGGAGATTGTTATGATCGTTATCTAGTAAGGATGGCAGAGAT
TAGGCAATCAATTAAGTTGCTTGAACAATGCTTGAATCGTCTTCCAAATGGTCCAATAAAAACAGATGATAGAAAAATTG
CTCCACCAAAAAGGTCGGAAATGAAAGAATCTATGGAAGCGTTAATACATCATTTTAAATTATATTCAGAGGGTTATAGT
GTTCCAATAGGAGAAACTTATATGGCTGTTGAAGCTCCAAAAGGTGAATTTGGTGTATACATAGTATCTGATGGAACAAA
TAAACCATATAGGTGTAGGATTAGAGCTCCTGGATTTGCTCATTTGCAAGCTATAGATATGATGGCAAAAGGTCATATGT
TAGCTGATTTAACAGCCATAATTGGGTCTTTAGATATAGTATTTGGAGAAATAGATAGGTAA

Upstream 100 bases:

>100_bases
TGTTAAATAAGAATTTCTCTTTATGCTATATAGAAGCTTGTTCTTGACATGTGATATATGTACTTACATAATTTATAGTT
ATATTCTTGGTAATTTGGTA

Downstream 100 bases:

>100_bases
TGAGTAATGTCTAATATACAGAAAAATAGTAATGAACATTATACTGAAACATTTAAATTTAATAAGGATAACTTAAAACA
AGCAAATGATACAATTAGTA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSDRVKITPMTLNFGPQHPAAHGVMRLVLEMGGEVIERIDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSPMCQEHA
YSLCVEKLLKCEIPIRAKYLRVIFCELTRILNHLLNISSQALDIGAMTPLLWMFEEREKILGFYERASGARFHSAYIRPG
GVAADVPDDLIDDIFKFIKTFPKFIDDVDELLTENRIWKQRNVDIGIVSKEQALDWGFSGPMLRACGIPWDLRKSQPYEI
YEDLEFEIPIGKKGDCYDRYLVRMAEIRQSIKLLEQCLNRLPNGPIKTDDRKIAPPKRSEMKESMEALIHHFKLYSEGYS
VPIGETYMAVEAPKGEFGVYIVSDGTNKPYRCRIRAPGFAHLQAIDMMAKGHMLADLTAIIGSLDIVFGEIDR

Sequences:

>Translated_393_residues
MSDRVKITPMTLNFGPQHPAAHGVMRLVLEMGGEVIERIDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSPMCQEHA
YSLCVEKLLKCEIPIRAKYLRVIFCELTRILNHLLNISSQALDIGAMTPLLWMFEEREKILGFYERASGARFHSAYIRPG
GVAADVPDDLIDDIFKFIKTFPKFIDDVDELLTENRIWKQRNVDIGIVSKEQALDWGFSGPMLRACGIPWDLRKSQPYEI
YEDLEFEIPIGKKGDCYDRYLVRMAEIRQSIKLLEQCLNRLPNGPIKTDDRKIAPPKRSEMKESMEALIHHFKLYSEGYS
VPIGETYMAVEAPKGEFGVYIVSDGTNKPYRCRIRAPGFAHLQAIDMMAKGHMLADLTAIIGSLDIVFGEIDR
>Mature_392_residues
SDRVKITPMTLNFGPQHPAAHGVMRLVLEMGGEVIERIDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSPMCQEHAY
SLCVEKLLKCEIPIRAKYLRVIFCELTRILNHLLNISSQALDIGAMTPLLWMFEEREKILGFYERASGARFHSAYIRPGG
VAADVPDDLIDDIFKFIKTFPKFIDDVDELLTENRIWKQRNVDIGIVSKEQALDWGFSGPMLRACGIPWDLRKSQPYEIY
EDLEFEIPIGKKGDCYDRYLVRMAEIRQSIKLLEQCLNRLPNGPIKTDDRKIAPPKRSEMKESMEALIHHFKLYSEGYSV
PIGETYMAVEAPKGEFGVYIVSDGTNKPYRCRIRAPGFAHLQAIDMMAKGHMLADLTAIIGSLDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=387, Percent_Identity=66.1498708010336, Blast_Score=567, Evalue=1e-162,
Organism=Homo sapiens, GI260898743, Length=378, Percent_Identity=66.1375661375661, Blast_Score=552, Evalue=1e-157,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=41.2987012987013, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1789076, Length=380, Percent_Identity=27.1052631578947, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788832, Length=380, Percent_Identity=27.1052631578947, Blast_Score=121, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17555284, Length=384, Percent_Identity=64.3229166666667, Blast_Score=547, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17568379, Length=384, Percent_Identity=64.3229166666667, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24638644, Length=395, Percent_Identity=65.8227848101266, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=60.2094240837696, Blast_Score=516, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45020; Mature: 44889

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRVKITPMTLNFGPQHPAAHGVMRLVLEMGGEVIERIDPHIGLLHRGTEKLIEYKTYL
CCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
QALPYFDRLDYVSPMCQEHAYSLCVEKLLKCEIPIRAKYLRVIFCELTRILNHLLNISSQ
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
ALDIGAMTPLLWMFEEREKILGFYERASGARFHSAYIRPGGVAADVPDDLIDDIFKFIKT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
FPKFIDDVDELLTENRIWKQRNVDIGIVSKEQALDWGFSGPMLRACGIPWDLRKSQPYEI
HHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHH
YEDLEFEIPIGKKGDCYDRYLVRMAEIRQSIKLLEQCLNRLPNGPIKTDDRKIAPPKRSE
HCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
MKESMEALIHHFKLYSEGYSVPIGETYMAVEAPKGEFGVYIVSDGTNKPYRCRIRAPGFA
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCHH
HLQAIDMMAKGHMLADLTAIIGSLDIVFGEIDR
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDRVKITPMTLNFGPQHPAAHGVMRLVLEMGGEVIERIDPHIGLLHRGTEKLIEYKTYL
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
QALPYFDRLDYVSPMCQEHAYSLCVEKLLKCEIPIRAKYLRVIFCELTRILNHLLNISSQ
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
ALDIGAMTPLLWMFEEREKILGFYERASGARFHSAYIRPGGVAADVPDDLIDDIFKFIKT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
FPKFIDDVDELLTENRIWKQRNVDIGIVSKEQALDWGFSGPMLRACGIPWDLRKSQPYEI
HHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHH
YEDLEFEIPIGKKGDCYDRYLVRMAEIRQSIKLLEQCLNRLPNGPIKTDDRKIAPPKRSE
HCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
MKESMEALIHHFKLYSEGYSVPIGETYMAVEAPKGEFGVYIVSDGTNKPYRCRIRAPGFA
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCHH
HLQAIDMMAKGHMLADLTAIIGSLDIVFGEIDR
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA