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The map label for this gene is coaBC [H]

Identifier: 88607244

GI number: 88607244

Start: 1363367

End: 1363900

Strand: Reverse

Name: coaBC [H]

Synonym: APH_1297

Alternate gene names: 88607244

Gene position: 1363900-1363367 (Counterclockwise)

Preceding gene: 88607063

Following gene: 88606781

Centisome position: 92.7

GC content: 42.13

Gene sequence:

>534_bases
ATGGATATACTACTACTAATAACAGGCAGCGTTGCTGCTTATAAAGCACTTGAGGTTATCAGAGAGTTAAGAAGAAGAAA
ATACAATTTACGTTGCGTTTTAAGTAAGGCGGGAGAACAATTCATCACACCGCTGTCTGTCTCAGCGCTTTCTGATGCTA
ATACTTACACTGAGAGTGACTCCTTTTCTCCGCAGGAGTGTATGAAGCATATTTCTTTGTCCAGGGGTACAGACCTAATA
TTGGTTGTTCCCGCAAGCGCTGATATCATGGGAAAGGCGGCTCATGGTATATGTGATGATCTGCCTACTACGATTCTTAT
GGCGGCTAATGTGCCTGTGATAATGGCTCCGGCTATGAACACTGTAATGTGGCAATCTCCAGCTATGCAGCGTAATTTAA
ATACTTTAAAGCAGGACAAAGTCTTTATTATTGAACCGGAAACAGGGATACTTGCTTGCGGTGAGGAAGGCCCGGGAAAA
ATGGCAAAAGTTGAAGATATAGTGGCATTTGTGGAAAAATTTCAGAAATGTTAG

Upstream 100 bases:

>100_bases
TGCTGGAAAACATCCCAGGTACTTCAGGTAATTTTGCAGTTTTGCCTACACGATTAGAAGGACTTGATGAAGAATTGTGT
ATTATTGCCATAGGTTAGAG

Downstream 100 bases:

>100_bases
TAGCGCTATAACTGCAACATTTCGGTTTCTGAACCTATCGCAATCAAGCTTCACATTTTTCATACAAATTTATGAAAGAT
GTCATGAGCCCGAAAGGGAA

Product: phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MDILLLITGSVAAYKALEVIRELRRRKYNLRCVLSKAGEQFITPLSVSALSDANTYTESDSFSPQECMKHISLSRGTDLI
LVVPASADIMGKAAHGICDDLPTTILMAANVPVIMAPAMNTVMWQSPAMQRNLNTLKQDKVFIIEPETGILACGEEGPGK
MAKVEDIVAFVEKFQKC

Sequences:

>Translated_177_residues
MDILLLITGSVAAYKALEVIRELRRRKYNLRCVLSKAGEQFITPLSVSALSDANTYTESDSFSPQECMKHISLSRGTDLI
LVVPASADIMGKAAHGICDDLPTTILMAANVPVIMAPAMNTVMWQSPAMQRNLNTLKQDKVFIIEPETGILACGEEGPGK
MAKVEDIVAFVEKFQKC
>Mature_177_residues
MDILLLITGSVAAYKALEVIRELRRRKYNLRCVLSKAGEQFITPLSVSALSDANTYTESDSFSPQECMKHISLSRGTDLI
LVVPASADIMGKAAHGICDDLPTTILMAANVPVIMAPAMNTVMWQSPAMQRNLNTLKQDKVFIIEPETGILACGEEGPGK
MAKVEDIVAFVEKFQKC

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=176, Percent_Identity=36.3636363636364, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI87082301, Length=162, Percent_Identity=40.1234567901235, Blast_Score=127, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17560194, Length=179, Percent_Identity=34.6368715083799, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=190, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=29.7297297297297, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 19333; Mature: 19333

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILLLITGSVAAYKALEVIRELRRRKYNLRCVLSKAGEQFITPLSVSALSDANTYTESD
CCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCHHHHHCCCCCCCCCC
SFSPQECMKHISLSRGTDLILVVPASADIMGKAAHGICDDLPTTILMAANVPVIMAPAMN
CCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEHHCCCCEEECCCCC
TVMWQSPAMQRNLNTLKQDKVFIIEPETGILACGEEGPGKMAKVEDIVAFVEKFQKC
HHHCCCCHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDILLLITGSVAAYKALEVIRELRRRKYNLRCVLSKAGEQFITPLSVSALSDANTYTESD
CCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCHHHHHCCCCCCCCCC
SFSPQECMKHISLSRGTDLILVVPASADIMGKAAHGICDDLPTTILMAANVPVIMAPAMN
CCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEHHCCCCEEECCCCC
TVMWQSPAMQRNLNTLKQDKVFIIEPETGILACGEEGPGKMAKVEDIVAFVEKFQKC
HHHCCCCHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]