Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 88608180

GI number: 88608180

Start: 855542

End: 856516

Strand: Direct

Name: hemE

Synonym: NSE_0968

Alternate gene names: 88608180

Gene position: 855542-856516 (Clockwise)

Preceding gene: 88608556

Following gene: 88607989

Centisome position: 99.6

GC content: 35.59

Gene sequence:

>975_bases
GTGTCACTGCTAGATAAAAAAATATCCACATGGTTTATGAGACAAGCAGGAAGGTATCTCCCTGAATATCTCAAAATATC
AAAAGAAATGACTTTTTTTCAGATGTGTGAATCACCTGAAATAGCATCAGAAATAACACTACAACCTATCAAAAGATTTG
ACCTTGACGCCGCAATAGTATTTTCTGATATTCTTGTCCTACCAAGAGCTCTTGGTTGTAATATAGATATCAAAAAAAGT
ACTGGTCCCGTAATAGAGAGGATAAATAACCCAAATTGGTTAACATATGATGCGTTCGAGGAGAAAATTTCTCCAACACT
AAATACGATTGCTATAACAAGAAAATCTCTTCCACAAAATAAGAGCCTAATAGGTTTTGCTGGAGGACCGTGGACAGTAG
CGCTCTATATCATTGAAGGTGGATGGGATAAGACTTTTTTAAGAACAAAAGAATTCATTAACAAAAGGTACCATGAGTTC
AAAGAAATAATATCGATTTTGACTGATGCAACAATTCAATACTTAAATAAACAACTCAAACACGGTGCGGACTTTATACA
AATATTTGAAAGTTTTGCTTGGGCAGCATCATCAAACGAGTTTAAAGAGTTCATAGTGGAACCGACGAGAAGAATAGTTT
CATCTATTGATGTTCCAGTTATAGGGTTCCCTAAAGGAGCTGGGGTGTCTTATCTTCAATATGTGAAAGAAACTTCAGTT
GACGTAATAAGTACTGACCATTCTCTACCACTCGATTGGATAGCAGACAATCTTCAAACTCATGCTGTTGTACAGGGAAA
CCTTGATCCTTATCTTCTGGCATTTAATAAAAAAGAAGCACTTCTGCAAACAGAGAGAATAGTAGATGCTTTCTCAGAAA
AGAATTTTATCTTCAATCTTGGTCATGGTATTTACAAGGAAACTCCGCTTTCCTCAGTGGAAGCAGTATTAGATTTTATA
AGAGCTAGGAATTAA

Upstream 100 bases:

>100_bases
CTAAAATCACATTAATAATAAAATATATATCTATAAAGTAAGTATGTAGTAGAATTAGAACTTACGTTACAGTAACTTAC
CTATAAGTTTCAAAGCGATT

Downstream 100 bases:

>100_bases
TAAGTAAATTTGTTACAACTACACCCGTGTCTCTTGTAATTACCTAAAAGTGGGCTTCCTTAAAAATCTTGAGAGAGAGA
TTGTGGAGCTAAAGAAAAAG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSLLDKKISTWFMRQAGRYLPEYLKISKEMTFFQMCESPEIASEITLQPIKRFDLDAAIVFSDILVLPRALGCNIDIKKS
TGPVIERINNPNWLTYDAFEEKISPTLNTIAITRKSLPQNKSLIGFAGGPWTVALYIIEGGWDKTFLRTKEFINKRYHEF
KEIISILTDATIQYLNKQLKHGADFIQIFESFAWAASSNEFKEFIVEPTRRIVSSIDVPVIGFPKGAGVSYLQYVKETSV
DVISTDHSLPLDWIADNLQTHAVVQGNLDPYLLAFNKKEALLQTERIVDAFSEKNFIFNLGHGIYKETPLSSVEAVLDFI
RARN

Sequences:

>Translated_324_residues
MSLLDKKISTWFMRQAGRYLPEYLKISKEMTFFQMCESPEIASEITLQPIKRFDLDAAIVFSDILVLPRALGCNIDIKKS
TGPVIERINNPNWLTYDAFEEKISPTLNTIAITRKSLPQNKSLIGFAGGPWTVALYIIEGGWDKTFLRTKEFINKRYHEF
KEIISILTDATIQYLNKQLKHGADFIQIFESFAWAASSNEFKEFIVEPTRRIVSSIDVPVIGFPKGAGVSYLQYVKETSV
DVISTDHSLPLDWIADNLQTHAVVQGNLDPYLLAFNKKEALLQTERIVDAFSEKNFIFNLGHGIYKETPLSSVEAVLDFI
RARN
>Mature_323_residues
SLLDKKISTWFMRQAGRYLPEYLKISKEMTFFQMCESPEIASEITLQPIKRFDLDAAIVFSDILVLPRALGCNIDIKKST
GPVIERINNPNWLTYDAFEEKISPTLNTIAITRKSLPQNKSLIGFAGGPWTVALYIIEGGWDKTFLRTKEFINKRYHEFK
EIISILTDATIQYLNKQLKHGADFIQIFESFAWAASSNEFKEFIVEPTRRIVSSIDVPVIGFPKGAGVSYLQYVKETSVD
VISTDHSLPLDWIADNLQTHAVVQGNLDPYLLAFNKKEALLQTERIVDAFSEKNFIFNLGHGIYKETPLSSVEAVLDFIR
ARN

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=330, Percent_Identity=33.6363636363636, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI2367337, Length=321, Percent_Identity=32.7102803738318, Blast_Score=182, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6320252, Length=319, Percent_Identity=34.7962382445141, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19921920, Length=334, Percent_Identity=38.0239520958084, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI221330099, Length=335, Percent_Identity=37.910447761194, Blast_Score=228, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_NEOSM (Q2GCG4)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506832.1
- ProteinModelPortal:   Q2GCG4
- SMR:   Q2GCG4
- STRING:   Q2GCG4
- GeneID:   3931747
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0968
- TIGR:   NSE_0968
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   QAGRYHK
- ProtClustDB:   CLSK2527762
- BioCyc:   NSEN222891:NSE_0968-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 36899; Mature: 36768

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 32-32 BINDING 63-63 BINDING 136-136 BINDING 191-191 BINDING 302-302

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLDKKISTWFMRQAGRYLPEYLKISKEMTFFQMCESPEIASEITLQPIKRFDLDAAIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHH
FSDILVLPRALGCNIDIKKSTGPVIERINNPNWLTYDAFEEKISPTLNTIAITRKSLPQN
HHHHHHHHHHHCCCEEEECCCCHHHHHCCCCCEEEHHHHHHHHCCCHHHHHEEHHCCCCC
KSLIGFAGGPWTVALYIIEGGWDKTFLRTKEFINKRYHEFKEIISILTDATIQYLNKQLK
CCEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGADFIQIFESFAWAASSNEFKEFIVEPTRRIVSSIDVPVIGFPKGAGVSYLQYVKETSV
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCC
DVISTDHSLPLDWIADNLQTHAVVQGNLDPYLLAFNKKEALLQTERIVDAFSEKNFIFNL
EEEECCCCCCHHHHHHCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEC
GHGIYKETPLSSVEAVLDFIRARN
CCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLLDKKISTWFMRQAGRYLPEYLKISKEMTFFQMCESPEIASEITLQPIKRFDLDAAIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHH
FSDILVLPRALGCNIDIKKSTGPVIERINNPNWLTYDAFEEKISPTLNTIAITRKSLPQN
HHHHHHHHHHHCCCEEEECCCCHHHHHCCCCCEEEHHHHHHHHCCCHHHHHEEHHCCCCC
KSLIGFAGGPWTVALYIIEGGWDKTFLRTKEFINKRYHEFKEIISILTDATIQYLNKQLK
CCEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGADFIQIFESFAWAASSNEFKEFIVEPTRRIVSSIDVPVIGFPKGAGVSYLQYVKETSV
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCC
DVISTDHSLPLDWIADNLQTHAVVQGNLDPYLLAFNKKEALLQTERIVDAFSEKNFIFNL
EEEECCCCCCHHHHHHCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEC
GHGIYKETPLSSVEAVLDFIRARN
CCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA