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The map label for this gene is gcp

Identifier: 88607637

GI number: 88607637

Start: 652281

End: 653309

Strand: Direct

Name: gcp

Synonym: APH_0626

Alternate gene names: 88607637

Gene position: 652281-653309 (Clockwise)

Preceding gene: 88607856

Following gene: 88607213

Centisome position: 44.33

GC content: 45.87

Gene sequence:

>1029_bases
GTGGGTGAAGTACTACTAGGAATAGAGACGAGTTGTGATGAGACTGCTGTTGCTATATTGACCGACAGTGGGGAAGTCTT
TGCGCATGAGGTCTTATCTCAAGTAGAGCATTCTGCATATGGTGGGGTGGTTCCTGAAATAGCTGCACGTGCTCACTACG
ATTTCCTGCAAGTGCTCGTGAAGAAGGCAATGAGCAATTCAGGTCTAAAATTCGATGATCTTTCAAGTATAGCTGTTACA
GCCGGGCCCGGGTTAGTAGGTTCTTTGATTGTGGGTGTTATGTTTGCAAAGGCTGTTTCCTATGCAACGAAAAAGCCTAT
CATAGCGGTAAATCATTTAGAAGCCCATGCTTTAGTAGCGCGGATGAATCAAGAGATTGTCTTTCCTTTTCTTGTCCTTA
TTGTTTCGGGCGGCCATTGTCAGTTTATGTTAGCTCATGACGTTGGTTGCTACAGTAAATTGGGCGGTGCAATTGATGAT
TCACTAGGTGAAGCGTTTGATAAAGTAGCGCGAATGCTTGGGTTAGGGTATCCGGGTGGTCCGGCTGTAGAATGTAAGGC
TAAGAATGGTCGTGGGGATAGATTCTTTTTCCCTCGGGCTTTACATAATAGACCTGGCTGTGATTTTTCATTTTCAGGAT
TAAAGACAGCGGTTCGTTATGCGATCGAGAGAGAAGGGCCTCTGGATGAAGAAATGGTATGTGACATATGTGCATCTTTT
CAGGAATGCGTTGGTGATATACTGGTGAGTAGGATACGGAATGCCATAAAGGCTGCTAGACAACTGAAGGAGGGTATAGA
TAAGCTGGTGGTTACTGGTGGGGTAGCATCGAATGGATTTTTAAGAACTATTATATCGCAGTGCGCAGAAGACATGGGTG
TTACTGCGGTATTCCCGCCACGCGAACTATGCACGGACAATGGCATAATGGTGGCTTGGGCAGGGGTGGAGAACTTCCGT
AAGGGTAACGCAGTTGCTTCACTAGGATTTGCTCCCAGAGCTAGATGGACTATGGAAAGCATTAGCTAG

Upstream 100 bases:

>100_bases
GATCTTCCGGGGGCATCAACAAGAGGTAGTGCGTTTGAGGTGCCATTGCATGAGGGTGCAGAAAAGTTTTATAGAGACTT
TGGTCTAATAACAGGCTAGC

Downstream 100 bases:

>100_bases
CCTTTTCTTTATACTGAAGTAAACTCTTTCTTGTTACTACTACAGTATTCGCCAGCATGTCGTGCCATGCCCTTTTTCTT
GAGTCAAAATTGGACCAAAT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MGEVLLGIETSCDETAVAILTDSGEVFAHEVLSQVEHSAYGGVVPEIAARAHYDFLQVLVKKAMSNSGLKFDDLSSIAVT
AGPGLVGSLIVGVMFAKAVSYATKKPIIAVNHLEAHALVARMNQEIVFPFLVLIVSGGHCQFMLAHDVGCYSKLGGAIDD
SLGEAFDKVARMLGLGYPGGPAVECKAKNGRGDRFFFPRALHNRPGCDFSFSGLKTAVRYAIEREGPLDEEMVCDICASF
QECVGDILVSRIRNAIKAARQLKEGIDKLVVTGGVASNGFLRTIISQCAEDMGVTAVFPPRELCTDNGIMVAWAGVENFR
KGNAVASLGFAPRARWTMESIS

Sequences:

>Translated_342_residues
MGEVLLGIETSCDETAVAILTDSGEVFAHEVLSQVEHSAYGGVVPEIAARAHYDFLQVLVKKAMSNSGLKFDDLSSIAVT
AGPGLVGSLIVGVMFAKAVSYATKKPIIAVNHLEAHALVARMNQEIVFPFLVLIVSGGHCQFMLAHDVGCYSKLGGAIDD
SLGEAFDKVARMLGLGYPGGPAVECKAKNGRGDRFFFPRALHNRPGCDFSFSGLKTAVRYAIEREGPLDEEMVCDICASF
QECVGDILVSRIRNAIKAARQLKEGIDKLVVTGGVASNGFLRTIISQCAEDMGVTAVFPPRELCTDNGIMVAWAGVENFR
KGNAVASLGFAPRARWTMESIS
>Mature_341_residues
GEVLLGIETSCDETAVAILTDSGEVFAHEVLSQVEHSAYGGVVPEIAARAHYDFLQVLVKKAMSNSGLKFDDLSSIAVTA
GPGLVGSLIVGVMFAKAVSYATKKPIIAVNHLEAHALVARMNQEIVFPFLVLIVSGGHCQFMLAHDVGCYSKLGGAIDDS
LGEAFDKVARMLGLGYPGGPAVECKAKNGRGDRFFFPRALHNRPGCDFSFSGLKTAVRYAIEREGPLDEEMVCDICASFQ
ECVGDILVSRIRNAIKAARQLKEGIDKLVVTGGVASNGFLRTIISQCAEDMGVTAVFPPRELCTDNGIMVAWAGVENFRK
GNAVASLGFAPRARWTMESIS

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=340, Percent_Identity=39.4117647058824, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI8923380, Length=320, Percent_Identity=29.6875, Blast_Score=122, Evalue=7e-28,
Organism=Escherichia coli, GI1789445, Length=339, Percent_Identity=42.1828908554572, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17557464, Length=326, Percent_Identity=33.1288343558282, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71995670, Length=322, Percent_Identity=31.6770186335404, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6320099, Length=366, Percent_Identity=31.9672131147541, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6322891, Length=357, Percent_Identity=25.7703081232493, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20129063, Length=339, Percent_Identity=39.2330383480826, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI21357207, Length=329, Percent_Identity=29.1793313069909, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_ANAPZ (Q2GK88)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505213.1
- ProteinModelPortal:   Q2GK88
- SMR:   Q2GK88
- STRING:   Q2GK88
- MEROPS:   M22.001
- GeneID:   3930901
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0626
- NMPDR:   fig|212042.5.peg.613
- TIGR:   APH_0626
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PLYGVNH
- PhylomeDB:   Q2GK88
- ProtClustDB:   PRK09604
- BioCyc:   APHA212042:APH_0626-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36508; Mature: 36376

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEVLLGIETSCDETAVAILTDSGEVFAHEVLSQVEHSAYGGVVPEIAARAHYDFLQVLV
CCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KKAMSNSGLKFDDLSSIAVTAGPGLVGSLIVGVMFAKAVSYATKKPIIAVNHLEAHALVA
HHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
RMNQEIVFPFLVLIVSGGHCQFMLAHDVGCYSKLGGAIDDSLGEAFDKVARMLGLGYPGG
HHCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
PAVECKAKNGRGDRFFFPRALHNRPGCDFSFSGLKTAVRYAIEREGPLDEEMVCDICASF
CEEEEECCCCCCCCEECCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QECVGDILVSRIRNAIKAARQLKEGIDKLVVTGGVASNGFLRTIISQCAEDMGVTAVFPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCEEECCC
RELCTDNGIMVAWAGVENFRKGNAVASLGFAPRARWTMESIS
HHHHCCCCEEEEECCHHHHCCCCCEEECCCCCCCCCCHHCCC
>Mature Secondary Structure 
GEVLLGIETSCDETAVAILTDSGEVFAHEVLSQVEHSAYGGVVPEIAARAHYDFLQVLV
CCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KKAMSNSGLKFDDLSSIAVTAGPGLVGSLIVGVMFAKAVSYATKKPIIAVNHLEAHALVA
HHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
RMNQEIVFPFLVLIVSGGHCQFMLAHDVGCYSKLGGAIDDSLGEAFDKVARMLGLGYPGG
HHCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
PAVECKAKNGRGDRFFFPRALHNRPGCDFSFSGLKTAVRYAIEREGPLDEEMVCDICASF
CEEEEECCCCCCCCEECCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QECVGDILVSRIRNAIKAARQLKEGIDKLVVTGGVASNGFLRTIISQCAEDMGVTAVFPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCEEECCC
RELCTDNGIMVAWAGVENFRKGNAVASLGFAPRARWTMESIS
HHHHCCCCEEEEECCHHHHCCCCCEEECCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA