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The map label for this gene is dxr

Identifier: 88608079

GI number: 88608079

Start: 360156

End: 361325

Strand: Direct

Name: dxr

Synonym: NSE_0443

Alternate gene names: 88608079

Gene position: 360156-361325 (Clockwise)

Preceding gene: 88608099

Following gene: 88608593

Centisome position: 41.93

GC content: 40.94

Gene sequence:

>1170_bases
ATGAAAAAAATTTCTATTTTAGGTTCAACTGGTTCGGTTGGCTGTCAGTCTGTTGATGTAGTTTCCCGTTTCTATAGCGG
TACAATTAAGGTTGACGCGCTGAGCTGTAACAGTAACCACGCATTGTTAATACAGCAGGCACGTTTATTGTCTCCACAAA
AGGTTTTTGTTGCTGATGAATCTTCTTATAAGGAAGTCAAAACAGCATTAGGTTCTCAAAATATAGAAGTCATACTTGAT
CGAGGGGTCGAAATAGGTGCTGCACTCTGCGATAACGACATGCTTGTTGTAGGCATTTCTGGAATTGCCGCTTTAAACCC
AATATACAGCGCTATAAGTCAGGGGATTAAAGTTGCAACCTCCAACAAGGAAAGCCTTGTATGTGGAGGTAGTTTACTCT
TACCTTTTGTTGACAAGATAATCCCTTTGGACTCCGAGCATCATGCTGTAGCTAAATTACTGCGTTCCAAACCCATTATG
TCTGTTTCGGGAATTACTTTGACTGCTAGTGGGGGACCATTTTTTCGAAAAGAGAAGCGAAATGTTACGGTTGCTTGTGC
TCTTGCTCATCCAATCTGGAAGATGGGTAAGAAAAACTCGGTGGATTCTGCCACTATGATGAATAAAGTTTTGGAGGTCG
TAGAGGCGCACTACCTCTTTCGGATACCAAAAGAGAAAATTTCTGTTCTGATACATCCAGAGGCTCTAATACATGGGATG
GTCGATTTTTTGGATGGTTCCCAGCATGCTTTTATATCCTTACCAGATATGAGAATTGGTATAAATAACGCACTTGCAGG
GTTGGTTGGTGGTGGTTATGAGAGCACTTATACCTATGGTAGAGTTCCCTTAGCAACGAGAAAACTTACATTCTATGCTG
CAAAGGAGGAAGAATTTCGAGTGCTAAAATTTCTTGGAACCGATCAAGAAATTGTGCTGAGCGCAGTAAATGATCTTGCA
GTAGAGGATTTTCTTGCTGGGAAACTAGATTTTCATAGCATACCGGACTTCATTTCTTCCGGGTTGGATAAATTTCAATA
CAACAAAGCTGATGTAAAAAATATTGGGGACGTCTTTTCCATTTATGATAAAGCTCAGCGTGTATGTAGGAGTGATAACA
GTGGCTCATTTGTCACGAAGGGGTATCACCCATTGGTATCAGGTGTGTAA

Upstream 100 bases:

>100_bases
ATAAGAGCGTGTTTGATTTATTCAAGGAATTGGGAATCAGATATATGCAAGGTAACTATCTACATGGAGCCAGTCCAGAG
TTAAAAGATACGGTTAATGC

Downstream 100 bases:

>100_bases
ACTTGTCCTATAGGTGTTTGTGCCCGTTAATTTTCTGAAGTGCGTTTCTGTATAGCAAAAACGGACCCTCTCGCATAAGA
GCTACTGAGAAGGCAAGATC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKKISILGSTGSVGCQSVDVVSRFYSGTIKVDALSCNSNHALLIQQARLLSPQKVFVADESSYKEVKTALGSQNIEVILD
RGVEIGAALCDNDMLVVGISGIAALNPIYSAISQGIKVATSNKESLVCGGSLLLPFVDKIIPLDSEHHAVAKLLRSKPIM
SVSGITLTASGGPFFRKEKRNVTVACALAHPIWKMGKKNSVDSATMMNKVLEVVEAHYLFRIPKEKISVLIHPEALIHGM
VDFLDGSQHAFISLPDMRIGINNALAGLVGGGYESTYTYGRVPLATRKLTFYAAKEEEFRVLKFLGTDQEIVLSAVNDLA
VEDFLAGKLDFHSIPDFISSGLDKFQYNKADVKNIGDVFSIYDKAQRVCRSDNSGSFVTKGYHPLVSGV

Sequences:

>Translated_389_residues
MKKISILGSTGSVGCQSVDVVSRFYSGTIKVDALSCNSNHALLIQQARLLSPQKVFVADESSYKEVKTALGSQNIEVILD
RGVEIGAALCDNDMLVVGISGIAALNPIYSAISQGIKVATSNKESLVCGGSLLLPFVDKIIPLDSEHHAVAKLLRSKPIM
SVSGITLTASGGPFFRKEKRNVTVACALAHPIWKMGKKNSVDSATMMNKVLEVVEAHYLFRIPKEKISVLIHPEALIHGM
VDFLDGSQHAFISLPDMRIGINNALAGLVGGGYESTYTYGRVPLATRKLTFYAAKEEEFRVLKFLGTDQEIVLSAVNDLA
VEDFLAGKLDFHSIPDFISSGLDKFQYNKADVKNIGDVFSIYDKAQRVCRSDNSGSFVTKGYHPLVSGV
>Mature_389_residues
MKKISILGSTGSVGCQSVDVVSRFYSGTIKVDALSCNSNHALLIQQARLLSPQKVFVADESSYKEVKTALGSQNIEVILD
RGVEIGAALCDNDMLVVGISGIAALNPIYSAISQGIKVATSNKESLVCGGSLLLPFVDKIIPLDSEHHAVAKLLRSKPIM
SVSGITLTASGGPFFRKEKRNVTVACALAHPIWKMGKKNSVDSATMMNKVLEVVEAHYLFRIPKEKISVLIHPEALIHGM
VDFLDGSQHAFISLPDMRIGINNALAGLVGGGYESTYTYGRVPLATRKLTFYAAKEEEFRVLKFLGTDQEIVLSAVNDLA
VEDFLAGKLDFHSIPDFISSGLDKFQYNKADVKNIGDVFSIYDKAQRVCRSDNSGSFVTKGYHPLVSGV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=402, Percent_Identity=35.5721393034826, Blast_Score=189, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42089; Mature: 42089

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISILGSTGSVGCQSVDVVSRFYSGTIKVDALSCNSNHALLIQQARLLSPQKVFVADE
CCEEEEECCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCEEEEEHHHHCCCCEEEEECC
SSYKEVKTALGSQNIEVILDRGVEIGAALCDNDMLVVGISGIAALNPIYSAISQGIKVAT
CHHHHHHHHHCCCCEEEEEECCCEECCEECCCCEEEEEECCHHHHHHHHHHHHCCEEEEE
SNKESLVCGGSLLLPFVDKIIPLDSEHHAVAKLLRSKPIMSVSGITLTASGGPFFRKEKR
CCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCEEECCEEEEECCCCCCHHCCC
NVTVACALAHPIWKMGKKNSVDSATMMNKVLEVVEAHYLFRIPKEKISVLIHPEALIHGM
CEEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHEEEEECHHHHHHHH
VDFLDGSQHAFISLPDMRIGINNALAGLVGGGYESTYTYGRVPLATRKLTFYAAKEEEFR
HHHHCCCCEEEEECCCEEECHHHHHHHHHCCCCCCCEEECCCCEEEEEEEEEECCCCCEE
VLKFLGTDQEIVLSAVNDLAVEDFLAGKLDFHSIPDFISSGLDKFQYNKADVKNIGDVFS
EEEHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHCCCCHHHHHHHHHHH
IYDKAQRVCRSDNSGSFVTKGYHPLVSGV
HHHHHHHHHCCCCCCCEEECCCCHHHCCC
>Mature Secondary Structure
MKKISILGSTGSVGCQSVDVVSRFYSGTIKVDALSCNSNHALLIQQARLLSPQKVFVADE
CCEEEEECCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCEEEEEHHHHCCCCEEEEECC
SSYKEVKTALGSQNIEVILDRGVEIGAALCDNDMLVVGISGIAALNPIYSAISQGIKVAT
CHHHHHHHHHCCCCEEEEEECCCEECCEECCCCEEEEEECCHHHHHHHHHHHHCCEEEEE
SNKESLVCGGSLLLPFVDKIIPLDSEHHAVAKLLRSKPIMSVSGITLTASGGPFFRKEKR
CCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCEEECCEEEEECCCCCCHHCCC
NVTVACALAHPIWKMGKKNSVDSATMMNKVLEVVEAHYLFRIPKEKISVLIHPEALIHGM
CEEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHEEEEECHHHHHHHH
VDFLDGSQHAFISLPDMRIGINNALAGLVGGGYESTYTYGRVPLATRKLTFYAAKEEEFR
HHHHCCCCEEEEECCCEEECHHHHHHHHHCCCCCCCEEECCCCEEEEEEEEEECCCCCEE
VLKFLGTDQEIVLSAVNDLAVEDFLAGKLDFHSIPDFISSGLDKFQYNKADVKNIGDVFS
EEEHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHCCCCHHHHHHHHHHH
IYDKAQRVCRSDNSGSFVTKGYHPLVSGV
HHHHHHHHHCCCCCCCEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA