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The map label for this gene is uvrC

Identifier: 88607092

GI number: 88607092

Start: 939819

End: 941663

Strand: Direct

Name: uvrC

Synonym: APH_0884

Alternate gene names: 88607092

Gene position: 939819-941663 (Clockwise)

Preceding gene: 88606912

Following gene: 88607664

Centisome position: 63.88

GC content: 40.6

Gene sequence:

>1845_bases
GTGAAAAACTCAAATGAACGCTTGAATGACGCTTTTTACGCTCTAAAAAAAGCTACATGTTCTGTCCGGAAAAGCGTTCC
CGGAGTATACAAGATGTTTGGCACAGAAGACCGCCTACTCTATGTAGGGAAAGCAAAAGACCTGAAAAAGCGGCTGAGTA
GCTACTTAAGCATTAATAGAATGTCTGTTAATGTGTATACGATGGTGAAGCAGATCGTCAGACTGGAAATTACCGTAACA
GAGAATGAAACAGAAGCGCTGCTACTGGAAGCAAAGCTGATAAAGTCCCTGAAGCCAAAGTACAATATAATCATGAGGGA
CGATAAATTTTATCCTTATATATTGTTTTCAAAGCATAAATATCCCCGTATCGTACTTCATAGAGAAAAGAGATCCGAGG
GACGCTATACCGGATTATACGGCCCATTTTTATCGTCTGTCATGACAAGGCACATAATTGCAACAATCAAAAAAGCGTTT
CTACTACGGTCGTGTCCGGATAACTTTTTCGCTACAAGAGCCAGACCATGCATTGAGTACGAAATTAAAAATTGCTCAGC
GCCCTGCATGCAAAAAATCACAGAAGAAGATTACGCAAAAGCGGTACAAATGGCCCACAAAGCCCTCACGGGACAGAGTA
AAGAAATACAGTGCGAGCTGTTTGAGATGATGTGCAGGTTTAGCAATAATCAAGATTATGAAAGTGCTATAGTATGCCGT
GATAGGCTGCATGCTCTCAAATCCATGAAGGAATGCATGGGATTTCAGACGGGAATACATGGTGATGTGGACTTCATAGC
CGTTTACAAACGCCAAGACTTATACTGTATGCAAGTGGTTTTTTTTAGAGATGGAGTAAATTACGGAAGCCAGCCTTATT
TTATAGAAAGCGTCGGTAATGCATCAGACGCAGATATTGTAAATATGTTTATGTTGCAAATATACAATGATTTTCCTTCT
GTAGTCTATGTAGACCTGCCTTCCGATTATGACACTAACATAATGAGCACTGCCATTAAGCAGCTTATGAAGCGCGAAGT
AGATATTAGGCTTCCCGCTACTAGAGATGAATTGAAAGCTATGGGATTAGCTCGGAATTACGCTATGGAAGCCTTAAATC
GTAGGGTACGAAATACTGCGCAAGATACAGATTTAGAAGAATTTGCCACATTTTTTGATTTACTGAAAGCGCCTGAAAGA
ATAGAGATATACGATAATAGCCACATTTCTGGCACTCATCCGTATGGAGTCATGGTAGTGTGCGGAAAAGATGGTCTCCT
AAAAAAAGAGTATAGGAAGTTTAAGATAAATACCGTAACCAACGGTGATGATTGCTCTATGATGCATGAAGTTATCTCCC
GCAGGTTTAAAGAGATACCAGATGTATTGCCTGATTTTATCCTAATTGATGGAGGTCGCGGCCAGAGATCAGCAGTATAT
GGCGAACTATCGCGCCTGGGTATACCGTTTGCATGTATTGCAAAGGGTCCTGGACGCGTAGCTGGCACAGAGGTTTTTTA
TTTTTCAAATGGAGAAAAGCTGTCTTTAGATCCAGCGAGTAAGCTTATGCACTTTCTTTGTAGATTACGTGACGAAGCAC
ACAGATTTGCCATAACTTCTCATAGAAAAAGCCGTGATGGTAAGCTGCAATTCTCTACACTCCTTAATGATATTCCAGGT
ATTGGAAAAACTAAAGGCAAAGCAATACTAGCTTATTTTGGTTCCATTCAAGCAATGAAACATGCTCGAGTGGAGGAAAT
AAGCAAGGTTCCTGGAATTAGTTTAAAACTAGCAAAACGCGTAGCAGACTATCTTAAAGAGTCGCAAACTACGTTACGTG
CATGA

Upstream 100 bases:

>100_bases
TCTTATCCCATAATAAAAGCGTGTATTCTGCGTTGAAGACCACAAAACTGTTATAAGTTATAATCACATAAAGGCACCAT
TAAGAATATGTAGAAATATC

Downstream 100 bases:

>100_bases
ATACTAAAGAGTAACTGAGCATTATTATCACATCGTACTTTGATCGCAAAAACCCCTATCAACTTTGCTTTCAGTAGTAG
TGCCTTAGCTTTCCGTTACG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MKNSNERLNDAFYALKKATCSVRKSVPGVYKMFGTEDRLLYVGKAKDLKKRLSSYLSINRMSVNVYTMVKQIVRLEITVT
ENETEALLLEAKLIKSLKPKYNIIMRDDKFYPYILFSKHKYPRIVLHREKRSEGRYTGLYGPFLSSVMTRHIIATIKKAF
LLRSCPDNFFATRARPCIEYEIKNCSAPCMQKITEEDYAKAVQMAHKALTGQSKEIQCELFEMMCRFSNNQDYESAIVCR
DRLHALKSMKECMGFQTGIHGDVDFIAVYKRQDLYCMQVVFFRDGVNYGSQPYFIESVGNASDADIVNMFMLQIYNDFPS
VVYVDLPSDYDTNIMSTAIKQLMKREVDIRLPATRDELKAMGLARNYAMEALNRRVRNTAQDTDLEEFATFFDLLKAPER
IEIYDNSHISGTHPYGVMVVCGKDGLLKKEYRKFKINTVTNGDDCSMMHEVISRRFKEIPDVLPDFILIDGGRGQRSAVY
GELSRLGIPFACIAKGPGRVAGTEVFYFSNGEKLSLDPASKLMHFLCRLRDEAHRFAITSHRKSRDGKLQFSTLLNDIPG
IGKTKGKAILAYFGSIQAMKHARVEEISKVPGISLKLAKRVADYLKESQTTLRA

Sequences:

>Translated_614_residues
MKNSNERLNDAFYALKKATCSVRKSVPGVYKMFGTEDRLLYVGKAKDLKKRLSSYLSINRMSVNVYTMVKQIVRLEITVT
ENETEALLLEAKLIKSLKPKYNIIMRDDKFYPYILFSKHKYPRIVLHREKRSEGRYTGLYGPFLSSVMTRHIIATIKKAF
LLRSCPDNFFATRARPCIEYEIKNCSAPCMQKITEEDYAKAVQMAHKALTGQSKEIQCELFEMMCRFSNNQDYESAIVCR
DRLHALKSMKECMGFQTGIHGDVDFIAVYKRQDLYCMQVVFFRDGVNYGSQPYFIESVGNASDADIVNMFMLQIYNDFPS
VVYVDLPSDYDTNIMSTAIKQLMKREVDIRLPATRDELKAMGLARNYAMEALNRRVRNTAQDTDLEEFATFFDLLKAPER
IEIYDNSHISGTHPYGVMVVCGKDGLLKKEYRKFKINTVTNGDDCSMMHEVISRRFKEIPDVLPDFILIDGGRGQRSAVY
GELSRLGIPFACIAKGPGRVAGTEVFYFSNGEKLSLDPASKLMHFLCRLRDEAHRFAITSHRKSRDGKLQFSTLLNDIPG
IGKTKGKAILAYFGSIQAMKHARVEEISKVPGISLKLAKRVADYLKESQTTLRA
>Mature_614_residues
MKNSNERLNDAFYALKKATCSVRKSVPGVYKMFGTEDRLLYVGKAKDLKKRLSSYLSINRMSVNVYTMVKQIVRLEITVT
ENETEALLLEAKLIKSLKPKYNIIMRDDKFYPYILFSKHKYPRIVLHREKRSEGRYTGLYGPFLSSVMTRHIIATIKKAF
LLRSCPDNFFATRARPCIEYEIKNCSAPCMQKITEEDYAKAVQMAHKALTGQSKEIQCELFEMMCRFSNNQDYESAIVCR
DRLHALKSMKECMGFQTGIHGDVDFIAVYKRQDLYCMQVVFFRDGVNYGSQPYFIESVGNASDADIVNMFMLQIYNDFPS
VVYVDLPSDYDTNIMSTAIKQLMKREVDIRLPATRDELKAMGLARNYAMEALNRRVRNTAQDTDLEEFATFFDLLKAPER
IEIYDNSHISGTHPYGVMVVCGKDGLLKKEYRKFKINTVTNGDDCSMMHEVISRRFKEIPDVLPDFILIDGGRGQRSAVY
GELSRLGIPFACIAKGPGRVAGTEVFYFSNGEKLSLDPASKLMHFLCRLRDEAHRFAITSHRKSRDGKLQFSTLLNDIPG
IGKTKGKAILAYFGSIQAMKHARVEEISKVPGISLKLAKRVADYLKESQTTLRA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=619, Percent_Identity=35.3796445880452, Blast_Score=376, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_ANAPZ (Q2GJJ1)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505460.1
- ProteinModelPortal:   Q2GJJ1
- SMR:   Q2GJJ1
- STRING:   Q2GJJ1
- GeneID:   3930235
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0884
- NMPDR:   fig|212042.5.peg.838
- TIGR:   APH_0884
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q2GJJ1
- ProtClustDB:   PRK00558
- BioCyc:   APHA212042:APH_0884-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70157; Mature: 70157

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSNERLNDAFYALKKATCSVRKSVPGVYKMFGTEDRLLYVGKAKDLKKRLSSYLSINR
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHH
MSVNVYTMVKQIVRLEITVTENETEALLLEAKLIKSLKPKYNIIMRDDKFYPYILFSKHK
EEEHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCC
YPRIVLHREKRSEGRYTGLYGPFLSSVMTRHIIATIKKAFLLRSCPDNFFATRARPCIEY
CCEEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEE
EIKNCSAPCMQKITEEDYAKAVQMAHKALTGQSKEIQCELFEMMCRFSNNQDYESAIVCR
EECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
DRLHALKSMKECMGFQTGIHGDVDFIAVYKRQDLYCMQVVFFRDGVNYGSQPYFIESVGN
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCC
ASDADIVNMFMLQIYNDFPSVVYVDLPSDYDTNIMSTAIKQLMKREVDIRLPATRDELKA
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEECCCCHHHHHH
MGLARNYAMEALNRRVRNTAQDTDLEEFATFFDLLKAPERIEIYDNSHISGTHPYGVMVV
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEE
CGKDGLLKKEYRKFKINTVTNGDDCSMMHEVISRRFKEIPDVLPDFILIDGGRGQRSAVY
ECCCCCCHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
GELSRLGIPFACIAKGPGRVAGTEVFYFSNGEKLSLDPASKLMHFLCRLRDEAHRFAITS
HHHHHCCCCEEEEECCCCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHEEHHC
HRKSRDGKLQFSTLLNDIPGIGKTKGKAILAYFGSIQAMKHARVEEISKVPGISLKLAKR
CCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VADYLKESQTTLRA
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKNSNERLNDAFYALKKATCSVRKSVPGVYKMFGTEDRLLYVGKAKDLKKRLSSYLSINR
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHH
MSVNVYTMVKQIVRLEITVTENETEALLLEAKLIKSLKPKYNIIMRDDKFYPYILFSKHK
EEEHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCC
YPRIVLHREKRSEGRYTGLYGPFLSSVMTRHIIATIKKAFLLRSCPDNFFATRARPCIEY
CCEEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEE
EIKNCSAPCMQKITEEDYAKAVQMAHKALTGQSKEIQCELFEMMCRFSNNQDYESAIVCR
EECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
DRLHALKSMKECMGFQTGIHGDVDFIAVYKRQDLYCMQVVFFRDGVNYGSQPYFIESVGN
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCC
ASDADIVNMFMLQIYNDFPSVVYVDLPSDYDTNIMSTAIKQLMKREVDIRLPATRDELKA
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEECCCCHHHHHH
MGLARNYAMEALNRRVRNTAQDTDLEEFATFFDLLKAPERIEIYDNSHISGTHPYGVMVV
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEE
CGKDGLLKKEYRKFKINTVTNGDDCSMMHEVISRRFKEIPDVLPDFILIDGGRGQRSAVY
ECCCCCCHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
GELSRLGIPFACIAKGPGRVAGTEVFYFSNGEKLSLDPASKLMHFLCRLRDEAHRFAITS
HHHHHCCCCEEEEECCCCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHEEHHC
HRKSRDGKLQFSTLLNDIPGIGKTKGKAILAYFGSIQAMKHARVEEISKVPGISLKLAKR
CCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VADYLKESQTTLRA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA