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The map label for this gene is hemH [H]

Identifier: 87201348

GI number: 87201348

Start: 3558219

End: 3559232

Strand: Direct

Name: hemH [H]

Synonym: Saro_3336

Alternate gene names: 87201348

Gene position: 3558219-3559232 (Clockwise)

Preceding gene: 87201347

Following gene: 87201349

Centisome position: 99.91

GC content: 67.26

Gene sequence:

>1014_bases
ATGCAGCGCCCCGCAGACCACCCCACTGTTCTCACCGGCAAGGTCGGGGTGCTTCTGGTCAACCTCGGCACGCCCGATGC
GCCCGATGCGGGCGCGGTGAAGCGCTATCTCAAGGAGTTCCTGTCCGACCGCCGTGTGGTGGAAATTCCCGCGCTCGTCT
GGCAGCCGATCCTGCGTGGCATCATCCTGAACACGCGCCCCCGGAAATCAGCGCACGCCTACGCCCAGGTATGGACGGAT
GAGGGATCGCCGCTGGCCGCGATCACGGCCGCGCAGGCACGCGCGCTTCAGGCACGGCTGGGCGAAAGCGCGATCGTGCG
GCACGCAATGCGCTACCAATCGCCCGCCATGGCGAAAGAGCTGGACGCGCTGCTGCAGGCCGGGTGCGAGCGCATTCTCG
TCGCGCCGCTCTACCCGCACTATTCGGGGGCGACGACGGCTTCCGCGCTCGATGCGGTGGCAGACTGGATCAAGGCGCGT
CGCCGCCTTCCCGCACTGCGCACCCTGCCGCCTTATCACGACGATCCGGCCTATATCGGCGCGCTTCACGCCGACCTCTC
GCGCCAGATCGACGCTCTCGACTTCGCGCCCGAACTGCTGCTGCTGAGTTATCACGGCATGCCCGAACGGACGCTGCACT
TGGGCGACCCCTACCACTGCCACTGCCGCAAGACCTCGCGCCTGCTGGGCGAGCGTTTTGCGCAGAGCAATCCGGCGCTG
CGGCTGGAGACCACGTTCCAGTCGCGTTTCGGCAAGGCAAAGTGGCTCGAGCCTGCAACCGATGCCGTGCTGGTCGACGA
AGCTCGCAAGGGCACGCGCCGCATCGCCATCGCCGCGCCCGGGTTTTCCGCCGATTGCCTGGAAACGCTCGAGGAACTGG
CGATCCGCGGCAAGGAAGATTTCGTCGCGGCGGGTGGTACGCACTTCGCCTCGCTCGCCTGTCTCAATGCGGGCGACGAC
GGCATGGACATGATCGAGGCGCTGGTCCGGCGCGAGCTTTCGGGCTGGATCTGA

Upstream 100 bases:

>100_bases
AATGGTCGCGGTGGCCCCGGCCATCGCCAATGCGCTGTTCTCCGCCACGGGCGTGCGCTTCCGCCGCCTGCCGCTCATTT
CCGAAGGACTTTGATTGCCG

Downstream 100 bases:

>100_bases
ACGTCCGACCAGAGCCGACATACGGCCTTGGCCCCTGTTGACATGCATGTTAATTACCCGGTTAAATCAGCCCACCGGGA
GAGAGCATGGCCAGCATCGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQRPADHPTVLTGKVGVLLVNLGTPDAPDAGAVKRYLKEFLSDRRVVEIPALVWQPILRGIILNTRPRKSAHAYAQVWTD
EGSPLAAITAAQARALQARLGESAIVRHAMRYQSPAMAKELDALLQAGCERILVAPLYPHYSGATTASALDAVADWIKAR
RRLPALRTLPPYHDDPAYIGALHADLSRQIDALDFAPELLLLSYHGMPERTLHLGDPYHCHCRKTSRLLGERFAQSNPAL
RLETTFQSRFGKAKWLEPATDAVLVDEARKGTRRIAIAAPGFSADCLETLEELAIRGKEDFVAAGGTHFASLACLNAGDD
GMDMIEALVRRELSGWI

Sequences:

>Translated_337_residues
MQRPADHPTVLTGKVGVLLVNLGTPDAPDAGAVKRYLKEFLSDRRVVEIPALVWQPILRGIILNTRPRKSAHAYAQVWTD
EGSPLAAITAAQARALQARLGESAIVRHAMRYQSPAMAKELDALLQAGCERILVAPLYPHYSGATTASALDAVADWIKAR
RRLPALRTLPPYHDDPAYIGALHADLSRQIDALDFAPELLLLSYHGMPERTLHLGDPYHCHCRKTSRLLGERFAQSNPAL
RLETTFQSRFGKAKWLEPATDAVLVDEARKGTRRIAIAAPGFSADCLETLEELAIRGKEDFVAAGGTHFASLACLNAGDD
GMDMIEALVRRELSGWI
>Mature_337_residues
MQRPADHPTVLTGKVGVLLVNLGTPDAPDAGAVKRYLKEFLSDRRVVEIPALVWQPILRGIILNTRPRKSAHAYAQVWTD
EGSPLAAITAAQARALQARLGESAIVRHAMRYQSPAMAKELDALLQAGCERILVAPLYPHYSGATTASALDAVADWIKAR
RRLPALRTLPPYHDDPAYIGALHADLSRQIDALDFAPELLLLSYHGMPERTLHLGDPYHCHCRKTSRLLGERFAQSNPAL
RLETTFQSRFGKAKWLEPATDAVLVDEARKGTRRIAIAAPGFSADCLETLEELAIRGKEDFVAAGGTHFASLACLNAGDD
GMDMIEALVRRELSGWI

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=304, Percent_Identity=26.6447368421053, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI60499025, Length=293, Percent_Identity=26.962457337884, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786681, Length=316, Percent_Identity=43.6708860759494, Blast_Score=237, Evalue=8e-64,
Organism=Drosophila melanogaster, GI17864156, Length=306, Percent_Identity=22.8758169934641, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36919; Mature: 36919

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPADHPTVLTGKVGVLLVNLGTPDAPDAGAVKRYLKEFLSDRRVVEIPALVWQPILRG
CCCCCCCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
IILNTRPRKSAHAYAQVWTDEGSPLAAITAAQARALQARLGESAIVRHAMRYQSPAMAKE
HHCCCCCCCHHHHHHEEECCCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHH
LDALLQAGCERILVAPLYPHYSGATTASALDAVADWIKARRRLPALRTLPPYHDDPAYIG
HHHHHHHCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHH
ALHADLSRQIDALDFAPELLLLSYHGMPERTLHLGDPYHCHCRKTSRLLGERFAQSNPAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHCCCCCE
RLETTFQSRFGKAKWLEPATDAVLVDEARKGTRRIAIAAPGFSADCLETLEELAIRGKED
EEEEHHHHHCCCCCCCCCCCCCEEHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCC
FVAAGGTHFASLACLNAGDDGMDMIEALVRRELSGWI
EEECCCCHHHHEEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQRPADHPTVLTGKVGVLLVNLGTPDAPDAGAVKRYLKEFLSDRRVVEIPALVWQPILRG
CCCCCCCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
IILNTRPRKSAHAYAQVWTDEGSPLAAITAAQARALQARLGESAIVRHAMRYQSPAMAKE
HHCCCCCCCHHHHHHEEECCCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHH
LDALLQAGCERILVAPLYPHYSGATTASALDAVADWIKARRRLPALRTLPPYHDDPAYIG
HHHHHHHCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHH
ALHADLSRQIDALDFAPELLLLSYHGMPERTLHLGDPYHCHCRKTSRLLGERFAQSNPAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHCCCCCE
RLETTFQSRFGKAKWLEPATDAVLVDEARKGTRRIAIAAPGFSADCLETLEELAIRGKED
EEEEHHHHHCCCCCCCCCCCCCEEHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCC
FVAAGGTHFASLACLNAGDDGMDMIEALVRRELSGWI
EEECCCCHHHHEEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA