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The map label for this gene is hemA [H]

Identifier: 88607512

GI number: 88607512

Start: 1313674

End: 1314918

Strand: Reverse

Name: hemA [H]

Synonym: APH_1243

Alternate gene names: 88607512

Gene position: 1314918-1313674 (Counterclockwise)

Preceding gene: 88607296

Following gene: 88607879

Centisome position: 89.37

GC content: 43.29

Gene sequence:

>1245_bases
ATGATAGATTACGAGGAAGTGTTTCGTGAGAGAATCAATGGCATAAAAGAAGAAGGTAGATACCGAGAGTTTACGGGGTT
TCGTCGTGTTCCTGGTAGGTTTCCATATGCTATTGAGTGCCAAACAGAGCGGGTAGTTACGCTATGGTGCAGTAATGATT
ATCTAGGAATGAGCCAGCACGAAAGCGTGTTATCTGCTGCTAGGAACCTAAATGTTAATGTGGGTGCTGGGGGCACTAGA
AATATTTCCGGTACTACTGAGGAAGTTATTGAGCTCGAACGTTCTCTTGCAGATCTACATAACAAACCTGCAGCATTGGC
CTTTGTGTGTGGTTACGTTGCGAATCAGACAAGTATAAGCACTATTTTGGCCACAATTCCGGATGTTGTGGTTTTTTCAG
ATGAGAAAAATCACTCTTCCATGATTGAGGGAATACGCGCTGGTAACAGAGTCAAACACATCTTCAGACATAATGATGTA
GAACATTTGGAGAGTTTGCTAAAGGCCGCAGGGGCTAGTCCTAAGATTATACTCTTTGAGTCCGTATACTCTATGGATGG
GGATATAGCTCCTATCAAGGAAATATGTGACTTGGCCAGCAAGTACAATGCTATAACGTATCTCGATGAGGTACACGCTG
TAGGGTTATATGGTGCTCGTGGGGGAGGCATATCAGAGATGGAAGGCCTTGCAGATAGGATTTCCGTTATACAGGGCACC
TTATCTAAGGCTTTTGGAGTTATGGGAGGCTATGTTGCGGCATCAAAGAGCCTTGTGGATGTTATCAGGAGTTTTGCTCC
TGGATTCATATTTACTACGGCTATATCACCGTTGATAGCTGCGTCTGCTCGTGCAAGTGTTGAGCATTTAAAAAACAGTA
ATATAGAACGAGAGAAGCATAGGGAAGTTATAGCCAAAGTGAAGAGTGCTTTGCTGCAGGCTGGTATTGAGTTTCTTATG
ACGGACACTCATATAATTCCTGTTATCATAGGGGATGCAACGATATGCAAGCAAGTTTCACAAGCTCTGTTGCGTGACCA
TGGAATATATATTCAATCCATTAATTACCCTACTGTGCCATTGGGGACTGAGAGGCTCAGAATCACACCTACCCCGTACC
ATACTGATGAAATGATAGATCACTTAGTCAAAGGGCTACAGGAAGTGTTTTCGAGGTTTTCGGTACCTGCGGGAAGGAGT
TATGCATATTTTGAGGCATTAGGTAAGTTAAAAGAAAGTCGTTAG

Upstream 100 bases:

>100_bases
ACGTTTGCATTATGCGGGATTAGTTGCGGTATATTGCAGCGATTAGTAGTAAAGCGCAGCATGTAGTTGTATTATCATAA
TAAATGTCGAGTTAACTCCT

Downstream 100 bases:

>100_bases
TCATGTGTATGGGCAAAGGGTATTCAGATACGTGGTTAGGCTGACACTAGCGAATAAGTCAGGGTGGCGCTAGGCAAGTA
TATCCATACCTAAAAGGATG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MIDYEEVFRERINGIKEEGRYREFTGFRRVPGRFPYAIECQTERVVTLWCSNDYLGMSQHESVLSAARNLNVNVGAGGTR
NISGTTEEVIELERSLADLHNKPAALAFVCGYVANQTSISTILATIPDVVVFSDEKNHSSMIEGIRAGNRVKHIFRHNDV
EHLESLLKAAGASPKIILFESVYSMDGDIAPIKEICDLASKYNAITYLDEVHAVGLYGARGGGISEMEGLADRISVIQGT
LSKAFGVMGGYVAASKSLVDVIRSFAPGFIFTTAISPLIAASARASVEHLKNSNIEREKHREVIAKVKSALLQAGIEFLM
TDTHIIPVIIGDATICKQVSQALLRDHGIYIQSINYPTVPLGTERLRITPTPYHTDEMIDHLVKGLQEVFSRFSVPAGRS
YAYFEALGKLKESR

Sequences:

>Translated_414_residues
MIDYEEVFRERINGIKEEGRYREFTGFRRVPGRFPYAIECQTERVVTLWCSNDYLGMSQHESVLSAARNLNVNVGAGGTR
NISGTTEEVIELERSLADLHNKPAALAFVCGYVANQTSISTILATIPDVVVFSDEKNHSSMIEGIRAGNRVKHIFRHNDV
EHLESLLKAAGASPKIILFESVYSMDGDIAPIKEICDLASKYNAITYLDEVHAVGLYGARGGGISEMEGLADRISVIQGT
LSKAFGVMGGYVAASKSLVDVIRSFAPGFIFTTAISPLIAASARASVEHLKNSNIEREKHREVIAKVKSALLQAGIEFLM
TDTHIIPVIIGDATICKQVSQALLRDHGIYIQSINYPTVPLGTERLRITPTPYHTDEMIDHLVKGLQEVFSRFSVPAGRS
YAYFEALGKLKESR
>Mature_414_residues
MIDYEEVFRERINGIKEEGRYREFTGFRRVPGRFPYAIECQTERVVTLWCSNDYLGMSQHESVLSAARNLNVNVGAGGTR
NISGTTEEVIELERSLADLHNKPAALAFVCGYVANQTSISTILATIPDVVVFSDEKNHSSMIEGIRAGNRVKHIFRHNDV
EHLESLLKAAGASPKIILFESVYSMDGDIAPIKEICDLASKYNAITYLDEVHAVGLYGARGGGISEMEGLADRISVIQGT
LSKAFGVMGGYVAASKSLVDVIRSFAPGFIFTTAISPLIAASARASVEHLKNSNIEREKHREVIAKVKSALLQAGIEFLM
TDTHIIPVIIGDATICKQVSQALLRDHGIYIQSINYPTVPLGTERLRITPTPYHTDEMIDHLVKGLQEVFSRFSVPAGRS
YAYFEALGKLKESR

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=405, Percent_Identity=42.962962962963, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI83977444, Length=405, Percent_Identity=42.962962962963, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI83977440, Length=405, Percent_Identity=42.962962962963, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI4502025, Length=439, Percent_Identity=43.7357630979499, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI40316939, Length=439, Percent_Identity=43.7357630979499, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI7657118, Length=345, Percent_Identity=33.9130434782609, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=33.9130434782609, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI119220554, Length=360, Percent_Identity=29.4444444444444, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4758668, Length=361, Percent_Identity=29.3628808864266, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=27.0161290322581, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1790046, Length=355, Percent_Identity=32.6760563380282, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1786993, Length=342, Percent_Identity=31.2865497076023, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=399, Percent_Identity=32.3308270676692, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=29.2682926829268, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560914, Length=356, Percent_Identity=27.8089887640449, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560912, Length=356, Percent_Identity=27.8089887640449, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=226, Percent_Identity=25.6637168141593, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=231, Percent_Identity=25.1082251082251, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=425, Percent_Identity=44.7058823529412, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320267, Length=426, Percent_Identity=25.8215962441315, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=258, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137420, Length=396, Percent_Identity=47.2222222222222, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=31.701030927835, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI17136286, Length=325, Percent_Identity=29.5384615384615, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24653280, Length=260, Percent_Identity=25, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24653276, Length=260, Percent_Identity=25, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24653278, Length=260, Percent_Identity=25, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 45582; Mature: 45582

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYEEVFRERINGIKEEGRYREFTGFRRVPGRFPYAIECQTERVVTLWCSNDYLGMSQH
CCCHHHHHHHHHHCHHHCCCCHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCHHH
ESVLSAARNLNVNVGAGGTRNISGTTEEVIELERSLADLHNKPAALAFVCGYVANQTSIS
HHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHH
TILATIPDVVVFSDEKNHSSMIEGIRAGNRVKHIFRHNDVEHLESLLKAAGASPKIILFE
HHHHHHCCEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEE
SVYSMDGDIAPIKEICDLASKYNAITYLDEVHAVGLYGARGGGISEMEGLADRISVIQGT
HHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHH
LSKAFGVMGGYVAASKSLVDVIRSFAPGFIFTTAISPLIAASARASVEHLKNSNIEREKH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
REVIAKVKSALLQAGIEFLMTDTHIIPVIIGDATICKQVSQALLRDHGIYIQSINYPTVP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCC
LGTERLRITPTPYHTDEMIDHLVKGLQEVFSRFSVPAGRSYAYFEALGKLKESR
CCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDYEEVFRERINGIKEEGRYREFTGFRRVPGRFPYAIECQTERVVTLWCSNDYLGMSQH
CCCHHHHHHHHHHCHHHCCCCHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCHHH
ESVLSAARNLNVNVGAGGTRNISGTTEEVIELERSLADLHNKPAALAFVCGYVANQTSIS
HHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHH
TILATIPDVVVFSDEKNHSSMIEGIRAGNRVKHIFRHNDVEHLESLLKAAGASPKIILFE
HHHHHHCCEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEE
SVYSMDGDIAPIKEICDLASKYNAITYLDEVHAVGLYGARGGGISEMEGLADRISVIQGT
HHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHH
LSKAFGVMGGYVAASKSLVDVIRSFAPGFIFTTAISPLIAASARASVEHLKNSNIEREKH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
REVIAKVKSALLQAGIEFLMTDTHIIPVIIGDATICKQVSQALLRDHGIYIQSINYPTVP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCC
LGTERLRITPTPYHTDEMIDHLVKGLQEVFSRFSVPAGRSYAYFEALGKLKESR
CCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]