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The map label for this gene is icd [H]

Identifier: 88606810

GI number: 88606810

Start: 1232135

End: 1233568

Strand: Reverse

Name: icd [H]

Synonym: APH_1166

Alternate gene names: 88606810

Gene position: 1233568-1232135 (Counterclockwise)

Preceding gene: 88607355

Following gene: 88607079

Centisome position: 83.84

GC content: 44.77

Gene sequence:

>1434_bases
ATGTCGGTACCGATAACAGTAGCTTATGGAGATGGTATAGGACCGGAAATTATGGAGGCTGTACTTCTAATATTAAAAGA
AGCACAGGCGGATATAGCGGTTGAAACTGCGGAGATAGGTCATGCACAGTATAAAAGGGACTGGCCCTGTGGTATCGCTC
CGTCTTCTTGGGCTTCTATCCGTAGAACCAAAGTCTTACTGAAGTCTCCTACTATGACTCCTCAAGGTGGAGGCCATAAG
AGCTTAAATGTCGCGTTACGTAAGAGCTTAGGTTTATACGCAAACGTGCGTCCCTGTGTCACGTATTCTCCTATCATAGA
TACCGGAAGTACTAATCTCGATATCGTGGTAGTCCGCGAAAATGAAGAGGACACGTATTGTGGTGTAGAGTATAGGATAT
CTCAAGATGCCTCGGTATGTGATAAAATTACCACAAGATCTGCTTCCGAAAGGCTCTGTGCGTATGCGTTTCGCTATGCC
CGAAGCCATAATAGAAAGCGGGTGACCTGTCTGATCAAGGATAATATTATGAAAATGACGGATGGGACATTTCGCAGTGC
CTTTCAAAAAATTGCTGCGATGTACCCTGACATATCTTCAGAGTACTGCATAGTGGATATAGGCATGGCAAGGATTGCTG
CACATCCTGAAGAATACGATGTAGTGGTAACTCCTAACCTGTATGGTGATATATTATCAGATGTTGTGGCTGTAGCTTCG
GGCTCCATTGGACTGTCAGGTAGTGCAAATCTCGGAGAAGAATACGCAATGTTTGAAGCAGTACACGGTTCTGCTCCAGA
TATAGCCGGACAAAATATAGCGAATCCGTCAGGGCTACTTAACGCTGCAGTGCAGATGCTGGTGCATATTGGACAAGAAT
CCACCGCCCAGGCCATATATAATGCGTTTTTGAAAACTTTAGAAGATGGTGTACATACTGCCGATATTTACAATGCAAAA
ACCAGCTCTAGTAGGGCTTCTACCACTGAGTTTGCGCAAGCTGTTGTAAATAATCTTGGAACTTCCCCAAAGTATCTACG
CAGCATGTTGATAAATAAGAATACCGAGGAGGCTATGCACTATGAGCGTGTGCAAGATACCTCTAAGAAGGTATTAGTTG
GAGCGGATGTAACAATCCATTGGTCTGGTGGTGACGGGTTAAATGAGTTGGTGCAATCTTTAGCGGCAGCCCTGCCTCCT
TCTGTCAAACTACGTCTCATACACGCGAAGGGCCTGGAGTTATGGCCTAATGCCCCATGTGTTTGTTCGTATATTGATCT
TTTGACATGCCGATTCGTCTATGATGCACAGGAAGGTGCGGATTCTACTTCTATTAGTCAATTATTGCTTTGCCTTGAAG
GGCTTGGTCTTGACGTTGTAAAACTGGTCAAGCTATACACATTTGATGGAGTGGAGGGCTTTTTCACGCCATAG

Upstream 100 bases:

>100_bases
ACGGAAAATACAGTCGGGTTCTTTGGGCTATACAATCTTAGGTACTTCCTGATTCTACAAAGATGCGCTATACTACTGCG
TTTTTTGGACAGGGAAGAAA

Downstream 100 bases:

>100_bases
ATAGTAAAGGATTTTATCGATTATCCACCGCGTTACTGTTGGTAAGAAGTTGTGTTACGCAGGATATGCTCTACGTGAGC
GAGTTATGGGGTGTTGCTTC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSVPITVAYGDGIGPEIMEAVLLILKEAQADIAVETAEIGHAQYKRDWPCGIAPSSWASIRRTKVLLKSPTMTPQGGGHK
SLNVALRKSLGLYANVRPCVTYSPIIDTGSTNLDIVVVRENEEDTYCGVEYRISQDASVCDKITTRSASERLCAYAFRYA
RSHNRKRVTCLIKDNIMKMTDGTFRSAFQKIAAMYPDISSEYCIVDIGMARIAAHPEEYDVVVTPNLYGDILSDVVAVAS
GSIGLSGSANLGEEYAMFEAVHGSAPDIAGQNIANPSGLLNAAVQMLVHIGQESTAQAIYNAFLKTLEDGVHTADIYNAK
TSSSRASTTEFAQAVVNNLGTSPKYLRSMLINKNTEEAMHYERVQDTSKKVLVGADVTIHWSGGDGLNELVQSLAAALPP
SVKLRLIHAKGLELWPNAPCVCSYIDLLTCRFVYDAQEGADSTSISQLLLCLEGLGLDVVKLVKLYTFDGVEGFFTP

Sequences:

>Translated_477_residues
MSVPITVAYGDGIGPEIMEAVLLILKEAQADIAVETAEIGHAQYKRDWPCGIAPSSWASIRRTKVLLKSPTMTPQGGGHK
SLNVALRKSLGLYANVRPCVTYSPIIDTGSTNLDIVVVRENEEDTYCGVEYRISQDASVCDKITTRSASERLCAYAFRYA
RSHNRKRVTCLIKDNIMKMTDGTFRSAFQKIAAMYPDISSEYCIVDIGMARIAAHPEEYDVVVTPNLYGDILSDVVAVAS
GSIGLSGSANLGEEYAMFEAVHGSAPDIAGQNIANPSGLLNAAVQMLVHIGQESTAQAIYNAFLKTLEDGVHTADIYNAK
TSSSRASTTEFAQAVVNNLGTSPKYLRSMLINKNTEEAMHYERVQDTSKKVLVGADVTIHWSGGDGLNELVQSLAAALPP
SVKLRLIHAKGLELWPNAPCVCSYIDLLTCRFVYDAQEGADSTSISQLLLCLEGLGLDVVKLVKLYTFDGVEGFFTP
>Mature_476_residues
SVPITVAYGDGIGPEIMEAVLLILKEAQADIAVETAEIGHAQYKRDWPCGIAPSSWASIRRTKVLLKSPTMTPQGGGHKS
LNVALRKSLGLYANVRPCVTYSPIIDTGSTNLDIVVVRENEEDTYCGVEYRISQDASVCDKITTRSASERLCAYAFRYAR
SHNRKRVTCLIKDNIMKMTDGTFRSAFQKIAAMYPDISSEYCIVDIGMARIAAHPEEYDVVVTPNLYGDILSDVVAVASG
SIGLSGSANLGEEYAMFEAVHGSAPDIAGQNIANPSGLLNAAVQMLVHIGQESTAQAIYNAFLKTLEDGVHTADIYNAKT
SSSRASTTEFAQAVVNNLGTSPKYLRSMLINKNTEEAMHYERVQDTSKKVLVGADVTIHWSGGDGLNELVQSLAAALPPS
VKLRLIHAKGLELWPNAPCVCSYIDLLTCRFVYDAQEGADSTSISQLLLCLEGLGLDVVKLVKLYTFDGVEGFFTP

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=310, Percent_Identity=41.6129032258065, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI4758582, Length=339, Percent_Identity=36.5781710914454, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI28178838, Length=308, Percent_Identity=37.6623376623377, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI28178821, Length=344, Percent_Identity=32.5581395348837, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI28178816, Length=305, Percent_Identity=34.4262295081967, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI28178819, Length=204, Percent_Identity=34.8039215686275, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1787381, Length=393, Percent_Identity=30.7888040712468, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1788101, Length=354, Percent_Identity=30.7909604519774, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI87081683, Length=348, Percent_Identity=29.0229885057471, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71986051, Length=324, Percent_Identity=41.6666666666667, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI25144293, Length=341, Percent_Identity=36.3636363636364, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17505779, Length=326, Percent_Identity=35.5828220858896, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17550882, Length=343, Percent_Identity=32.0699708454811, Blast_Score=172, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324709, Length=341, Percent_Identity=40.7624633431085, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324291, Length=342, Percent_Identity=36.8421052631579, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322097, Length=360, Percent_Identity=31.3888888888889, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319830, Length=269, Percent_Identity=28.6245353159851, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643270, Length=339, Percent_Identity=41.2979351032448, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24643268, Length=339, Percent_Identity=41.2979351032448, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24661184, Length=342, Percent_Identity=39.1812865497076, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI161078635, Length=322, Percent_Identity=34.1614906832298, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI161078633, Length=322, Percent_Identity=34.1614906832298, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24650122, Length=322, Percent_Identity=34.1614906832298, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI161078637, Length=322, Percent_Identity=34.1614906832298, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI161078639, Length=317, Percent_Identity=34.384858044164, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI281362242, Length=343, Percent_Identity=33.8192419825073, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24648872, Length=343, Percent_Identity=33.8192419825073, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20130355, Length=340, Percent_Identity=26.7647058823529, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI45550436, Length=207, Percent_Identity=22.7053140096618, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 51652; Mature: 51521

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPITVAYGDGIGPEIMEAVLLILKEAQADIAVETAEIGHAQYKRDWPCGIAPSSWASI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEHHHHCCHHHCCCCCCCCCCCHHHHH
RRTKVLLKSPTMTPQGGGHKSLNVALRKSLGLYANVRPCVTYSPIIDTGSTNLDIVVVRE
HHHHHEEECCCCCCCCCCCCHHHHHHHHHCCCEECCCCCEEECCEECCCCCCEEEEEEEE
NEEDTYCGVEYRISQDASVCDKITTRSASERLCAYAFRYARSHNRKRVTCLIKDNIMKMT
CCCCCEECEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHC
DGTFRSAFQKIAAMYPDISSEYCIVDIGMARIAAHPEEYDVVVTPNLYGDILSDVVAVAS
CCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHC
GSIGLSGSANLGEEYAMFEAVHGSAPDIAGQNIANPSGLLNAAVQMLVHIGQESTAQAIY
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
NAFLKTLEDGVHTADIYNAKTSSSRASTTEFAQAVVNNLGTSPKYLRSMLINKNTEEAMH
HHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
YERVQDTSKKVLVGADVTIHWSGGDGLNELVQSLAAALPPSVKLRLIHAKGLELWPNAPC
HHHHHCCCCEEEEECCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCH
VCSYIDLLTCRFVYDAQEGADSTSISQLLLCLEGLGLDVVKLVKLYTFDGVEGFFTP
HHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SVPITVAYGDGIGPEIMEAVLLILKEAQADIAVETAEIGHAQYKRDWPCGIAPSSWASI
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEHHHHCCHHHCCCCCCCCCCCHHHHH
RRTKVLLKSPTMTPQGGGHKSLNVALRKSLGLYANVRPCVTYSPIIDTGSTNLDIVVVRE
HHHHHEEECCCCCCCCCCCCHHHHHHHHHCCCEECCCCCEEECCEECCCCCCEEEEEEEE
NEEDTYCGVEYRISQDASVCDKITTRSASERLCAYAFRYARSHNRKRVTCLIKDNIMKMT
CCCCCEECEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHC
DGTFRSAFQKIAAMYPDISSEYCIVDIGMARIAAHPEEYDVVVTPNLYGDILSDVVAVAS
CCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHC
GSIGLSGSANLGEEYAMFEAVHGSAPDIAGQNIANPSGLLNAAVQMLVHIGQESTAQAIY
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
NAFLKTLEDGVHTADIYNAKTSSSRASTTEFAQAVVNNLGTSPKYLRSMLINKNTEEAMH
HHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
YERVQDTSKKVLVGADVTIHWSGGDGLNELVQSLAAALPPSVKLRLIHAKGLELWPNAPC
HHHHHCCCCEEEEECCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCH
VCSYIDLLTCRFVYDAQEGADSTSISQLLLCLEGLGLDVVKLVKLYTFDGVEGFFTP
HHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA