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The map label for this gene is folP

Identifier: 88608700

GI number: 88608700

Start: 401238

End: 402062

Strand: Reverse

Name: folP

Synonym: NSE_0485

Alternate gene names: 88608700

Gene position: 402062-401238 (Counterclockwise)

Preceding gene: 88608128

Following gene: 88608044

Centisome position: 46.81

GC content: 36.97

Gene sequence:

>825_bases
TTGTGTATCCTACTCTATTTTTATATAAAACGTAAGATAATGATTTCAAAAATCGTTGGGGTTTTAAATATTACCCCGGA
TTCATTCTTTGATGGAGGAAAATTTTTTAAGAGAGATGATGCTGTAAGACACGCACTGCACATGATACAAAATGGTGCTG
ATATAATAGAAATGGGTGCGGAGTCAACAAGACCAGATGGAGATCCAATTTCACAGAGGGAAGAAATAAACCGCCTGGAT
GGAATCCTCCAGGAGATAGTTGAGCTATGTAAGAAGCATGGTACCGTTGCAGCGATCGACAGTTACAATCCAGAAACGGT
CGAATTTGCTCTAGAAAACGGTGTTACATTTGTTAACAGTCAAAAAAATGTAGAGGAAGTAGCAAAACTCCTTGTTAGAA
AAGGCAAGGTAGATTTTCCACTGCTCTTGCCTCATGCATTAACCATACCAGTAAAGGGAGATCTCAACCTTCCGGATAAT
ATAGATGTCATTGAAACCTTAAAAACATGGTTTGAAGAAAAATTAGCAGTTCTCGAATCAATAGGTATACCAAGAAAAAA
TATCTTAATTGACCCTGGTCTAGGTTTTGGAAAAACGAATCAGCAGTGCTATACCATCATAAAGAATATAGAGAGTCTAA
GATGTTTCTCCTTGCCGATTTTTGCTGGTCACTCAAACAAGAGGCTTGTTAAACACTTAAATGACCAGTGTCCTGGAGTA
AATTTCACCCTTCCCATATCCGCTATTTTATTTACAAAAAAAGTTGAGTATGTAAGGGTGCACTCAGTAAAGGAACATCA
TGTATTACGTTCAAATTTCTTTTAA

Upstream 100 bases:

>100_bases
ATATGTTATAAGTATGAATACAGTTATAACTGATCTGAATCTGTAGCTCTTGAACTGAGTGGGTATACTGTTGTCTCCCT
TACGCTGAAGTGTATATAAG

Downstream 100 bases:

>100_bases
ACCATTGCATTGAATTCTTCGTCTGGGAGGACTTATTCCAAAGAAAAAAATGTCTTGGTATGGGAAAGCTGTCATTTTAG
CAAAAAATATCAGAGTAAAA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MCILLYFYIKRKIMISKIVGVLNITPDSFFDGGKFFKRDDAVRHALHMIQNGADIIEMGAESTRPDGDPISQREEINRLD
GILQEIVELCKKHGTVAAIDSYNPETVEFALENGVTFVNSQKNVEEVAKLLVRKGKVDFPLLLPHALTIPVKGDLNLPDN
IDVIETLKTWFEEKLAVLESIGIPRKNILIDPGLGFGKTNQQCYTIIKNIESLRCFSLPIFAGHSNKRLVKHLNDQCPGV
NFTLPISAILFTKKVEYVRVHSVKEHHVLRSNFF

Sequences:

>Translated_274_residues
MCILLYFYIKRKIMISKIVGVLNITPDSFFDGGKFFKRDDAVRHALHMIQNGADIIEMGAESTRPDGDPISQREEINRLD
GILQEIVELCKKHGTVAAIDSYNPETVEFALENGVTFVNSQKNVEEVAKLLVRKGKVDFPLLLPHALTIPVKGDLNLPDN
IDVIETLKTWFEEKLAVLESIGIPRKNILIDPGLGFGKTNQQCYTIIKNIESLRCFSLPIFAGHSNKRLVKHLNDQCPGV
NFTLPISAILFTKKVEYVRVHSVKEHHVLRSNFF
>Mature_274_residues
MCILLYFYIKRKIMISKIVGVLNITPDSFFDGGKFFKRDDAVRHALHMIQNGADIIEMGAESTRPDGDPISQREEINRLD
GILQEIVELCKKHGTVAAIDSYNPETVEFALENGVTFVNSQKNVEEVAKLLVRKGKVDFPLLLPHALTIPVKGDLNLPDN
IDVIETLKTWFEEKLAVLESIGIPRKNILIDPGLGFGKTNQQCYTIIKNIESLRCFSLPIFAGHSNKRLVKHLNDQCPGV
NFTLPISAILFTKKVEYVRVHSVKEHHVLRSNFF

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=250, Percent_Identity=31.6, Blast_Score=131, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30952; Mature: 30952

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCILLYFYIKRKIMISKIVGVLNITPDSFFDGGKFFKRDDAVRHALHMIQNGADIIEMGA
CEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCC
ESTRPDGDPISQREEINRLDGILQEIVELCKKHGTVAAIDSYNPETVEFALENGVTFVNS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHEEEEHHCCEEEECC
QKNVEEVAKLLVRKGKVDFPLLLPHALTIPVKGDLNLPDNIDVIETLKTWFEEKLAVLES
CCCHHHHHHHHHHCCCCCCCEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IGIPRKNILIDPGLGFGKTNQQCYTIIKNIESLRCFSLPIFAGHSNKRLVKHLNDQCPGV
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHEECEEEECCCCHHHHHHHHHCCCCC
NFTLPISAILFTKKVEYVRVHSVKEHHVLRSNFF
EEEHHHHHHHHHHHHHHHEECCHHHHHHHHHCCC
>Mature Secondary Structure
MCILLYFYIKRKIMISKIVGVLNITPDSFFDGGKFFKRDDAVRHALHMIQNGADIIEMGA
CEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCC
ESTRPDGDPISQREEINRLDGILQEIVELCKKHGTVAAIDSYNPETVEFALENGVTFVNS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHEEEEHHCCEEEECC
QKNVEEVAKLLVRKGKVDFPLLLPHALTIPVKGDLNLPDNIDVIETLKTWFEEKLAVLES
CCCHHHHHHHHHHCCCCCCCEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IGIPRKNILIDPGLGFGKTNQQCYTIIKNIESLRCFSLPIFAGHSNKRLVKHLNDQCPGV
CCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHEECEEEECCCCHHHHHHHHHCCCCC
NFTLPISAILFTKKVEYVRVHSVKEHHVLRSNFF
EEEHHHHHHHHHHHHHHHEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]