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Identifier: 88608749

GI number: 88608749

Start: 200705

End: 201694

Strand: Reverse

Name: gcp

Synonym: NSE_0236

Alternate gene names: 88608749

Gene position: 201694-200705 (Counterclockwise)

Preceding gene: 88608161

Following gene: 88608847

Centisome position: 23.48

GC content: 41.31

Gene sequence:

>990_bases
ATGAATAATCATTTAATTTTAGGTGTAGAGACAAGTTGCGATGAAACCTCAGTCGCCATTGTTTCTGAAGAAGGGGAGGT
TTGCTTTCACGAAATTTTCACCCAAGACCATAGCAAATATAATGGTGTCTACCCGGAATTTGCATCCAGGGAGCATTTGA
AAATTTTACCCCAGATACTACGAAGGGCAGTTCAAGCGCACGATCTTGAAAAATTAACAGCCATTGCTTGTACAGTTGGC
CCAGGGTTGGTTGGATCGCTGATAGTTGGAGTGATGATGGCTCGCGGTCTTGCATTTTCACTTAAAAAACCTGTTTTCGG
AGTAAACCACCTCGAAGGCCACCTACTTGCTGTGAGACTTGTAGAGAAAATTAATTTCCCATTTGTTTGTCTCGTGATTT
CAGGAGGACATTCTCAACTTATCGATGCAAGAGGAATAGGTGACTATGTTCTTCTTGGAGAAACACTGGATGATGCATTT
GGTGAAGCATTTGATAAACTAGCAACTATGCTTGGATTTACATATCCAGGAGGAAAAACCGTAGAAAAGCTCGCAATCAA
GGGTGACTCAGAACGTTTTCGTTTGCCGGCAGCAATGATAAATCAATCTGGTTGTAATTTTTCCCTATCAGGGATAAAAA
CAGCTCTAAAAAAAATAATTACTTCATTGCCCCAAATAACAGAAAAAGATAAGGCAGATATTTGCGCATCATTCCAGGCA
TGCGTGGCAAGGATTATGGTCAACAAGTTGGAACAAGCCGTGAAAATTTGTGGTCATTCTAGGATCGTGTTAGCTGGGGG
AGTTGGCTCCAATCGTTACATAAGAGAAACACTAGAAGAGTTTGCAAAGAATCACAACTTGTCGCTGCACTTTCCAGAAG
GTATTCTATGTACAGATAACGCAGCAATGATAGCTTGGGCAGCTATAGAAAGACTTAAAGCAGGCTGCACAGAACTATCT
CTGGAACCACAACCAAGATTATGTTGGTAG

Upstream 100 bases:

>100_bases
TCATTCCAGAAGCTGGAAATATACCAATTCATCCAGGCGCGAAACAGTTTTACAAGCAAATTGGTCTCCTGCGAGAGTCT
GTAGGGAAGGCTTACCCTAA

Downstream 100 bases:

>100_bases
AGTTTCTATTACTTCCATGAGAGTATAGCTAAGAGTGATCATTCAATTTCATTCTTGATAATTATCTGTGACCAAACATA
CGTGCATATTGAGTACTTTT

Product: metalloendopeptidase glycoprotease family

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNNHLILGVETSCDETSVAIVSEEGEVCFHEIFTQDHSKYNGVYPEFASREHLKILPQILRRAVQAHDLEKLTAIACTVG
PGLVGSLIVGVMMARGLAFSLKKPVFGVNHLEGHLLAVRLVEKINFPFVCLVISGGHSQLIDARGIGDYVLLGETLDDAF
GEAFDKLATMLGFTYPGGKTVEKLAIKGDSERFRLPAAMINQSGCNFSLSGIKTALKKIITSLPQITEKDKADICASFQA
CVARIMVNKLEQAVKICGHSRIVLAGGVGSNRYIRETLEEFAKNHNLSLHFPEGILCTDNAAMIAWAAIERLKAGCTELS
LEPQPRLCW

Sequences:

