Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 88607948

GI number: 88607948

Start: 845328

End: 846059

Strand: Reverse

Name: lepB [H]

Synonym: APH_0802

Alternate gene names: 88607948

Gene position: 846059-845328 (Counterclockwise)

Preceding gene: 88607379

Following gene: 88607532

Centisome position: 57.5

GC content: 42.62

Gene sequence:

>732_bases
GTGCTGAAGGGGAAGAGGAGCGCTGTCGTTGAGTTAATCAAGGTATTGTTGGTAGCGTTAGTAGCGGTTGGTTGCTTCCG
TAGTTTCGTTATAGAGCCTTTTCATATACCGTCTGGTTCAATGAAGAGTACTCTTTTGGTGGGTGATTATTTATTTGTTG
GAAAGTATAGCTACGGTTACGGGCGCTATTCCACGGTTCTCACGCCCATTTTGTCGAGGATTCCTTTTTTGACTCTTAAG
GGGAGGGTGTTATATACCCCTCCAAAAGCTGGTGATGTGGTGGTATTCAGGTTGCCTTCGGATCCGAGTACTAGTTATAT
AAAAAGGGTGATTGGTCTTCCTGGGGATAGTGTACAGATTAAAAATGGGCATCTGTATATAAATGGGAAGGAGATGCACT
ATGAAGTCGTGGGAGATTTCATGGACGGAGACAGAGCGGTGCGTCGGTATGTTGAGACTTTGTACAATGGCAAGTCATAT
GAGATATTAGATGAGCGTGAAAATAGTTCATTAGATAATACTCCTGTATATAAGGTGCCGCCTGGGCATATTTTTGTGCT
TGGTGATAATAGGGATGATTCTCGGGATAGTCGCTTTGTAACAGAAGTTGGGAATATCCCAATTGATAACATTATAGGAA
AGGCGCTTATAGTTGTTCTTTCTTTTCAGGGTAGTGATGGCTGGTTTCCATTCAAGATTAGGGCGGATAGAATCTTACAT
AAGGTGCGATAA

Upstream 100 bases:

>100_bases
ATGAATGGGTCAAGGTTCGTGGTGAATAACCCTGGTGTAAAGTTTGGTTGTGGCTGTGGGAACAGTTTTTCGTTGTGAGA
AGAAAGCGCCTCTTGGTTCA

Downstream 100 bases:

>100_bases
AATGTTATATTGTGTGCAGTTTGGGAGAAGGGTCATAAGGCTGGTATCTGCAACTGTGCACGGTTTCTTTTTGACGCTTC
TGGCAATGTTTAAGCCCAAA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLKGKRSAVVELIKVLLVALVAVGCFRSFVIEPFHIPSGSMKSTLLVGDYLFVGKYSYGYGRYSTVLTPILSRIPFLTLK
GRVLYTPPKAGDVVVFRLPSDPSTSYIKRVIGLPGDSVQIKNGHLYINGKEMHYEVVGDFMDGDRAVRRYVETLYNGKSY
EILDERENSSLDNTPVYKVPPGHIFVLGDNRDDSRDSRFVTEVGNIPIDNIIGKALIVVLSFQGSDGWFPFKIRADRILH
KVR

Sequences:

>Translated_243_residues
MLKGKRSAVVELIKVLLVALVAVGCFRSFVIEPFHIPSGSMKSTLLVGDYLFVGKYSYGYGRYSTVLTPILSRIPFLTLK
GRVLYTPPKAGDVVVFRLPSDPSTSYIKRVIGLPGDSVQIKNGHLYINGKEMHYEVVGDFMDGDRAVRRYVETLYNGKSY
EILDERENSSLDNTPVYKVPPGHIFVLGDNRDDSRDSRFVTEVGNIPIDNIIGKALIVVLSFQGSDGWFPFKIRADRILH
KVR
>Mature_243_residues
MLKGKRSAVVELIKVLLVALVAVGCFRSFVIEPFHIPSGSMKSTLLVGDYLFVGKYSYGYGRYSTVLTPILSRIPFLTLK
GRVLYTPPKAGDVVVFRLPSDPSTSYIKRVIGLPGDSVQIKNGHLYINGKEMHYEVVGDFMDGDRAVRRYVETLYNGKSY
EILDERENSSLDNTPVYKVPPGHIFVLGDNRDDSRDSRFVTEVGNIPIDNIIGKALIVVLSFQGSDGWFPFKIRADRILH
KVR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=266, Percent_Identity=33.0827067669173, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 27248; Mature: 27248

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGKRSAVVELIKVLLVALVAVGCFRSFVIEPFHIPSGSMKSTLLVGDYLFVGKYSYGY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECEEEEECCCCCC
GRYSTVLTPILSRIPFLTLKGRVLYTPPKAGDVVVFRLPSDPSTSYIKRVIGLPGDSVQI
CHHHHHHHHHHHHCCEEEECCEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEE
KNGHLYINGKEMHYEVVGDFMDGDRAVRRYVETLYNGKSYEILDERENSSLDNTPVYKVP
ECCEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEC
PGHIFVLGDNRDDSRDSRFVTEVGNIPIDNIIGKALIVVLSFQGSDGWFPFKIRADRILH
CCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHEEEEEEEECCCCCEEEEEEEHHHHHH
KVR
HCC
>Mature Secondary Structure
MLKGKRSAVVELIKVLLVALVAVGCFRSFVIEPFHIPSGSMKSTLLVGDYLFVGKYSYGY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECEEEEECCCCCC
GRYSTVLTPILSRIPFLTLKGRVLYTPPKAGDVVVFRLPSDPSTSYIKRVIGLPGDSVQI
CHHHHHHHHHHHHCCEEEECCEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEE
KNGHLYINGKEMHYEVVGDFMDGDRAVRRYVETLYNGKSYEILDERENSSLDNTPVYKVP
ECCEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEC
PGHIFVLGDNRDDSRDSRFVTEVGNIPIDNIIGKALIVVLSFQGSDGWFPFKIRADRILH
CCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHEEEEEEEECCCCCEEEEEEEHHHHHH
KVR
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA