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The map label for this gene is atpB

Identifier: 88608811

GI number: 88608811

Start: 323162

End: 323893

Strand: Direct

Name: atpB

Synonym: NSE_0396

Alternate gene names: 88608811

Gene position: 323162-323893 (Clockwise)

Preceding gene: 88608217

Following gene: 88608692

Centisome position: 37.62

GC content: 39.21

Gene sequence:

>732_bases
ATGAGTCCTTTAAAGCAATTTGAGATTTTTCCCTTAATTCGTCTTCCAGAATTTTTCGGTTGGGATATCAATTTTACTAA
CTCCTCATTGTATATGGTGCTTACGGTTGTATTCGCCTCCCTTTTTCTTTTTGCTGGTGTTTTCAGAGGTAAGGTGATAC
CAGGACCAATGCAATCTTTTGTTGAGATAGTATGTAGTTTTGTGTTGGGAATCATTAAGGGTAGTTGTGGAAAGGCCGGT
TCGGACTATTTCCCTTTGATTCTGTCAGTGTTCTTGTATGTTCTGTTTGCAAACCTTGTTGGAATGTTACCGCTTCCTAT
GAGCTTCACAGTGACAAGTCATATAGTTGTGACACTTGCACTTGCAATGGTCGTCTTTATTTTTGTGACTCTCATTGGGT
TGAAAAAGCAAGGCATGGGTTTCTTTGCCATGTTCCTTCCTGATGGAACGCCTAATTGGATAGCTCCACTAATGATATTT
CTTGAGGTGTGCACCTATCTCTTTAGGCCAATTAGCCTTGCTATTCGACTAACTGCGAATATGATTGCTGGTCACACAAT
ACTTAAGGTCATTGCTGGGTTTGTATATCCAACCTCTTTGTTGATAAGCCCTTTATCTTTTTTGTTTGTGGTGGTACTAA
TAGTGTTCGAAGTGTTCATAGCTATGTTGCAGGCGTATATTTTTGTTATGTTGACCTGCGTCTATTTGAATGATTCACTG
TTCAAACACTAA

Upstream 100 bases:

>100_bases
GCTTTGTAATTTCGCAAGCGATAAGTATCAATACTAGCCATATTATTTGACATTTCTATAATTGTGAAAGAACATCCGAT
TGTGAGAGCTGTACTGCTGT

Downstream 100 bases:

>100_bases
CATGGTTATTTTATAAGGGTATATGGAGTTAGAAGGTCTAAAATTTTTGGGAATTGGTCTCTCTGTCGTTGGTATGTTGG
GGGCTGCTATAGGAGTGAGT

Product: F0F1 ATP synthase subunit A

Products: ATP; H+; H2O [C]

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSPLKQFEIFPLIRLPEFFGWDINFTNSSLYMVLTVVFASLFLFAGVFRGKVIPGPMQSFVEIVCSFVLGIIKGSCGKAG
SDYFPLILSVFLYVLFANLVGMLPLPMSFTVTSHIVVTLALAMVVFIFVTLIGLKKQGMGFFAMFLPDGTPNWIAPLMIF
LEVCTYLFRPISLAIRLTANMIAGHTILKVIAGFVYPTSLLISPLSFLFVVVLIVFEVFIAMLQAYIFVMLTCVYLNDSL
FKH

Sequences:

>Translated_243_residues
MSPLKQFEIFPLIRLPEFFGWDINFTNSSLYMVLTVVFASLFLFAGVFRGKVIPGPMQSFVEIVCSFVLGIIKGSCGKAG
SDYFPLILSVFLYVLFANLVGMLPLPMSFTVTSHIVVTLALAMVVFIFVTLIGLKKQGMGFFAMFLPDGTPNWIAPLMIF
LEVCTYLFRPISLAIRLTANMIAGHTILKVIAGFVYPTSLLISPLSFLFVVVLIVFEVFIAMLQAYIFVMLTCVYLNDSL
FKH
>Mature_242_residues
SPLKQFEIFPLIRLPEFFGWDINFTNSSLYMVLTVVFASLFLFAGVFRGKVIPGPMQSFVEIVCSFVLGIIKGSCGKAGS
DYFPLILSVFLYVLFANLVGMLPLPMSFTVTSHIVVTLALAMVVFIFVTLIGLKKQGMGFFAMFLPDGTPNWIAPLMIFL
EVCTYLFRPISLAIRLTANMIAGHTILKVIAGFVYPTSLLISPLSFLFVVVLIVFEVFIAMLQAYIFVMLTCVYLNDSLF
KH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=166, Percent_Identity=30.7228915662651, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1790176, Length=207, Percent_Identity=31.4009661835749, Blast_Score=84, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6226527, Length=254, Percent_Identity=32.6771653543307, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_NEOSM (Q2GE13)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506283.1
- ProteinModelPortal:   Q2GE13
- SMR:   Q2GE13
- STRING:   Q2GE13
- GeneID:   3931865
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0396
- TIGR:   NSE_0396
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   YIFTILT
- PhylomeDB:   Q2GE13
- ProtClustDB:   PRK05815
- BioCyc:   NSEN222891:NSE_0396-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14 [C]

Molecular weight: Translated: 27096; Mature: 26965

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf7eaa24)-; HASH(0x10cc4630)-; HASH(0x10c8bc88)-; HASH(0x10cc69b0)-; HASH(0x10cc6ab8)-; HASH(0x10c9e4f4)-; HASH(0x10cc4570)-; HASH(0xf76819c)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCH
>Mature Secondary Structure 
SPLKQFEIFPLIRLPEFFGWDINFTNSSLYMVLTVVFASLFLFAGVFRGKVIPGPMQSF
CCHHHHHHHHHHHCHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VEIVCSFVLGIIKGSCGKAGSDYFPLILSVFLYVLFANLVGMLPLPMSFTVTSHIVVTLA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LAMVVFIFVTLIGLKKQGMGFFAMFLPDGTPNWIAPLMIFLEVCTYLFRPISLAIRLTAN
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIAGHTILKVIAGFVYPTSLLISPLSFLFVVVLIVFEVFIAMLQAYIFVMLTCVYLNDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKH
HCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ADP; H+; Phosphate [C]

Specific reaction: ADP + (4) H+ + Phosphate <==> ATP + (3) H+ + H2O [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA