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The map label for this gene is murE [H]

Identifier: 88607959

GI number: 88607959

Start: 207848

End: 209257

Strand: Reverse

Name: murE [H]

Synonym: NSE_0245

Alternate gene names: 88607959

Gene position: 209257-207848 (Counterclockwise)

Preceding gene: 88608856

Following gene: 88608426

Centisome position: 24.36

GC content: 41.63

Gene sequence:

>1410_bases
GTGCTATACGAGCAAATTTGCCTGGAAATATCAAAGGGGAGAATCAAGAACATTACTTCGGATCCTCAAAAAGTTGGGAA
AGATTTCCTATTTTATGCACCATCAGAAAAGGAACACGCACACATCCGGGAGGCAATCAATCGTGGTGCAAGGAGCATAC
TAACAAATCAAAAATATGAAGAAGAATGCCTCGCACAAGGAGTTAATTTCTTTGTACACACTCAACCACAGCAGATATAT
CATGAGGTATGCTCTTGCATGTGGAAGAAACAACCAGCATACATGTGTGCAGTAACTGGCACAAGTGGAAAGAGAAGTGT
TGGGCATTTTTTCTCTCAAGTATGCACACTGGCCGGAAAAAAAGCCGTTTCTTTAAGTGCCTCAAATGAACCAACAGATG
CTCTTGGGTTATGGCAAGAGAAAGATCATATGATATTAGACGCAGCAGACATGTATAGCATTCTTGACGATCTAGCAGGT
AGAAGAATCGAATATTGTTGCTTAGCAATTTCAGGTGCAGCGATTGAAAGCAGGATGATAGATAGTGTCAACTTAAAGGC
GGCTGCTTTCAGCAATCTGCTACGCGACGATTTAGAACAACCCGAAGATATAGACAAACGCTTCCAGATGAAGGTACGAC
TCCTCTCAGAGGTATTACCTGAGGACGGCATTATGGTACTGCCAGTAGCTAGTGAGTATACAACAAGGATAATACAACAC
TGTCCAAATAAAAAAGTTTGTACATACGGAAGAGCCACAAGCGACATACAGTTGATCTCTCAATTGCCAACACAAAAAGG
ACAAATACTAACAATGAAAGTCCTTGGGAAAGAAATGGTTATTCATACAAATATACTCGGAAAGTTCCACGGGAATAATC
TGGTAACCGCAATGGGATTAGCTATCTCATGCGGAATAGATCCATCCAGCATTGAACATGAACAAATCAGCCCACTAGCC
GGGTATATGGAGTTTCTAGAAGAGTACGGAGAGGAGCGCAAAATTATGACAGATTGTGCCCAGACCCCGAGTGAACTGCA
TGATCTTCTACTTTCTATCAAGTGGCATTTTCCATATAATGATGTCACCCTTGTGCTCAGATGCAGCGAGAATTATGAGG
GAAAGAATACCCTAAAGATGGCCAAAATCGCAGCAAAAATGGTGAATAGGATAATCTTCACTAGCGATAGCAATGGTAGC
ACTTTAACGGAGAAAAGTCGGCGCGAACTTATGTCTTGCTGCCCAAAAGCAATTGAAATTGAGGATAGAAAAAAAGCGAT
GGAATACGCGATAAATAACTGCAAACCATCTGAGATTATCGTGATGCAAGGAGTGAAATCATCAATAGACAAGCGTGGTG
TTGTAAACGATGCAGCTGCAATGCTAAAAGCCGTAGTTGCTCCTCAATAA

Upstream 100 bases:

>100_bases
AAGCGCCAAATAAGGTAAATTTATTGTATGGAATCCTGCTTCAGATAGGGTGAACTCATCGCAGAAGATGGAGTAAATTT
AGGGGAGGAAGAAGATGTCT

Downstream 100 bases:

>100_bases
GTTTCTGTTTCCCCAAAGCTTACTTTTGCCTGGACATACCATCATGCATATACCGGGGACTATGATTGCTACATTTAGGT
GAACGGGCTTCGTTCATTCT

Product: hypothetical protein

Products: NA

Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MLYEQICLEISKGRIKNITSDPQKVGKDFLFYAPSEKEHAHIREAINRGARSILTNQKYEEECLAQGVNFFVHTQPQQIY
HEVCSCMWKKQPAYMCAVTGTSGKRSVGHFFSQVCTLAGKKAVSLSASNEPTDALGLWQEKDHMILDAADMYSILDDLAG
RRIEYCCLAISGAAIESRMIDSVNLKAAAFSNLLRDDLEQPEDIDKRFQMKVRLLSEVLPEDGIMVLPVASEYTTRIIQH
CPNKKVCTYGRATSDIQLISQLPTQKGQILTMKVLGKEMVIHTNILGKFHGNNLVTAMGLAISCGIDPSSIEHEQISPLA
GYMEFLEEYGEERKIMTDCAQTPSELHDLLLSIKWHFPYNDVTLVLRCSENYEGKNTLKMAKIAAKMVNRIIFTSDSNGS
TLTEKSRRELMSCCPKAIEIEDRKKAMEYAINNCKPSEIIVMQGVKSSIDKRGVVNDAAAMLKAVVAPQ

Sequences:

>Translated_469_residues
MLYEQICLEISKGRIKNITSDPQKVGKDFLFYAPSEKEHAHIREAINRGARSILTNQKYEEECLAQGVNFFVHTQPQQIY
HEVCSCMWKKQPAYMCAVTGTSGKRSVGHFFSQVCTLAGKKAVSLSASNEPTDALGLWQEKDHMILDAADMYSILDDLAG
RRIEYCCLAISGAAIESRMIDSVNLKAAAFSNLLRDDLEQPEDIDKRFQMKVRLLSEVLPEDGIMVLPVASEYTTRIIQH
CPNKKVCTYGRATSDIQLISQLPTQKGQILTMKVLGKEMVIHTNILGKFHGNNLVTAMGLAISCGIDPSSIEHEQISPLA
GYMEFLEEYGEERKIMTDCAQTPSELHDLLLSIKWHFPYNDVTLVLRCSENYEGKNTLKMAKIAAKMVNRIIFTSDSNGS
TLTEKSRRELMSCCPKAIEIEDRKKAMEYAINNCKPSEIIVMQGVKSSIDKRGVVNDAAAMLKAVVAPQ
>Mature_469_residues
MLYEQICLEISKGRIKNITSDPQKVGKDFLFYAPSEKEHAHIREAINRGARSILTNQKYEEECLAQGVNFFVHTQPQQIY
HEVCSCMWKKQPAYMCAVTGTSGKRSVGHFFSQVCTLAGKKAVSLSASNEPTDALGLWQEKDHMILDAADMYSILDDLAG
RRIEYCCLAISGAAIESRMIDSVNLKAAAFSNLLRDDLEQPEDIDKRFQMKVRLLSEVLPEDGIMVLPVASEYTTRIIQH
CPNKKVCTYGRATSDIQLISQLPTQKGQILTMKVLGKEMVIHTNILGKFHGNNLVTAMGLAISCGIDPSSIEHEQISPLA
GYMEFLEEYGEERKIMTDCAQTPSELHDLLLSIKWHFPYNDVTLVLRCSENYEGKNTLKMAKIAAKMVNRIIFTSDSNGS
TLTEKSRRELMSCCPKAIEIEDRKKAMEYAINNCKPSEIIVMQGVKSSIDKRGVVNDAAAMLKAVVAPQ

Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]

COG id: COG0769

COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family. MurE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR005761 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.13 [H]

Molecular weight: Translated: 52434; Mature: 52434

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYEQICLEISKGRIKNITSDPQKVGKDFLFYAPSEKEHAHIREAINRGARSILTNQKYE
CCHHHHHHHHHCCHHCCCCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHH
EECLAQGVNFFVHTQPQQIYHEVCSCMWKKQPAYMCAVTGTSGKRSVGHFFSQVCTLAGK
HHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCC
KAVSLSASNEPTDALGLWQEKDHMILDAADMYSILDDLAGRRIEYCCLAISGAAIESRMI
CEEEECCCCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHCCCCEEHHEEEECCHHHHHHHH
DSVNLKAAAFSNLLRDDLEQPEDIDKRFQMKVRLLSEVLPEDGIMVLPVASEYTTRIIQH
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHH
CPNKKVCTYGRATSDIQLISQLPTQKGQILTMKVLGKEMVIHTNILGKFHGNNLVTAMGL
CCCCCEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCHHEEEEHHHHEECCCCCEEECCE
AISCGIDPSSIEHEQISPLAGYMEFLEEYGEERKIMTDCAQTPSELHDLLLSIKWHFPYN
EEECCCCCCCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHEEEECCCC
DVTLVLRCSENYEGKNTLKMAKIAAKMVNRIIFTSDSNGSTLTEKSRRELMSCCPKAIEI
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCH
EDRKKAMEYAINNCKPSEIIVMQGVKSSIDKRGVVNDAAAMLKAVVAPQ
HHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLYEQICLEISKGRIKNITSDPQKVGKDFLFYAPSEKEHAHIREAINRGARSILTNQKYE
CCHHHHHHHHHCCHHCCCCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHH
EECLAQGVNFFVHTQPQQIYHEVCSCMWKKQPAYMCAVTGTSGKRSVGHFFSQVCTLAGK
HHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCC
KAVSLSASNEPTDALGLWQEKDHMILDAADMYSILDDLAGRRIEYCCLAISGAAIESRMI
CEEEECCCCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHCCCCEEHHEEEECCHHHHHHHH
DSVNLKAAAFSNLLRDDLEQPEDIDKRFQMKVRLLSEVLPEDGIMVLPVASEYTTRIIQH
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHH
CPNKKVCTYGRATSDIQLISQLPTQKGQILTMKVLGKEMVIHTNILGKFHGNNLVTAMGL
CCCCCEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCHHEEEEHHHHEECCCCCEEECCE
AISCGIDPSSIEHEQISPLAGYMEFLEEYGEERKIMTDCAQTPSELHDLLLSIKWHFPYN
EEECCCCCCCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHEEEECCCC
DVTLVLRCSENYEGKNTLKMAKIAAKMVNRIIFTSDSNGSTLTEKSRRELMSCCPKAIEI
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCH
EDRKKAMEYAINNCKPSEIIVMQGVKSSIDKRGVVNDAAAMLKAVVAPQ
HHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA