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The map label for this gene is proC [H]

Identifier: 88657880

GI number: 88657880

Start: 10949

End: 11758

Strand: Direct

Name: proC [H]

Synonym: ECH_0013

Alternate gene names: 88657880

Gene position: 10949-11758 (Clockwise)

Preceding gene: 88657991

Following gene: 88657800

Centisome position: 0.93

GC content: 30.25

Gene sequence:

>810_bases
ATGAACATATTACTAATAGGATGCGGTAACTTAGGAAGTATATTATTAAATAAATGGTCACATAGTGATCAAATATCAAA
AGTGACTGTAGTACAGCCTAGCTTATCAAAAAAGGATACTTTTAACAATATAACTAAGGTAGTCTTTGTAAAAAGTCATG
AGGAAGTAGATAAAGATTTTATACCTCAAATTGTAGTAATTGCAATAAAACCACAACTGGTGTCTGATGTTATGCCAAAC
TACAGAATTTATAGTGAATCTGCATCTTTTATATCTTTATGTGCCGGAATTGATATTAATTTTCTAAAAACATGCTTAAG
TCCTACAGCAACAATAATTAGGGTAATGCCTAATATTGCCATGTCACTAGGCAAAAGTGTAAACCTTTCTTATATAGAAG
AAGAATTACCACATGAAAAACAAAAAGTATCAACTATTTTTAATAACACAGGACTTATATATTGGATACAAAAAGAAGAT
ATCTTTGACAAATTATCTCCTATTACTGGTTCTGGTCCTGCATACTTTTTTTCTCTTGCAGAAGAATTAGTAAAAAATAC
TATAGCTGCAGGTATCAATGAAGAAGATGCTATTAAACTTGTATCTCAAACATTTATAGGAAGTGCTAAATTGCTAGAAA
CAAGACAAAATACTATAAGTCATCTTATATCATCTATAACAAGCCGCGGCGGAATAACACAAGCTGCACTGCAGGTGTTA
AATTTACATTTACCTCAAACAATTAGTTCATGTTTAAAGGCAGCCATGGAAAGGCTATTATACTTAAAAGGATTAGATAA
AAATAAATAA

Upstream 100 bases:

>100_bases
GAATAAATGCTAATTTTATAAAAACTATTTATAATTTACAAATTTATTTGAGTATTATAATATTACACAATTGTATTTAT
TATCGTTTACCTAATAAACA

Downstream 100 bases:

>100_bases
TAAGTGTTACGCAACACTTATTAGTAGTTATTTTTAGAAAAAATAAACTAAAAATTTTATTTGATATTTCTTTAAGTTAA
ATTATAATGCAAAGGGTAAT

Product: putative pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MNILLIGCGNLGSILLNKWSHSDQISKVTVVQPSLSKKDTFNNITKVVFVKSHEEVDKDFIPQIVVIAIKPQLVSDVMPN
YRIYSESASFISLCAGIDINFLKTCLSPTATIIRVMPNIAMSLGKSVNLSYIEEELPHEKQKVSTIFNNTGLIYWIQKED
IFDKLSPITGSGPAYFFSLAEELVKNTIAAGINEEDAIKLVSQTFIGSAKLLETRQNTISHLISSITSRGGITQAALQVL
NLHLPQTISSCLKAAMERLLYLKGLDKNK

Sequences:

>Translated_269_residues
MNILLIGCGNLGSILLNKWSHSDQISKVTVVQPSLSKKDTFNNITKVVFVKSHEEVDKDFIPQIVVIAIKPQLVSDVMPN
YRIYSESASFISLCAGIDINFLKTCLSPTATIIRVMPNIAMSLGKSVNLSYIEEELPHEKQKVSTIFNNTGLIYWIQKED
IFDKLSPITGSGPAYFFSLAEELVKNTIAAGINEEDAIKLVSQTFIGSAKLLETRQNTISHLISSITSRGGITQAALQVL
NLHLPQTISSCLKAAMERLLYLKGLDKNK
>Mature_269_residues
MNILLIGCGNLGSILLNKWSHSDQISKVTVVQPSLSKKDTFNNITKVVFVKSHEEVDKDFIPQIVVIAIKPQLVSDVMPN
YRIYSESASFISLCAGIDINFLKTCLSPTATIIRVMPNIAMSLGKSVNLSYIEEELPHEKQKVSTIFNNTGLIYWIQKED
IFDKLSPITGSGPAYFFSLAEELVKNTIAAGINEEDAIKLVSQTFIGSAKLLETRQNTISHLISSITSRGGITQAALQVL
NLHLPQTISSCLKAAMERLLYLKGLDKNK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=184, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI24797097, Length=184, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI21361454, Length=251, Percent_Identity=24.3027888446215, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786585, Length=246, Percent_Identity=28.4552845528455, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17540664, Length=257, Percent_Identity=24.5136186770428, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569021, Length=229, Percent_Identity=23.5807860262009, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358587, Length=206, Percent_Identity=26.6990291262136, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29685; Mature: 29685

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILLIGCGNLGSILLNKWSHSDQISKVTVVQPSLSKKDTFNNITKVVFVKSHEEVDKDF
CEEEEEECCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHEEEEEEECHHHCCHHH
IPQIVVIAIKPQLVSDVMPNYRIYSESASFISLCAGIDINFLKTCLSPTATIIRVMPNIA
CCEEEEEEECHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHH
MSLGKSVNLSYIEEELPHEKQKVSTIFNNTGLIYWIQKEDIFDKLSPITGSGPAYFFSLA
HHHCCCCCHHHHHHHCCHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCCCCHHHHHHHH
EELVKNTIAAGINEEDAIKLVSQTFIGSAKLLETRQNTISHLISSITSRGGITQAALQVL
HHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NLHLPQTISSCLKAAMERLLYLKGLDKNK
HCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNILLIGCGNLGSILLNKWSHSDQISKVTVVQPSLSKKDTFNNITKVVFVKSHEEVDKDF
CEEEEEECCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHEEEEEEECHHHCCHHH
IPQIVVIAIKPQLVSDVMPNYRIYSESASFISLCAGIDINFLKTCLSPTATIIRVMPNIA
CCEEEEEEECHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHH
MSLGKSVNLSYIEEELPHEKQKVSTIFNNTGLIYWIQKEDIFDKLSPITGSGPAYFFSLA
HHHCCCCCHHHHHHHCCHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCCCCHHHHHHHH
EELVKNTIAAGINEEDAIKLVSQTFIGSAKLLETRQNTISHLISSITSRGGITQAALQVL
HHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NLHLPQTISSCLKAAMERLLYLKGLDKNK
HCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]