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The map label for this gene is bioA

Identifier: 88608024

GI number: 88608024

Start: 540562

End: 541905

Strand: Direct

Name: bioA

Synonym: NSE_0618

Alternate gene names: 88608024

Gene position: 540562-541905 (Clockwise)

Preceding gene: 88608873

Following gene: 88608122

Centisome position: 62.93

GC content: 39.96

Gene sequence:

>1344_bases
ATGTATCAACATAATAAAACAGTTAACCTGTCTGTGAGGGATAAGAGCCTAATTTGGCACCCACTTACACAAGAAAAAAC
CTCTTCTCCATCAATCGCGATAATTAGGGGAGAAGGTGAGTACCTCTATGATGAGCAAAACAAAAAATACTTGGACCTTA
TATCGAGTTGGTGGGTAAACTTACACGGTCATGCTAATCCAGCAATCGCACATGCGATATATGAGCAGGCACTAAAACTT
GAACAAGTAATTTTCGCAGGTTTTACGCACGATCAAGCCATCCAATTATGCGAAAACCTCAAAGTAGAATTGCCTGAAAA
CCTTACAAGATTTTTTTTCTCTGATAACGGGTCTACATCAGTTGAGGTAGCATTGAAAATCGCATTGCAGTTCTGGAAAA
ACTCAGGTGAGAAACAGCGGGATATCTTTATTTCATTTGATAAGGGGTATCACGGAGACACCGTTGGAGCAATGAGCTTG
GGTGCATCATCTGGCTTTTTCGACCAATACAAGAAAATTCTATTCGAGACAGTGCATGTGCCTTTTCCTGCAACCTGGGA
AAACGATCCAGATGTAGAGATAAAGGAGGAGGCTTCACTAAATACAATCCAAAACTTTCTAGAACAAAATTTAAACCGAG
TAGCAGGTTTCATAGCTGAACCATTAGTCCAGGGAGCTGGAGGTATGCGGATGTGTCGATACAAGTACCTCGAACAGTGT
GTAAAGTTATTTAAAGAATATGGCATACTGACCATATTTGATGAAATCATGACTGGTTTTTACCGTACAGGCAAAATGTT
CGCCTCGGATTATATCCTTAGCAAACCAGATATTTTATGTCTCTCAAAAGGATTAACAGGCGGCTTTTTACCACTATCGC
TCACGATTACGACTGAGAGAGTGTACAACGCATTCTTATCTGACAACTTTAGTAGTGCGCTAATTCATAGTCACTCATAC
ACCGGAAATCCCCTTGGCTGCGCAGCTGCTATTGCCTCATTAGAATTACTTAAAAGTACAAGCACACTCGACAAAATTGC
TAAGATTGAACAACTACATAGAAGTTTCATTTGTGATCTGAAACTTACGTTACCAGAAATAATTAAAGCAGAAAGGGTTT
GTGGAACCATTGTGGCATTTAATCTCTTTTCAGAGGAATGCAATTACAATCACACGATTGCAGTAAAACTAAGAGAGATA
TTCATGAAAGAGGGACTGCTAATAAGACCACTCGGAAACACGATTTACTTAATGCCGCCTTACTGCATCTCTGAGAAAGC
GCTAAAAGAGGCACACTGCAAAGTAATGGAGCTAATTAGCTCCATTGCAGGCTCTTTTACCTAA

Upstream 100 bases:

>100_bases
AAGTCTGTTCAGCGCTATTATAAAGATATTAATTTAACTTGTGTTACAACACGGGTAATAGTAGAATCCGCATAAAAACA
CCTACGCGGCTATAGGAGAG

Downstream 100 bases:

>100_bases
TTACATCCTTTAAATAATTGCGTTGGTGGCACCGTAAGAAATTACCTTTTTACTGCCCAGTTGATTGATCCATCACAGTT
TCAATTTATACATCAAGAAC

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MYQHNKTVNLSVRDKSLIWHPLTQEKTSSPSIAIIRGEGEYLYDEQNKKYLDLISSWWVNLHGHANPAIAHAIYEQALKL
EQVIFAGFTHDQAIQLCENLKVELPENLTRFFFSDNGSTSVEVALKIALQFWKNSGEKQRDIFISFDKGYHGDTVGAMSL
GASSGFFDQYKKILFETVHVPFPATWENDPDVEIKEEASLNTIQNFLEQNLNRVAGFIAEPLVQGAGGMRMCRYKYLEQC
VKLFKEYGILTIFDEIMTGFYRTGKMFASDYILSKPDILCLSKGLTGGFLPLSLTITTERVYNAFLSDNFSSALIHSHSY
TGNPLGCAAAIASLELLKSTSTLDKIAKIEQLHRSFICDLKLTLPEIIKAERVCGTIVAFNLFSEECNYNHTIAVKLREI
FMKEGLLIRPLGNTIYLMPPYCISEKALKEAHCKVMELISSIAGSFT

Sequences:

>Translated_447_residues
MYQHNKTVNLSVRDKSLIWHPLTQEKTSSPSIAIIRGEGEYLYDEQNKKYLDLISSWWVNLHGHANPAIAHAIYEQALKL
EQVIFAGFTHDQAIQLCENLKVELPENLTRFFFSDNGSTSVEVALKIALQFWKNSGEKQRDIFISFDKGYHGDTVGAMSL
GASSGFFDQYKKILFETVHVPFPATWENDPDVEIKEEASLNTIQNFLEQNLNRVAGFIAEPLVQGAGGMRMCRYKYLEQC
VKLFKEYGILTIFDEIMTGFYRTGKMFASDYILSKPDILCLSKGLTGGFLPLSLTITTERVYNAFLSDNFSSALIHSHSY
TGNPLGCAAAIASLELLKSTSTLDKIAKIEQLHRSFICDLKLTLPEIIKAERVCGTIVAFNLFSEECNYNHTIAVKLREI
FMKEGLLIRPLGNTIYLMPPYCISEKALKEAHCKVMELISSIAGSFT
>Mature_447_residues
MYQHNKTVNLSVRDKSLIWHPLTQEKTSSPSIAIIRGEGEYLYDEQNKKYLDLISSWWVNLHGHANPAIAHAIYEQALKL
EQVIFAGFTHDQAIQLCENLKVELPENLTRFFFSDNGSTSVEVALKIALQFWKNSGEKQRDIFISFDKGYHGDTVGAMSL
GASSGFFDQYKKILFETVHVPFPATWENDPDVEIKEEASLNTIQNFLEQNLNRVAGFIAEPLVQGAGGMRMCRYKYLEQC
VKLFKEYGILTIFDEIMTGFYRTGKMFASDYILSKPDILCLSKGLTGGFLPLSLTITTERVYNAFLSDNFSSALIHSHSY
TGNPLGCAAAIASLELLKSTSTLDKIAKIEQLHRSFICDLKLTLPEIIKAERVCGTIVAFNLFSEECNYNHTIAVKLREI
FMKEGLLIRPLGNTIYLMPPYCISEKALKEAHCKVMELISSIAGSFT

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=429, Percent_Identity=26.3403263403263, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI226442705, Length=431, Percent_Identity=25.754060324826, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI4557809, Length=439, Percent_Identity=28.246013667426, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI24119277, Length=430, Percent_Identity=24.4186046511628, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=25.6345177664975, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI284507298, Length=337, Percent_Identity=28.1899109792285, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13994255, Length=327, Percent_Identity=27.217125382263, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=37.799043062201, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI145693181, Length=391, Percent_Identity=30.4347826086957, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1788044, Length=404, Percent_Identity=27.2277227722772, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=27.3170731707317, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789759, Length=318, Percent_Identity=27.9874213836478, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789016, Length=415, Percent_Identity=25.5421686746988, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786349, Length=328, Percent_Identity=27.4390243902439, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=421, Percent_Identity=25.41567695962, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=27.8688524590164, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=25.858123569794, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=231, Percent_Identity=29.8701298701299, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324386, Length=461, Percent_Identity=31.4533622559653, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6324432, Length=410, Percent_Identity=27.5609756097561, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323470, Length=426, Percent_Identity=28.8732394366197, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21357415, Length=423, Percent_Identity=26.4775413711584, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=25.4079254079254, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28574759, Length=424, Percent_Identity=26.4150943396226, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161085790, Length=423, Percent_Identity=26.241134751773, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281366494, Length=268, Percent_Identity=25.7462686567164, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24667139, Length=268, Percent_Identity=25.7462686567164, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24667143, Length=268, Percent_Identity=25.7462686567164, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50374; Mature: 50374

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHNKTVNLSVRDKSLIWHPLTQEKTSSPSIAIIRGEGEYLYDEQNKKYLDLISSWWVN
CCCCCCEEEEEEECCCEEECCCCCCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHEE
LHGHANPAIAHAIYEQALKLEQVIFAGFTHDQAIQLCENLKVELPENLTRFFFSDNGSTS
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHEECCCCCCH
VEVALKIALQFWKNSGEKQRDIFISFDKGYHGDTVGAMSLGASSGFFDQYKKILFETVHV
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCC
PFPATWENDPDVEIKEEASLNTIQNFLEQNLNRVAGFIAEPLVQGAGGMRMCRYKYLEQC
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VKLFKEYGILTIFDEIMTGFYRTGKMFASDYILSKPDILCLSKGLTGGFLPLSLTITTER
HHHHHHCCHHHHHHHHHHHHHHHCHHHHHCHHCCCCCEEEEECCCCCCCEEEEEEEEHHH
VYNAFLSDNFSSALIHSHSYTGNPLGCAAAIASLELLKSTSTLDKIAKIEQLHRSFICDL
HHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLTLPEIIKAERVCGTIVAFNLFSEECNYNHTIAVKLREIFMKEGLLIRPLGNTIYLMPP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCEEEEECCCEEEEECC
YCISEKALKEAHCKVMELISSIAGSFT
HHCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYQHNKTVNLSVRDKSLIWHPLTQEKTSSPSIAIIRGEGEYLYDEQNKKYLDLISSWWVN
CCCCCCEEEEEEECCCEEECCCCCCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHEE
LHGHANPAIAHAIYEQALKLEQVIFAGFTHDQAIQLCENLKVELPENLTRFFFSDNGSTS
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHEECCCCCCH
VEVALKIALQFWKNSGEKQRDIFISFDKGYHGDTVGAMSLGASSGFFDQYKKILFETVHV
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCC
PFPATWENDPDVEIKEEASLNTIQNFLEQNLNRVAGFIAEPLVQGAGGMRMCRYKYLEQC
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VKLFKEYGILTIFDEIMTGFYRTGKMFASDYILSKPDILCLSKGLTGGFLPLSLTITTER
HHHHHHCCHHHHHHHHHHHHHHHCHHHHHCHHCCCCCEEEEECCCCCCCEEEEEEEEHHH
VYNAFLSDNFSSALIHSHSYTGNPLGCAAAIASLELLKSTSTLDKIAKIEQLHRSFICDL
HHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLTLPEIIKAERVCGTIVAFNLFSEECNYNHTIAVKLREIFMKEGLLIRPLGNTIYLMPP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCEEEEECCCEEEEECC
YCISEKALKEAHCKVMELISSIAGSFT
HHCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]