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The map label for this gene is gmk

Identifier: 88608460

GI number: 88608460

Start: 649064

End: 649684

Strand: Direct

Name: gmk

Synonym: NSE_0726

Alternate gene names: 88608460

Gene position: 649064-649684 (Clockwise)

Preceding gene: 88607990

Following gene: 88608282

Centisome position: 75.56

GC content: 40.9

Gene sequence:

>621_bases
ATGCGGAAGGGAATTCTGTTTATAATCTCCTCCCCTTCTGGTGGAGGAAAAACGACAGTAGCGGATTTCTTGGTCGGTCA
GGACTTATCTATTAAGCGGTCCATCTCATTTACCACCAGGCAACCCCGTGGAGAGGAAAAGGATGGTATAGATTATTATT
TTGTAAGTAAGGATGAATTTAATCGATTGCTACAAGAAGGAGAAATGCTCGAGCATGCAACAGTTTTGCAAAATCAATAT
GGGACCTCACATAGATACATAGAAGAAACTCTGGCACTTGGTATAGATGTTCTTTGTTGTATAGACTGGCAGGGAGCTGA
GCAAATTCGCAAGAAGACCAATTGCATTTCCATATTTCTTCTACCGCCTAGTTTGCAAAAATTAAAAACACGGCTAACCA
GCAGAGGCACAGACACAGCAGACGTTATTGAATACAGACTAAAAGTTGCGCTTGAAGAAATTCAACATTTTTCAAAGTAT
GACTACGTACTTGTGAATGATGACCTGACGGAAACAAAACAAAAGGTACTCTCAATCATCACCGCGGAGAGAGAGAAACT
TGTACAAAACCACCGAGTGGTAGAATGCTTTGTAGCATCACTACTCGAACAAACCATATGA

Upstream 100 bases:

>100_bases
ATTTTTAGTGAAAATAAACTACACGATGTAGACCTTACGAAAGCTGATCTAGAAGGAAGTACCTTCCATAAATAAATGTT
AACTCAAAGGAAGATTGCGC

Downstream 100 bases:

>100_bases
TGCACGCTGTGCTAAGTATCACTCACTGTGCATGAACGAATTCCTGCTATCTAGAACAGGCCATTCATACTTAGTGCTTG
GTAAGTTATTTCCCTCTTCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRKGILFIISSPSGGGKTTVADFLVGQDLSIKRSISFTTRQPRGEEKDGIDYYFVSKDEFNRLLQEGEMLEHATVLQNQY
GTSHRYIEETLALGIDVLCCIDWQGAEQIRKKTNCISIFLLPPSLQKLKTRLTSRGTDTADVIEYRLKVALEEIQHFSKY
DYVLVNDDLTETKQKVLSIITAEREKLVQNHRVVECFVASLLEQTI

Sequences:

>Translated_206_residues
MRKGILFIISSPSGGGKTTVADFLVGQDLSIKRSISFTTRQPRGEEKDGIDYYFVSKDEFNRLLQEGEMLEHATVLQNQY
GTSHRYIEETLALGIDVLCCIDWQGAEQIRKKTNCISIFLLPPSLQKLKTRLTSRGTDTADVIEYRLKVALEEIQHFSKY
DYVLVNDDLTETKQKVLSIITAEREKLVQNHRVVECFVASLLEQTI
>Mature_206_residues
MRKGILFIISSPSGGGKTTVADFLVGQDLSIKRSISFTTRQPRGEEKDGIDYYFVSKDEFNRLLQEGEMLEHATVLQNQY
GTSHRYIEETLALGIDVLCCIDWQGAEQIRKKTNCISIFLLPPSLQKLKTRLTSRGTDTADVIEYRLKVALEEIQHFSKY
DYVLVNDDLTETKQKVLSIITAEREKLVQNHRVVECFVASLLEQTI

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=185, Percent_Identity=33.5135135135135, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI226874833, Length=185, Percent_Identity=33.5135135135135, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4504221, Length=185, Percent_Identity=33.5135135135135, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1790080, Length=205, Percent_Identity=43.4146341463415, Blast_Score=170, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=185, Percent_Identity=34.0540540540541, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17508835, Length=185, Percent_Identity=34.0540540540541, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=36.2637362637363, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21356141, Length=152, Percent_Identity=37.5, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_NEOSM (Q2GD44)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506602.1
- ProteinModelPortal:   Q2GD44
- STRING:   Q2GD44
- GeneID:   3931826
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0726
- TIGR:   NSE_0726
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q2GD44
- ProtClustDB:   PRK00300
- BioCyc:   NSEN222891:NSE_0726-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23493; Mature: 23493

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGILFIISSPSGGGKTTVADFLVGQDLSIKRSISFTTRQPRGEEKDGIDYYFVSKDEF
CCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEECEEECCCCCCCCCCCCCEEEEECHHHH
NRLLQEGEMLEHATVLQNQYGTSHRYIEETLALGIDVLCCIDWQGAEQIRKKTNCISIFL
HHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCEEEEEE
LPPSLQKLKTRLTSRGTDTADVIEYRLKVALEEIQHFSKYDYVLVNDDLTETKQKVLSII
ECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHH
TAEREKLVQNHRVVECFVASLLEQTI
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKGILFIISSPSGGGKTTVADFLVGQDLSIKRSISFTTRQPRGEEKDGIDYYFVSKDEF
CCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEECEEECCCCCCCCCCCCCEEEEECHHHH
NRLLQEGEMLEHATVLQNQYGTSHRYIEETLALGIDVLCCIDWQGAEQIRKKTNCISIFL
HHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCEEEEEE
LPPSLQKLKTRLTSRGTDTADVIEYRLKVALEEIQHFSKYDYVLVNDDLTETKQKVLSII
ECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHH
TAEREKLVQNHRVVECFVASLLEQTI
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA