Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 88608149

GI number: 88608149

Start: 519074

End: 519703

Strand: Reverse

Name: mdmC [H]

Synonym: NSE_0598

Alternate gene names: 88608149

Gene position: 519703-519074 (Counterclockwise)

Preceding gene: 88608244

Following gene: 88608307

Centisome position: 60.5

GC content: 39.52

Gene sequence:

>630_bases
ATGCGTTTTGAGGATTCATGGGCTGAAGAATACATCATTTCCAAGTTACCGGTCGAATGTCAGTTGATGAAGAAAATTAG
GGAGGAAACTTTTTCTGATGAGAGGCGATTTATCCAAATTGGGCAGATAGAATCGGCGATTCTAGCATTTCTGATAAGGA
TGAATAATGTAAAGACCATCGTTGAGGTTGGAACATTAGTTGGCTACTCGGCGATTTGCATGGCAAAGGCTGTTGGGAAT
GGTGGTAAAGTATACACGATTGAAAAGAATCCTGAATATGCGCAAATTGCACTAAGAAACTTCTCCACTTTTCCACAAAT
AGAGCTTTTCACAGGTGATGCAAAGGTTAAGCTCTCGGAGCTTAGCTTCTTTGGTCCTTTTGATATGCTGTTTATTGATG
CAGAAAAGTCCGGTTATCCAACTTATCTTGAATGGGGAGAAGTCAATGTAAGGGTTGGGGGACTCATTGTTGCTGATAAC
ACACTTAGTTTTGGAAAAAATAATCCTTCCAGTAATAGTAGGGCCTGGCAATTTATGGAGCGGTTTAACACAATGATTAG
CGATTCAGATAAATATGATTCAATTATCTTGCCAACTGCTAATGGCCTTACTGTTGCAATAAAGAGGTAA

Upstream 100 bases:

>100_bases
CAGATGAAGTGATACTTCTAGGACATAAGTATCTTGACGCAGCCATGTAAGTTTTGTGTCGTGCGCTTTTCCATATTGTT
GATCTTAGTCGATACTAGCC

Downstream 100 bases:

>100_bases
TTTTATAGAGGTGGAAAAGTGGATGTGTTCATAGCCTTCGTAGCTGTGGTCTGGTCTACCGTTTTTATTCTTACCACTGC
TGACAAAAGGGGTGCCTTAT

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MRFEDSWAEEYIISKLPVECQLMKKIREETFSDERRFIQIGQIESAILAFLIRMNNVKTIVEVGTLVGYSAICMAKAVGN
GGKVYTIEKNPEYAQIALRNFSTFPQIELFTGDAKVKLSELSFFGPFDMLFIDAEKSGYPTYLEWGEVNVRVGGLIVADN
TLSFGKNNPSSNSRAWQFMERFNTMISDSDKYDSIILPTANGLTVAIKR

Sequences:

>Translated_209_residues
MRFEDSWAEEYIISKLPVECQLMKKIREETFSDERRFIQIGQIESAILAFLIRMNNVKTIVEVGTLVGYSAICMAKAVGN
GGKVYTIEKNPEYAQIALRNFSTFPQIELFTGDAKVKLSELSFFGPFDMLFIDAEKSGYPTYLEWGEVNVRVGGLIVADN
TLSFGKNNPSSNSRAWQFMERFNTMISDSDKYDSIILPTANGLTVAIKR
>Mature_209_residues
MRFEDSWAEEYIISKLPVECQLMKKIREETFSDERRFIQIGQIESAILAFLIRMNNVKTIVEVGTLVGYSAICMAKAVGN
GGKVYTIEKNPEYAQIALRNFSTFPQIELFTGDAKVKLSELSFFGPFDMLFIDAEKSGYPTYLEWGEVNVRVGGLIVADN
TLSFGKNNPSSNSRAWQFMERFNTMISDSDKYDSIILPTANGLTVAIKR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI25148771, Length=220, Percent_Identity=30.9090909090909, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565612, Length=213, Percent_Identity=28.6384976525822, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI72001127, Length=217, Percent_Identity=27.1889400921659, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23616; Mature: 23616

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFEDSWAEEYIISKLPVECQLMKKIREETFSDERRFIQIGQIESAILAFLIRMNNVKTI
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHEEEECCHHHHHHHHHHHHCCHHHH
VEVGTLVGYSAICMAKAVGNGGKVYTIEKNPEYAQIALRNFSTFPQIELFTGDAKVKLSE
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEEECCCEEEEEE
LSFFGPFDMLFIDAEKSGYPTYLEWGEVNVRVGGLIVADNTLSFGKNNPSSNSRAWQFME
EEECCCEEEEEEECCCCCCCCEEECCEEEEEEEEEEEECCEEECCCCCCCCCHHHHHHHH
RFNTMISDSDKYDSIILPTANGLTVAIKR
HHHHHHCCCCCCCEEEEECCCCEEEEEEC
>Mature Secondary Structure
MRFEDSWAEEYIISKLPVECQLMKKIREETFSDERRFIQIGQIESAILAFLIRMNNVKTI
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHEEEECCHHHHHHHHHHHHCCHHHH
VEVGTLVGYSAICMAKAVGNGGKVYTIEKNPEYAQIALRNFSTFPQIELFTGDAKVKLSE
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEEECCCEEEEEE
LSFFGPFDMLFIDAEKSGYPTYLEWGEVNVRVGGLIVADNTLSFGKNNPSSNSRAWQFME
EEECCCEEEEEEECCCCCCCCEEECCEEEEEEEEEEEECCEEECCCCCCCCCHHHHHHHH
RFNTMISDSDKYDSIILPTANGLTVAIKR
HHHHHHCCCCCCCEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]