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The map label for this gene is fabZ

Identifier: 88607258

GI number: 88607258

Start: 1276426

End: 1276863

Strand: Reverse

Name: fabZ

Synonym: APH_1208

Alternate gene names: 88607258

Gene position: 1276863-1276426 (Counterclockwise)

Preceding gene: 88607800

Following gene: 88607678

Centisome position: 86.79

GC content: 45.66

Gene sequence:

>438_bases
ATGCAGATGGATCATAAACAGGTAATGCGAGCATTGCCGCACTCTTATCCATTTTTGTTGGTGGACAAAGTGACGGAGTG
TATTCCTGGAGAGTGTATCGTTGCGGTTAAGAATGTTACGTTCAATGAGCCGTTTTTTGTGGGGCATTTTCCTGGTAACC
CCATCATGCCGGGGGTGCTTATTGTAGAGGCTTTGGCGCAGGCTTCTATGTTGTGTGTTGTGTGTGATGCTGATGGGGAG
AGTACGGGTGATACGTCTGTTCTTTTTATGTCCATTGATTCAGCGAGATTTCGCAAGGTTGTAGTGCCGGGGGATGTTTT
AGTGTTGAAATCAAGTGTGTGTCATAGACGTGGTAACAGCTGTAGGTTTGACTGTCGTGCTTATGTAGAAGATGTCTTGG
TGACTGAGGCGCAGATCTTGGCAATGATGAATAAATAG

Upstream 100 bases:

>100_bases
TATGTAGATGAGAAGGCTGATATTACTGAGAAAATATTGGAGACGCTTAATAAAGATTTGTCGCGCGTCAGCCTGGGTAA
TTAGTGAAGACAAGGTGTCT

Downstream 100 bases:

>100_bases
TGGATAAAGCAATGGATATGCAGAAAACAAAAGTGGCTCTTTTATCCGTAACGGATAAGGAGGGAGTAGAGGAGTTGGCT
CGCTTTTTGGTGAAAAACGG

Product: (3R)-hydroxymyristoyl-ACP dehydratase

Products: but-2-enoyl-[acyl-carrier protein]; H2O

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MQMDHKQVMRALPHSYPFLLVDKVTECIPGECIVAVKNVTFNEPFFVGHFPGNPIMPGVLIVEALAQASMLCVVCDADGE
STGDTSVLFMSIDSARFRKVVVPGDVLVLKSSVCHRRGNSCRFDCRAYVEDVLVTEAQILAMMNK

Sequences:

>Translated_145_residues
MQMDHKQVMRALPHSYPFLLVDKVTECIPGECIVAVKNVTFNEPFFVGHFPGNPIMPGVLIVEALAQASMLCVVCDADGE
STGDTSVLFMSIDSARFRKVVVPGDVLVLKSSVCHRRGNSCRFDCRAYVEDVLVTEAQILAMMNK
>Mature_145_residues
MQMDHKQVMRALPHSYPFLLVDKVTECIPGECIVAVKNVTFNEPFFVGHFPGNPIMPGVLIVEALAQASMLCVVCDADGE
STGDTSVLFMSIDSARFRKVVVPGDVLVLKSSVCHRRGNSCRFDCRAYVEDVLVTEAQILAMMNK

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=135, Percent_Identity=42.962962962963, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_ANAPZ (Q2GIR2)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505739.1
- ProteinModelPortal:   Q2GIR2
- SMR:   Q2GIR2
- STRING:   Q2GIR2
- GeneID:   3930096
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_1208
- NMPDR:   fig|212042.5.peg.1158
- TIGR:   APH_1208
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   KNIRADY
- ProtClustDB:   PRK00006
- BioCyc:   APHA212042:APH_1208-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.58

Molecular weight: Translated: 15966; Mature: 15966

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: ACT_SITE 49-49

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
10.3 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
10.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMDHKQVMRALPHSYPFLLVDKVTECIPGECIVAVKNVTFNEPFFVGHFPGNPIMPGVL
CCCCHHHHHHHCCCCCCEEEHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHH
IVEALAQASMLCVVCDADGESTGDTSVLFMSIDSARFRKVVVPGDVLVLKSSVCHRRGNS
HHHHHHHCCEEEEEECCCCCCCCCCEEEEEEECCCCEEEEECCCCEEEEEHHHHHHCCCC
CRFDCRAYVEDVLVTEAQILAMMNK
CEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQMDHKQVMRALPHSYPFLLVDKVTECIPGECIVAVKNVTFNEPFFVGHFPGNPIMPGVL
CCCCHHHHHHHCCCCCCEEEHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHH
IVEALAQASMLCVVCDADGESTGDTSVLFMSIDSARFRKVVVPGDVLVLKSSVCHRRGNS
HHHHHHHCCEEEEEECCCCCCCCCCEEEEEEECCCCEEEEECCCCEEEEEHHHHHHCCCC
CRFDCRAYVEDVLVTEAQILAMMNK
CEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxybutanoyl-[acyl-carrier protein]

Specific reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = but-2-enoyl-[acyl-carrier protein] + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA