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The map label for this gene is virB11

Identifier: 88608308

GI number: 88608308

Start: 660527

End: 661522

Strand: Reverse

Name: virB11

Synonym: NSE_0740

Alternate gene names: 88608308

Gene position: 661522-660527 (Counterclockwise)

Preceding gene: 88608478

Following gene: 88608007

Centisome position: 77.01

GC content: 44.48

Gene sequence:

>996_bases
ATGCAATACACAGCCCTGAATAAATACCTGGAGCCCTTGGATGCACTATTTCAGGATAGTGATGTCAACGAGATCTCGAT
CAATAAACCCGGGGAGGTGTGGATCGAAAAGAAGGGTGAGATTATGAGATCTGAACTTCCTGAGCTTGACTTTCAACACC
TTAAAGGACTTGCGAAATTGGTTGCTCAAGCCACAGAGCAAAATGTAAGTGGAGAGTTTCCACTTCTCTCTGCTTCTCTG
CCAAATGAATGTCGGATCCAGTTGGCTTTGCCACCCGTTGCAGAGGCGGGGACGGTTGTAATTTCAATAAGGAAACCTAG
CAGTATACAATTGTCTCTTGGTGATTATGAGGCAATGGGCGCATTTGAGAAACTTAAGTGTCGTGATGTTTCACTTGATA
TAGATAATCGCCTCCGCGAGCTCTTGAAGGGTGGTGATGTGAAAAGTTTCCTCGAACTTGCGATAAAAGAGAAAAAGAAC
ATCATCATCAGCGGTGGTACATCGACTGGTAAGACAACTTTTACTAATAGTCTGCTTCGCGAAATACCGATTTATGAAAG
AATTATCACGGTCGAAGATGCTCGGGAGGTAGTGTTGTCTAAGCATCCGAATAGGGTGCATTTAGTTGCCTCAAAGGGTG
GACAGGGTCGTGCCAATGTTACAACTCAGGATCTGATAGAGGCGTGCCTGCGTCTTCGTCCTGATAGAATTATAGTTGGT
GAATTAAGGGGTGCGGAGGCTTTTAGTTTTCTTAGGGCTATTAATACAGGGCATCCGGGCTCGATTTCCACTTTGCATGC
GGATGCCCCAAAGATGGCCATAGAGCAACTGAAACTTATGGTAATGCAGGCCGGTTTGGGAATTCCTCCTGTGCAAATTA
AGGAATATATAATGAATGTGGTAGATGTTATTGTTCAGCTCAAAAGAGCGGGTCATGGGAAGAGATTTGTTTCTGAGATC
TTGCTTACCAAGGATTTGCTTGAGAGTGGTAGTTGA

Upstream 100 bases:

>100_bases
TTACTGTGAACCAGGGTACAAGGCTTAAGGTATTCGTAAATCAAGACGTGGTTTTTCCAAGAGCCGCGTTTCAAGAGTAT
AAGGTGCTTAACTGATTCGT

Downstream 100 bases:

>100_bases
GCATGGGCATTGGGTGAGTCAGAGCGCGTTATGAGACAGCTTAGGAATATTATAACGATATTTTTTCTTCTGGCGTTCAT
TTTTGCCTTGGCCCTTTACA

Product: type IV secretion system ATPase VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MQYTALNKYLEPLDALFQDSDVNEISINKPGEVWIEKKGEIMRSELPELDFQHLKGLAKLVAQATEQNVSGEFPLLSASL
PNECRIQLALPPVAEAGTVVISIRKPSSIQLSLGDYEAMGAFEKLKCRDVSLDIDNRLRELLKGGDVKSFLELAIKEKKN
IIISGGTSTGKTTFTNSLLREIPIYERIITVEDAREVVLSKHPNRVHLVASKGGQGRANVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADAPKMAIEQLKLMVMQAGLGIPPVQIKEYIMNVVDVIVQLKRAGHGKRFVSEI
LLTKDLLESGS

Sequences:

>Translated_331_residues
MQYTALNKYLEPLDALFQDSDVNEISINKPGEVWIEKKGEIMRSELPELDFQHLKGLAKLVAQATEQNVSGEFPLLSASL
PNECRIQLALPPVAEAGTVVISIRKPSSIQLSLGDYEAMGAFEKLKCRDVSLDIDNRLRELLKGGDVKSFLELAIKEKKN
IIISGGTSTGKTTFTNSLLREIPIYERIITVEDAREVVLSKHPNRVHLVASKGGQGRANVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADAPKMAIEQLKLMVMQAGLGIPPVQIKEYIMNVVDVIVQLKRAGHGKRFVSEI
LLTKDLLESGS
>Mature_331_residues
MQYTALNKYLEPLDALFQDSDVNEISINKPGEVWIEKKGEIMRSELPELDFQHLKGLAKLVAQATEQNVSGEFPLLSASL
PNECRIQLALPPVAEAGTVVISIRKPSSIQLSLGDYEAMGAFEKLKCRDVSLDIDNRLRELLKGGDVKSFLELAIKEKKN
IIISGGTSTGKTTFTNSLLREIPIYERIITVEDAREVVLSKHPNRVHLVASKGGQGRANVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADAPKMAIEQLKLMVMQAGLGIPPVQIKEYIMNVVDVIVQLKRAGHGKRFVSEI
LLTKDLLESGS

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36441; Mature: 36441

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYTALNKYLEPLDALFQDSDVNEISINKPGEVWIEKKGEIMRSELPELDFQHLKGLAKL
CCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHH
VAQATEQNVSGEFPLLSASLPNECRIQLALPPVAEAGTVVISIRKPSSIQLSLGDYEAMG
HHHHHHCCCCCCCCEEECCCCCCCEEEEECCCCCCCCEEEEEEECCCEEEEECCCHHHHC
AFEKLKCRDVSLDIDNRLRELLKGGDVKSFLELAIKEKKNIIISGGTSTGKTTFTNSLLR
HHHHHHHEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
EIPIYERIITVEDAREVVLSKHPNRVHLVASKGGQGRANVTTQDLIEACLRLRPDRIIVG
HCCHHHHHEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEE
ELRGAEAFSFLRAINTGHPGSISTLHADAPKMAIEQLKLMVMQAGLGIPPVQIKEYIMNV
CCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VDVIVQLKRAGHGKRFVSEILLTKDLLESGS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQYTALNKYLEPLDALFQDSDVNEISINKPGEVWIEKKGEIMRSELPELDFQHLKGLAKL
CCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHH
VAQATEQNVSGEFPLLSASLPNECRIQLALPPVAEAGTVVISIRKPSSIQLSLGDYEAMG
HHHHHHCCCCCCCCEEECCCCCCCEEEEECCCCCCCCEEEEEEECCCEEEEECCCHHHHC
AFEKLKCRDVSLDIDNRLRELLKGGDVKSFLELAIKEKKNIIISGGTSTGKTTFTNSLLR
HHHHHHHEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
EIPIYERIITVEDAREVVLSKHPNRVHLVASKGGQGRANVTTQDLIEACLRLRPDRIIVG
HCCHHHHHEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEE
ELRGAEAFSFLRAINTGHPGSISTLHADAPKMAIEQLKLMVMQAGLGIPPVQIKEYIMNV
CCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VDVIVQLKRAGHGKRFVSEILLTKDLLESGS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]