Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 88608525

GI number: 88608525

Start: 361526

End: 362551

Strand: Reverse

Name: obgE

Synonym: NSE_0444

Alternate gene names: 88608525

Gene position: 362551-361526 (Counterclockwise)

Preceding gene: 88608279

Following gene: 88608647

Centisome position: 42.21

GC content: 39.38

Gene sequence:

>1026_bases
TTGAAATTTATAGACGAAGTAAAAGTCTTTTTGAAGGCAGGAAATGGTGGCGATGGCTGTTCAAGTTTTCGGAGAGAGAA
GTTTGTTGAGTTTGGTGGACCGGATGGTGGTTGTGGGGGAGATGGAGGAAACGTGATCTTTATCACAGATGAGAATCTAA
ACACGTTGCTGGATTACCGACATAGGGTTCATCTTAAAGCCGAAAATGGAAAACCTGGAAGAAAATCTAATAAACGTGGT
GAGAGTGGCTCTGATTTGGTTTGTAAGGTACCTATAGGTACTCAAATACTTACGCAGGACAGAGTACTCTTGTCTGATTT
GGAGCAACCCAAACAAAGCTTTATTTCGGCTTTCGGTGGAAAAGGTGGTCGTGGCAATGCAACATTCAAAAATTCACTAA
ACCGGGCTGCAACTGAGTTTACCTGTGGTGAACCCGGCGAAGAAAAGACCGTAATTCTAAATTTAAAAATATTAGCAGAT
ATTGGTTTAATTGGACTCCCAAATGCAGGAAAATCTACATTTTTGTCTAGGTGTTCGAACGCTAAACCAAAAATCGCTGA
CTACCCTTTTTCAACACTTGAGCCAATCGTCGGAATAGCAAAAATAAATAACCACGAAATAGTCATAGCAGATATTCCTG
GTATTATCGAAGGAGCTCACAAAAACCTTGGGTTAGGGGTCAAATTTTTGAAACATATAGAACGCTGTAAGGCATTGATA
TACCTCATAGATGGAACAGAAAAGGATATTTACTCAGTTTATACACTCTTATCGAATGAACTCTCTCTATACAGCAAAAA
GCTGGAAATAAAAGAGCACTTTATCCTTATTACAAAATCAGATCTACTTGGTAAAGATGAAGTACAAGAAAAGTGCCAAT
ATATTCGGGAAAAAACCGGAAAGCTTACTTTGCACACAGGTATCGATCAGGAACTTGCGTCTTCTCTGAAGGCCGCTCAA
AAACTTGTCGAACTTCACCAACCAGGAAACAAATCACGTGGTAAATATAATCCACTAGAAGTGTAG

Upstream 100 bases:

>100_bases
TTTAGATAAAAATAAAAAATTACTATACAATGAACCTCACAGAAGACGATTTTCAGAGTACGAGCAGTACAGAAAACACA
CCTTAAATGGAGAGTGAAAT

Downstream 100 bases:

>100_bases
TTTCCATATCCTTTAGCATACAAGGCAGAAACTTACTGGAGGAGGTCTTACATGGACTGCTTCGATAAAAAGCATAGCAC
TGCACAAACAAAAGTTAGTA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKFIDEVKVFLKAGNGGDGCSSFRREKFVEFGGPDGGCGGDGGNVIFITDENLNTLLDYRHRVHLKAENGKPGRKSNKRG
ESGSDLVCKVPIGTQILTQDRVLLSDLEQPKQSFISAFGGKGGRGNATFKNSLNRAATEFTCGEPGEEKTVILNLKILAD
IGLIGLPNAGKSTFLSRCSNAKPKIADYPFSTLEPIVGIAKINNHEIVIADIPGIIEGAHKNLGLGVKFLKHIERCKALI
YLIDGTEKDIYSVYTLLSNELSLYSKKLEIKEHFILITKSDLLGKDEVQEKCQYIREKTGKLTLHTGIDQELASSLKAAQ
KLVELHQPGNKSRGKYNPLEV

Sequences:

>Translated_341_residues
MKFIDEVKVFLKAGNGGDGCSSFRREKFVEFGGPDGGCGGDGGNVIFITDENLNTLLDYRHRVHLKAENGKPGRKSNKRG
ESGSDLVCKVPIGTQILTQDRVLLSDLEQPKQSFISAFGGKGGRGNATFKNSLNRAATEFTCGEPGEEKTVILNLKILAD
IGLIGLPNAGKSTFLSRCSNAKPKIADYPFSTLEPIVGIAKINNHEIVIADIPGIIEGAHKNLGLGVKFLKHIERCKALI
YLIDGTEKDIYSVYTLLSNELSLYSKKLEIKEHFILITKSDLLGKDEVQEKCQYIREKTGKLTLHTGIDQELASSLKAAQ
KLVELHQPGNKSRGKYNPLEV
>Mature_341_residues
MKFIDEVKVFLKAGNGGDGCSSFRREKFVEFGGPDGGCGGDGGNVIFITDENLNTLLDYRHRVHLKAENGKPGRKSNKRG
ESGSDLVCKVPIGTQILTQDRVLLSDLEQPKQSFISAFGGKGGRGNATFKNSLNRAATEFTCGEPGEEKTVILNLKILAD
IGLIGLPNAGKSTFLSRCSNAKPKIADYPFSTLEPIVGIAKINNHEIVIADIPGIIEGAHKNLGLGVKFLKHIERCKALI
YLIDGTEKDIYSVYTLLSNELSLYSKKLEIKEHFILITKSDLLGKDEVQEKCQYIREKTGKLTLHTGIDQELASSLKAAQ
KLVELHQPGNKSRGKYNPLEV

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=300, Percent_Identity=42, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI111955139, Length=293, Percent_Identity=33.4470989761092, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI111955063, Length=127, Percent_Identity=44.0944881889764, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4557537, Length=103, Percent_Identity=35.9223300970874, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789574, Length=307, Percent_Identity=46.5798045602606, Blast_Score=243, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17508313, Length=292, Percent_Identity=41.4383561643836, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17552324, Length=310, Percent_Identity=31.6129032258064, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321962, Length=159, Percent_Identity=40.251572327044, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321612, Length=91, Percent_Identity=35.1648351648352, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319281, Length=87, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI20129375, Length=282, Percent_Identity=39.0070921985816, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24585318, Length=307, Percent_Identity=34.8534201954397, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_NEOSM (Q2GDW7)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506329.1
- HSSP:   Q5SJ29
- ProteinModelPortal:   Q2GDW7
- SMR:   Q2GDW7
- STRING:   Q2GDW7
- GeneID:   3932090
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0444
- TIGR:   NSE_0444
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- ProtClustDB:   PRK12299
- BioCyc:   NSEN222891:NSE_0444-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 37285; Mature: 37285

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIDEVKVFLKAGNGGDGCSSFRREKFVEFGGPDGGCGGDGGNVIFITDENLNTLLDYR
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHCC
HRVHLKAENGKPGRKSNKRGESGSDLVCKVPIGTQILTQDRVLLSDLEQPKQSFISAFGG
CEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCEEHHCCHHHHHHHHHHHHHHHHHHCC
KGGRGNATFKNSLNRAATEFTCGEPGEEKTVILNLKILADIGLIGLPNAGKSTFLSRCSN
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCEEECCCCCHHHHHHHHCC
AKPKIADYPFSTLEPIVGIAKINNHEIVIADIPGIIEGAHKNLGLGVKFLKHIERCKALI
CCCCCCCCCCHHHHHHHHHEEECCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHEEE
YLIDGTEKDIYSVYTLLSNELSLYSKKLEIKEHFILITKSDLLGKDEVQEKCQYIREKTG
EEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCC
KLTLHTGIDQELASSLKAAQKLVELHQPGNKSRGKYNPLEV
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKFIDEVKVFLKAGNGGDGCSSFRREKFVEFGGPDGGCGGDGGNVIFITDENLNTLLDYR
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHCC
HRVHLKAENGKPGRKSNKRGESGSDLVCKVPIGTQILTQDRVLLSDLEQPKQSFISAFGG
CEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCEEHHCCHHHHHHHHHHHHHHHHHHCC
KGGRGNATFKNSLNRAATEFTCGEPGEEKTVILNLKILADIGLIGLPNAGKSTFLSRCSN
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCEEECCCCCHHHHHHHHCC
AKPKIADYPFSTLEPIVGIAKINNHEIVIADIPGIIEGAHKNLGLGVKFLKHIERCKALI
CCCCCCCCCCHHHHHHHHHEEECCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHEEE
YLIDGTEKDIYSVYTLLSNELSLYSKKLEIKEHFILITKSDLLGKDEVQEKCQYIREKTG
EEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCC
KLTLHTGIDQELASSLKAAQKLVELHQPGNKSRGKYNPLEV
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA