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The map label for this gene is mutS

Identifier: 88608613

GI number: 88608613

Start: 273806

End: 276253

Strand: Direct

Name: mutS

Synonym: NSE_0335

Alternate gene names: 88608613

Gene position: 273806-276253 (Clockwise)

Preceding gene: 88608301

Following gene: 88608693

Centisome position: 31.87

GC content: 41.63

Gene sequence:

>2448_bases
ATGTCAGAAGAATTCCCGCCTGCGATGAAACGGTATTTGGAAGTCCGATGCCAATACCCAGATGCGGTTGTTTTCTATAG
AGTAGGTGATTTCTACGAGATGTTTTTCGAAGATGCACGCGAGGTATCGCATCTACTAGGGTTGCATCTTACTCGAAGGG
GTACGTACAAGGGGAAAGATATTCCGATGTGTGGGGTACCAGTTTCTTCTTGTGAAGTTTACATAAACAAATTAGTAAAG
CTAGGTCGTAAGGTTGCTATTTGTGAGCAATTGGAAACAGCAGAGGAAGCAAAAAAACGTGGTGCCACAGCTATAGTCAG
AAGAGATGTAGTTCGGCTGGTTACTCCTGGGACACTTACTGAGGATAATCTTCTAGTGAGTGGGGAGAACAACTATTTAC
TCTGTGTTGCTCCTGGGAAGAATGAGATTGGTCTGGCATGGTTGGATATTTCTACAAAGAAGATTGTCTTCACAAGTGCC
AACCCAGCTTCTTTGGAAAGCTATCTCGCGAAAATTGAGCCCAAGGAGGTATTACTTCCAGATGCAATTGATTCAGAACT
GAGAAAAGTTATAGAACAACACAACATCCATATAACGAGACGTCCCAATAACCTTTTTCAATTTGATTATGCCGCAAATG
AATTGAGAGGGTTTTATAATGTTCTTCAATTGGGTTTTATGGATGCTAGATCTCCATGCGAAATTGTTGCTTGTGGTGCT
CTGATTGCTTATGCGCGTGCAACACAAATGGGGGAGCTAAAACGGTTAGAATTTCCAAAACGATACGAGAAGGGCTACTA
TCTTGCGCTTGATGCATCAACTATTCGAGGTCTGGAGTTAATCGAATCGCAAACACCAGGTGAGAAGAATAGTTTACTGC
AAGTAATTGACCAGACGTGTACAGCAGGAGGTAAAAGGCTTCTAAAGAGCTATATCGTTTCTCCGCTGATATCGGTCGAA
GAAATTCAAGCCCGTCAAGACAAGGTAGAATTTTTCTTTATACAAGAAGAGTTGCGAAAAAAGGTGCGTACCGAACTTGC
TAACATTCCAGATGCAGAGCGAGCACTGTCGCGCATTGCACTGAATCGTGGAGAACCAATTGATTGTCTTGCTGTGCATT
CCTGTATGAGGAGTTCGCTATTACTCGCTGAGTGTTTTTCTGCTTTCCTAGAGAATGGTTATATTAGAAGCATATATGAC
AAATGTGCTCCAGATGATGAATTGATGGAGACTTTGCGCACTGCGTTTTTACCAACTTCTAATAGAAAAGTGGATGGCCC
GTTTCTAGATCCTACACATCATCCCAAACTTCTAGAGTTGAATAGGTTATCCACCAACGCTGATGTGGTGATAAATGATT
TGTTAAACACATACAAAAGGAATACTGGGATTAACTCTTTGAAATTGGGTAAGAACAACCTTATAGGCTACTATGTTGAG
GTTCCTAAGTCCGCGCCGCTTCTTGATAGTGAAGTTTTTATCCACAGACAATCCTTGTTGAACAATATACGCTATACAAC
TCTTGAGTTGCAGAATTTGGAGGCACAGATAGCAAAAGCAAACGAGAACTACAGAAAGTTAGAATTGGAACTTTTCAGGG
AACTGTGTGGAAAAATTCTTGCATCTGAGGGTCCACTGAAAGAAATGATCGCAGCAATAGCAGAACTGGATGTTATAGCT
TCCTTTGCTGAGATTGCTGTTCAAAGAAAATATGTGCGTCCACAGGTTGATAATAGTAACGAACTGCGCATTTCTGGGGG
TAGACACCCATTTGTAGAACAGGTGAATGCATTTGTGCCAAATGATCTAGCTTTTACCTCCGCAGAGCGTGTGTGTGTTT
TAACTGGGCCTAATATGGCTGGAAAAAGTACTTACCTGCGTCAAAATGCATTGATAACTATACTTGCTCAAATGGGTTCG
TTTGTGCCAGCTGATTCTGCTCACATCGGTGTTGTAGATAGGGTTTTTAGTCGCATTGGCGCATCTGATAATATTGCCAT
GGGCAAGTCAACGTTTATGGTGGAAATGATGGAGACAGCAAATATAGTTAATAATGCGACATGCAGATCTCTCGTAATCT
TAGATGAGGTTGGGAGAGGTACGTCTACTCTAGACGGTATCTCAATCGCACAAGCTGTTCTTGAATATTTGCATGACTCA
GTGAACTGTAAGACTATTTTTGCAACTCATTACAACGAGCTTTGTGATCTGGAAAGTAAACTCCCACGGATGAAATGTTA
CTCAATTGAAGTAAAGCGCTGGCGAGATGAGGTTCTTCTAATGTATAAAATTGTTCCTGGGCGAGGTGATAATTCGTATG
GAATACATACAGCAATGCTTTCTGGTATTCCAGAAGCGATTATCCGTCGCGCAACCGAAATAGCGAAGGAAAAGAATCTC
AGCATTGAGAATTCCCTTTCTAATGAAAGGATCAGAGTGAAACACTAG

Upstream 100 bases:

>100_bases
TTTACTTGCTGTCACTAATCTATCTTTAAGCACATTTGCTTCTGGCAATCTCCGCTTTAGTGAGAGAGAATTGTTCATTT
TGGACTGGTCTTGTTTGTTT

Downstream 100 bases:

>100_bases
TGAGGGATGGTACGTATCATTTGTTCTTAAATTTTTTGAGTTTCTCATGAGTCAATATGGGTTACTGGGTCGGTGTGGGG
TATTCTTTAGGTTATTAATT

Product: DNA mismatch repair protein MutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MSEEFPPAMKRYLEVRCQYPDAVVFYRVGDFYEMFFEDAREVSHLLGLHLTRRGTYKGKDIPMCGVPVSSCEVYINKLVK
LGRKVAICEQLETAEEAKKRGATAIVRRDVVRLVTPGTLTEDNLLVSGENNYLLCVAPGKNEIGLAWLDISTKKIVFTSA
NPASLESYLAKIEPKEVLLPDAIDSELRKVIEQHNIHITRRPNNLFQFDYAANELRGFYNVLQLGFMDARSPCEIVACGA
LIAYARATQMGELKRLEFPKRYEKGYYLALDASTIRGLELIESQTPGEKNSLLQVIDQTCTAGGKRLLKSYIVSPLISVE
EIQARQDKVEFFFIQEELRKKVRTELANIPDAERALSRIALNRGEPIDCLAVHSCMRSSLLLAECFSAFLENGYIRSIYD
KCAPDDELMETLRTAFLPTSNRKVDGPFLDPTHHPKLLELNRLSTNADVVINDLLNTYKRNTGINSLKLGKNNLIGYYVE
VPKSAPLLDSEVFIHRQSLLNNIRYTTLELQNLEAQIAKANENYRKLELELFRELCGKILASEGPLKEMIAAIAELDVIA
SFAEIAVQRKYVRPQVDNSNELRISGGRHPFVEQVNAFVPNDLAFTSAERVCVLTGPNMAGKSTYLRQNALITILAQMGS
FVPADSAHIGVVDRVFSRIGASDNIAMGKSTFMVEMMETANIVNNATCRSLVILDEVGRGTSTLDGISIAQAVLEYLHDS
VNCKTIFATHYNELCDLESKLPRMKCYSIEVKRWRDEVLLMYKIVPGRGDNSYGIHTAMLSGIPEAIIRRATEIAKEKNL
SIENSLSNERIRVKH

Sequences:

>Translated_815_residues
MSEEFPPAMKRYLEVRCQYPDAVVFYRVGDFYEMFFEDAREVSHLLGLHLTRRGTYKGKDIPMCGVPVSSCEVYINKLVK
LGRKVAICEQLETAEEAKKRGATAIVRRDVVRLVTPGTLTEDNLLVSGENNYLLCVAPGKNEIGLAWLDISTKKIVFTSA
NPASLESYLAKIEPKEVLLPDAIDSELRKVIEQHNIHITRRPNNLFQFDYAANELRGFYNVLQLGFMDARSPCEIVACGA
LIAYARATQMGELKRLEFPKRYEKGYYLALDASTIRGLELIESQTPGEKNSLLQVIDQTCTAGGKRLLKSYIVSPLISVE
EIQARQDKVEFFFIQEELRKKVRTELANIPDAERALSRIALNRGEPIDCLAVHSCMRSSLLLAECFSAFLENGYIRSIYD
KCAPDDELMETLRTAFLPTSNRKVDGPFLDPTHHPKLLELNRLSTNADVVINDLLNTYKRNTGINSLKLGKNNLIGYYVE
VPKSAPLLDSEVFIHRQSLLNNIRYTTLELQNLEAQIAKANENYRKLELELFRELCGKILASEGPLKEMIAAIAELDVIA
SFAEIAVQRKYVRPQVDNSNELRISGGRHPFVEQVNAFVPNDLAFTSAERVCVLTGPNMAGKSTYLRQNALITILAQMGS
FVPADSAHIGVVDRVFSRIGASDNIAMGKSTFMVEMMETANIVNNATCRSLVILDEVGRGTSTLDGISIAQAVLEYLHDS
VNCKTIFATHYNELCDLESKLPRMKCYSIEVKRWRDEVLLMYKIVPGRGDNSYGIHTAMLSGIPEAIIRRATEIAKEKNL
SIENSLSNERIRVKH
>Mature_814_residues
SEEFPPAMKRYLEVRCQYPDAVVFYRVGDFYEMFFEDAREVSHLLGLHLTRRGTYKGKDIPMCGVPVSSCEVYINKLVKL
GRKVAICEQLETAEEAKKRGATAIVRRDVVRLVTPGTLTEDNLLVSGENNYLLCVAPGKNEIGLAWLDISTKKIVFTSAN
PASLESYLAKIEPKEVLLPDAIDSELRKVIEQHNIHITRRPNNLFQFDYAANELRGFYNVLQLGFMDARSPCEIVACGAL
IAYARATQMGELKRLEFPKRYEKGYYLALDASTIRGLELIESQTPGEKNSLLQVIDQTCTAGGKRLLKSYIVSPLISVEE
IQARQDKVEFFFIQEELRKKVRTELANIPDAERALSRIALNRGEPIDCLAVHSCMRSSLLLAECFSAFLENGYIRSIYDK
CAPDDELMETLRTAFLPTSNRKVDGPFLDPTHHPKLLELNRLSTNADVVINDLLNTYKRNTGINSLKLGKNNLIGYYVEV
PKSAPLLDSEVFIHRQSLLNNIRYTTLELQNLEAQIAKANENYRKLELELFRELCGKILASEGPLKEMIAAIAELDVIAS
FAEIAVQRKYVRPQVDNSNELRISGGRHPFVEQVNAFVPNDLAFTSAERVCVLTGPNMAGKSTYLRQNALITILAQMGSF
VPADSAHIGVVDRVFSRIGASDNIAMGKSTFMVEMMETANIVNNATCRSLVILDEVGRGTSTLDGISIAQAVLEYLHDSV
NCKTIFATHYNELCDLESKLPRMKCYSIEVKRWRDEVLLMYKIVPGRGDNSYGIHTAMLSGIPEAIIRRATEIAKEKNLS
IENSLSNERIRVKH

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI4557761, Length=866, Percent_Identity=26.6743648960739, Blast_Score=263, Evalue=6e-70,
Organism=Homo sapiens, GI284813531, Length=292, Percent_Identity=41.4383561643836, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI4504191, Length=618, Percent_Identity=30.0970873786408, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI26638666, Length=729, Percent_Identity=26.3374485596708, Blast_Score=202, Evalue=7e-52,
Organism=Homo sapiens, GI4505253, Length=729, Percent_Identity=26.3374485596708, Blast_Score=202, Evalue=7e-52,
Organism=Homo sapiens, GI26638664, Length=730, Percent_Identity=26.3013698630137, Blast_Score=199, Evalue=1e-50,
Organism=Homo sapiens, GI36949366, Length=348, Percent_Identity=33.0459770114943, Blast_Score=185, Evalue=2e-46,
Organism=Homo sapiens, GI262231786, Length=572, Percent_Identity=27.6223776223776, Blast_Score=176, Evalue=5e-44,
Organism=Escherichia coli, GI1789089, Length=799, Percent_Identity=35.0438047559449, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17508445, Length=566, Percent_Identity=30.565371024735, Blast_Score=229, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17508447, Length=364, Percent_Identity=34.0659340659341, Blast_Score=189, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17534743, Length=589, Percent_Identity=26.8251273344652, Blast_Score=161, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17539736, Length=339, Percent_Identity=26.2536873156342, Blast_Score=126, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324482, Length=772, Percent_Identity=28.6269430051813, Blast_Score=280, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6320302, Length=900, Percent_Identity=26.3333333333333, Blast_Score=267, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6319935, Length=888, Percent_Identity=28.2657657657658, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321912, Length=304, Percent_Identity=39.4736842105263, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321109, Length=505, Percent_Identity=28.7128712871287, Blast_Score=167, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6320047, Length=659, Percent_Identity=23.5204855842185, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24584320, Length=680, Percent_Identity=28.0882352941176, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24664545, Length=308, Percent_Identity=37.6623376623377, Blast_Score=199, Evalue=6e-51,
Organism=Drosophila melanogaster, GI62471629, Length=565, Percent_Identity=26.0176991150442, Blast_Score=134, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 91534; Mature: 91402

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEFPPAMKRYLEVRCQYPDAVVFYRVGDFYEMFFEDAREVSHLLGLHLTRRGTYKGKD
CCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
IPMCGVPVSSCEVYINKLVKLGRKVAICEQLETAEEAKKRGATAIVRRDVVRLVTPGTLT
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
EDNLLVSGENNYLLCVAPGKNEIGLAWLDISTKKIVFTSANPASLESYLAKIEPKEVLLP
CCCEEEECCCCEEEEEECCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHCCCHHEECC
DAIDSELRKVIEQHNIHITRRPNNLFQFDYAANELRGFYNVLQLGFMDARSPCEIVACGA
CHHHHHHHHHHHHCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LIAYARATQMGELKRLEFPKRYEKGYYLALDASTIRGLELIESQTPGEKNSLLQVIDQTC
HHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHH
TAGGKRLLKSYIVSPLISVEEIQARQDKVEFFFIQEELRKKVRTELANIPDAERALSRIA
HHHHHHHHHHHHHHHCCCHHHHHHHHCCHHEEEEHHHHHHHHHHHHHCCCCHHHHHHHHH
LNRGEPIDCLAVHSCMRSSLLLAECFSAFLENGYIRSIYDKCAPDDELMETLRTAFLPTS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCC
NRKVDGPFLDPTHHPKLLELNRLSTNADVVINDLLNTYKRNTGINSLKLGKNNLIGYYVE
CCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEE
VPKSAPLLDSEVFIHRQSLLNNIRYTTLELQNLEAQIAKANENYRKLELELFRELCGKIL
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ASEGPLKEMIAAIAELDVIASFAEIAVQRKYVRPQVDNSNELRISGGRHPFVEQVNAFVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCC
NDLAFTSAERVCVLTGPNMAGKSTYLRQNALITILAQMGSFVPADSAHIGVVDRVFSRIG
CCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
ASDNIAMGKSTFMVEMMETANIVNNATCRSLVILDEVGRGTSTLDGISIAQAVLEYLHDS
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
VNCKTIFATHYNELCDLESKLPRMKCYSIEVKRWRDEVLLMYKIVPGRGDNSYGIHTAML
CCCEEEEEHHHHHHHHHHHCCCCCEEEEEHHHHHHCCEEEEEEEECCCCCCCCCHHHHHH
SGIPEAIIRRATEIAKEKNLSIENSLSNERIRVKH
HCCHHHHHHHHHHHHHHCCCCHHCCCCCCCEEECC
>Mature Secondary Structure 
SEEFPPAMKRYLEVRCQYPDAVVFYRVGDFYEMFFEDAREVSHLLGLHLTRRGTYKGKD
CCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
IPMCGVPVSSCEVYINKLVKLGRKVAICEQLETAEEAKKRGATAIVRRDVVRLVTPGTLT
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
EDNLLVSGENNYLLCVAPGKNEIGLAWLDISTKKIVFTSANPASLESYLAKIEPKEVLLP
CCCEEEECCCCEEEEEECCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHCCCHHEECC
DAIDSELRKVIEQHNIHITRRPNNLFQFDYAANELRGFYNVLQLGFMDARSPCEIVACGA
CHHHHHHHHHHHHCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LIAYARATQMGELKRLEFPKRYEKGYYLALDASTIRGLELIESQTPGEKNSLLQVIDQTC
HHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHH
TAGGKRLLKSYIVSPLISVEEIQARQDKVEFFFIQEELRKKVRTELANIPDAERALSRIA
HHHHHHHHHHHHHHHCCCHHHHHHHHCCHHEEEEHHHHHHHHHHHHHCCCCHHHHHHHHH
LNRGEPIDCLAVHSCMRSSLLLAECFSAFLENGYIRSIYDKCAPDDELMETLRTAFLPTS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCC
NRKVDGPFLDPTHHPKLLELNRLSTNADVVINDLLNTYKRNTGINSLKLGKNNLIGYYVE
CCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEE
VPKSAPLLDSEVFIHRQSLLNNIRYTTLELQNLEAQIAKANENYRKLELELFRELCGKIL
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ASEGPLKEMIAAIAELDVIASFAEIAVQRKYVRPQVDNSNELRISGGRHPFVEQVNAFVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCC
NDLAFTSAERVCVLTGPNMAGKSTYLRQNALITILAQMGSFVPADSAHIGVVDRVFSRIG
CCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
ASDNIAMGKSTFMVEMMETANIVNNATCRSLVILDEVGRGTSTLDGISIAQAVLEYLHDS
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
VNCKTIFATHYNELCDLESKLPRMKCYSIEVKRWRDEVLLMYKIVPGRGDNSYGIHTAML
CCCEEEEEHHHHHHHHHHHCCCCCEEEEEHHHHHHCCEEEEEEEECCCCCCCCCHHHHHH
SGIPEAIIRRATEIAKEKNLSIENSLSNERIRVKH
HCCHHHHHHHHHHHHHHCCCCHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA