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The map label for this gene is atpA

Identifier: 88608054

GI number: 88608054

Start: 107976

End: 109505

Strand: Reverse

Name: atpA

Synonym: NSE_0131

Alternate gene names: 88608054

Gene position: 109505-107976 (Counterclockwise)

Preceding gene: 88608208

Following gene: 88608134

Centisome position: 12.75

GC content: 43.07

Gene sequence:

>1530_bases
ATGAGTTTAGACGTTAATGCATCCGAAGTTTTAAGGATAATAAAGGAAAAAATCAAAGATTTTGATCAGCAGATTTTTTC
CGAAGAAATAGGCGAGGTAATCTCGGTCAAGGACGGTGTTGTAATAGCTTGCGGTCTCGAAAATGCGGAGTTTAACGAAA
AGGTTGTTTTTCCGAATGGCGAAATTGGGCTCATACAAAGCATAGAATATGATCACGTAGGGATAGTTATCTTAACTAAT
ACACAAGACATAAAGGAAGGTGACACCGTTAGGCGTACGAAGGAGGCTTTGCGCATCCCGGTAGGAAAAAAGTTACTTGG
TAGAGTTATCGATCCTTTAGGTAATCCACTGGACGGTGCTGGGCAAATCTTCGCGGATGCATATTCTCCAATCGAGGTAA
AAGCACCAGGGATTTTAGACCGTCAGTCCGTAAAAGAGCCTCTTCAAACGGGAATAAAGGTGATTGATTTACTTATTCCT
ATTGGTCGCGGGCAGAGGGAGCTTATCATTGGAGACAGGCAAACAGGAAAGACAACTATTGCCTTAGATAGCATAATCAA
TCAGAGAGATATAAATAAGAATCTCCCTGATGAAAAAAAACTATACTGCGTTTACGTTGCAATTGGTCAAAAATGTTCAA
CAGTCGCAAGAATCATGAAGACTTTGCAGGAACAAGGTGCCATGGACTACACTACCATTGTGTTGGCGGGCGCATCTGAT
TCTGCACAATCGCAGTTCCTGGCTCCGTACGCGGGTTGTTCTATAGGGGAATACTTCCGTGACAACGGTATGCATTGTCT
CATTGTGTACGACGACCTTTCTAAACACGCCGTTGCATACAGGCAAATGTCTTTGCTTTTAAGGCGTCCACCCGGTCGCG
AAGCCTATCCTGGTGATGTATTTTACATTCACTCAAGATTACTTGAGCGTGCTGCAAAAATGTCTGATAAACATGGTGCA
GGCTCGCTTACAGCTCTCCCAATCATAGAAACACAGGCTGGGGATGTGTCTGCTTACATTCCAACTAACGTAATCTCCAT
TACTGACGGACAGATTTTTCTCGAAACCGAGTTATTCAATAAAGGCGTGAAGCCGGCTGTAAATGTCGGTCTGTCTGTAT
CTCGTGTTGGTTCGGCTGCACAGATCAAGGCGATAAAACAGGTTGCCAGATCCATCAAATTGGAACTAGCTCAGTATAGA
GAAATGGAAGCCTTTGCACAATTTGGCGCAGACCTCGATGAAACAACGCAAGCGTTGTTAGAAAAAGGCAAAAAGCTTAC
TGAGCTCTTAAAACAAAATCAGCATGAAACCTTGCCGGTAGAAGAACAAGTTGTTCTTATGTTCGCTGCAAATGAGGGTT
ACTTTGATAATATCGACGTAACAGGAATAAGTACTGCCGCGAAGAACCTGTTAGGGTCTTTTCGTTTATATCACCGGGAT
TTATTGGAAGACATTAAAGAAAAAAGTATAATTGGAGACTTAGCTTCGCTCTCGAGTGCGCTGCAGGGCTGCAAAACTAC
CAATGCTTAG

Upstream 100 bases:

>100_bases
AATTCAATAATGATAGACCTTTCCATCGCTGGAAGGTTAGCAAAATGTAAAAGTATAGGACAAAGTACAATTCTCGAGAT
ATTTCAATAAGAAGGAAAAA

Downstream 100 bases:

>100_bases
TCAAGCTAAACTTGGAGAGCTTTGTCTTTCCGATGTGTGCTCTTGATTTATAGATGTATTTGATTCTCTCTTTTCGGATG
AGGCATGTGTCTTCAGCGGT

Product: ATP synthase F1 subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSLDVNASEVLRIIKEKIKDFDQQIFSEEIGEVISVKDGVVIACGLENAEFNEKVVFPNGEIGLIQSIEYDHVGIVILTN
TQDIKEGDTVRRTKEALRIPVGKKLLGRVIDPLGNPLDGAGQIFADAYSPIEVKAPGILDRQSVKEPLQTGIKVIDLLIP
IGRGQRELIIGDRQTGKTTIALDSIINQRDINKNLPDEKKLYCVYVAIGQKCSTVARIMKTLQEQGAMDYTTIVLAGASD
SAQSQFLAPYAGCSIGEYFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKMSDKHGA
GSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETELFNKGVKPAVNVGLSVSRVGSAAQIKAIKQVARSIKLELAQYR
EMEAFAQFGADLDETTQALLEKGKKLTELLKQNQHETLPVEEQVVLMFAANEGYFDNIDVTGISTAAKNLLGSFRLYHRD
LLEDIKEKSIIGDLASLSSALQGCKTTNA

Sequences:

>Translated_509_residues
MSLDVNASEVLRIIKEKIKDFDQQIFSEEIGEVISVKDGVVIACGLENAEFNEKVVFPNGEIGLIQSIEYDHVGIVILTN
TQDIKEGDTVRRTKEALRIPVGKKLLGRVIDPLGNPLDGAGQIFADAYSPIEVKAPGILDRQSVKEPLQTGIKVIDLLIP
IGRGQRELIIGDRQTGKTTIALDSIINQRDINKNLPDEKKLYCVYVAIGQKCSTVARIMKTLQEQGAMDYTTIVLAGASD
SAQSQFLAPYAGCSIGEYFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKMSDKHGA
GSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETELFNKGVKPAVNVGLSVSRVGSAAQIKAIKQVARSIKLELAQYR
EMEAFAQFGADLDETTQALLEKGKKLTELLKQNQHETLPVEEQVVLMFAANEGYFDNIDVTGISTAAKNLLGSFRLYHRD
LLEDIKEKSIIGDLASLSSALQGCKTTNA
>Mature_508_residues
SLDVNASEVLRIIKEKIKDFDQQIFSEEIGEVISVKDGVVIACGLENAEFNEKVVFPNGEIGLIQSIEYDHVGIVILTNT
QDIKEGDTVRRTKEALRIPVGKKLLGRVIDPLGNPLDGAGQIFADAYSPIEVKAPGILDRQSVKEPLQTGIKVIDLLIPI
GRGQRELIIGDRQTGKTTIALDSIINQRDINKNLPDEKKLYCVYVAIGQKCSTVARIMKTLQEQGAMDYTTIVLAGASDS
AQSQFLAPYAGCSIGEYFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKMSDKHGAG
SLTALPIIETQAGDVSAYIPTNVISITDGQIFLETELFNKGVKPAVNVGLSVSRVGSAAQIKAIKQVARSIKLELAQYRE
MEAFAQFGADLDETTQALLEKGKKLTELLKQNQHETLPVEEQVVLMFAANEGYFDNIDVTGISTAAKNLLGSFRLYHRDL
LEDIKEKSIIGDLASLSSALQGCKTTNA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=479, Percent_Identity=60.9603340292276, Blast_Score=595, Evalue=1e-170,
Organism=Homo sapiens, GI4757810, Length=479, Percent_Identity=60.9603340292276, Blast_Score=595, Evalue=1e-170,
Organism=Homo sapiens, GI19913428, Length=295, Percent_Identity=29.8305084745763, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI19913426, Length=299, Percent_Identity=28.4280936454849, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI32189394, Length=377, Percent_Identity=24.9336870026525, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI19913424, Length=325, Percent_Identity=24.3076923076923, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1790172, Length=496, Percent_Identity=51.4112903225806, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1790170, Length=363, Percent_Identity=24.5179063360882, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1788251, Length=312, Percent_Identity=27.2435897435897, Blast_Score=105, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=486, Percent_Identity=61.7283950617284, Blast_Score=610, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI71988080, Length=486, Percent_Identity=61.7283950617284, Blast_Score=608, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI71988074, Length=486, Percent_Identity=58.2304526748971, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17510931, Length=359, Percent_Identity=28.4122562674095, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17570191, Length=358, Percent_Identity=27.3743016759777, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144756, Length=396, Percent_Identity=24.2424242424242, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=66, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565854, Length=264, Percent_Identity=24.6212121212121, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=508, Percent_Identity=58.2677165354331, Blast_Score=591, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319603, Length=360, Percent_Identity=30, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322581, Length=422, Percent_Identity=25.1184834123223, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24658560, Length=487, Percent_Identity=59.5482546201232, Blast_Score=586, Evalue=1e-167,
Organism=Drosophila melanogaster, GI281361666, Length=302, Percent_Identity=27.8145695364238, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24646341, Length=302, Percent_Identity=27.8145695364238, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17136796, Length=302, Percent_Identity=27.8145695364238, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI28574560, Length=380, Percent_Identity=27.3684210526316, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24638766, Length=377, Percent_Identity=25.9946949602122, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24583992, Length=334, Percent_Identity=24.5508982035928, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583988, Length=336, Percent_Identity=24.4047619047619, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583986, Length=336, Percent_Identity=24.4047619047619, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583984, Length=336, Percent_Identity=24.4047619047619, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_NEOSM (Q2GER5)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506031.1
- ProteinModelPortal:   Q2GER5
- SMR:   Q2GER5
- STRING:   Q2GER5
- GeneID:   3932148
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0131
- TIGR:   NSE_0131
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- PhylomeDB:   Q2GER5
- ProtClustDB:   CLSK2527682
- BioCyc:   NSEN222891:NSE_0131-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55770; Mature: 55639

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDVNASEVLRIIKEKIKDFDQQIFSEEIGEVISVKDGVVIACGLENAEFNEKVVFPNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCCCCCCCEEECCCC
EIGLIQSIEYDHVGIVILTNTQDIKEGDTVRRTKEALRIPVGKKLLGRVIDPLGNPLDGA
CEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCC
GQIFADAYSPIEVKAPGILDRQSVKEPLQTGIKVIDLLIPIGRGQRELIIGDRQTGKTTI
CHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEE
ALDSIINQRDINKNLPDEKKLYCVYVAIGQKCSTVARIMKTLQEQGAMDYTTIVLAGASD
EHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
SAQSQFLAPYAGCSIGEYFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDV
CCHHHHCCCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
FYIHSRLLERAAKMSDKHGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETELFN
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEEHHHC
KGVKPAVNVGLSVSRVGSAAQIKAIKQVARSIKLELAQYREMEAFAQFGADLDETTQALL
CCCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EKGKKLTELLKQNQHETLPVEEQVVLMFAANEGYFDNIDVTGISTAAKNLLGSFRLYHRD
HCCHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLEDIKEKSIIGDLASLSSALQGCKTTNA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SLDVNASEVLRIIKEKIKDFDQQIFSEEIGEVISVKDGVVIACGLENAEFNEKVVFPNG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCCCCCCCEEECCCC
EIGLIQSIEYDHVGIVILTNTQDIKEGDTVRRTKEALRIPVGKKLLGRVIDPLGNPLDGA
CEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCC
GQIFADAYSPIEVKAPGILDRQSVKEPLQTGIKVIDLLIPIGRGQRELIIGDRQTGKTTI
CHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEE
ALDSIINQRDINKNLPDEKKLYCVYVAIGQKCSTVARIMKTLQEQGAMDYTTIVLAGASD
EHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
SAQSQFLAPYAGCSIGEYFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDV
CCHHHHCCCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
FYIHSRLLERAAKMSDKHGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETELFN
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEEHHHC
KGVKPAVNVGLSVSRVGSAAQIKAIKQVARSIKLELAQYREMEAFAQFGADLDETTQALL
CCCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EKGKKLTELLKQNQHETLPVEEQVVLMFAANEGYFDNIDVTGISTAAKNLLGSFRLYHRD
HCCHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLEDIKEKSIIGDLASLSSALQGCKTTNA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA