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The map label for this gene is nuoD

Identifier: 88608146

GI number: 88608146

Start: 491751

End: 492917

Strand: Reverse

Name: nuoD

Synonym: NSE_0566

Alternate gene names: 88608146

Gene position: 492917-491751 (Counterclockwise)

Preceding gene: 88608354

Following gene: 88608881

Centisome position: 57.38

GC content: 45.07

Gene sequence:

>1167_bases
ATGACCGTAATAAAGGAGCTTAACTTCGGGCCTCAGCATCCGGCTGCGCATGGGGTGCTCCGCCTGATTATGCAGCTTGA
TGGGGAGACAGTTGAGCGCCTTGATCCGCATATTGGTTTTTTACACAGAGGAACTGAGAAGCTAATAGAGCATAAAACGT
ATCTTCAGGCTTTACCGTACTTTGATAGGCTGGATTATGTCTCACCGATGGCACAGGAGCATGCCTATTCGCTTTGCGTA
GAAAAGCTGCTCGGCATTACGGTACCTCCTAGAGCGCAGTATCTGAGGGTAATCTTTGTCGAGATCACTCGCATTTTGAA
TCACCTACTAAATGTCACTACTCACGCGCTTGACGTAGGTGCTATGAATCCCTTGTTTTGGATGTTTGAGGAGCGTGAGA
AGATGCTTTCTTTCTATGAAAAGGCTTCTGGGGCGAGATTCCATGCTGCGTATATACGTCCTGGTGGACTGGCTGCTGAT
ATACCAGATGGTCTCGACGAAGAAATAATGTCCTTCTTGGAGAGTTTCACACATAAGCTTGACGATGTGGCAGATGTTCT
TACAGACAATCCAATTTTTAAACAACGCTTAGTTGATATAGGTAAAGTAAGTAAACGGGAAGCAGTTGCACTTGGTTTCT
CTGGACCAGTTTTGCGTGCTTCGGGTGTACCTTGGGATCTACGTAAAAGTCAGCCATACGAAGTATATGAGTCGTTGGAT
TTTGCGATTCCGGTGGGAAGTTGCGGAGATTCGTACGATAGATATTTGGTGAGGATGGCTGAAATGTATGAATCAGTCAA
AATCATTAAACAATGTATAGATAAGCTTCCAGAAGGGCCGGTTGTGGTGGATGATAGGAAAGTTGCTCCGCCGAGTCGTG
CTGAAATGAAAACTTCCATGGAAGCTCTTATTCATCACTTTAAGCTTTATTCAGAGGGCTATCATGTTCCTGAGGGGGAG
ACATATTTTGCAGTAGAATCTCCAAAAGGAGAGTTTGGAGTTTATATTGTTTCCGATGGCACGAATAAGCCATATCGTTG
CAGGATCCGTGCACCTGGGTTTGTTCATCTACAAGCCCTTGATACTCTTTCACGGAAACATCTTCTTGCCGACGTACCTG
CTATTCTTGGGTCCTTGGACATTGTTTTTGGTGAGGTAGACAGATGA

Upstream 100 bases:

>100_bases
GTTCGAGCCCGGCCCGAGGAGCGTCTGGCTCTGATGGTTGCGAGCTACGGTTGGTATCCGGGTTATACGGTGCCCTTTCT
TTTTCATATTTGTATTAGGT

Downstream 100 bases:

>100_bases
TCGATTGGTACGGCCTGGTTTTTGAGAGGAGTAAGAGTTTTTATTTGGTGTCACTGGTGATTTTCATGTGTATAGTTGGG
CTAAGTGGCTTTGGTTTGTA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTVIKELNFGPQHPAAHGVLRLIMQLDGETVERLDPHIGFLHRGTEKLIEHKTYLQALPYFDRLDYVSPMAQEHAYSLCV
EKLLGITVPPRAQYLRVIFVEITRILNHLLNVTTHALDVGAMNPLFWMFEEREKMLSFYEKASGARFHAAYIRPGGLAAD
IPDGLDEEIMSFLESFTHKLDDVADVLTDNPIFKQRLVDIGKVSKREAVALGFSGPVLRASGVPWDLRKSQPYEVYESLD
FAIPVGSCGDSYDRYLVRMAEMYESVKIIKQCIDKLPEGPVVVDDRKVAPPSRAEMKTSMEALIHHFKLYSEGYHVPEGE
TYFAVESPKGEFGVYIVSDGTNKPYRCRIRAPGFVHLQALDTLSRKHLLADVPAILGSLDIVFGEVDR

Sequences:

>Translated_388_residues
MTVIKELNFGPQHPAAHGVLRLIMQLDGETVERLDPHIGFLHRGTEKLIEHKTYLQALPYFDRLDYVSPMAQEHAYSLCV
EKLLGITVPPRAQYLRVIFVEITRILNHLLNVTTHALDVGAMNPLFWMFEEREKMLSFYEKASGARFHAAYIRPGGLAAD
IPDGLDEEIMSFLESFTHKLDDVADVLTDNPIFKQRLVDIGKVSKREAVALGFSGPVLRASGVPWDLRKSQPYEVYESLD
FAIPVGSCGDSYDRYLVRMAEMYESVKIIKQCIDKLPEGPVVVDDRKVAPPSRAEMKTSMEALIHHFKLYSEGYHVPEGE
TYFAVESPKGEFGVYIVSDGTNKPYRCRIRAPGFVHLQALDTLSRKHLLADVPAILGSLDIVFGEVDR
>Mature_387_residues
TVIKELNFGPQHPAAHGVLRLIMQLDGETVERLDPHIGFLHRGTEKLIEHKTYLQALPYFDRLDYVSPMAQEHAYSLCVE
KLLGITVPPRAQYLRVIFVEITRILNHLLNVTTHALDVGAMNPLFWMFEEREKMLSFYEKASGARFHAAYIRPGGLAADI
PDGLDEEIMSFLESFTHKLDDVADVLTDNPIFKQRLVDIGKVSKREAVALGFSGPVLRASGVPWDLRKSQPYEVYESLDF
AIPVGSCGDSYDRYLVRMAEMYESVKIIKQCIDKLPEGPVVVDDRKVAPPSRAEMKTSMEALIHHFKLYSEGYHVPEGET
YFAVESPKGEFGVYIVSDGTNKPYRCRIRAPGFVHLQALDTLSRKHLLADVPAILGSLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=389, Percent_Identity=65.8097686375321, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI260898743, Length=383, Percent_Identity=65.0130548302872, Blast_Score=530, Evalue=1e-151,
Organism=Escherichia coli, GI145693162, Length=383, Percent_Identity=39.9477806788512, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1789076, Length=381, Percent_Identity=27.8215223097113, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788832, Length=380, Percent_Identity=25.5263157894737, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17555284, Length=382, Percent_Identity=59.9476439790576, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17568379, Length=382, Percent_Identity=59.4240837696335, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24638644, Length=382, Percent_Identity=65.1832460732984, Blast_Score=550, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=61.4583333333333, Blast_Score=508, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_NEOSM (Q2GDJ8)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506448.1
- HSSP:   Q56220
- ProteinModelPortal:   Q2GDJ8
- SMR:   Q2GDJ8
- STRING:   Q2GDJ8
- GeneID:   3931446
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0566
- TIGR:   NSE_0566
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   MADVITI
- PhylomeDB:   Q2GDJ8
- ProtClustDB:   PRK06075
- BioCyc:   NSEN222891:NSE_0566-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 43791; Mature: 43660

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00535 COMPLEX1_49K; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIKELNFGPQHPAAHGVLRLIMQLDGETVERLDPHIGFLHRGTEKLIEHKTYLQALPY
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCH
FDRLDYVSPMAQEHAYSLCVEKLLGITVPPRAQYLRVIFVEITRILNHLLNVTTHALDVG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AMNPLFWMFEEREKMLSFYEKASGARFHAAYIRPGGLAADIPDGLDEEIMSFLESFTHKL
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
DDVADVLTDNPIFKQRLVDIGKVSKREAVALGFSGPVLRASGVPWDLRKSQPYEVYESLD
HHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHHCCC
FAIPVGSCGDSYDRYLVRMAEMYESVKIIKQCIDKLPEGPVVVDDRKVAPPSRAEMKTSM
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHH
EALIHHFKLYSEGYHVPEGETYFAVESPKGEFGVYIVSDGTNKPYRCRIRAPGFVHLQAL
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCEEEHHHH
DTLSRKHLLADVPAILGSLDIVFGEVDR
HHHHHHHHHHHHHHHHCCHHHEECCCCC
>Mature Secondary Structure 
TVIKELNFGPQHPAAHGVLRLIMQLDGETVERLDPHIGFLHRGTEKLIEHKTYLQALPY
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCH
FDRLDYVSPMAQEHAYSLCVEKLLGITVPPRAQYLRVIFVEITRILNHLLNVTTHALDVG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AMNPLFWMFEEREKMLSFYEKASGARFHAAYIRPGGLAADIPDGLDEEIMSFLESFTHKL
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
DDVADVLTDNPIFKQRLVDIGKVSKREAVALGFSGPVLRASGVPWDLRKSQPYEVYESLD
HHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHHCCC
FAIPVGSCGDSYDRYLVRMAEMYESVKIIKQCIDKLPEGPVVVDDRKVAPPSRAEMKTSM
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHH
EALIHHFKLYSEGYHVPEGETYFAVESPKGEFGVYIVSDGTNKPYRCRIRAPGFVHLQAL
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCEEEHHHH
DTLSRKHLLADVPAILGSLDIVFGEVDR
HHHHHHHHHHHHHHHHCCHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA