| Definition | Ehrlichia chaffeensis str. Arkansas, complete genome. |
|---|---|
| Accession | NC_007799 |
| Length | 1,176,248 |
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The map label for this gene is virB4-1 [H]
Identifier: 88657911
GI number: 88657911
Start: 481344
End: 483746
Strand: Direct
Name: virB4-1 [H]
Synonym: ECH_0495
Alternate gene names: 88657911
Gene position: 481344-483746 (Clockwise)
Preceding gene: 88657764
Following gene: 88658009
Centisome position: 40.92
GC content: 31.63
Gene sequence:
>2403_bases ATGTTAAAATTTCAACAATTGCAAACGAAAAAAAGAAAAGTAATTAAGAGGGAATATCATGAATCTAATTTTATTCCCTA TAGTGAACATTGGAATTCTTCTACATTGATGACAAAAGATGGATCTATGCTTAAGGTTATTAAGTTGTCTGGTTATGCTT TTGAAACTGCAGATGATGAGGATTTATCTATACAAAACTCTATACGCAATCAAATGTTAAGAAGTATATCTTCTGCATCT TTTGGCTTATATTTTCATGTAATTAGACGTAGAAGAAATGCTTTTTCAGAAGGGTTTGCAAGCGATAAAGTGTCTAGTTC GTTTGCCAATTATGTAAATGTAAGATGGCGGGAAAAACATGCAACAAAGCAATCTTTTACTAATGATTTATATATTACAA TAGTTAGAGAAGGTGGTAAAAAAGGAGTAGAATTTTTATCTAGTATTTTTGATAAATTTGGAAAAGTTGCATCACAGGAC TCATGGATTAAAGATTTACAGGCTATTTCTGAAGATTTAGATGAAGTAACTAATCGTGTTTTTACAAGTTTACGTAATTA TGCACCCAGAATTTTAGGTATTAGAGAAACACCAAAGGGGGTGTTTTCTGAAATTATGGAATTTTTGTTACAGGTAGTAA ATTGTGGGTCTTTTCAACGTGTATTATTCCATGTGGGGAATGTATCAAAGTACTTACCTATGCATAGGTTATATTTTGGA CATAAAACAATACAAATAGTTGCGCATAATGAATGTAAATATGCAGGGTTAATTAGTTTAAAAGAATACGGTCAAACAAC ATCTGCTGGTATGCTAGATGCATTTTTACAATTGCCATATGAGTTTATTATCACACAATCTTTTAAGTTTACTAACAGAC AAAGTGCTATTACCAAAATGCAGATTCAACAAAACCGTATGATACAATCTGCAGATAAAGCAGTATCACAGGTAGTAGAA ATAAGTCAAGCTTTGGATGATGCAATGAGTGGTAGAATTGCTTTTGGACAGCATCATCTTACTATTTTATGTACAGAAAG AAGTCTCAAAACTCTTGATAATGCATTGTCTTTAATAGAATCTGAGTTATCTAACTGTGGTGTATATCCGGTTAGGGAGA GAGTTAATTTAGAACCAGCTTTTTGGGCTCAATTGCCAGGTAATTTTGAATATATAGTTCGTAAAGCTATAATCAGTACG TTAAATATGGCTGGGTTTGCATCTCAGCATAATTATCCTATTGGAAAGAAATTTAACAATCATTGGGGAGAAGCAGTAAC AGTATTTGATACTACTTCTGGAACTCCTTTCTTTTTTAATTTTCATATTCGTGATGTTGGTCACACTGCAATTATAGGAC CTACTGGTGGTGGTAAGACAGTATTAATGAATTTCTTATGTGCTCAGGCTATGAAGTTTTCACCAAGGATTTTCTTTTTT GATAAAGATTATGGTGCTGAAATTTTCATTAGAGCATTGAGTGGGGTGTATATGGTTATAGAACCAAGACATCCTACAGG ATTCAATCCTTTGCATCTTGATGATACTCCAGATAATCGTACATTCTTAATGGAGTGGATAAAATCTTTAATATCGGTAT TTAATGATAAATTTACTTCTGAAGATATAACTCGTATTAATGATGCAATAGAAGGTAACTTTAAGTTAAAAAAAGAACAT AGAGTATTGTGTAATTTAGTACCATTTTTAGGGTTGGATGGTCCTAATACTTTAGCTGGAGCTATATCTATGTGGCATAG TAGTGGATCTCATGCAGCAATTTTTGATAATGCGGAAGATTTATTGGATTTTAATAAATCAAGAGTTTTTGGTTTTGAAA TGAGCCATTTATTAAAAGATCCAGTATCTCTTGCTCCTGTATTGTTATATTTATTTCATAGAATTAGTATTTCTTTAGAT GGTACTCCATCTATTATTGTTTTAGATGAAGCATGGGCACTAATAGATAATCCAGTGTTTGCACCAAAAATAAAAGATTG GTTAAAAGTTTTAAGAAAATTGAATACATTTGTAATTTTTGCTACTCAAAGTGTTGAGGATGCTAGTAAGAGTGCGATTA GTGACACTTTAGTACAACAAACTGCTACTCAAATATTTTTACCTAATTTAAAAGCTACGAGTGCTTATAGGAATGTATTT ATGTTAACTGAAAGGGAATATACATTAATAAAGCATACTGATCCAAGTACAAGGTTCTTTTTAGTGAAACAGGGAGTAGG TGCAGTAGTTGCAAGAATTAATTTGAGTGGACTTGAAGATATAATAAGTGTTTTATCTGGTAGGGCAGAAACAGTATTAA TGTTACATGATTTAATAAAAGAAGTAGGAGATGATCCAAATGTTTGGTTGCCTATATTTTATGAAAGAGTAAAGCATGTG TAA
Upstream 100 bases:
>100_bases AAGAACCATTATTCTTGGAGTTATTTATGCTGAGGATGAAGAAGTGTAGTAAATGTTTGAATAGATTTTATCATAATGCT AATTCTTATGATGTAATGTG
Downstream 100 bases:
>100_bases ATTTAATAATTAAGAATATTCTTTATAAAAGAGTTGATTATGCTAAAAGTTAGTAAGAGTATAATATATGTATTAATGTT ATTTTTGATTAATGTTAATT
Product: type IV secretion system ATPase VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 800; Mature: 800
Protein sequence:
>800_residues MLKFQQLQTKKRKVIKREYHESNFIPYSEHWNSSTLMTKDGSMLKVIKLSGYAFETADDEDLSIQNSIRNQMLRSISSAS FGLYFHVIRRRRNAFSEGFASDKVSSSFANYVNVRWREKHATKQSFTNDLYITIVREGGKKGVEFLSSIFDKFGKVASQD SWIKDLQAISEDLDEVTNRVFTSLRNYAPRILGIRETPKGVFSEIMEFLLQVVNCGSFQRVLFHVGNVSKYLPMHRLYFG HKTIQIVAHNECKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQSAITKMQIQQNRMIQSADKAVSQVVE ISQALDDAMSGRIAFGQHHLTILCTERSLKTLDNALSLIESELSNCGVYPVRERVNLEPAFWAQLPGNFEYIVRKAIIST LNMAGFASQHNYPIGKKFNNHWGEAVTVFDTTSGTPFFFNFHIRDVGHTAIIGPTGGGKTVLMNFLCAQAMKFSPRIFFF DKDYGAEIFIRALSGVYMVIEPRHPTGFNPLHLDDTPDNRTFLMEWIKSLISVFNDKFTSEDITRINDAIEGNFKLKKEH RVLCNLVPFLGLDGPNTLAGAISMWHSSGSHAAIFDNAEDLLDFNKSRVFGFEMSHLLKDPVSLAPVLLYLFHRISISLD GTPSIIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATSAYRNVF MLTEREYTLIKHTDPSTRFFLVKQGVGAVVARINLSGLEDIISVLSGRAETVLMLHDLIKEVGDDPNVWLPIFYERVKHV
Sequences:
>Translated_800_residues MLKFQQLQTKKRKVIKREYHESNFIPYSEHWNSSTLMTKDGSMLKVIKLSGYAFETADDEDLSIQNSIRNQMLRSISSAS FGLYFHVIRRRRNAFSEGFASDKVSSSFANYVNVRWREKHATKQSFTNDLYITIVREGGKKGVEFLSSIFDKFGKVASQD SWIKDLQAISEDLDEVTNRVFTSLRNYAPRILGIRETPKGVFSEIMEFLLQVVNCGSFQRVLFHVGNVSKYLPMHRLYFG HKTIQIVAHNECKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQSAITKMQIQQNRMIQSADKAVSQVVE ISQALDDAMSGRIAFGQHHLTILCTERSLKTLDNALSLIESELSNCGVYPVRERVNLEPAFWAQLPGNFEYIVRKAIIST LNMAGFASQHNYPIGKKFNNHWGEAVTVFDTTSGTPFFFNFHIRDVGHTAIIGPTGGGKTVLMNFLCAQAMKFSPRIFFF DKDYGAEIFIRALSGVYMVIEPRHPTGFNPLHLDDTPDNRTFLMEWIKSLISVFNDKFTSEDITRINDAIEGNFKLKKEH RVLCNLVPFLGLDGPNTLAGAISMWHSSGSHAAIFDNAEDLLDFNKSRVFGFEMSHLLKDPVSLAPVLLYLFHRISISLD GTPSIIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATSAYRNVF MLTEREYTLIKHTDPSTRFFLVKQGVGAVVARINLSGLEDIISVLSGRAETVLMLHDLIKEVGDDPNVWLPIFYERVKHV >Mature_800_residues MLKFQQLQTKKRKVIKREYHESNFIPYSEHWNSSTLMTKDGSMLKVIKLSGYAFETADDEDLSIQNSIRNQMLRSISSAS FGLYFHVIRRRRNAFSEGFASDKVSSSFANYVNVRWREKHATKQSFTNDLYITIVREGGKKGVEFLSSIFDKFGKVASQD SWIKDLQAISEDLDEVTNRVFTSLRNYAPRILGIRETPKGVFSEIMEFLLQVVNCGSFQRVLFHVGNVSKYLPMHRLYFG HKTIQIVAHNECKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQSAITKMQIQQNRMIQSADKAVSQVVE ISQALDDAMSGRIAFGQHHLTILCTERSLKTLDNALSLIESELSNCGVYPVRERVNLEPAFWAQLPGNFEYIVRKAIIST LNMAGFASQHNYPIGKKFNNHWGEAVTVFDTTSGTPFFFNFHIRDVGHTAIIGPTGGGKTVLMNFLCAQAMKFSPRIFFF DKDYGAEIFIRALSGVYMVIEPRHPTGFNPLHLDDTPDNRTFLMEWIKSLISVFNDKFTSEDITRINDAIEGNFKLKKEH RVLCNLVPFLGLDGPNTLAGAISMWHSSGSHAAIFDNAEDLLDFNKSRVFGFEMSHLLKDPVSLAPVLLYLFHRISISLD GTPSIIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATSAYRNVF MLTEREYTLIKHTDPSTRFFLVKQGVGAVVARINLSGLEDIISVLSGRAETVLMLHDLIKEVGDDPNVWLPIFYERVKHV
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 90719; Mature: 90719
Theoretical pI: Translated: 8.66; Mature: 8.66
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLKFQQLQTKKRKVIKREYHESNFIPYSEHWNSSTLMTKDGSMLKVIKLSGYAFETADDE CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEEECCEEEECCCCC DLSIQNSIRNQMLRSISSASFGLYFHVIRRRRNAFSEGFASDKVSSSFANYVNVRWREKH CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEHHHH ATKQSFTNDLYITIVREGGKKGVEFLSSIFDKFGKVASQDSWIKDLQAISEDLDEVTNRV HHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH FTSLRNYAPRILGIRETPKGVFSEIMEFLLQVVNCGSFQRVLFHVGNVSKYLPMHRLYFG HHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHCCHHHHHHC HKTIQIVAHNECKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQSAITKM CEEEEEEEECCCCEEEEEEHHHCCCCCCHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHH QIQQNRMIQSADKAVSQVVEISQALDDAMSGRIAFGQHHLTILCTERSLKTLDNALSLIE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCHHHHHHHHHHHHHH SELSNCGVYPVRERVNLEPAFWAQLPGNFEYIVRKAIISTLNMAGFASQHNYPIGKKFNN HHHHHCCCCCCHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC HWGEAVTVFDTTSGTPFFFNFHIRDVGHTAIIGPTGGGKTVLMNFLCAQAMKFSPRIFFF CCCCEEEEEECCCCCEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEE DKDYGAEIFIRALSGVYMVIEPRHPTGFNPLHLDDTPDNRTFLMEWIKSLISVFNDKFTS ECCCCHHHHHHHHCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCC EDITRINDAIEGNFKLKKEHRVLCNLVPFLGLDGPNTLAGAISMWHSSGSHAAIFDNAED HHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCHHH LLDFNKSRVFGFEMSHLLKDPVSLAPVLLYLFHRISISLDGTPSIIVLDEAWALIDNPVF HHCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCEEEEECCHHHHCCCCC APKIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATSAYRNVF CHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCEEE MLTEREYTLIKHTDPSTRFFLVKQGVGAVVARINLSGLEDIISVLSGRAETVLMLHDLIK EEECCCEEEEEECCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHH EVGDDPNVWLPIFYERVKHV HHCCCCCEEHHHHHHHHCCC >Mature Secondary Structure MLKFQQLQTKKRKVIKREYHESNFIPYSEHWNSSTLMTKDGSMLKVIKLSGYAFETADDE CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEEECCEEEECCCCC DLSIQNSIRNQMLRSISSASFGLYFHVIRRRRNAFSEGFASDKVSSSFANYVNVRWREKH CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEHHHH ATKQSFTNDLYITIVREGGKKGVEFLSSIFDKFGKVASQDSWIKDLQAISEDLDEVTNRV HHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH FTSLRNYAPRILGIRETPKGVFSEIMEFLLQVVNCGSFQRVLFHVGNVSKYLPMHRLYFG HHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHCCHHHHHHC HKTIQIVAHNECKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQSAITKM CEEEEEEEECCCCEEEEEEHHHCCCCCCHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHH QIQQNRMIQSADKAVSQVVEISQALDDAMSGRIAFGQHHLTILCTERSLKTLDNALSLIE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCHHHHHHHHHHHHHH SELSNCGVYPVRERVNLEPAFWAQLPGNFEYIVRKAIISTLNMAGFASQHNYPIGKKFNN HHHHHCCCCCCHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC HWGEAVTVFDTTSGTPFFFNFHIRDVGHTAIIGPTGGGKTVLMNFLCAQAMKFSPRIFFF CCCCEEEEEECCCCCEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEE DKDYGAEIFIRALSGVYMVIEPRHPTGFNPLHLDDTPDNRTFLMEWIKSLISVFNDKFTS ECCCCHHHHHHHHCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCC EDITRINDAIEGNFKLKKEHRVLCNLVPFLGLDGPNTLAGAISMWHSSGSHAAIFDNAED HHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCHHH LLDFNKSRVFGFEMSHLLKDPVSLAPVLLYLFHRISISLDGTPSIIVLDEAWALIDNPVF HHCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCEEEEECCHHHHCCCCC APKIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATSAYRNVF CHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCEEE MLTEREYTLIKHTDPSTRFFLVKQGVGAVVARINLSGLEDIISVLSGRAETVLMLHDLIK EEECCCEEEEEECCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHH EVGDDPNVWLPIFYERVKHV HHCCCCCEEHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]