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The map label for this gene is gltA [H]

Identifier: 88607107

GI number: 88607107

Start: 1302342

End: 1303577

Strand: Reverse

Name: gltA [H]

Synonym: APH_1232

Alternate gene names: 88607107

Gene position: 1303577-1302342 (Counterclockwise)

Preceding gene: 88607947

Following gene: 88607826

Centisome position: 88.6

GC content: 44.01

Gene sequence:

>1236_bases
ATGGTAGAAAAAGCTGTTTTGGAGTGTGGAGACCGTAGGATTAGTTTGCCGGTTTTACGCGGCACGGACGGGACCCCAGT
GGTTGATATCACAACCCTATATAGGGAGAACAATGTGCTCACATATGACCCGGGTTTTATGTCCACTGCTGCTTGCAGAT
CAGAGATAACTTTCATTGATGGAAACAAGGGAACTCTACGCTACAGGGGTATTGATATAGAAAATCTGATCGGTACACCC
AATAGCTTCAGTAGTATAGTGTATTTGTTATTGAAGGGTACTCTGCCTTCTGAAACTGAGCATGAAGAGTTTGTGCGGAT
TTTGGGCGCTGAATACGATGTGCCTGAACAAGTTATGAACGTTATTAGATCATTCCCTCGAGATTCGCATCCTATGGCTA
TTCTCATAGCTAGCTTTTCTGCTTTAGCTGCTAATTACCACGCAAGTCGCATTGATCCGCTTACAGGTGCTATCATCGCA
ATTGCGAAAGTACCCGGCATTGTTGCAAGTATTTATAGGCACACTGCAAATCTAGATTTTATACAAGCTGACGCAAACTT
AGAGTACACGCATCACTTTATCAGGATGATGTTTGGCGACATGGATGATGCACATCGTGATATTATGCACAAAGCTCTAG
ATGCAATTTTTATAATGCACGCAGATCATGAGCAGAATGCCTCTACTTCCACTGTGCGTATGACAGGATCTTCTGGAGCA
GGTTTATTTGCATGTTTGTGCGCAGGAGTGGCCACTCTGTGGGGGCCAGCGCATGGGGGCGCAAATGAGGCTGTTATAAA
GATGCTTGCTGAGATTGGTTCACCAGAAAATGTTTCGTCATTTATCGACAAGGTAAAAAACAACAAGGGCAAAAGTCGTC
TTATGGGGTTTGGGCACCGTGTTTATAAAAGCTATGACCCTAGAGCGCGTGTTTTGCGTACAATCTGTAAAGATGTATTA
GATTCTCTAGGTAGAGATGAGAATTTGCTAGCTGTTGCAGAAGAGTTAGAAAGTCAGGCTTTGCAGGATGAGTATTTTAT
TGAGCGCAAGTTGTACCCAAATGTCGACTTTTACTCAGGTATAGTGCTAAGAGCTATGGGGGTTCCGGTAGATATGTATA
CTGCATTCTTTGCCTTGGCACGGACGTCTGGATGGGCATCTCAATGGTATGAGATGATTCAAAGTGATGAAGGGAAACGG
ATCAGCCGCCCACGCCAGTTATACACAGGAAAATAA

Upstream 100 bases:

>100_bases
GCCGAGAGTAAATCGGGTGGTATACGACGTAACTTCAAAGCCACCAGCGACGATCGAGTGGGAATAGAAACAGTAATAAA
TTGTATTATCAGAGTATTAT

Downstream 100 bases:

>100_bases
GTGGTTTCAAACTCACGTATTGTATACAGTTCCTGCAAAGCACCTGTAGGGGTGTGTATTGCTTGTGTTTTCAGTAGTTA
TAGGGTTACGAAAGCGCACA

Product: citrate synthase I

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MVEKAVLECGDRRISLPVLRGTDGTPVVDITTLYRENNVLTYDPGFMSTAACRSEITFIDGNKGTLRYRGIDIENLIGTP
NSFSSIVYLLLKGTLPSETEHEEFVRILGAEYDVPEQVMNVIRSFPRDSHPMAILIASFSALAANYHASRIDPLTGAIIA
IAKVPGIVASIYRHTANLDFIQADANLEYTHHFIRMMFGDMDDAHRDIMHKALDAIFIMHADHEQNASTSTVRMTGSSGA
GLFACLCAGVATLWGPAHGGANEAVIKMLAEIGSPENVSSFIDKVKNNKGKSRLMGFGHRVYKSYDPRARVLRTICKDVL
DSLGRDENLLAVAEELESQALQDEYFIERKLYPNVDFYSGIVLRAMGVPVDMYTAFFALARTSGWASQWYEMIQSDEGKR
ISRPRQLYTGK

Sequences:

>Translated_411_residues
MVEKAVLECGDRRISLPVLRGTDGTPVVDITTLYRENNVLTYDPGFMSTAACRSEITFIDGNKGTLRYRGIDIENLIGTP
NSFSSIVYLLLKGTLPSETEHEEFVRILGAEYDVPEQVMNVIRSFPRDSHPMAILIASFSALAANYHASRIDPLTGAIIA
IAKVPGIVASIYRHTANLDFIQADANLEYTHHFIRMMFGDMDDAHRDIMHKALDAIFIMHADHEQNASTSTVRMTGSSGA
GLFACLCAGVATLWGPAHGGANEAVIKMLAEIGSPENVSSFIDKVKNNKGKSRLMGFGHRVYKSYDPRARVLRTICKDVL
DSLGRDENLLAVAEELESQALQDEYFIERKLYPNVDFYSGIVLRAMGVPVDMYTAFFALARTSGWASQWYEMIQSDEGKR
ISRPRQLYTGK
>Mature_411_residues
MVEKAVLECGDRRISLPVLRGTDGTPVVDITTLYRENNVLTYDPGFMSTAACRSEITFIDGNKGTLRYRGIDIENLIGTP
NSFSSIVYLLLKGTLPSETEHEEFVRILGAEYDVPEQVMNVIRSFPRDSHPMAILIASFSALAANYHASRIDPLTGAIIA
IAKVPGIVASIYRHTANLDFIQADANLEYTHHFIRMMFGDMDDAHRDIMHKALDAIFIMHADHEQNASTSTVRMTGSSGA
GLFACLCAGVATLWGPAHGGANEAVIKMLAEIGSPENVSSFIDKVKNNKGKSRLMGFGHRVYKSYDPRARVLRTICKDVL
DSLGRDENLLAVAEELESQALQDEYFIERKLYPNVDFYSGIVLRAMGVPVDMYTAFFALARTSGWASQWYEMIQSDEGKR
ISRPRQLYTGK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=389, Percent_Identity=25.4498714652956, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786939, Length=408, Percent_Identity=49.2647058823529, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1786527, Length=350, Percent_Identity=29.7142857142857, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17555174, Length=392, Percent_Identity=26.7857142857143, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319850, Length=350, Percent_Identity=26.2857142857143, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324328, Length=351, Percent_Identity=26.7806267806268, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=389, Percent_Identity=25.1928020565553, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24640126, Length=372, Percent_Identity=26.8817204301075, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640124, Length=372, Percent_Identity=26.8817204301075, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356863, Length=395, Percent_Identity=27.0886075949367, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 45621; Mature: 45621

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKAVLECGDRRISLPVLRGTDGTPVVDITTLYRENNVLTYDPGFMSTAACRSEITFID
CCCHHHHHCCCCEEEEEEEECCCCCCEEEEEEEEECCCEEEECCCCHHHHHHHCCEEEEE
GNKGTLRYRGIDIENLIGTPNSFSSIVYLLLKGTLPSETEHEEFVRILGAEYDVPEQVMN
CCCCEEEEECCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHH
VIRSFPRDSHPMAILIASFSALAANYHASRIDPLTGAIIAIAKVPGIVASIYRHTANLDF
HHHHCCCCCCCCEEHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
IQADANLEYTHHFIRMMFGDMDDAHRDIMHKALDAIFIMHADHEQNASTSTVRMTGSSGA
EEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEECCCCC
GLFACLCAGVATLWGPAHGGANEAVIKMLAEIGSPENVSSFIDKVKNNKGKSRLMGFGHR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
VYKSYDPRARVLRTICKDVLDSLGRDENLLAVAEELESQALQDEYFIERKLYPNVDFYSG
HHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IVLRAMGVPVDMYTAFFALARTSGWASQWYEMIQSDEGKRISRPRQLYTGK
HHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MVEKAVLECGDRRISLPVLRGTDGTPVVDITTLYRENNVLTYDPGFMSTAACRSEITFID
CCCHHHHHCCCCEEEEEEEECCCCCCEEEEEEEEECCCEEEECCCCHHHHHHHCCEEEEE
GNKGTLRYRGIDIENLIGTPNSFSSIVYLLLKGTLPSETEHEEFVRILGAEYDVPEQVMN
CCCCEEEEECCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHH
VIRSFPRDSHPMAILIASFSALAANYHASRIDPLTGAIIAIAKVPGIVASIYRHTANLDF
HHHHCCCCCCCCEEHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
IQADANLEYTHHFIRMMFGDMDDAHRDIMHKALDAIFIMHADHEQNASTSTVRMTGSSGA
EEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEECCCCC
GLFACLCAGVATLWGPAHGGANEAVIKMLAEIGSPENVSSFIDKVKNNKGKSRLMGFGHR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
VYKSYDPRARVLRTICKDVLDSLGRDENLLAVAEELESQALQDEYFIERKLYPNVDFYSG
HHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IVLRAMGVPVDMYTAFFALARTSGWASQWYEMIQSDEGKRISRPRQLYTGK
HHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112124; 9823893; 7557459 [H]