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The map label for this gene is lon

Identifier: 88608076

GI number: 88608076

Start: 284981

End: 287461

Strand: Reverse

Name: lon

Synonym: NSE_0347

Alternate gene names: 88608076

Gene position: 287461-284981 (Counterclockwise)

Preceding gene: 88608414

Following gene: 88608645

Centisome position: 33.46

GC content: 42.36

Gene sequence:

>2481_bases
ATGTCAGAAGAAGAGCTGAATAATCGTGACACAGAGTCAAAGCAAGAACATGATGAAAACAATTCTAACTTTGAAGCAGG
GTCAGCACACATGAATTTACCGGTTCTACCTCTTAGGGAGGTTATCTTTTTTCCCGGTGATTACCTTCCAATATTTATAG
GAAGGAAAGGATCTATACAGGCAATGGATAAGGCACTGGCGGAAACATCTGAAAATACTGGAAGGATGCTCTTGATTGCA
CAGAAGAACCCAAAAAAGGAAATTCCAGAAGGTAAGGATTTGTACGAGGTGGGTGTCATAGCAAAAATTGCTGAACCAAA
GATCAATCTCCAAGATGGCGGTGTCAAGCTCATGGTAATTGTTGAGTGTCGTGCACGCGCTGTGAATTTCAGAAAAAGCG
AGGGAGTACTTGAAGCCGACGTCCTTCCAATAGAGGAGGAGGAAAGCGACAACGTGGACATAGAGGCATATCGAAGGGCA
GTCGTTCAGAATTTCGAAAAGTGCGTTAAGTTGAGCGAGACAATTCCAGATGAAATCATTGGACTCCTCTCTCAAATAGA
TTCCACTAGCAGAATAGCGGACTTGGTAACTGCAAGTATAAACCTGAAGCTTAGTGTAAAACAAGAAATACTCGAAACTG
TAGACCTCTTAGAAAGGATAAAAAAAGTCCATGCCCTCCTGGAGAAAGAGCTTGGAGTATTGCAGGTAAAACAGCAGATT
AAGGAAAAGACAGAGAGTCAAATTAAGAAATCGCATAAGGTATACCTACTTAATGAACAACTGAAAGCAATTACCAAGGA
ACTATACGACAAAGAAGGTGAAGAATATGATGAACTTGTCGATCTAGAGAAAAAAATAGGAAATGGTAAGCTCTCTGCAG
AAGCAAAAGAAAAAGTTTCGAAAGAACTAAAAAAGCTCAAGAACATGGTGCCCATGTCTGCTGAAGCAACTGTGGTTCGT
AATTACGTAGACTGGATCATTTCCCTTCCTTGGAAAAAGAAGGGTAAGATGATTACGGATATTGCAGCATCAGAACGAAT
TCTAAAAGCGAGCCATTACGGCATAGAAAAGGTCAAAGAGCGCATTATTGAATACTTGGCTGTGCAAAACCGTACGAAAT
CGTTTAAGGGCTCCATACTGTGTTTACTTGGTCCTCCAGGCGTTGGAAAGACCTCGCTTGCTAGCGCGATAGCGGAAGCT
ACTGGCAGACCGTTTGTTAGGATGTCACTCGGCGGAATAAAGGATGAATCTGAAATTAAAGGTCATAGAAGGACTTACAT
AGGTGCAATGCCAGGAAAGATAATCCAGCATATGAAAAAGGCAAAATTATCTAATCCTGTCTTCCTTCTTGATGAAATAG
ATAAAATGTCTTCGGATTTCAGAAGCGATCCTGCTTTTGCACTTCTAGAAGTGCTAGATCCAGAACAGAACGCACACTTT
GTAGATCACTACTTGGAAGTTGAATACGATTTGAGTGATGTCATGTTCGTTGCAACTGCAAACAGCTTAAATATGATTCC
CGCATTGTTAGATCGCTTGGAAATAATACGTCTGGAGGCCTATTCAGAAGAAGAAAAATTACAGATCGCGGAGCACTATC
TCATCGGGAAACTGCAAAGGGAACACGGTTTGAAAAAAAGCGAGTGGAGCATTTCCAAGGAAGCACTGAAATTACTCATA
CGTCGTTATACTCGTGAAAGCGGAGTACGAAATTTGAAGAGAGAGCTTGCAAACCTGATGAGGAAAGCTGTCAAGAAGTT
AGGTGTGCAATCTGGTCTTAAATCTATAGAGGTTTCAGTTAAAAATCTGAAGAAGTATGCCGGCGTAGAAAAATATACTT
TCGGTACTGCAGAACCGGAAAATTTAGTAGGTATGACTACGGGTCTTGCTTACACACAAACCGGAGGGGATTTAATCATG
ATAGAGGCAGTCTTACTCCCAGGAAAAGGCGAGATTCGTTCTACGGGAAAGCTTGGAGAAGTAATGCAAGAATCTGTCCA
AGCGGCTTATAGCTTCGTCTGCTCAAATTGTAACAAGTTTGGTTTCACATCGAAGTTCTTTAAAAGCAAGGATGTGCACC
TTCATGTACCCGAGGGTGCAACTTCAAAGGATGGTCCGTCTGCAGGGGTTGCGATATGCACTTCTATCGTCTCGGTGATG
ACTGGAATTCCAGTACGCTCAAACGTTGCAATGACTGGAGAAGTGAGTCTCAGAGGAAAAGTAATGGAAATTGGTGGTCT
GAAGGAAAAACTTCTAGCGGCTGTGCGTGGTGGTATAAAAATTGTCCTGATACCAGCAAGCAATGAAAAGGATTTGGAAA
ACATTCCAAAATCGGTGAAAAACGCTGTGAGGATCATTCCTGTCTCCACCGTATCAGAGGCACTAACGTTCACTCTTGCC
GAGCAACCAACGCCACTTGCGGTTGACGTCTGGCCAGATATCCCGTTGTCTTCGACACAACAGTCAGAACAAAGGGTATA
A

Upstream 100 bases:

>100_bases
AAAAAGTTGGTATTGCGGGAATTAATTTGTATAATGACCGTCTGTGAGCTTGAATACAAAATTCTAGCACCCATATATCA
CGTAAGGAAATGCATTTTTT

Downstream 100 bases:

>100_bases
CCTCCAGATCAGGTTTCTTTTGTGCTAGTTAAGTTCTCCGAAACTAGTCCTTGCTTGTTTTGAACGGTTGTTTCTGCACC
AATTATGTATTAACAAGCAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 826; Mature: 825

Protein sequence:

>826_residues
MSEEELNNRDTESKQEHDENNSNFEAGSAHMNLPVLPLREVIFFPGDYLPIFIGRKGSIQAMDKALAETSENTGRMLLIA
QKNPKKEIPEGKDLYEVGVIAKIAEPKINLQDGGVKLMVIVECRARAVNFRKSEGVLEADVLPIEEEESDNVDIEAYRRA
VVQNFEKCVKLSETIPDEIIGLLSQIDSTSRIADLVTASINLKLSVKQEILETVDLLERIKKVHALLEKELGVLQVKQQI
KEKTESQIKKSHKVYLLNEQLKAITKELYDKEGEEYDELVDLEKKIGNGKLSAEAKEKVSKELKKLKNMVPMSAEATVVR
NYVDWIISLPWKKKGKMITDIAASERILKASHYGIEKVKERIIEYLAVQNRTKSFKGSILCLLGPPGVGKTSLASAIAEA
TGRPFVRMSLGGIKDESEIKGHRRTYIGAMPGKIIQHMKKAKLSNPVFLLDEIDKMSSDFRSDPAFALLEVLDPEQNAHF
VDHYLEVEYDLSDVMFVATANSLNMIPALLDRLEIIRLEAYSEEEKLQIAEHYLIGKLQREHGLKKSEWSISKEALKLLI
RRYTRESGVRNLKRELANLMRKAVKKLGVQSGLKSIEVSVKNLKKYAGVEKYTFGTAEPENLVGMTTGLAYTQTGGDLIM
IEAVLLPGKGEIRSTGKLGEVMQESVQAAYSFVCSNCNKFGFTSKFFKSKDVHLHVPEGATSKDGPSAGVAICTSIVSVM
TGIPVRSNVAMTGEVSLRGKVMEIGGLKEKLLAAVRGGIKIVLIPASNEKDLENIPKSVKNAVRIIPVSTVSEALTFTLA
EQPTPLAVDVWPDIPLSSTQQSEQRV

Sequences:

>Translated_826_residues
MSEEELNNRDTESKQEHDENNSNFEAGSAHMNLPVLPLREVIFFPGDYLPIFIGRKGSIQAMDKALAETSENTGRMLLIA
QKNPKKEIPEGKDLYEVGVIAKIAEPKINLQDGGVKLMVIVECRARAVNFRKSEGVLEADVLPIEEEESDNVDIEAYRRA
VVQNFEKCVKLSETIPDEIIGLLSQIDSTSRIADLVTASINLKLSVKQEILETVDLLERIKKVHALLEKELGVLQVKQQI
KEKTESQIKKSHKVYLLNEQLKAITKELYDKEGEEYDELVDLEKKIGNGKLSAEAKEKVSKELKKLKNMVPMSAEATVVR
NYVDWIISLPWKKKGKMITDIAASERILKASHYGIEKVKERIIEYLAVQNRTKSFKGSILCLLGPPGVGKTSLASAIAEA
TGRPFVRMSLGGIKDESEIKGHRRTYIGAMPGKIIQHMKKAKLSNPVFLLDEIDKMSSDFRSDPAFALLEVLDPEQNAHF
VDHYLEVEYDLSDVMFVATANSLNMIPALLDRLEIIRLEAYSEEEKLQIAEHYLIGKLQREHGLKKSEWSISKEALKLLI
RRYTRESGVRNLKRELANLMRKAVKKLGVQSGLKSIEVSVKNLKKYAGVEKYTFGTAEPENLVGMTTGLAYTQTGGDLIM
IEAVLLPGKGEIRSTGKLGEVMQESVQAAYSFVCSNCNKFGFTSKFFKSKDVHLHVPEGATSKDGPSAGVAICTSIVSVM
TGIPVRSNVAMTGEVSLRGKVMEIGGLKEKLLAAVRGGIKIVLIPASNEKDLENIPKSVKNAVRIIPVSTVSEALTFTLA
EQPTPLAVDVWPDIPLSSTQQSEQRV
>Mature_825_residues
SEEELNNRDTESKQEHDENNSNFEAGSAHMNLPVLPLREVIFFPGDYLPIFIGRKGSIQAMDKALAETSENTGRMLLIAQ
KNPKKEIPEGKDLYEVGVIAKIAEPKINLQDGGVKLMVIVECRARAVNFRKSEGVLEADVLPIEEEESDNVDIEAYRRAV
VQNFEKCVKLSETIPDEIIGLLSQIDSTSRIADLVTASINLKLSVKQEILETVDLLERIKKVHALLEKELGVLQVKQQIK
EKTESQIKKSHKVYLLNEQLKAITKELYDKEGEEYDELVDLEKKIGNGKLSAEAKEKVSKELKKLKNMVPMSAEATVVRN
YVDWIISLPWKKKGKMITDIAASERILKASHYGIEKVKERIIEYLAVQNRTKSFKGSILCLLGPPGVGKTSLASAIAEAT
GRPFVRMSLGGIKDESEIKGHRRTYIGAMPGKIIQHMKKAKLSNPVFLLDEIDKMSSDFRSDPAFALLEVLDPEQNAHFV
DHYLEVEYDLSDVMFVATANSLNMIPALLDRLEIIRLEAYSEEEKLQIAEHYLIGKLQREHGLKKSEWSISKEALKLLIR
RYTRESGVRNLKRELANLMRKAVKKLGVQSGLKSIEVSVKNLKKYAGVEKYTFGTAEPENLVGMTTGLAYTQTGGDLIMI
EAVLLPGKGEIRSTGKLGEVMQESVQAAYSFVCSNCNKFGFTSKFFKSKDVHLHVPEGATSKDGPSAGVAICTSIVSVMT
GIPVRSNVAMTGEVSLRGKVMEIGGLKEKLLAAVRGGIKIVLIPASNEKDLENIPKSVKNAVRIIPVSTVSEALTFTLAE
QPTPLAVDVWPDIPLSSTQQSEQRV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=698, Percent_Identity=39.2550143266476, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI31377667, Length=672, Percent_Identity=38.9880952380952, Blast_Score=469, Evalue=1e-132,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=50.5761843790013, Blast_Score=780, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=691, Percent_Identity=39.0738060781476, Blast_Score=461, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17556486, Length=818, Percent_Identity=33.7408312958435, Blast_Score=413, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319449, Length=756, Percent_Identity=36.7724867724868, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI221513036, Length=627, Percent_Identity=41.7862838915471, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24666867, Length=627, Percent_Identity=41.7862838915471, Blast_Score=470, Evalue=1e-132,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_NEOSM (Q2GE60)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506236.1
- ProteinModelPortal:   Q2GE60
- STRING:   Q2GE60
- MEROPS:   S16.001
- GeneID:   3931624
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0347
- TIGR:   NSE_0347
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   HTFQDHY
- PhylomeDB:   Q2GE60
- ProtClustDB:   CLSK2527693
- BioCyc:   NSEN222891:NSE_0347-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 91693; Mature: 91562

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 707-707 ACT_SITE 750-750

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEELNNRDTESKQEHDENNSNFEAGSAHMNLPVLPLREVIFFPGDYLPIFIGRKGSIQ
CCCHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCHH
AMDKALAETSENTGRMLLIAQKNPKKEIPEGKDLYEVGVIAKIAEPKINLQDGGVKLMVI
HHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHEECCCCEEECCCCEEEEEE
VECRARAVNFRKSEGVLEADVLPIEEEESDNVDIEAYRRAVVQNFEKCVKLSETIPDEII
EEEHHHHHCCHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
GLLSQIDSTSRIADLVTASINLKLSVKQEILETVDLLERIKKVHALLEKELGVLQVKQQI
HHHHHCCCHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKTESQIKKSHKVYLLNEQLKAITKELYDKEGEEYDELVDLEKKIGNGKLSAEAKEKVS
HHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
KELKKLKNMVPMSAEATVVRNYVDWIISLPWKKKGKMITDIAASERILKASHYGIEKVKE
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHCCHHHHHH
RIIEYLAVQNRTKSFKGSILCLLGPPGVGKTSLASAIAEATGRPFVRMSLGGIKDESEIK
HHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHC
GHRRTYIGAMPGKIIQHMKKAKLSNPVFLLDEIDKMSSDFRSDPAFALLEVLDPEQNAHF
CCHHHEECCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHH
VDHYLEVEYDLSDVMFVATANSLNMIPALLDRLEIIRLEAYSEEEKLQIAEHYLIGKLQR
HHHHEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EHGLKKSEWSISKEALKLLIRRYTRESGVRNLKRELANLMRKAVKKLGVQSGLKSIEVSV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
KNLKKYAGVEKYTFGTAEPENLVGMTTGLAYTQTGGDLIMIEAVLLPGKGEIRSTGKLGE
HHHHHHCCCCEEECCCCCCCHHEEEECCCEEEECCCCEEEEEEEEECCCCCCCCCCHHHH
VMQESVQAAYSFVCSNCNKFGFTSKFFKSKDVHLHVPEGATSKDGPSAGVAICTSIVSVM
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
TGIPVRSNVAMTGEVSLRGKVMEIGGLKEKLLAAVRGGIKIVLIPASNEKDLENIPKSVK
HCCCCCCCEEEEEEEEECCEEEECCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHH
NAVRIIPVSTVSEALTFTLAEQPTPLAVDVWPDIPLSSTQQSEQRV
HHEEEEEHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SEEELNNRDTESKQEHDENNSNFEAGSAHMNLPVLPLREVIFFPGDYLPIFIGRKGSIQ
CCHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCHH
AMDKALAETSENTGRMLLIAQKNPKKEIPEGKDLYEVGVIAKIAEPKINLQDGGVKLMVI
HHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHEECCCCEEECCCCEEEEEE
VECRARAVNFRKSEGVLEADVLPIEEEESDNVDIEAYRRAVVQNFEKCVKLSETIPDEII
EEEHHHHHCCHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
GLLSQIDSTSRIADLVTASINLKLSVKQEILETVDLLERIKKVHALLEKELGVLQVKQQI
HHHHHCCCHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKTESQIKKSHKVYLLNEQLKAITKELYDKEGEEYDELVDLEKKIGNGKLSAEAKEKVS
HHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
KELKKLKNMVPMSAEATVVRNYVDWIISLPWKKKGKMITDIAASERILKASHYGIEKVKE
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHCCHHHHHH
RIIEYLAVQNRTKSFKGSILCLLGPPGVGKTSLASAIAEATGRPFVRMSLGGIKDESEIK
HHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHC
GHRRTYIGAMPGKIIQHMKKAKLSNPVFLLDEIDKMSSDFRSDPAFALLEVLDPEQNAHF
CCHHHEECCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHH
VDHYLEVEYDLSDVMFVATANSLNMIPALLDRLEIIRLEAYSEEEKLQIAEHYLIGKLQR
HHHHEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EHGLKKSEWSISKEALKLLIRRYTRESGVRNLKRELANLMRKAVKKLGVQSGLKSIEVSV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
KNLKKYAGVEKYTFGTAEPENLVGMTTGLAYTQTGGDLIMIEAVLLPGKGEIRSTGKLGE
HHHHHHCCCCEEECCCCCCCHHEEEECCCEEEECCCCEEEEEEEEECCCCCCCCCCHHHH
VMQESVQAAYSFVCSNCNKFGFTSKFFKSKDVHLHVPEGATSKDGPSAGVAICTSIVSVM
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
TGIPVRSNVAMTGEVSLRGKVMEIGGLKEKLLAAVRGGIKIVLIPASNEKDLENIPKSVK
HCCCCCCCEEEEEEEEECCEEEECCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHH
NAVRIIPVSTVSEALTFTLAEQPTPLAVDVWPDIPLSSTQQSEQRV
HHEEEEEHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA