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The map label for this gene is grxC

Identifier: 88608660

GI number: 88608660

Start: 253796

End: 254065

Strand: Reverse

Name: grxC

Synonym: NSE_0311

Alternate gene names: 88608660

Gene position: 254065-253796 (Counterclockwise)

Preceding gene: 88608313

Following gene: 88608069

Centisome position: 29.58

GC content: 42.59

Gene sequence:

>270_bases
ATGAATCACAAGGTCGTAATATATGTGAAAGAATTTTGTCCTTACTGTAGCAGGGCGAAGGAGTTGCTCGACAGAAAAGG
TGTCTTGTACACGGTAGTGGACATTACCAATGATCCGGATCTAGCCGTAGTTATGATGGAAAGATCAGGTGGGAGGAAGA
CTGTTCCCCAAGTTTTCATTAATGACGTGTGTGTAGGTGGCTTTGATGATCTCAACAGCCTAAACGAGAGTGGCAAGCTC
AATGAGCTCTTATTTTTGAACAATCAGTAA

Upstream 100 bases:

>100_bases
AACGCGTCAGTATGGGTGTATAAAGTAGCAAACCTAGAAAAGCTTGATATTCGTGTCATGTGAGCTTATAAATGCCAAAG
TACATCATCCCCGTCGCGCT

Downstream 100 bases:

>100_bases
AGGTGTTTTATTCTTCTTCTGGCTCAGAAAAGGCAACATCTGTTGCCGCGTTTATTAGTTCGCGTTACGGAATAAAGTGC
ATTGACGCTCCAGAGGCAGT

Product: glutaredoxin 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 89; Mature: 89

Protein sequence:

>89_residues
MNHKVVIYVKEFCPYCSRAKELLDRKGVLYTVVDITNDPDLAVVMMERSGGRKTVPQVFINDVCVGGFDDLNSLNESGKL
NELLFLNNQ

Sequences:

>Translated_89_residues
MNHKVVIYVKEFCPYCSRAKELLDRKGVLYTVVDITNDPDLAVVMMERSGGRKTVPQVFINDVCVGGFDDLNSLNESGKL
NELLFLNNQ
>Mature_89_residues
MNHKVVIYVKEFCPYCSRAKELLDRKGVLYTVVDITNDPDLAVVMMERSGGRKTVPQVFINDVCVGGFDDLNSLNESGKL
NELLFLNNQ

Specific function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins [H]

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI169646776, Length=82, Percent_Identity=43.9024390243902, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI4504025, Length=82, Percent_Identity=43.9024390243902, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790039, Length=80, Percent_Identity=48.75, Blast_Score=73, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011900
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 10039; Mature: 10039

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHKVVIYVKEFCPYCSRAKELLDRKGVLYTVVDITNDPDLAVVMMERSGGRKTVPQVFI
CCCEEEEEHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCCCCHHHHH
NDVCVGGFDDLNSLNESGKLNELLFLNNQ
HHEECCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MNHKVVIYVKEFCPYCSRAKELLDRKGVLYTVVDITNDPDLAVVMMERSGGRKTVPQVFI
CCCEEEEEHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCCCCHHHHH
NDVCVGGFDDLNSLNESGKLNELLFLNNQ
HHEECCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA