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The map label for this gene is ribD

Identifier: 88608126

GI number: 88608126

Start: 419393

End: 420511

Strand: Direct

Name: ribD

Synonym: NSE_0499

Alternate gene names: 88608126

Gene position: 419393-420511 (Clockwise)

Preceding gene: 88608640

Following gene: 88608805

Centisome position: 48.82

GC content: 39.68

Gene sequence:

>1119_bases
ATGAGTTTTTCCAAAATGCACGGCCGTATTGTATATTACATGGAAGCGGCAGTAAATGCTTCGCTTTTTGGACAAGGTTT
TACCGCTGATAATCCCTCTGTTGGATGTATTATCGTAAAAGATGACGAGGTAGTTGGAAAAGGTGTAACTGGGATTAATG
GTTCCCCACATGCGGAAGCGGTTGCTCTAAAAGTTGCCGGTATCAAGGCAAGAGGCGCCGACTTGTACACCACACTCGAG
CCATGTGCACACCACGGGAGAACGGCACCTTGCACAGATTTAATTATTGAATCCGGTATAAAGAACGTCTTCATCGGAAC
TAGGGACCCAGATACTAGGGTTAATGGTAAAGGCATACAAAAGCTTCAGGAAAGCGGAATTGTAGTTACTACTGGAATTT
TAAAAAGGGAGTGCTGTGTTAGCAACATAGGGTATTTTTACCGTCAAGTTCTTGGGAAACCATTTGTTATCCTTAAGACT
GCAACTACCCTTGATGGAAAAATTGCTTGTTTTAATGGCAAGAGCGCTTGGATTACGAGTCCTGCTATGAGGAGAACAGC
GCACATGCTGAGACGTATGTCTTCATCTGTTATGATTAGCTATTCAACTCTTAAACATGATGATCCACAGCTTAGCTGTA
GGTTACCAGGTGTGAAAAAAGAGTCGATTAAAGTGGTACTTGATACTCGAGGTGAGATTTCTTCTCCTAATTTTAAAATC
TTCAATGACGGAATTGTCTGGTCATTCGGTAAAAGAAATATATTCAAACATAAAAATTTCTTTAATTTTGAAGCTAATCT
AAACGGGGAGATGTTGGATCTGGAGGACGTCTTGCAGCAACTTGGGACGATGGGTATTAATAGCGTGTTGGTAGAATGTG
GAGGCAAACTATTTTCATCGTTTATAACTGGGGATTTATTCGATCAGATTATCTGGTTTAGATCCAATAAAGTTGCCGGT
GGTGATGCACTGAGTTGTTGCAGTAATTTGAATTTCAATCATCCTTTGAAGTTTATTAAATTAAGAAAAACTAACGAAAT
AAAAATTCACGATGAATCAGTCGAGTCTTTTGCCAACGATAACTCTGAGAGATTCAATACTATTCTAGGAAGTTTGTAG

Upstream 100 bases:

>100_bases
AAACTCTTTTTCACAATTAAAGCTAACAAATAAAATACTAAAAATCGTTGTTCTGCAAAGAGATAGATGATAGTTTTGTT
GCTGTCATTCCCGTATTTAC

Downstream 100 bases:

>100_bases
TGACTGTACGGTGAAAAAATCGCTTTATCCATTATTAGTTGGAGCTTGTCTCTTTCTTAAGAGCAGGTGTGTTGTTCCCA
TTTGTGAATTCTATGAGGGT

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSFSKMHGRIVYYMEAAVNASLFGQGFTADNPSVGCIIVKDDEVVGKGVTGINGSPHAEAVALKVAGIKARGADLYTTLE
PCAHHGRTAPCTDLIIESGIKNVFIGTRDPDTRVNGKGIQKLQESGIVVTTGILKRECCVSNIGYFYRQVLGKPFVILKT
ATTLDGKIACFNGKSAWITSPAMRRTAHMLRRMSSSVMISYSTLKHDDPQLSCRLPGVKKESIKVVLDTRGEISSPNFKI
FNDGIVWSFGKRNIFKHKNFFNFEANLNGEMLDLEDVLQQLGTMGINSVLVECGGKLFSSFITGDLFDQIIWFRSNKVAG
GDALSCCSNLNFNHPLKFIKLRKTNEIKIHDESVESFANDNSERFNTILGSL

Sequences:

>Translated_372_residues
MSFSKMHGRIVYYMEAAVNASLFGQGFTADNPSVGCIIVKDDEVVGKGVTGINGSPHAEAVALKVAGIKARGADLYTTLE
PCAHHGRTAPCTDLIIESGIKNVFIGTRDPDTRVNGKGIQKLQESGIVVTTGILKRECCVSNIGYFYRQVLGKPFVILKT
ATTLDGKIACFNGKSAWITSPAMRRTAHMLRRMSSSVMISYSTLKHDDPQLSCRLPGVKKESIKVVLDTRGEISSPNFKI
FNDGIVWSFGKRNIFKHKNFFNFEANLNGEMLDLEDVLQQLGTMGINSVLVECGGKLFSSFITGDLFDQIIWFRSNKVAG
GDALSCCSNLNFNHPLKFIKLRKTNEIKIHDESVESFANDNSERFNTILGSL
>Mature_371_residues
SFSKMHGRIVYYMEAAVNASLFGQGFTADNPSVGCIIVKDDEVVGKGVTGINGSPHAEAVALKVAGIKARGADLYTTLEP
CAHHGRTAPCTDLIIESGIKNVFIGTRDPDTRVNGKGIQKLQESGIVVTTGILKRECCVSNIGYFYRQVLGKPFVILKTA
TTLDGKIACFNGKSAWITSPAMRRTAHMLRRMSSSVMISYSTLKHDDPQLSCRLPGVKKESIKVVLDTRGEISSPNFKIF
NDGIVWSFGKRNIFKHKNFFNFEANLNGEMLDLEDVLQQLGTMGINSVLVECGGKLFSSFITGDLFDQIIWFRSNKVAGG
DALSCCSNLNFNHPLKFIKLRKTNEIKIHDESVESFANDNSERFNTILGSL

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=332, Percent_Identity=36.144578313253, Blast_Score=224, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40878; Mature: 40746

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSKMHGRIVYYMEAAVNASLFGQGFTADNPSVGCIIVKDDEVVGKGVTGINGSPHAEA
CCCCHHCCEEEEEEEECCCHHHCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCEE
VALKVAGIKARGADLYTTLEPCAHHGRTAPCTDLIIESGIKNVFIGTRDPDTRVNGKGIQ
EEEEEECCEECCCCCEEEHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHH
KLQESGIVVTTGILKRECCVSNIGYFYRQVLGKPFVILKTATTLDGKIACFNGKSAWITS
HHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEEC
PAMRRTAHMLRRMSSSVMISYSTLKHDDPQLSCRLPGVKKESIKVVLDTRGEISSPNFKI
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEE
FNDGIVWSFGKRNIFKHKNFFNFEANLNGEMLDLEDVLQQLGTMGINSVLVECGGKLFSS
EECCEEEECCCCCHHCCCCEEEEEECCCCCEECHHHHHHHHHHCCHHHHHHHHHHHHHHH
FITGDLFDQIIWFRSNKVAGGDALSCCSNLNFNHPLKFIKLRKTNEIKIHDESVESFAND
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCEEEEEHHHHHHHHCC
NSERFNTILGSL
CHHHHHHHHCCC
>Mature Secondary Structure 
SFSKMHGRIVYYMEAAVNASLFGQGFTADNPSVGCIIVKDDEVVGKGVTGINGSPHAEA
CCCHHCCEEEEEEEECCCHHHCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCEE
VALKVAGIKARGADLYTTLEPCAHHGRTAPCTDLIIESGIKNVFIGTRDPDTRVNGKGIQ
EEEEEECCEECCCCCEEEHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHH
KLQESGIVVTTGILKRECCVSNIGYFYRQVLGKPFVILKTATTLDGKIACFNGKSAWITS
HHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEEC
PAMRRTAHMLRRMSSSVMISYSTLKHDDPQLSCRLPGVKKESIKVVLDTRGEISSPNFKI
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEE
FNDGIVWSFGKRNIFKHKNFFNFEANLNGEMLDLEDVLQQLGTMGINSVLVECGGKLFSS
EECCEEEECCCCCHHCCCCEEEEEECCCCCEECHHHHHHHHHHCCHHHHHHHHHHHHHHH
FITGDLFDQIIWFRSNKVAGGDALSCCSNLNFNHPLKFIKLRKTNEIKIHDESVESFAND
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCEEEEEHHHHHHHHCC
NSERFNTILGSL
CHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 2112225; 9068650 [H]