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The map label for this gene is zitB [H]

Identifier: 88606868

GI number: 88606868

Start: 1455628

End: 1456533

Strand: Reverse

Name: zitB [H]

Synonym: APH_1395

Alternate gene names: 88606868

Gene position: 1456533-1455628 (Counterclockwise)

Preceding gene: 88607459

Following gene: 88607560

Centisome position: 99.0

GC content: 42.83

Gene sequence:

>906_bases
ATGTGGTGTGTAATGACAAGTTGCGATAGTCAGTATTCTCCTAGCATGCACAGACGGATGGTAATGGCCATTGTTGTAGT
AGCGTGCACGTTGGTAGTCGAGACAATCGGTGGTTTTGTATCGCACTCATTGGTTCTTCTTTCTGATGCAGGACATGTAT
TTATTGATTTAGTGGCGCTTATCCTGAGCTTTGCGGCGTACAGGTTGGCCACTAAAGAGGCTGATGAACAGAGATCTTAC
GGTTATCATCGGTTTCAGGTTATGGCAGCATTCGTCAATGGAATATCCTGGTTCGTCATAGCTGCTCTAATAGTAATTGA
GTCTATCAAACGTTTTGTGAACCCTGTGGAAGTGCACGGACATCTGATGCTACCCGTGGCTGTAGTAGGGTTTGCTGCAA
ATATCTTTGTATTTTGTATGATGTACAGAAGGGGGGAACATAATCTCAATATCCGCAGTGCTGTTCTGCATGTTATTGGA
GATCTCCTTTGTTCTGTGGCTGCTATTGCTTCATCGATAATCATCAGGTTTAGCGGGTGGCAGATAATAGACCCAATGTT
GTCTTTATTGGTCAGTACCGTGATGTTGATCAGCGCATTTAGTATTGTAAAAAACTCAAGTAACATTTTGCTCGAGGGCA
AGCCGTATAATATCGACGTAGGTGAGCTGCAAAGGAATATCACAAGTGCAATACCGAATGTAATTGATGTGCACCATGTG
CATCTTTGGTCATTAACTGCAGAGTATCCAATAATGACTATGCACGTGCGTATCGCCTGCGGTTCTTCTGACGTGGCAAG
TTCTGTACAAGTAGTTAAATCGATCAAGAAGTTGTTACAGGAAAGGTTTAGTATCTCGCATGTTACGATAGAGATCGAAC
ATGAAGAGTGTTCAGACGCTAATTAA

Upstream 100 bases:

>100_bases
TATCCTATTATAGCAAATATTGGGTGATTAGCTCAGGTGGTAGAGCGTTTGCTTGACGTGCAAAAGGCCACTGGTTCGAG
TCCAGTATCACCCACTCTTG

Downstream 100 bases:

>100_bases
GAAAAGTAGTCTAAAGGCGTATGTATTAATCTTACGATAATCACTACTGATTAGTATATTATACGTCGGTATTGTAATGG
TAGAGATGTTCTGGAAGTGC

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MWCVMTSCDSQYSPSMHRRMVMAIVVVACTLVVETIGGFVSHSLVLLSDAGHVFIDLVALILSFAAYRLATKEADEQRSY
GYHRFQVMAAFVNGISWFVIAALIVIESIKRFVNPVEVHGHLMLPVAVVGFAANIFVFCMMYRRGEHNLNIRSAVLHVIG
DLLCSVAAIASSIIIRFSGWQIIDPMLSLLVSTVMLISAFSIVKNSSNILLEGKPYNIDVGELQRNITSAIPNVIDVHHV
HLWSLTAEYPIMTMHVRIACGSSDVASSVQVVKSIKKLLQERFSISHVTIEIEHEECSDAN

Sequences:

>Translated_301_residues
MWCVMTSCDSQYSPSMHRRMVMAIVVVACTLVVETIGGFVSHSLVLLSDAGHVFIDLVALILSFAAYRLATKEADEQRSY
GYHRFQVMAAFVNGISWFVIAALIVIESIKRFVNPVEVHGHLMLPVAVVGFAANIFVFCMMYRRGEHNLNIRSAVLHVIG
DLLCSVAAIASSIIIRFSGWQIIDPMLSLLVSTVMLISAFSIVKNSSNILLEGKPYNIDVGELQRNITSAIPNVIDVHHV
HLWSLTAEYPIMTMHVRIACGSSDVASSVQVVKSIKKLLQERFSISHVTIEIEHEECSDAN
>Mature_301_residues
MWCVMTSCDSQYSPSMHRRMVMAIVVVACTLVVETIGGFVSHSLVLLSDAGHVFIDLVALILSFAAYRLATKEADEQRSY
GYHRFQVMAAFVNGISWFVIAALIVIESIKRFVNPVEVHGHLMLPVAVVGFAANIFVFCMMYRRGEHNLNIRSAVLHVIG
DLLCSVAAIASSIIIRFSGWQIIDPMLSLLVSTVMLISAFSIVKNSSNILLEGKPYNIDVGELQRNITSAIPNVIDVHHV
HLWSLTAEYPIMTMHVRIACGSSDVASSVQVVKSIKKLLQERFSISHVTIEIEHEECSDAN

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=308, Percent_Identity=25.3246753246753, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI21359890, Length=321, Percent_Identity=26.4797507788162, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI289803013, Length=273, Percent_Identity=29.3040293040293, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI289803009, Length=273, Percent_Identity=29.3040293040293, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI289803007, Length=273, Percent_Identity=29.3040293040293, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI289803003, Length=273, Percent_Identity=29.3040293040293, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI64762489, Length=273, Percent_Identity=29.3040293040293, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI21361112, Length=303, Percent_Identity=26.4026402640264, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI20070323, Length=308, Percent_Identity=25.974025974026, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI14210520, Length=221, Percent_Identity=26.2443438914027, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI52351208, Length=127, Percent_Identity=35.4330708661417, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI222080086, Length=109, Percent_Identity=37.6146788990826, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40255009, Length=109, Percent_Identity=37.6146788990826, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=285, Percent_Identity=41.4035087719298, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI193210990, Length=311, Percent_Identity=28.2958199356913, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17555794, Length=308, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17555796, Length=285, Percent_Identity=29.1228070175439, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32564488, Length=306, Percent_Identity=25.1633986928105, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320411, Length=235, Percent_Identity=29.3617021276596, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323899, Length=136, Percent_Identity=33.8235294117647, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=155, Percent_Identity=25.8064516129032, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24583858, Length=318, Percent_Identity=26.4150943396226, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24656728, Length=351, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24656724, Length=351, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24656720, Length=351, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24656715, Length=351, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357035, Length=351, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24584409, Length=160, Percent_Identity=28.125, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574430, Length=160, Percent_Identity=28.125, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585900, Length=135, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585898, Length=135, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585896, Length=135, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921672, Length=135, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24645863, Length=103, Percent_Identity=36.8932038834951, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33317; Mature: 33317

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWCVMTSCDSQYSPSMHRRMVMAIVVVACTLVVETIGGFVSHSLVLLSDAGHVFIDLVAL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHH
ILSFAAYRLATKEADEQRSYGYHRFQVMAAFVNGISWFVIAALIVIESIKRFVNPVEVHG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCC
HLMLPVAVVGFAANIFVFCMMYRRGEHNLNIRSAVLHVIGDLLCSVAAIASSIIIRFSGW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QIIDPMLSLLVSTVMLISAFSIVKNSSNILLEGKPYNIDVGELQRNITSAIPNVIDVHHV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHH
HLWSLTAEYPIMTMHVRIACGSSDVASSVQVVKSIKKLLQERFSISHVTIEIEHEECSDA
EEEEEECCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCCC
N
C
>Mature Secondary Structure
MWCVMTSCDSQYSPSMHRRMVMAIVVVACTLVVETIGGFVSHSLVLLSDAGHVFIDLVAL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHH
ILSFAAYRLATKEADEQRSYGYHRFQVMAAFVNGISWFVIAALIVIESIKRFVNPVEVHG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCC
HLMLPVAVVGFAANIFVFCMMYRRGEHNLNIRSAVLHVIGDLLCSVAAIASSIIIRFSGW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QIIDPMLSLLVSTVMLISAFSIVKNSSNILLEGKPYNIDVGELQRNITSAIPNVIDVHHV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHH
HLWSLTAEYPIMTMHVRIACGSSDVASSVQVVKSIKKLLQERFSISHVTIEIEHEECSDA
EEEEEECCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]