>Translated_329_residues
MNNHLILGVETSCDETSVAIVSEEGEVCFHEIFTQDHSKYNGVYPEFASREHLKILPQILRRAVQAHDLEKLTAIACTVG
PGLVGSLIVGVMMARGLAFSLKKPVFGVNHLEGHLLAVRLVEKINFPFVCLVISGGHSQLIDARGIGDYVLLGETLDDAF
GEAFDKLATMLGFTYPGGKTVEKLAIKGDSERFRLPAAMINQSGCNFSLSGIKTALKKIITSLPQITEKDKADICASFQA
CVARIMVNKLEQAVKICGHSRIVLAGGVGSNRYIRETLEEFAKNHNLSLHFPEGILCTDNAAMIAWAAIERLKAGCTELS
LEPQPRLCW
>Mature_329_residues
MNNHLILGVETSCDETSVAIVSEEGEVCFHEIFTQDHSKYNGVYPEFASREHLKILPQILRRAVQAHDLEKLTAIACTVG
PGLVGSLIVGVMMARGLAFSLKKPVFGVNHLEGHLLAVRLVEKINFPFVCLVISGGHSQLIDARGIGDYVLLGETLDDAF
GEAFDKLATMLGFTYPGGKTVEKLAIKGDSERFRLPAAMINQSGCNFSLSGIKTALKKIITSLPQITEKDKADICASFQA
CVARIMVNKLEQAVKICGHSRIVLAGGVGSNRYIRETLEEFAKNHNLSLHFPEGILCTDNAAMIAWAAIERLKAGCTELS
LEPQPRLCW

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=337, Percent_Identity=36.7952522255193, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI8923380, Length=314, Percent_Identity=30.2547770700637, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1789445, Length=327, Percent_Identity=42.5076452599388, Blast_Score=263, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17557464, Length=323, Percent_Identity=31.5789473684211, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71995670, Length=316, Percent_Identity=29.1139240506329, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320099, Length=338, Percent_Identity=31.0650887573964, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322891, Length=350, Percent_Identity=27.4285714285714, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI20129063, Length=338, Percent_Identity=36.094674556213, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI21357207, Length=324, Percent_Identity=28.0864197530864, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_NEOSM (Q2GEG6)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506130.1
- ProteinModelPortal:   Q2GEG6
- SMR:   Q2GEG6
- STRING:   Q2GEG6
- MEROPS:   M22.001
- GeneID:   3931636
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0236
- TIGR:   NSE_0236
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q2GEG6
- ProtClustDB:   PRK09604
- BioCyc:   NSEN222891:NSE_0236-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 35865; Mature: 35865

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNHLILGVETSCDETSVAIVSEEGEVCFHEIFTQDHSKYNGVYPEFASREHLKILPQIL
CCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
RRAVQAHDLEKLTAIACTVGPGLVGSLIVGVMMARGLAFSLKKPVFGVNHLEGHLLAVRL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHH
VEKINFPFVCLVISGGHSQLIDARGIGDYVLLGETLDDAFGEAFDKLATMLGFTYPGGKT
HHHCCCCEEEEEEECCCHHEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCH
VEKLAIKGDSERFRLPAAMINQSGCNFSLSGIKTALKKIITSLPQITEKDKADICASFQA
HHHHEECCCCCCEECCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
CVARIMVNKLEQAVKICGHSRIVLAGGVGSNRYIRETLEEFAKNHNLSLHFPEGILCTDN
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCEEECCC
AAMIAWAAIERLKAGCTELSLEPQPRLCW
CHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNNHLILGVETSCDETSVAIVSEEGEVCFHEIFTQDHSKYNGVYPEFASREHLKILPQIL
CCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
RRAVQAHDLEKLTAIACTVGPGLVGSLIVGVMMARGLAFSLKKPVFGVNHLEGHLLAVRL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHH
VEKINFPFVCLVISGGHSQLIDARGIGDYVLLGETLDDAFGEAFDKLATMLGFTYPGGKT
HHHCCCCEEEEEEECCCHHEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCH
VEKLAIKGDSERFRLPAAMINQSGCNFSLSGIKTALKKIITSLPQITEKDKADICASFQA
HHHHEECCCCCCEECCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
CVARIMVNKLEQAVKICGHSRIVLAGGVGSNRYIRETLEEFAKNHNLSLHFPEGILCTDN
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCEEECCC
AAMIAWAAIERLKAGCTELSLEPQPRLCW
CHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA