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The map label for this gene is purE

Identifier: 88608847

GI number: 88608847

Start: 200085

End: 200564

Strand: Reverse

Name: purE

Synonym: NSE_0235

Alternate gene names: 88608847

Gene position: 200564-200085 (Counterclockwise)

Preceding gene: 88608749

Following gene: 88608684

Centisome position: 23.35

GC content: 45.83

Gene sequence:

>480_bases
ATGGGTTCTGAAAAAGTAGCGATAGTAATGGGCAGTACGTCTGATTATCCTACTATGCAGCATGCGGAGAAAATACTAGA
ACAGCTGGTAGTACACTTTGAGACTTATGTGATATCAGCGCACAGAACTCCAGCAAGGTTATATGAGTTTTCAAAAAACG
CAGCAGACAAAGGAATTAGGACAATAATAGCAGGTGCTGGAGGAGCAGCTCATTTACCAGGAATGATTGCAGCCATAAGC
GATATTCCGGTCCTAGGAGTACCAGTAGAAAGTAAGACGCTCAACGGTTTGGATAGCTTACTTTCAATATGCCAGATGCC
TGCAGGCACGCCAGTCGGCACTCTTTCTATAGGAAAGGCCGGCGCAGAAAACGCAGCACTCCTCGCCTGTAGGATACTCG
CCCTACAAGATAAGGACCTACAAGACAGACTGCGAATCTGGATCAGAAAACAAACAGAGACTGTACCTGAAAGACCCTAA

Upstream 100 bases:

>100_bases
ATTCAATTTCATTCTTGATAATTATCTGTGACCAAACATACGTGCATATTGAGTACTTTTATGGATGAATTAGAATTTTA
TATTTGTTACGGTGGTGAGA

Downstream 100 bases:

>100_bases
GAGCACTCAACCAAGATGGACGCGACATCTACCTGTGGCACGAGAAAAGGAGAAAATCTACTCCTAGTCGACAGCATTAG
TGCTACGATCCTCTCGCTTA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MGSEKVAIVMGSTSDYPTMQHAEKILEQLVVHFETYVISAHRTPARLYEFSKNAADKGIRTIIAGAGGAAHLPGMIAAIS
DIPVLGVPVESKTLNGLDSLLSICQMPAGTPVGTLSIGKAGAENAALLACRILALQDKDLQDRLRIWIRKQTETVPERP

Sequences:

>Translated_159_residues
MGSEKVAIVMGSTSDYPTMQHAEKILEQLVVHFETYVISAHRTPARLYEFSKNAADKGIRTIIAGAGGAAHLPGMIAAIS
DIPVLGVPVESKTLNGLDSLLSICQMPAGTPVGTLSIGKAGAENAALLACRILALQDKDLQDRLRIWIRKQTETVPERP
>Mature_158_residues
GSEKVAIVMGSTSDYPTMQHAEKILEQLVVHFETYVISAHRTPARLYEFSKNAADKGIRTIIAGAGGAAHLPGMIAAISD
IPVLGVPVESKTLNGLDSLLSICQMPAGTPVGTLSIGKAGAENAALLACRILALQDKDLQDRLRIWIRKQTETVPERP

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=61.2903225806452, Blast_Score=154, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=50, Blast_Score=148, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16987; Mature: 16856

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSEKVAIVMGSTSDYPTMQHAEKILEQLVVHFETYVISAHRTPARLYEFSKNAADKGIR
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHCCHHHHHHH
TIIAGAGGAAHLPGMIAAISDIPVLGVPVESKTLNGLDSLLSICQMPAGTPVGTLSIGKA
EEEECCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCC
GAENAALLACRILALQDKDLQDRLRIWIRKQTETVPERP
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GSEKVAIVMGSTSDYPTMQHAEKILEQLVVHFETYVISAHRTPARLYEFSKNAADKGIR
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHCCHHHHHHH
TIIAGAGGAAHLPGMIAAISDIPVLGVPVESKTLNGLDSLLSICQMPAGTPVGTLSIGKA
EEEECCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCC
GAENAALLACRILALQDKDLQDRLRIWIRKQTETVPERP
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]