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The map label for this gene is lspA

Identifier: 88608487

GI number: 88608487

Start: 812233

End: 812787

Strand: Reverse

Name: lspA

Synonym: NSE_0915

Alternate gene names: 88608487

Gene position: 812787-812233 (Counterclockwise)

Preceding gene: 88608482

Following gene: 88608715

Centisome position: 94.62

GC content: 42.34

Gene sequence:

>555_bases
TTGTCCTCGGGTTCTTTGTTTTCAAGGTGCGTTTTACAAAGTGTGGTTTGCGTGTTGCGAAGAAAGTTGTTCGAGGGATC
CGTTTTCTTTCGGCGAGTTTTAGTGATTCTAGGTGCGTGTTGCGTGACCTCCTTGGACTTATACACTAAGCGTCTATGTG
CTTCAATGTTTGAGAATATCACTGAGGTAAAGCTTTTGCCCATTCTTAATTTCGTCAAGGTGCACAATACTGGCATGAGT
TTTGGGCTTTTCGCTGGGTACCAGTTCTCGAACCTTTTTTTTCTTCTTATCAATGTACCCGCAGTACTAGTTGTGCTGTT
CCTTTCTTTTCGTGAAAAGAGATTGGTTGCTTGTGTTGCGTGGAGTTTTATTCTTGGAGGGGCTGTTGCTAACGTGACTG
ACAGAGTGCGTTTTGGTGCTGTGCGCGATTTTATTGACTTTCATTTTTTGGATCTCCATTGGCCGGTTTTTAATGTTGCT
GATGCAGCGATTTTTCTTGGTGTTGTGTTTGTACTTTTTCATTCAACCAGTGAGAAAGTCGGTAGCATAAATTAG

Upstream 100 bases:

>100_bases
GTGTATACTAAGGGGGCGCGCTGTTCCATGGACGAGTTAATCACAAGGCTTACTGGTGAGCCGCTCGACTGCAGATTTTT
TAAGAAGTTTGACCAGTAAT

Downstream 100 bases:

>100_bases
ATAAGAAATATTATGAAGCAGCTTTTATCTTGTTTGCTCTGTGTTTTTTCATTTTTCTTTTTGAGCCTTGGGCATTCGAA
AGGGGATGAGCGTATCCATT

Product: signal peptidase II

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSSGSLFSRCVLQSVVCVLRRKLFEGSVFFRRVLVILGACCVTSLDLYTKRLCASMFENITEVKLLPILNFVKVHNTGMS
FGLFAGYQFSNLFFLLINVPAVLVVLFLSFREKRLVACVAWSFILGGAVANVTDRVRFGAVRDFIDFHFLDLHWPVFNVA
DAAIFLGVVFVLFHSTSEKVGSIN

Sequences:

>Translated_184_residues
MSSGSLFSRCVLQSVVCVLRRKLFEGSVFFRRVLVILGACCVTSLDLYTKRLCASMFENITEVKLLPILNFVKVHNTGMS
FGLFAGYQFSNLFFLLINVPAVLVVLFLSFREKRLVACVAWSFILGGAVANVTDRVRFGAVRDFIDFHFLDLHWPVFNVA
DAAIFLGVVFVLFHSTSEKVGSIN
>Mature_183_residues
SSGSLFSRCVLQSVVCVLRRKLFEGSVFFRRVLVILGACCVTSLDLYTKRLCASMFENITEVKLLPILNFVKVHNTGMSF
GLFAGYQFSNLFFLLINVPAVLVVLFLSFREKRLVACVAWSFILGGAVANVTDRVRFGAVRDFIDFHFLDLHWPVFNVAD
AAIFLGVVFVLFHSTSEKVGSIN

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=134, Percent_Identity=31.3432835820896, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 20604; Mature: 20473

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGSLFSRCVLQSVVCVLRRKLFEGSVFFRRVLVILGACCVTSLDLYTKRLCASMFENI
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEVKLLPILNFVKVHNTGMSFGLFAGYQFSNLFFLLINVPAVLVVLFLSFREKRLVACVA
HHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WSFILGGAVANVTDRVRFGAVRDFIDFHFLDLHWPVFNVADAAIFLGVVFVLFHSTSEKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHC
GSIN
CCCC
>Mature Secondary Structure 
SSGSLFSRCVLQSVVCVLRRKLFEGSVFFRRVLVILGACCVTSLDLYTKRLCASMFENI
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEVKLLPILNFVKVHNTGMSFGLFAGYQFSNLFFLLINVPAVLVVLFLSFREKRLVACVA
HHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WSFILGGAVANVTDRVRFGAVRDFIDFHFLDLHWPVFNVADAAIFLGVVFVLFHSTSEKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHC
GSIN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA