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The map label for this gene is guaA [H]

Identifier: 88607947

GI number: 88607947

Start: 1303611

End: 1305200

Strand: Reverse

Name: guaA [H]

Synonym: APH_1233

Alternate gene names: 88607947

Gene position: 1305200-1303611 (Counterclockwise)

Preceding gene: 88606703

Following gene: 88607107

Centisome position: 88.71

GC content: 43.77

Gene sequence:

>1590_bases
GTGTTAACGATTGCCATAATTGACTTTGGTTCACAGGTTACCCAGCTGATTGCACGCAGAGTAAGAGAACTTGGAGTGTA
TAGTGAGGTTTTTTCTGTAGATACTGACTTCCCTGCTTTACTTGCGCAAGGGAAAAAAATAGCAGCTTTTATACTGTCCG
GAGGGCCGAATTCAGTATCAGAATTGCAAAACATACCGAAAGTGGTTTCAGATGTATTAGAAATAAATTTGAAAACTGGA
ACCCCAATTATGGGAATATGCTACGGATTCCAGTTACTTGCACATAGCTTTAGTAGCACGGTAGAGTCAGACAAAGCACG
CGAATATGGTCATGCACAGCTGCAAATTGTCGGTGAATCTGCTATCACGAAAGGTATATGGTCTGTAGGTCAAACAGCTT
GTGTATGGATGAGCCACTCCGATAGCGTTGTTGATAATGTTCCTCAGGGTTTTAACGTAGTTGCTCGCAGTATGAATACC
CAAGCTATAGCCTTTATTAGCAATGAGGAAAGGAAAATTTATGGCCTGCAGTTTCATCCAGAGGTCTCTCATACACCTGA
AGGTAGAGATATACTAAATAGCTTCTTAACTACTGTTGGCTGCGCTAGAAACTGGACAGTTAGCTCCTTCTTGAACACTC
AGATTGATGATATAAGGAGGACAGTTGGCAATGGTGTGGTTGTAGCCGCCATCAGTGGCGGAGTAGATTCCTCTGTAGCA
TCTGTGCTATTGCATCGGGCAATTGGCGATCAGTTGAAGTGTGTGTTCGTTGATACAGGGCTTCTGCGTAAAGGAGAAGT
TGAAACAGTGCGGGAGTTTTTTGTAGACAAACTTAAGATGTCAGTCTCAATCGTGAGTGCTGCGTTCTTGTTCATAGAAC
GTTTGAGAGGGGTTGTAGATCCTGAAGAAAAACGCAAGATCATAGGCAACACATTTATCGAAGTGTTTGAGCAGGAAGCA
AAAAAACTGGGAGATGCACAGTTTCTAATGCAGGGGACAATCTATCCCGATGTTATTGAATCGGGAGCTAGTGGTTTAGG
TGTCAAAATCAAGTCGCATCACAATGTTGGGGGGCTACCTGAAAATATGAATCTCTCACTGGTAGAGCCACTAAGATGTT
TATTTAAGGACGAAGTTCGCGCACTTGGCAGTGAATTGGGGTTACCTGACGTAATTTTGAAGCGCCATCCATTCCCAGGA
CCGGGGCTCGCAGTGCGAATTATTGGGGAGGTAACTGAGGAGAAACTTCAGTTATTGCAGGAAATAGACAATATATACAT
AAGTATGCTCTATGAGAGTGGTCTCTACCATGATATATGGCAAGCGTTTTCGGTTTTGATCCCTGCGCGCACTGTTGGTG
TGATGGGTGATAGCAGAACTTATGGACATGTTTGCTGTCTTAGAGCTGTGACCTCTTCCGATGGTATGACAGCAGATTGT
TTTCCTTTTGGAGAAGCTAAAGAGAAGCAGTTAAAGTTTCTGGAGTTTTTGCAGAAAGTTAGCGTGGCGATAGTAGGAAG
TCTGCCGAGAGTAAATCGGGTGGTATACGACGTAACTTCAAAGCCACCAGCGACGATCGAGTGGGAATAG

Upstream 100 bases:

>100_bases
CTTCTCCTTTTGAACAATAAGCGTTGCTCTTCCCTGTGTATGTGCATTGTCCACTGAGCACTAATGTCTTACAATGTGTG
TGAGTATATTGGAGTAGTAA

Downstream 100 bases:

>100_bases
AAACAGTAATAAATTGTATTATCAGAGTATTATATGGTAGAAAAAGCTGTTTTGGAGTGTGGAGACCGTAGGATTAGTTT
GCCGGTTTTACGCGGCACGG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MLTIAIIDFGSQVTQLIARRVRELGVYSEVFSVDTDFPALLAQGKKIAAFILSGGPNSVSELQNIPKVVSDVLEINLKTG
TPIMGICYGFQLLAHSFSSTVESDKAREYGHAQLQIVGESAITKGIWSVGQTACVWMSHSDSVVDNVPQGFNVVARSMNT
QAIAFISNEERKIYGLQFHPEVSHTPEGRDILNSFLTTVGCARNWTVSSFLNTQIDDIRRTVGNGVVVAAISGGVDSSVA
SVLLHRAIGDQLKCVFVDTGLLRKGEVETVREFFVDKLKMSVSIVSAAFLFIERLRGVVDPEEKRKIIGNTFIEVFEQEA
KKLGDAQFLMQGTIYPDVIESGASGLGVKIKSHHNVGGLPENMNLSLVEPLRCLFKDEVRALGSELGLPDVILKRHPFPG
PGLAVRIIGEVTEEKLQLLQEIDNIYISMLYESGLYHDIWQAFSVLIPARTVGVMGDSRTYGHVCCLRAVTSSDGMTADC
FPFGEAKEKQLKFLEFLQKVSVAIVGSLPRVNRVVYDVTSKPPATIEWE

Sequences:

>Translated_529_residues
MLTIAIIDFGSQVTQLIARRVRELGVYSEVFSVDTDFPALLAQGKKIAAFILSGGPNSVSELQNIPKVVSDVLEINLKTG
TPIMGICYGFQLLAHSFSSTVESDKAREYGHAQLQIVGESAITKGIWSVGQTACVWMSHSDSVVDNVPQGFNVVARSMNT
QAIAFISNEERKIYGLQFHPEVSHTPEGRDILNSFLTTVGCARNWTVSSFLNTQIDDIRRTVGNGVVVAAISGGVDSSVA
SVLLHRAIGDQLKCVFVDTGLLRKGEVETVREFFVDKLKMSVSIVSAAFLFIERLRGVVDPEEKRKIIGNTFIEVFEQEA
KKLGDAQFLMQGTIYPDVIESGASGLGVKIKSHHNVGGLPENMNLSLVEPLRCLFKDEVRALGSELGLPDVILKRHPFPG
PGLAVRIIGEVTEEKLQLLQEIDNIYISMLYESGLYHDIWQAFSVLIPARTVGVMGDSRTYGHVCCLRAVTSSDGMTADC
FPFGEAKEKQLKFLEFLQKVSVAIVGSLPRVNRVVYDVTSKPPATIEWE
>Mature_529_residues
MLTIAIIDFGSQVTQLIARRVRELGVYSEVFSVDTDFPALLAQGKKIAAFILSGGPNSVSELQNIPKVVSDVLEINLKTG
TPIMGICYGFQLLAHSFSSTVESDKAREYGHAQLQIVGESAITKGIWSVGQTACVWMSHSDSVVDNVPQGFNVVARSMNT
QAIAFISNEERKIYGLQFHPEVSHTPEGRDILNSFLTTVGCARNWTVSSFLNTQIDDIRRTVGNGVVVAAISGGVDSSVA
SVLLHRAIGDQLKCVFVDTGLLRKGEVETVREFFVDKLKMSVSIVSAAFLFIERLRGVVDPEEKRKIIGNTFIEVFEQEA
KKLGDAQFLMQGTIYPDVIESGASGLGVKIKSHHNVGGLPENMNLSLVEPLRCLFKDEVRALGSELGLPDVILKRHPFPG
PGLAVRIIGEVTEEKLQLLQEIDNIYISMLYESGLYHDIWQAFSVLIPARTVGVMGDSRTYGHVCCLRAVTSSDGMTADC
FPFGEAKEKQLKFLEFLQKVSVAIVGSLPRVNRVVYDVTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=572, Percent_Identity=35.6643356643357, Blast_Score=280, Evalue=3e-75,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=47.9477611940299, Blast_Score=467, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71992710, Length=526, Percent_Identity=37.8326996197719, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI71992717, Length=526, Percent_Identity=37.6425855513308, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI133901714, Length=526, Percent_Identity=37.6425855513308, Blast_Score=274, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6323873, Length=536, Percent_Identity=46.455223880597, Blast_Score=469, Evalue=1e-133,
Organism=Drosophila melanogaster, GI281365319, Length=565, Percent_Identity=33.4513274336283, Blast_Score=238, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57955; Mature: 57955

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00442 GATASE_TYPE_I ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIAIIDFGSQVTQLIARRVRELGVYSEVFSVDTDFPALLAQGKKIAAFILSGGPNSVS
CEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHCCCEEEEEEECCCCCCHH
ELQNIPKVVSDVLEINLKTGTPIMGICYGFQLLAHSFSSTVESDKAREYGHAQLQIVGES
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHH
AITKGIWSVGQTACVWMSHSDSVVDNVPQGFNVVARSMNTQAIAFISNEERKIYGLQFHP
HHHHHHHHCCCEEEEEECCCCHHHHCCCCCHHHHHHCCCCEEEEEEECCCCEEEEEEECC
EVSHTPEGRDILNSFLTTVGCARNWTVSSFLNTQIDDIRRTVGNGVVVAAISGGVDSSVA
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
SVLLHRAIGDQLKCVFVDTGLLRKGEVETVREFFVDKLKMSVSIVSAAFLFIERLRGVVD
HHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEEKRKIIGNTFIEVFEQEAKKLGDAQFLMQGTIYPDVIESGASGLGVKIKSHHNVGGLP
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCEEEEECCCCCCCCC
ENMNLSLVEPLRCLFKDEVRALGSELGLPDVILKRHPFPGPGLAVRIIGEVTEEKLQLLQ
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHH
EIDNIYISMLYESGLYHDIWQAFSVLIPARTVGVMGDSRTYGHVCCLRAVTSSDGMTADC
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCEECC
FPFGEAKEKQLKFLEFLQKVSVAIVGSLPRVNRVVYDVTSKPPATIEWE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCEEEEEECCCCCCCEECC
>Mature Secondary Structure
MLTIAIIDFGSQVTQLIARRVRELGVYSEVFSVDTDFPALLAQGKKIAAFILSGGPNSVS
CEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHCCCEEEEEEECCCCCCHH
ELQNIPKVVSDVLEINLKTGTPIMGICYGFQLLAHSFSSTVESDKAREYGHAQLQIVGES
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHH
AITKGIWSVGQTACVWMSHSDSVVDNVPQGFNVVARSMNTQAIAFISNEERKIYGLQFHP
HHHHHHHHCCCEEEEEECCCCHHHHCCCCCHHHHHHCCCCEEEEEEECCCCEEEEEEECC
EVSHTPEGRDILNSFLTTVGCARNWTVSSFLNTQIDDIRRTVGNGVVVAAISGGVDSSVA
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
SVLLHRAIGDQLKCVFVDTGLLRKGEVETVREFFVDKLKMSVSIVSAAFLFIERLRGVVD
HHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEEKRKIIGNTFIEVFEQEAKKLGDAQFLMQGTIYPDVIESGASGLGVKIKSHHNVGGLP
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCEEEEECCCCCCCCC
ENMNLSLVEPLRCLFKDEVRALGSELGLPDVILKRHPFPGPGLAVRIIGEVTEEKLQLLQ
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHH
EIDNIYISMLYESGLYHDIWQAFSVLIPARTVGVMGDSRTYGHVCCLRAVTSSDGMTADC
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCEECC
FPFGEAKEKQLKFLEFLQKVSVAIVGSLPRVNRVVYDVTSKPPATIEWE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCEEEEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA