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The map label for this gene is ubiA

Identifier: 88608698

GI number: 88608698

Start: 716757

End: 717599

Strand: Direct

Name: ubiA

Synonym: NSE_0806

Alternate gene names: 88608698

Gene position: 716757-717599 (Clockwise)

Preceding gene: 88608600

Following gene: 88608799

Centisome position: 83.44

GC content: 41.87

Gene sequence:

>843_bases
ATGAAAATTAAAAAGTATGCTTCCCTGATTCGGTTCCAGAGTCTTGGTGGGATGTGGTTGTGTTTTTTTCCCGCTCTATT
CGTGGTTGCGCTCCTTGGAAATAGTTTCTACTCATTCTTGTGGATTCCCTTCTTTCTTTTAGGTGCTTTCCTTGTAAGAT
CAGCGGGCTGTATCGCAAATGATATTGCCGACCGAAATATCGATGGAAAAGTTAAAAGAACGGCTTCACGACCTATAGCA
TCTGGAGAGGTAAGAGTTACCGAAGCGGTATTGCTGTTTTTAATTCTACTCGTACTAGCAACGGTGTTATTGGCTTTCCT
TCCTCTCGAAGCAACCGCCCTTGGAGCATTCACGATTGTAGGAGTGGTGGTTTATCCATTTTCCAAAAGATATTTTGCTT
ATCCTCAATTGCTCCTCGCAGTTATCTTCAATGTCGGAGCTCTTTTCGCATCGATTGTAGTTGTTAATTCTATCCATGCC
TCAGCGCTTTTTGTTTATTTGGCTTGTTTTTTCTGGACGCTTTACTATGACACAATATACGGACACCAAGACAAATGCTA
CGATGTGGCACTCGGTGTACATTCCTTATCACTGGGAAAGTTTGGTTCGAGGGAATGGTTGAAGAAATACGCAAGGCTGG
CACTCTCCTTTCTTGCTTTCTCTGCTGTGCTACCTGGACTTAACCTTCTGTATTACATTGGCTTAGCAGCTCTATTCCTT
GTGGAGGAAAAATTTACGGAATCTATAAACTTAGATGATCCAAAAAACTGCGGAATGGCGTTCAAGCGAATGAATTTTGT
TGGCGTGCTCATTTTCCTTATTATTCTACTAGGTAGACTATGA

Upstream 100 bases:

>100_bases
ATCTTATCTTCCAAATTTGCATACTCGAATTTCACTCCTTTGCGTGGTATTACAAGAACGGATTCAAATCTACAACTTCT
CGACAGAACTACCTTGAAAA

Downstream 100 bases:

>100_bases
GCGACGAAGCCTTATTTAAAGAGTGTATGAGTCGATTTGCTACAGGAATATCAGTTGTAGCAACCAGTTTCATGGGAGAA
AAGTATGGAATAACAGTTAG

Product: 4-hydroxybenzoate octaprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKIKKYASLIRFQSLGGMWLCFFPALFVVALLGNSFYSFLWIPFFLLGAFLVRSAGCIANDIADRNIDGKVKRTASRPIA
SGEVRVTEAVLLFLILLVLATVLLAFLPLEATALGAFTIVGVVVYPFSKRYFAYPQLLLAVIFNVGALFASIVVVNSIHA
SALFVYLACFFWTLYYDTIYGHQDKCYDVALGVHSLSLGKFGSREWLKKYARLALSFLAFSAVLPGLNLLYYIGLAALFL
VEEKFTESINLDDPKNCGMAFKRMNFVGVLIFLIILLGRL

Sequences:

>Translated_280_residues
MKIKKYASLIRFQSLGGMWLCFFPALFVVALLGNSFYSFLWIPFFLLGAFLVRSAGCIANDIADRNIDGKVKRTASRPIA
SGEVRVTEAVLLFLILLVLATVLLAFLPLEATALGAFTIVGVVVYPFSKRYFAYPQLLLAVIFNVGALFASIVVVNSIHA
SALFVYLACFFWTLYYDTIYGHQDKCYDVALGVHSLSLGKFGSREWLKKYARLALSFLAFSAVLPGLNLLYYIGLAALFL
VEEKFTESINLDDPKNCGMAFKRMNFVGVLIFLIILLGRL
>Mature_280_residues
MKIKKYASLIRFQSLGGMWLCFFPALFVVALLGNSFYSFLWIPFFLLGAFLVRSAGCIANDIADRNIDGKVKRTASRPIA
SGEVRVTEAVLLFLILLVLATVLLAFLPLEATALGAFTIVGVVVYPFSKRYFAYPQLLLAVIFNVGALFASIVVVNSIHA
SALFVYLACFFWTLYYDTIYGHQDKCYDVALGVHSLSLGKFGSREWLKKYARLALSFLAFSAVLPGLNLLYYIGLAALFL
VEEKFTESINLDDPKNCGMAFKRMNFVGVLIFLIILLGRL

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=286, Percent_Identity=34.6153846153846, Blast_Score=151, Evalue=6e-37,
Organism=Escherichia coli, GI1790473, Length=284, Percent_Identity=32.3943661971831, Blast_Score=121, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17553718, Length=284, Percent_Identity=33.0985915492958, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI32565247, Length=285, Percent_Identity=30.8771929824561, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17553720, Length=186, Percent_Identity=34.4086021505376, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32565243, Length=151, Percent_Identity=35.7615894039735, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=35.4609929078014, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324370, Length=263, Percent_Identity=31.9391634980989, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21355567, Length=284, Percent_Identity=35.2112676056338, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 31160; Mature: 31160

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKKYASLIRFQSLGGMWLCFFPALFVVALLGNSFYSFLWIPFFLLGAFLVRSAGCIAN
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DIADRNIDGKVKRTASRPIASGEVRVTEAVLLFLILLVLATVLLAFLPLEATALGAFTIV
HHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVVYPFSKRYFAYPQLLLAVIFNVGALFASIVVVNSIHASALFVYLACFFWTLYYDTIY
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHQDKCYDVALGVHSLSLGKFGSREWLKKYARLALSFLAFSAVLPGLNLLYYIGLAALFL
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEEKFTESINLDDPKNCGMAFKRMNFVGVLIFLIILLGRL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIKKYASLIRFQSLGGMWLCFFPALFVVALLGNSFYSFLWIPFFLLGAFLVRSAGCIAN
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DIADRNIDGKVKRTASRPIASGEVRVTEAVLLFLILLVLATVLLAFLPLEATALGAFTIV
HHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVVYPFSKRYFAYPQLLLAVIFNVGALFASIVVVNSIHASALFVYLACFFWTLYYDTIY
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHQDKCYDVALGVHSLSLGKFGSREWLKKYARLALSFLAFSAVLPGLNLLYYIGLAALFL
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEEKFTESINLDDPKNCGMAFKRMNFVGVLIFLIILLGRL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA